LOCUS       NM_001399667            3085 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Rattus norvegicus EPS8 signaling adaptor L2 (Eps8l2), mRNA.
ACCESSION   NM_001399667 XM_006230562
VERSION     NM_001399667.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3085)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3085)
  AUTHORS   Furness,D.N., Johnson,S.L., Manor,U., Ruttiger,L., Tocchetti,A.,
            Offenhauser,N., Olt,J., Goodyear,R.J., Vijayakumar,S., Dai,Y.,
            Hackney,C.M., Franz,C., Di Fiore,P.P., Masetto,S., Jones,S.M.,
            Knipper,M., Holley,M.C., Richardson,G.P., Kachar,B. and Marcotti,W.
  TITLE     Progressive hearing loss and gradual deterioration of sensory hair
            bundles in the ears of mice lacking the actin-binding protein
            Eps8L2
  JOURNAL   Proc Natl Acad Sci U S A 110 (34), 13898-13903 (2013)
   PUBMED   23918390
REFERENCE   3  (bases 1 to 3085)
  AUTHORS   Kesimer,M., Scull,M., Brighton,B., DeMaria,G., Burns,K., O'Neal,W.,
            Pickles,R.J. and Sheehan,J.K.
  TITLE     Characterization of exosome-like vesicles released from human
            tracheobronchial ciliated epithelium: a possible role in innate
            defense
  JOURNAL   FASEB J 23 (6), 1858-1868 (2009)
   PUBMED   19190083
REFERENCE   4  (bases 1 to 3085)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 3085)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3085)
  AUTHORS   Offenhauser,N., Borgonovo,A., Disanza,A., Romano,P., Ponzanelli,I.,
            Iannolo,G., Di Fiore,P.P. and Scita,G.
  TITLE     The eps8 family of proteins links growth factor stimulation to
            actin reorganization generating functional redundancy in the
            Ras/Rac pathway
  JOURNAL   Mol Biol Cell 15 (1), 91-98 (2004)
   PUBMED   14565974
  REMARK    Erratum:[Mol Biol Cell. 2019 Sep 1;30(19):2535. doi:
            10.1091/mbc.E03-06-0427-corr. PMID: 31465253]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006230562.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166805.1, SRR26643295.4686.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000001.1  205875825-205875902
            79-160              JAXUCZ010000001.1  205878794-205878875
            161-216             JAXUCZ010000001.1  205878958-205879013
            217-281             JAXUCZ010000001.1  205879832-205879896
            282-443             JAXUCZ010000001.1  205893052-205893213
            444-593             JAXUCZ010000001.1  205893749-205893898
            594-673             JAXUCZ010000001.1  205893972-205894051
            674-822             JAXUCZ010000001.1  205894195-205894343
            823-893             JAXUCZ010000001.1  205894437-205894507
            894-1020            JAXUCZ010000001.1  205894648-205894774
            1021-1109           JAXUCZ010000001.1  205894946-205895034
            1110-1184           JAXUCZ010000001.1  205895137-205895211
            1185-1333           JAXUCZ010000001.1  205895438-205895586
            1334-1466           JAXUCZ010000001.1  205895682-205895814
            1467-1579           JAXUCZ010000001.1  205896101-205896213
            1580-1685           JAXUCZ010000001.1  205898449-205898554
            1686-1805           JAXUCZ010000001.1  205899112-205899231
            1806-1878           JAXUCZ010000001.1  205899487-205899559
            1879-2059           JAXUCZ010000001.1  205899673-205899853
            2060-2192           JAXUCZ010000001.1  205899940-205900072
            2193-3085           JAXUCZ010000001.1  205900217-205901109
FEATURES             Location/Qualifiers
     source          1..3085
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..3085
                     /gene="Eps8l2"
                     /note="EPS8 signaling adaptor L2"
                     /db_xref="GeneID:361674"
                     /db_xref="RGD:1310912"
     exon            1..78
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            79..160
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2306
                     /gene="Eps8l2"
                     /note="EPS8-like 2"
                     /codon_start=1
                     /product="epidermal growth factor receptor kinase
                     substrate 8-like protein 2"
                     /protein_id="NP_001386596.1"
                     /db_xref="GeneID:361674"
                     /db_xref="RGD:1310912"
                     /translation="MSQSANMSCCPGAANGSLGRSDGVPRMSAKDLFEQRKKYSNSNV
                     IMHETSQYHVQHLATFIMDKSEAIATVDDAIRKLVQLSSKEKVWAQEVLLQVNDKSLR
                     LLDVESQEELENFPLPTVQHSQTVLNQLRYPSVLLLVCQDSDQNKPDIHFFHCDEVEA
                     DLVQEDIESALADYRLGKKMRPQTLKGHQEKIRQRQSILPPPQSPAPIPFQRQPGDSP
                     QAKNRVGLPLPASFSEPGYRRRESQDEEPRAVLAQRIEKETQILNCTLDDIEWFVARL
                     QKAAEAFKQLNQRKKGKKKNKKGPAEGVLTLRARPPTEGEFVDCFQKTKLAINLLAKL
                     QKHIQNPSAAELVHFLFGPLDLIINTCGGPDLARSVSSPLLSTDAVSFLRGHLVPKEM
                     TLWESLGETWMRPRSEWPREPQVPLYVPKFRSGWEPPLDVLQEAPWEIEGLTSVPSDQ
                     LNPKSRLSVRHSPKHSLSSEPQVPEDVAPPGSSPHANRGYHPTPAMTKYVKILYDFTA
                     RNANELSVLKDEVLEVLEDGRQWWKLRNRSGQAGYVPCNILAEARQEDVGAPLEQSGQ
                     KYWGPASPTHKLPPIFAGNKEELIHHMDEVNDELMKKISHIKTQPQRNFRVERSQPVH
                     LPLTFESGPEEVRAWLEAKAFSGRIVENLGILTGPQLFSLNKEELKKVCGEEGSRVYS
                     QLTVQKSFLEKQQSGSELEKLMNKIRRAEDSYSNVHTSPEAEGAPHL"
     exon            161..216
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..281
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            282..443
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            444..593
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..673
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..822
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            823..893
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1020
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1109
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1184
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1333
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1466
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1579
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1685
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1805
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1878
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2059
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2192
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..3085
                     /gene="Eps8l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggctctg acagacagcc ggtggacaag ctgaccgagg ggcctagcca agcacaggcc
       61 ctgagggacg gagagcaggt ctgctctcct tgaccctggc taccactggg aacgtcatga
      121 gccagtcagc aaacatgagt tgctgcccag gagccgccaa tggcagtctg ggccggtctg
      181 atggtgtgcc caggatgagc gcaaaggacc tgtttgagca gaggaagaag tactccaact
      241 ccaacgtcat catgcacgag acctcacagt accatgtgca gcacctggcc acattcatca
      301 tggacaagag tgaggctatc gccacagtgg atgatgccat ccggaagctg gtgcagctga
      361 gctccaagga gaaggtctgg gcccaggaag tcctgctgca ggtgaacgac aagtcactgc
      421 gactgctgga tgttgagtct caggaagagc tggagaactt tccgctgccc actgtgcagc
      481 acagccagac agtgctaaac cagttgcgct acccctcggt gctgctgctg gtgtgccagg
      541 actcagacca gaacaagccc gacatccact tctttcactg tgacgaggtg gaggccgacc
      601 tggtgcagga agacattgag agtgctctgg ctgactaccg gctggggaaa aagatgcggc
      661 cacagaccct aaagggacac caggagaaga tccgtcagcg gcagtctatc ttgccccctc
      721 cacagagccc agcccccatc cccttccagc gacagcctgg agattcccct caggccaaga
      781 accgcgtggg cctgccactg cccgcatcat tcagtgagcc aggctatcga cgtagggaat
      841 cccaggacga ggaaccgcgg gctgtgctgg ctcagagaat agagaaggaa acgcaaatcc
      901 tgaactgtac cctggatgac attgaatggt tcgtggcccg gctgcagaag gcagctgagg
      961 ctttcaagca gttgaaccag cggaaaaagg ggaagaagaa gaacaagaag gggccggcag
     1021 agggtgtcct cacacttcgg gcacgccccc ccacagaagg agagtttgtt gactgtttcc
     1081 agaaaaccaa gctagccatc aacctgctgg caaagctgca gaagcacatc caaaacccca
     1141 gtgcggctga gctggttcac ttcctcttcg ggcctctgga tctgatcatc aatacctgtg
     1201 gtggcccaga cctagcacgc tccgtctcca gccctttgct gtccactgat gctgtgagct
     1261 tcttgcgtgg acatctggtc cccaaagaga tgacgctgtg ggaatcattg ggggagacct
     1321 ggatgaggcc tcgctctgag tggccccggg agccacaggt gccgctctat gtgcccaagt
     1381 tccgtagcgg ctgggaacca cccctggatg tcctacagga ggctccctgg gagatagaag
     1441 gactaacatc tgtgcccagt gaccagctga accccaagag ccgactatcc gtacgacact
     1501 ccccgaagca cagcctctct tctgagcccc aagtcccaga ggacgttgca ccaccaggca
     1561 gctccccaca tgctaacaga ggctaccacc cgacaccagc catgaccaag tatgtgaaga
     1621 tcctctacga tttcacagca cgaaacgcca acgagctgtc tgtgctcaag gatgaggtcc
     1681 tagaggtgct ggaggatggc cggcagtggt ggaagctacg aaatcgcagt ggccaggcag
     1741 gctacgtgcc ctgcaacatc ctggctgagg ctcggcagga ggacgtgggt gcccccttgg
     1801 aacagtctgg ccagaaatac tggggtccag ccagccccac ccacaagctg cccccaattt
     1861 tcgccgggaa caaagaagag ctaatccacc atatggacga ggtcaatgac gagctcatga
     1921 aaaagatcag ccacatcaag acacagccgc agcgcaactt ccgcgtggag cgcagccagc
     1981 ctgtgcacct gccgcttacc ttcgagtcag gtccggaaga ggtccgtgcc tggctggaag
     2041 ccaaggcgtt cagtggcagg atcgtggaga acctgggcat cttgactgga ccccagctct
     2101 tctccctcaa caaggaggaa ctgaaaaaag tgtgtgggga agagggcagt cgcgtgtaca
     2161 gccagctcac cgttcagaag tccttcctgg agaaacaaca aagtgggtcg gagctggaga
     2221 agcttatgaa caagatcagg agggccgagg acagctattc caacgtacac acttccccag
     2281 aggcagaggg ggcgccgcac ctgtagtggg cccaacctga atgcacggag tattattttt
     2341 atatgtgtat tattttatac caaggacaca gatgggctgg gtgtaactgg cttacctgcc
     2401 tccaggcaga gtcctgtgca taagcctagc tacacctggg gatggctcct tggccacccc
     2461 tgccccagcc ccaacccata ctctcctccc aaaaccaagg ccagcctcag ccaaacctgt
     2521 acctggcagt gccagtccct tctcaacctg ctgccaaggc cccaggactc tccaggtgga
     2581 caaggcctct tcccctggtc ttctccatgc acatggaggt tcctgtcccc taggatgcta
     2641 ggccccagtt ccattgctct cccctgtgtt gcttgcttct atgttcacat tcccctgctg
     2701 tgccctaact gcaggatggg cctgagctct cggctggcca gcctgatgtc cttgcctaca
     2761 gatttgccca ctcccttcat gctgctagca ccctaggaac gacctagtca ggggctccag
     2821 gacaggaggc cttgggtgac ctgctggtat agagtatgct gtattctttc tcctttgaga
     2881 tctaagaatg caccagacat aggttctgac ttcaaatgtc ccatcccgcc caaagagcct
     2941 gtgataacag atatctctgg ctatttccac cagccgtggc tggtgactgg tgagtttccc
     3001 agccctgggt ggagcttcag tcccagagat gagagtgggg atcctcagct atgtcaataa
     3061 accagctgtc tcctagcaac ttaca
//
