LOCUS       NM_001108467            3828 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Rattus norvegicus EPS8 signaling adaptor L1 (Eps8l1), mRNA.
ACCESSION   NM_001108467 XM_001071045 XM_341782
VERSION     NM_001108467.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3828)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3828)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 3828)
  AUTHORS   Kesti,T., Ruppelt,A., Wang,J.H., Liss,M., Wagner,R., Tasken,K. and
            Saksela,K.
  TITLE     Reciprocal regulation of SH3 and SH2 domain binding via tyrosine
            phosphorylation of a common site in CD3epsilon
  JOURNAL   J Immunol 179 (2), 878-885 (2007)
   PUBMED   17617578
REFERENCE   4  (bases 1 to 3828)
  AUTHORS   Offenhauser,N., Borgonovo,A., Disanza,A., Romano,P., Ponzanelli,I.,
            Iannolo,G., Di Fiore,P.P. and Scita,G.
  TITLE     The eps8 family of proteins links growth factor stimulation to
            actin reorganization generating functional redundancy in the
            Ras/Rac pathway
  JOURNAL   Mol Biol Cell 15 (1), 91-98 (2004)
   PUBMED   14565974
  REMARK    Erratum:[Mol Biol Cell. 2019 Sep 1;30(19):2535. doi:
            10.1091/mbc.E03-06-0427-corr. PMID: 31465253]
REFERENCE   5  (bases 1 to 3828)
  AUTHORS   Hori,K., Konno,D., Maruoka,H. and Sobue,K.
  TITLE     MALS is a binding partner of IRSp53 at cell-cell contacts
  JOURNAL   FEBS Lett 554 (1-2), 30-34 (2003)
   PUBMED   14596909
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474075.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001071045.1, XM_341782.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132270
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3828
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..3828
                     /gene="Eps8l1"
                     /note="EPS8 signaling adaptor L1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
     exon            1..158
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2295
                     /gene="Eps8l1"
                     /note="EPS8-like 1"
                     /codon_start=1
                     /product="epidermal growth factor receptor kinase
                     substrate 8-like protein 1"
                     /protein_id="NP_001101937.1"
                     /db_xref="GeneID:361503"
                     /db_xref="RGD:1311146"
                     /translation="MSTTTGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYHVNHLVTF
                     CLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPGHVTLLDPVSKEELESYPLD
                     AIVRCDAVMPRGRSRSLLLLVCQEPERAQPDVHFFQGLLLGAELIREDIQGALQNYRS
                     GRGERRAAALRATQEELRRGASPAAETPPLQRRPSVRAVINTVEPSAVRGRPQVEPIP
                     ETEEARKPDPARTTTRSSDPTSPDLGPRGPELAGLQAERDVDILNHVFDDVESFVSRL
                     QKSAEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARL
                     RGNIANPSSPELLHFLFGPLQMIVNTSGGPEFPRSVRRPHLTLEAVALLRDNVTPREN
                     ELWTSLGDSWTRPGVELPPEEGSPYSPEFYSGWEPPATDPQGRPWEDPVEKQLQHEKR
                     RRQQSAPQVAVNGHQDPELETESQLEEKARKWVLCNYDFQARNGSELSVKHRDVLEVL
                     DDRRKWWKVRDHQGQEGYVPYNILTPHPGPQVHCSQSSAINLETSPPPPPPAAAPAPT
                     QVRPQWDSCDSLNSLDPSDKEKFSQMLCVNEELQARLAQGRSGPSRVTPGLRAPEPQL
                     SPRSEASVVRAWLQTKGFSSGTVDALGVLTGAQLFSLQKEELRSVCPEEGARVYSQVT
                     VQRALLEDREKVSELEAVMEKQKKKVEGETKTEVI"
     exon            159..199
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..258
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..420
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..570
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..653
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..918
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1045
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1134
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1209
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1358
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1500
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1529
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1659
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1791
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1900
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2075
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2208
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..3828
                     /gene="Eps8l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccaggct ggtgcctgaa catctcagtt tgagggagga ggcttggatc aggatcctgt
       61 gcctgaagcc aagtcagtca ctcacgtctt tgctggctct caaggaacct ccaagcggac
      121 agagcacctc ttctggccac catgagcacc accacagggc ctgaagctgc acccaaacca
      181 agtgcaaagt ctatctatga gcagagaaaa cgttactcca ctgtggttat ggctgatgtg
      241 tcccagtatc atgtcaatca cctggtcacc ttctgcttgg gggaggaaga tggcgtgcac
      301 actgtggaag atgcttccag aaagctggca gtcatggaca gccaggggcg tgtctgggca
      361 caggagatgc tactgagagt gtcacctggt catgtcactc tgcttgatcc agtctctaag
      421 gaggaactag agtcatatcc tctcgacgcc atcgtacgct gcgacgcggt gatgccccga
      481 ggacggagcc gctcgttgct gctcctggtg tgccaagagc cagagcgtgc acagccagat
      541 gtccatttct tccagggcct gctcctcggg gcggagctga tccgtgagga catccaaggg
      601 gctctgcaga actaccgctc cggacgtggg gaacgcaggg cggcagcact cagggctacg
      661 caggaggagc tgcgacgcgg tgcctctcca gcagcggaga ccccgccctt acagcgtcgc
      721 ccttctgtcc gcgcggtgat caacacggtg gaaccatccg cggtgcgcgg gcgaccccaa
      781 gtggagccaa ttccagagac tgaggaagcg aggaaacccg acccagcgcg cacgacgact
      841 aggagctctg atcctacctc cccagacctg ggcccaaggg gtcctgagct ggccggtctg
      901 caggcggagc gggatgtgga tatcctgaac catgtgtttg acgacgtgga gagttttgta
      961 tccagactgc aaaagtcagc agaggctacc cgggttttgg agcaccgtga gcgcggccgc
     1021 aggacacgac gccgagctgc tggagagggc ctgctgaccc taagggccaa gccacccaca
     1081 gaggctgaat acactgatgt gcttcagaaa atcaaatacg ccttcagtct gctggcccgg
     1141 ttgcggggca acatcgccaa cccctcctct ccagagctgt tacactttct gttcggacct
     1201 ctgcagatga ttgtgaacac ttcaggcggc cctgagttcc cgaggagtgt gcgacgacca
     1261 catttgacct tggaggctgt ggcgctgctc cgcgacaatg tcactcctcg tgaaaatgaa
     1321 ctatggacct cactggggga ctcctggacc cgcccagggg tggagctgcc ccctgaagaa
     1381 gggtctccat acagtccgga attctacagc ggttgggaac ctccggccac tgacccgcag
     1441 ggccgcccct gggaggaccc agtggaaaaa cagctacagc acgagaagcg gcgcaggcag
     1501 caaagcgccc cccaagtcgc ggtcaatggt catcaagatc cagaactgga aactgagtcc
     1561 cagctagaag agaaagccag aaaatgggtt ctgtgtaatt atgacttcca ggcccgaaat
     1621 ggcagcgagc tatctgtcaa gcaccgagat gtgttggagg tcctggatga caggcgcaaa
     1681 tggtggaagg ttcgggacca tcaaggacaa gagggctatg taccctataa tatcctgaca
     1741 ccccaccctg gacctcaggt gcactgcagc caaagctccg caataaacct agagactagc
     1801 ccacctcctc ccccacctgc tgcagctcca gcccccactc aggtgcggcc ccagtgggac
     1861 agttgcgaca gtctaaacag tttggatccc agcgacaagg agaaattttc ccagatgctt
     1921 tgtgtcaatg aggagctgca ggcgcgcctg gcgcagggcc gttcgggtcc cagccgggta
     1981 accccggggc ttcgagcccc ggagccccag ctcagcccac gctctgaggc ctcggtggtc
     2041 cgtgcctggc tgcagaccaa gggctttagc tccgggactg tggatgcgct tggagtgctg
     2101 actggcgcac agctgttctc gcttcaaaag gaagagttgc ggtcggtgtg cccggaagaa
     2161 ggggcgcgag tatatagcca agtcactgtg cagcgggcgc tactggagga cagagaaaaa
     2221 gtatcagagc tggaggccgt aatggagaaa caaaagaaaa aagtggaagg cgagaccaaa
     2281 acagaagtca tttgatcctg gttcattcat aaaaagtgat gagatggtgg ggttcccagc
     2341 gccccgaaag acaacagtca ccagactcct cccccaacgt cagtagcagt agatgccgta
     2401 aaggaccgcc caccctgggt tccccgcggt cctggcgggc ggactgcatt gacagtgctg
     2461 accggaacct ttccagaggg actgatggga atggggaagg gaacagagca tggacactac
     2521 tagaaaggca cgcccaagag gcgcgatgat ggccctgtgc gttgtgatgc gctataaaca
     2581 gcctcctttt aggctatgtc cacctgctgt ccccccccac acacaccccc tctcttgccg
     2641 gccaccaaga tgccaggaat ctagaagaca tccatatttt ctctccacaa acctggagat
     2701 tccaacccag gcttcctctt aagcaccaat ctatccttgc tctaacacta tctacaatct
     2761 ctctctggtt caaaatcctt tcctgtcaac tagcgtgagg cctgggattt tcctttcaaa
     2821 ggcagagggt gtctccttcc accccccatt ttgggtcaac ccctccaatc acaggcattt
     2881 ccgcacttac tgcttctgct ggttggagca gcttccatca atgtggctca actcacctac
     2941 attccatgga tgcctgtgcc agccactaag gattcagcta tgaagatcgg gatgctatag
     3001 gctcttgggt cttccagtcc ccagaacttt ctccctgcca agtcctgcaa cttgtctggt
     3061 ttatttaggt ggctagtaag agctggtttt ctcattgaga ctagataccc ctaaggtttt
     3121 tttttttcct gctgtggcac ttccctttgc atccctaaaa cacttcaaga gtcacaccag
     3181 tgcagttggc ctctgctctc caggcagttc agctcttacc tgagccacca gtggcacacc
     3241 tcaaatccaa gctagaaaag ccagcctttg ggctgacagc ttcactatac ccactttgct
     3301 ccagaacact atccacaata gatctctttc ccacttcctg tctacctctc aagcatgtct
     3361 cttggcttct cccgacagat gggataaaac ctaaccccag catgaaagtt gatatacatg
     3421 accactccag gttcagggcc ctcttcctcc cttttcagga ccccaagcat tggttcgtgc
     3481 tgttggctct gctaggaatg tcctggcctt ttggagtcta atcactgcct gtcgttcctt
     3541 atgtcagggt tgggtggtta gttggttgat tggttttgtt ggagatagtc tggatatagc
     3601 ctcaaagtct caattctgtt tcagtttcct gcatgctgag attcctggca gatgccctcc
     3661 tgccttcttt tctaagaaac ttaaaaacac aagcagtttg cccaaactgt ttttgactct
     3721 gcagtgagct cccaggctcc aggctgcagg ctgccgtgca ggcagggacc agctggcttg
     3781 ctggaacacc agatgcctct agctctctat ggtctggaat ctgatcat
//
