LOCUS       NM_001365390            5166 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus epidermal growth factor receptor pathway
            substrate 15 (Eps15), transcript variant 1, mRNA.
ACCESSION   NM_001365390
VERSION     NM_001365390.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5166)
  AUTHORS   Catsburg,L.A., Westra,M., van Schaik,A.M. and MacGillavry,H.D.
  TITLE     Dynamics and nanoscale organization of the postsynaptic endocytic
            zone at excitatory synapses
  JOURNAL   Elife 11, e74387 (2022)
   PUBMED   35072626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5166)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5166)
  AUTHORS   Lin,A. and Man,H.Y.
  TITLE     Endocytic adaptor epidermal growth factor receptor substrate 15
            (Eps15) is involved in the trafficking of ubiquitinated
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
  JOURNAL   J Biol Chem 289 (35), 24652-24664 (2014)
   PUBMED   25023288
  REMARK    GeneRIF: Knockdown of Eps15 suppresses the internalization of GluA1
            but not the mutant GluA1 that lacks ubiquitination sites,
            indicating a role of Eps15 for the internalization of ubiquitinated
            AMPARs
REFERENCE   4  (bases 1 to 5166)
  AUTHORS   Yuan,W.C., Lee,Y.R., Lin,S.Y., Chang,L.Y., Tan,Y.P., Hung,C.C.,
            Kuo,J.C., Liu,C.H., Lin,M.Y., Xu,M., Chen,Z.J. and Chen,R.H.
  TITLE     K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin
            E3 Ligase Regulates Protein Trafficking
  JOURNAL   Mol Cell 54 (4), 586-600 (2014)
   PUBMED   24768539
REFERENCE   5  (bases 1 to 5166)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5166)
  AUTHORS   Fernandez-Chacon,R., Achiriloaie,M., Janz,R., Albanesi,J.P. and
            Sudhof,T.C.
  TITLE     SCAMP1 function in endocytosis
  JOURNAL   J Biol Chem 275 (17), 12752-12756 (2000)
   PUBMED   10777571
REFERENCE   7  (bases 1 to 5166)
  AUTHORS   Rosenthal,J.A., Chen,H., Slepnev,V.I., Pellegrini,L., Salcini,A.E.,
            Di Fiore,P.P. and De Camilli,P.
  TITLE     The epsins define a family of proteins that interact with
            components of the clathrin coat and contain a new protein module
  JOURNAL   J Biol Chem 274 (48), 33959-33965 (1999)
   PUBMED   10567358
REFERENCE   8  (bases 1 to 5166)
  AUTHORS   Chen,H., Slepnev,V.I., Di Fiore,P.P. and De Camilli,P.
  TITLE     The interaction of epsin and Eps15 with the clathrin adaptor AP-2
            is inhibited by mitotic phosphorylation and enhanced by
            stimulation-dependent dephosphorylation in nerve terminals
  JOURNAL   J Biol Chem 274 (6), 3257-3260 (1999)
   PUBMED   9920862
REFERENCE   9  (bases 1 to 5166)
  AUTHORS   Haffner,C., Takei,K., Chen,H., Ringstad,N., Hudson,A., Butler,M.H.,
            Salcini,A.E., Di Fiore,P.P. and De Camilli,P.
  TITLE     Synaptojanin 1: localization on coated endocytic intermediates in
            nerve terminals and interaction of its 170 kDa isoform with Eps15
  JOURNAL   FEBS Lett 419 (2-3), 175-180 (1997)
   PUBMED   9428629
REFERENCE   10 (bases 1 to 5166)
  AUTHORS   Tebar,F., Confalonieri,S., Carter,R.E., Di Fiore,P.P. and Sorkin,A.
  TITLE     Eps15 is constitutively oligomerized due to homophilic interaction
            of its coiled-coil region
  JOURNAL   J Biol Chem 272 (24), 15413-15418 (1997)
   PUBMED   9182572
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1 and AB262963.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB262963.1, SRR22582416.1257697.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000005.1  129274565-129274689
            126-2819            AB262963.1         1-2694
            2820-5166           JAXUCZ010000005.1  129372510-129374856
FEATURES             Location/Qualifiers
     source          1..5166
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34-q35"
     gene            1..5166
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /note="epidermal growth factor receptor pathway substrate
                     15"
                     /db_xref="GeneID:313474"
                     /db_xref="RGD:1305550"
     exon            1..158
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..2819
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /codon_start=1
                     /product="epidermal growth factor receptor substrate 15"
                     /protein_id="NP_001352319.1"
                     /db_xref="GeneID:313474"
                     /db_xref="RGD:1305550"
                     /translation="MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLK
                     KSGLPDLILGKIWDLADTDGKGVLNKQEFFIALRLVACAQNGLEVSLSSLNLAVPPPR
                     FHDSSSPLLTSGTSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKL
                     PVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTW
                     VVSPAEKAKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSTLLAHIWALCDTKNCGK
                     LSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDRSSLQKNTIGSSPVADFSAIKE
                     LDTLNNEIIDLQREKNNVEQDLKEKEDTVRQRTTEAQDLQDEVQRESLNLQKLQAQKQ
                     QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAEITSQESQISTYEEELSKA
                     REELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRLAMKDLETDNNQS
                     NWCSSPQSILVNGAADYCSLSTSSSETANLNEHAEGQNNLESEPIHPESSVRSSPEIA
                     PSDVTDESEVVTAADIEKVSPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDP
                     FVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFATSSTDPFSASSNSS
                     NTSVETWKHNDPFAPGGTVVAATDSATDPFASVFGNESFGDGFADFSTLSKVSNEDPF
                     NPTISSSASSVVIPKPVLEETPSKSEDVPPALPPKTGTPTRPCPPPPGKRPINKLDSS
                     DPFKLNDPFQPFPGNDSPKEKDPDMFCDPFTSSSTTANKEAEPSNFANFSAYPSEEDM
                     IEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA"
     exon            159..200
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            201..290
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            291..338
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            339..434
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            435..500
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            501..626
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            627..686
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            687..776
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            777..922
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1079
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1165
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1238
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1400
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1598
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1799
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1916
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2007
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2043
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2180
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2247
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2324
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2487
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2672
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..5166
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgtcgaag ttcggggaga cgcccggccg ccggcctcgc ctacggcctg tccctccgcc
       61 tccttcccgc cccgggcccc cgtcagtccg tccttccttc ccctcccgtg catgatggaa
      121 acaccatggc tgcggcagcc cagctctccc tgacacagtt gtcaagtggg aatcctgtat
      181 atgaaaaata ctatagacag gttgaagcag gcaatactgg aagggtgttg gctttagatg
      241 ctgctgcatt cctgaaaaag tcagggcttc cagacctgat tcttggaaag atttgggatt
      301 tagctgacac agatggcaaa ggtgtcctga acaaacaaga attctttatt gctttacggc
      361 ttgtggcatg cgcccagaat ggactggaag tgtcactgag tagcctaaat ctggctgttc
      421 ctccaccaag atttcatgac tccagtagtc ctttgctaac cagtgggacc tcagttgctg
      481 agctcccatg ggctgtaaag tctgaagata aagccaaata tgatgcaatt tttgacagtt
      541 taagcccagt ggatggattt ttgtctggtg ataaagtgaa accagtgttg ctcaactcta
      601 agttacctgt ggaaatcctt ggaagagttt gggagttgag tgatattgac cacgatggaa
      661 agctggacag agatgagttt gcagttgcca tgtttttggt atactgtgca ctggagaaag
      721 aacctgtgcc aatgtccttg cctccagcct tggtgccacc ttctaagaga aaaacgtggg
      781 ttgtgtcccc tgcagaaaaa gctaaatatg atgaaatctt tctgaaaact gataaggata
      841 tggatggata tgtgtctgga ctggaggtcc gtgaaacctt cctaaaaaca ggtttacctt
      901 ctaccttgct agcccacatt tgggcactat gtgacacaaa gaattgtggg aagctttcaa
      961 aagaccagtt tgccttggct tttcacttaa tcaatcagaa gttaataaaa ggcattgacc
     1021 ctcctcatag tctcactcct gagatgattc caccatcaga caggtccagt ttacaaaaga
     1081 acaccatagg atcaagtcct gttgcagatt tctctgctat taaggaacta gataccctta
     1141 acaatgaaat aattgacctg cagagggaaa agaacaatgt ggaacaggac ctgaaagaga
     1201 aggaggacac agtgaggcag aggaccaccg aggctcagga tcttcaagat gaagttcaaa
     1261 gggagagtct taatctacaa aaactgcagg cccagaagca gcaggtgcag gaactcctgg
     1321 atgaactgga tgagcagaaa gcccagctgg aagagcagct caaagaagtc agaaaaaaat
     1381 gtgctgagga ggcccagctg atttcttccc tgaaagcaga aataaccagt caagaatctc
     1441 agatctccac ttatgaggaa gaattgtcga aagctagaga agaactaagt cgcctacaac
     1501 aagaaacggc acaattggaa gaaagtgtgg agtcaggaaa ggctcagcta gaacctcttc
     1561 agcagcacct acaagattcg caacaggaaa tcagttcaat gcaaatgaga ttggcaatga
     1621 aagatctgga aacggacaat aaccaatcaa attggtgcag tagcccacaa agcattctgg
     1681 tcaatggtgc tgcagattat tgtagcctca gcaccagcag cagtgaaaca gccaacctca
     1741 atgaacatgc tgaaggccag aataacctag agtctgagcc catccatccg gagtcatcag
     1801 tgagaagtag tcctgaaata gcgccttctg atgtgactga tgaaagcgaa gttgtgactg
     1861 cagctgatat tgaaaaagtt agtcccagat ttgatgatga caagcactca aaagaggaag
     1921 atccatttaa tgtagaatcc agttcactga cagatgcagt tgcagataca aacttggatt
     1981 ttttccagtc tgaccctttt gttggcagtg atcctttcaa ggatgatcct tttggaaaaa
     2041 ttgatccatt tggtggtgat cctttcaaag gttcagaccc atttgcatct gattgcttct
     2101 ttaaacagac ttctactgat ccttttgcca cttcaagtac tgaccctttc agtgcatcca
     2161 gcaatagcag taatacatcg gtagagactt ggaagcacaa tgacccattt gctcctggtg
     2221 ggacagttgt tgcagctact gactcagcca cagacccttt tgcttctgtt tttggaaatg
     2281 aatcatttgg agatggattt gctgacttca gcacattatc taaggtcagc aatgaagatc
     2341 cttttaatcc taccatatca agttctgcca gcagtgtggt cattccaaaa cctgtgttag
     2401 aggaaacacc cagcaagagt gaagatgtgc ctccagcact gccacccaag accggcactc
     2461 caacaagacc ctgcccacca ccccctggga aaagacccat caacaaattg gattcttctg
     2521 atccctttaa actgaatgat ccatttcagc ctttcccagg caatgatagt cccaaagaaa
     2581 aggatcctga tatgttttgt gatccattca cttcttcttc taccactgcc aataaagagg
     2641 ctgagccaag caattttgct aacttcagtg cttatccctc tgaagaagac atgattgagt
     2701 gggccaagag ggagagtgag cgagaagaag agcagaggct cgccagacta aatcagcagg
     2761 aacaagaaga cttggaactg gccattgcac ttagcaaatc agagatctca gaagcatgaa
     2821 gagtcctctg tccccgtcag ccgcacatgc tcttcctgaa taccgaagct gtttaccatg
     2881 tgcatccaac tacctatgag catgggatac aaaggtttgc gattcctgta aatgtgacaa
     2941 gtctagtttg ttcgtttggg ggggggggaa cttcaaatgt gtcttttatt ttttcttcca
     3001 aaagcagtac cctaattaaa cagctttgcc tagacccctg tcctggtgtg catttacagt
     3061 gagctcctgc ctgcttgtac tagtccctat aaagctaggg caccaagcct ctgccttctg
     3121 gaacctagca gatagagttt cgcgctgtgc tgcctttgtc ctgtataact ttgacaacga
     3181 ctggagttct gaaagtgtgc aagtattctc cctgagctga gtggtggagg gaggggaagg
     3241 gaaagggtat cctgtttctt ctgatcggta caaattagcc aatttaaagt atattatatg
     3301 tacttctgga gaaaatataa ttaagttatt ctttagagac aggaaaataa tctgcataga
     3361 tcaactgcag tattggaaac cagatgaatt aagttaaacc attgttgctc cagctcaagt
     3421 aattcctaaa ttaaagtatt aaagccttgt atatgaaaca tgtttttaaa acagttctct
     3481 ctggagaatt ttaattttaa gattaacaaa tacctcacta catgtttcct agttaaaaac
     3541 aagcaaacca atttcttaca agtaaacttt gtaaggaaat gttcatttta agtcctagtg
     3601 aggaaaattg taatttaaaa tacaacctat ccacttacgg taagcagacc cttagcccgt
     3661 gcccactttg cctttgtggc tgcactgact gtagttcata agtgtcctga ggtccaggaa
     3721 gctagagttg gaaggtactg tggtattctt tatgtgtttg gtttctttag tgaaggccca
     3781 gccatttgca gtgatacaaa tggaagaata acatttgtta atgtcctctt gttttctttt
     3841 ctatcgtctt tgtagtttaa attactttat ttacttgctc tatttttctc acctataaaa
     3901 ttgacaagtg accccatccc acccaaaaaa attttctagt tttcaaattg agagaaaaat
     3961 aaactgagtt gccaaattac cagagccctg cttttgttaa aagcccttct tctgctagac
     4021 tggcctgact gacagctgga tttgaatgga tttgaagtag actataattt ttaaaatatg
     4081 atactaattt agtgtttgtt ataccaagat aaacaaaaat gcacctacaa actatttaaa
     4141 attctttagg ataaccaagt taagatggca ttgaactgtt gttaagcaga gtaatttata
     4201 gcctggccta taaataaatt cctgtgtctg gtcagaccat cttgaaatgg tgctttcttc
     4261 cccccacaca ctattggaca gctaggattt aaagcaaact taattaaacc acttccttgc
     4321 actgttaact tttttctact tttgtaaata aatatttcag cataaaagtt aaacatatga
     4381 agtaagggct gaattgtact cacaaggctt taatggtgat aactagtcta gtggcctaag
     4441 tgtttgctgc aaagagtgat gagcaggttg tgttgggttg tggtaggtgg tgtctctgtt
     4501 tgcccccttc ctctcactcc tcaggagaaa ggtaagttga cttgaataaa ctttgtttgc
     4561 actgagaaaa gtgaaaaatg tttgaaatgc tttaaatttt tttaattaaa aaaactctgg
     4621 aaatattaaa tgtctataac ttataaacag caacttttga catgtagtaa gtgtgcccta
     4681 atcttcagtg cgcttagctg ggtcataacg actcttaccc tttgttaaga tgtgggccaa
     4741 tgtcatactg aagtgtgtat atatgatata aacatatctg tgtctccatg cttgactgta
     4801 tggaatgaat gtcttaaggc catctgtgat gtttatggtg ttgaccctgg ctccagagcc
     4861 tgcgctggaa acaaagacat gagttttaac catcttttat gcactagttc agcttcattt
     4921 gagctctctt catagaattt tcctcgtgtt tcaaacttat aaattacagt tgtaattatg
     4981 agaataataa actttaataa atagaagtgt gtactatctc attttgcatc ggagctttgc
     5041 actgttgctg attgtgtgca tatggtagga gggcaagtta ctgtcagcat acattatcct
     5101 ggacaaagtg tttctgacaa tactatgtag actaaataaa tgttgaatgt ttactctata
     5161 aaccaa
//
