LOCUS       NM_001107037            2690 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus eosinophil peroxidase (Epx), mRNA.
ACCESSION   NM_001107037 XM_001081178 XM_220834
VERSION     NM_001107037.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2690)
  AUTHORS   Mukherjee M, Bulir DC, Radford K, Kjarsgaard M, Huang CM, Jacobsen
            EA, Ochkur SI, Catuneanu A, Lamothe-Kipnes H, Mahony J, Lee JJ,
            Lacy P and Nair PK.
  TITLE     Sputum autoantibodies in patients with severe eosinophilic asthma
  JOURNAL   J Allergy Clin Immunol 141 (4), 1269-1279 (2018)
   PUBMED   28751233
REFERENCE   2  (bases 1 to 2690)
  AUTHORS   Rank MA, Ochkur SI, Lewis JC, Teaford HG 3rd, Wesselius LJ, Helmers
            RA, Lee NA, Nair P and Lee JJ.
  TITLE     Nasal and pharyngeal eosinophil peroxidase levels in adults with
            poorly controlled asthma correlate with sputum eosinophilia
  JOURNAL   Allergy 71 (4), 567-570 (2016)
   PUBMED   26645423
REFERENCE   3  (bases 1 to 2690)
  AUTHORS   Broekema M, Timens W, Vonk JM, Volbeda F, Lodewijk ME, Hylkema MN,
            Ten Hacken NH and Postma DS.
  TITLE     Persisting remodeling and less airway wall eosinophil activation in
            complete remission of asthma
  JOURNAL   Am J Respir Crit Care Med 183 (3), 310-316 (2011)
   PUBMED   20813885
REFERENCE   4  (bases 1 to 2690)
  AUTHORS   Specht S, Saeftel M, Arndt M, Endl E, Dubben B, Lee NA, Lee JJ and
            Hoerauf A.
  TITLE     Lack of eosinophil peroxidase or major basic protein impairs
            defense against murine filarial infection
  JOURNAL   Infect Immun 74 (9), 5236-5243 (2006)
   PUBMED   16926417
REFERENCE   5  (bases 1 to 2690)
  AUTHORS   Khalil Kalaajieh W and Hoilat R.
  TITLE     Asthma attack severity and urinary concentration of eosinophil X
            protein in children
  JOURNAL   Allergol Immunopathol (Madr) 30 (4), 225-231 (2002)
   PUBMED   12199967
REFERENCE   6  (bases 1 to 2690)
  AUTHORS   Oymar K.
  TITLE     High levels of urinary eosinophil protein X in young asthmatic
            children predict persistent atopic asthma
  JOURNAL   Pediatr Allergy Immunol 12 (6), 312-317 (2001)
   PUBMED   11846868
REFERENCE   7  (bases 1 to 2690)
  AUTHORS   Horton MA, Larson KA, Lee JJ and Lee NA.
  TITLE     Cloning of the murine eosinophil peroxidase gene (mEPO):
            characterization of a conserved subgroup of mammalian hematopoietic
            peroxidases
  JOURNAL   J Leukoc Biol 60 (2), 285-294 (1996)
   PUBMED   8773591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_220834.4, XM_001081178.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2690
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2690
                     /gene="Epx"
                     /note="eosinophil peroxidase"
                     /db_xref="GeneID:303414"
                     /db_xref="RGD:1311882"
     exon            1..196
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2268
                     /gene="Epx"
                     /EC_number="1.11.1.7"
                     /codon_start=1
                     /product="eosinophil peroxidase precursor"
                     /protein_id="NP_001100507.1"
                     /db_xref="GeneID:303414"
                     /db_xref="RGD:1311882"
                     /translation="MQLLLALLGVLATFILTQLAEGTVPAPPSPVENSVLQDCIAEAK
                     LLVDTAYNRTQKSIVQRLQSGSASPMDLLAYFKQPVAATRRVVQAADYMHVALGLLEE
                     KLQPQESRPFNVTDVLTEPQLRLLSQASGCALQDQVEKCSNKYRTITGRCNNRRRPWL
                     GASNQALARWLPAEYEDHRSLPFGWTPGKRRNGFLLPLVRAVSNQIVRFPSKKLTSDQ
                     GRSLMFMQWGQFIDHDLDFTPESPARVTFNMGVDCEKTCAQLPPCFPIKIPPNDPRIK
                     SQRDCIPFFRSAPACPQNRNKVRNQINSLTSFVDASMVYGSEVSLALRLRNRTNYLGL
                     LATNQQFQDNGRALLPFDNLHEDPCLLTNRLVRIPCFLAGDSRASETPKLAALHTLFV
                     REHNRLATELKRLNPHWSGDKLYNEARKIVGAMVQIITYRDFLPLVLGKARMRRTLGP
                     YRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRTSAPNSHVLLSSAFFASWR
                     IVYEGGIDPILRGLMATPAKLNRQDSMLVDELRDKLFQQVRRIGLDLAALNMQRSRDH
                     GLPGYNAWRRFCGLSQPRNLAQLSRVLKNRNLARKFLNLYKTPDNIDIWVGAIAEPLL
                     PGARVGPLLACLFENQFRRARDGDRFWWQKWGVFTKRQRKALRRISLSRIVCDNTGIS
                     TVSRDIFRANIYPQGFVSCSRIPKLNLSAWRGK"
     exon            197..290
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            291..466
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            467..584
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            585..714
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            715..921
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1240
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1401
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1657
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1828
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2066
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2279
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2690
                     /gene="Epx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtaagcag aaagaaacca tctcaggtcc tctagaggag agaggaacgg gacactcacc
       61 tccgtggtgt ccgtgggtat tgcttgcctg ctcggctgta gcgagggttc tgcttgcacg
      121 atgcagctgc tgctggccct gttaggggtc ttagccacgt tcatcctcac acaactcgct
      181 gagggcactg tcccagctcc ccccagtcca gtggagaatt cagtccttca agactgcata
      241 gcagaggcga agttgctggt ggacactgcc tacaatcgga cacagaagag cattgtgcag
      301 cgtcttcaaa gcggctcggc cagccccatg gacctcctgg cctacttcaa acagccagta
      361 gcagccacca gaagagttgt tcaggcggct gattatatgc atgtggcctt agggctgctg
      421 gaagagaagc ttcagcctca ggaatccaga cccttcaatg tcactgatgt gctcacagaa
      481 ccgcagctgc gcctgctgtc ccaggccagt ggctgtgctc tccaggacca ggtcgagaag
      541 tgcagcaaca aataccgaac tataacaggg agatgcaaca acaggaggag accctggctg
      601 ggagcttcca accaggccct ggcccgctgg ttaccagctg agtatgaaga ccacaggtct
      661 ctccccttcg gctggacccc tggcaagagg cggaatggct tcctccttcc tcttgtccgg
      721 gctgtctcca atcagattgt gcgcttcccc agtaagaagc tgacctcaga ccagggccgg
      781 tccctcatgt tcatgcagtg gggccagttc atcgaccatg acttggactt caccccagag
      841 tccccagcca gagtgacctt caacatgggc gtggactgtg agaagacctg tgcccagctg
      901 cctccctgct tccccatcaa gataccaccc aatgaccccc gcatcaagag ccagcgagac
      961 tgcatccctt tcttccgctc tgcccctgcg tgcccccaaa acaggaacaa ggtccgtaac
     1021 cagattaact cgcttacatc cttcgtggac gccagcatgg tgtatggcag tgaggtgtcc
     1081 ctcgccctgc gacttcgaaa tcggaccaac tacctggggc tcctggccac taaccagcaa
     1141 ttccaggaca atggccgagc cctactgcct ttcgacaacc tgcatgagga cccttgtctc
     1201 ctgactaacc gattagtacg catcccgtgc ttcctggcag gtgacagtcg ggcaagtgaa
     1261 acccccaaac tggcggcctt gcacacgcta tttgtgagag aacacaatcg cctagccaca
     1321 gagctgaagc gtctgaatcc ccactggagt ggagacaagc tgtacaatga agcccggaag
     1381 atcgtgggtg ccatggtcca gatcatcacc taccgagact ttctgcctct ggttctgggc
     1441 aaggcccgga tgagaagaac cttgggtccc tacagagggt actgctccaa cgtggacccc
     1501 cgcgtagcca atgtcttcac cctggctttc cgcttcggcc acaccatgct gcagcccttc
     1561 atgttccgtt tggacagcca gtaccggacc tcagcaccca actcccacgt tctgctcagc
     1621 tctgctttct tcgccagctg gcgtattgta tacgaaggtg gcatcgaccc tatcctccga
     1681 ggtctcatgg ccaccccagc taagctgaac cggcaagatt ccatgctggt ggatgagctt
     1741 cgggacaagt tgtttcagca agtgagaagg atcgggctgg atctggcagc tctaaacatg
     1801 cagcgcagcc gggaccacgg gcttccagga tacaatgcct ggaggcgctt ctgtggcctt
     1861 tcccagcccc gaaacttagc ccagcttagt cgggtgctaa aaaatcggaa tttggcaagg
     1921 aagtttctga acctgtacaa gacgcccgac aacattgaca tctgggtggg agccatagca
     1981 gagcctcttc tgccgggggc ccgagtgggg cctcttctgg cttgtctttt tgagaaccag
     2041 ttcagaagag cccgagacgg agacagattc tggtggcaga aatggggcgt tttcaccaaa
     2101 agacaacgca aagccctgag gcgaatttct ttatctcgga ttgtgtgcga caatactggc
     2161 atcagcaccg tttcgaggga catcttcagg gctaacatct acccacaggg ttttgtgagc
     2221 tgtagccgta ttcccaagtt gaacctgtca gcctggcgag gcaaatgagg cttctgcagg
     2281 attctacgcc aggaccccaa gccttggaga tgagggcaac ggggagatca tgaggctgct
     2341 ctctcccccg caaaccactg tttcctgctg gagcttttgc tggttacact gagagctggc
     2401 tttgctggtt gagagtatca agggtgctat ggcaacaggc ccacttacct tgggaacctc
     2461 ttagatatca ggctatgaat cagcaccaga tataggagcc tatgagccgg gccataagac
     2521 tttgaggtct cagcaagaca ctgcgggagg gcttccagca ccttcttctg cccctgcccc
     2581 ccagcatgac tggaaggcca cagtcctggc tctcagctat cccatcttcc tcggggcccg
     2641 caggaacagc agcactgata cttcttctac caataaaaca atgcaagggc
//
