LOCUS       NP_001386405             437 aa            linear   ROD 01-APR-2024
DEFINITION  GTPase Era, mitochondrial isoform 1 [Rattus norvegicus].
ACCESSION   NP_001386405 XP_038942413
VERSION     NP_001386405.1
DBSOURCE    REFSEQ: accession NM_001399476.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 437)
  AUTHORS   Chatzispyrou,I.A., Alders,M., Guerrero-Castillo,S., Zapata
            Perez,R., Haagmans,M.A., Mouchiroud,L., Koster,J., Ofman,R.,
            Baas,F., Waterham,H.R., Spelbrink,J.N., Auwerx,J., Mannens,M.M.,
            Houtkooper,R.H. and Plomp,A.S.
  TITLE     A homozygous missense mutation in ERAL1, encoding a mitochondrial
            rRNA chaperone, causes Perrault syndrome
  JOURNAL   Hum Mol Genet 26 (13), 2541-2550 (2017)
   PUBMED   28449065
REFERENCE   2  (residues 1 to 437)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (residues 1 to 437)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (residues 1 to 437)
  AUTHORS   Zhong,Y.Q., Li,K.C. and Zhang,X.
  TITLE     Potentiation of excitatory transmission in substantia gelatinosa
            neurons of rat spinal cord by inhibition of estrogen receptor alpha
  JOURNAL   Mol Pain 6, 92 (2010)
   PUBMED   21143988
  REMARK    GeneRIF: nociceptive transmission evoked by Adelta- and C-fiber
            stimulation could be potentiated by blocking ERalpha in the spinal
            neurons. Thus, the spinal estrogen may negatively regulate the
            nociceptive transmission through the activation of ERalpha.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 437)
  AUTHORS   Dennerlein,S., Rozanska,A., Wydro,M., Chrzanowska-Lightowlers,Z.M.
            and Lightowlers,R.N.
  TITLE     Human ERAL1 is a mitochondrial RNA chaperone involved in the
            assembly of the 28S small mitochondrial ribosomal subunit
  JOURNAL   Biochem J 430 (3), 551-558 (2010)
   PUBMED   20604745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 10, 2022 this sequence version replaced XP_038942413.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.40639.1,
                                           SRR26643297.34986.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     Protein         1..437
                     /product="GTPase Era, mitochondrial isoform 1"
                     /note="GTPase Era, mitochondrial; ERA-like protein 1;
                     Era-like 1; GTP-binding protein era homolog; Era
                     (G-protein)-like 1"
                     /calculated_mol_wt=46124
     transit_peptide 1..20
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q5EBA0.2)"
                     /calculated_mol_wt=2274
     mat_peptide     21..437
                     /product="GTPase Era, mitochondrial. /id=PRO_0000404546"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EBA0.2)"
                     /calculated_mol_wt=46124
     Region          116..434
                     /region_name="era"
                     /note="GTPase Era; Reviewed; PRK00089"
                     /db_xref="CDD:234624"
     Region          120..127
                     /region_name="G1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01050"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EBA0.2)"
     Region          146..150
                     /region_name="G2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01050"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EBA0.2)"
     Region          167..170
                     /region_name="G3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01050"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EBA0.2)"
     Site            173
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75616; propagated from
                     UniProtKB/Swiss-Prot (Q5EBA0.2)"
     Region          236..239
                     /region_name="G4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01050"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EBA0.2)"
     Region          272..293
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EBA0.2)"
     Region          308..310
                     /region_name="G5.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01050"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EBA0.2)"
     CDS             1..437
                     /gene="Eral1"
                     /coded_by="NM_001399476.1:14..1327"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:363646"
                     /db_xref="RGD:1304714"
ORIGIN      
        1 maaprryfpg ivrallgawq vgshagrewv sppgsllgnh vrcvscvvga tfsgpllasa
       61 ssrygqdsal drilgfpqpd sslvpcvpav svhrdeqnll lvhtpdmpen prvlrvvllg
      121 apnagkstls nqllgrkvfp vskkvhttrc qalgviteke tqvilldtpg iispvkqkrh
      181 hlelslledp wksmesadlv vvlvdvsdkw trsrlspqvl qcltkfsqvp silvlnkvdc
      241 lkqksvllel taaltegvvn gkmlnvrqaf rsrpsthcpg petedpntha vrspqrtgwp
      301 yfqeifmlsa lnnkdvntlk qylltqaqpg pwefhsgvlt sqtpeeican kireklleyl
      361 peevpysvqq ktviweegps gelviqqnll vpkeshvril igqkgllisq iaqevsqdlm
      421 diflcdvllr lsvkllk
//
