LOCUS       NP_001352319             897 aa            linear   ROD 26-APR-2024
DEFINITION  epidermal growth factor receptor substrate 15 [Rattus norvegicus].
ACCESSION   NP_001352319
VERSION     NP_001352319.1
DBSOURCE    REFSEQ: accession NM_001365390.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 897)
  AUTHORS   Catsburg,L.A., Westra,M., van Schaik,A.M. and MacGillavry,H.D.
  TITLE     Dynamics and nanoscale organization of the postsynaptic endocytic
            zone at excitatory synapses
  JOURNAL   Elife 11, e74387 (2022)
   PUBMED   35072626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 897)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 897)
  AUTHORS   Lin,A. and Man,H.Y.
  TITLE     Endocytic adaptor epidermal growth factor receptor substrate 15
            (Eps15) is involved in the trafficking of ubiquitinated
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
  JOURNAL   J Biol Chem 289 (35), 24652-24664 (2014)
   PUBMED   25023288
  REMARK    GeneRIF: Knockdown of Eps15 suppresses the internalization of GluA1
            but not the mutant GluA1 that lacks ubiquitination sites,
            indicating a role of Eps15 for the internalization of ubiquitinated
            AMPARs
REFERENCE   4  (residues 1 to 897)
  AUTHORS   Yuan,W.C., Lee,Y.R., Lin,S.Y., Chang,L.Y., Tan,Y.P., Hung,C.C.,
            Kuo,J.C., Liu,C.H., Lin,M.Y., Xu,M., Chen,Z.J. and Chen,R.H.
  TITLE     K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin
            E3 Ligase Regulates Protein Trafficking
  JOURNAL   Mol Cell 54 (4), 586-600 (2014)
   PUBMED   24768539
REFERENCE   5  (residues 1 to 897)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 897)
  AUTHORS   Fernandez-Chacon,R., Achiriloaie,M., Janz,R., Albanesi,J.P. and
            Sudhof,T.C.
  TITLE     SCAMP1 function in endocytosis
  JOURNAL   J Biol Chem 275 (17), 12752-12756 (2000)
   PUBMED   10777571
REFERENCE   7  (residues 1 to 897)
  AUTHORS   Rosenthal,J.A., Chen,H., Slepnev,V.I., Pellegrini,L., Salcini,A.E.,
            Di Fiore,P.P. and De Camilli,P.
  TITLE     The epsins define a family of proteins that interact with
            components of the clathrin coat and contain a new protein module
  JOURNAL   J Biol Chem 274 (48), 33959-33965 (1999)
   PUBMED   10567358
REFERENCE   8  (residues 1 to 897)
  AUTHORS   Chen,H., Slepnev,V.I., Di Fiore,P.P. and De Camilli,P.
  TITLE     The interaction of epsin and Eps15 with the clathrin adaptor AP-2
            is inhibited by mitotic phosphorylation and enhanced by
            stimulation-dependent dephosphorylation in nerve terminals
  JOURNAL   J Biol Chem 274 (6), 3257-3260 (1999)
   PUBMED   9920862
REFERENCE   9  (residues 1 to 897)
  AUTHORS   Haffner,C., Takei,K., Chen,H., Ringstad,N., Hudson,A., Butler,M.H.,
            Salcini,A.E., Di Fiore,P.P. and De Camilli,P.
  TITLE     Synaptojanin 1: localization on coated endocytic intermediates in
            nerve terminals and interaction of its 170 kDa isoform with Eps15
  JOURNAL   FEBS Lett 419 (2-3), 175-180 (1997)
   PUBMED   9428629
REFERENCE   10 (residues 1 to 897)
  AUTHORS   Tebar,F., Confalonieri,S., Carter,R.E., Di Fiore,P.P. and Sorkin,A.
  TITLE     Eps15 is constitutively oligomerized due to homophilic interaction
            of its coiled-coil region
  JOURNAL   J Biol Chem 272 (24), 15413-15418 (1997)
   PUBMED   9182572
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1 and AB262963.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB262963.1, SRR22582416.1257697.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34-q35"
     Protein         1..897
                     /product="epidermal growth factor receptor substrate 15"
                     /calculated_mol_wt=98483
     Region          13..103
                     /region_name="EH"
                     /note="Eps15 homology domain; smart00027"
                     /db_xref="CDD:197477"
     Region          121..215
                     /region_name="EH"
                     /note="Eps15 homology domain; smart00027"
                     /db_xref="CDD:197477"
     Region          218..313
                     /region_name="EH"
                     /note="Eps15 homology domain; smart00027"
                     /db_xref="CDD:197477"
     Region          330..>493
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..897
                     /gene="Eps15"
                     /gene_synonym="RGD1307641"
                     /coded_by="NM_001365390.1:126..2819"
                     /db_xref="GeneID:313474"
                     /db_xref="RGD:1305550"
ORIGIN      
        1 maaaaqlslt qlssgnpvye kyyrqveagn tgrvlaldaa aflkksglpd lilgkiwdla
       61 dtdgkgvlnk qeffialrlv acaqnglevs lsslnlavpp prfhdssspl ltsgtsvael
      121 pwavksedka kydaifdsls pvdgflsgdk vkpvllnskl pveilgrvwe lsdidhdgkl
      181 drdefavamf lvycalekep vpmslppalv ppskrktwvv spaekakyde iflktdkdmd
      241 gyvsglevre tflktglpst llahiwalcd tkncgklskd qfalafhlin qklikgidpp
      301 hsltpemipp sdrsslqknt igsspvadfs aikeldtlnn eiidlqrekn nveqdlkeke
      361 dtvrqrttea qdlqdevqre slnlqklqaq kqqvqellde ldeqkaqlee qlkevrkkca
      421 eeaqlisslk aeitsqesqi styeeelska reelsrlqqe taqleesves gkaqleplqq
      481 hlqdsqqeis smqmrlamkd letdnnqsnw csspqsilvn gaadycslst sssetanlne
      541 haegqnnles epihpessvr sspeiapsdv tdesevvtaa diekvsprfd ddkhskeedp
      601 fnvesssltd avadtnldff qsdpfvgsdp fkddpfgkid pfggdpfkgs dpfasdcffk
      661 qtstdpfats stdpfsassn ssntsvetwk hndpfapggt vvaatdsatd pfasvfgnes
      721 fgdgfadfst lskvsnedpf nptisssass vvipkpvlee tpsksedvpp alppktgtpt
      781 rpcppppgkr pinkldssdp fklndpfqpf pgndspkekd pdmfcdpfts ssttankeae
      841 psnfanfsay pseedmiewa kresereeeq rlarlnqqeq edlelaials kseisea
//
