LOCUS       NP_001385893            4488 aa            linear   ROD 09-APR-2024
DEFINITION  epiplakin [Rattus norvegicus].
ACCESSION   NP_001385893 XP_017450878
VERSION     NP_001385893.1
DBSOURCE    REFSEQ: accession NM_001398964.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 4488)
  AUTHORS   Kokado,M., Okada,Y., Miyamoto,T., Yamanaka,O. and Saika,S.
  TITLE     Effects of epiplakin-knockdown in cultured corneal epithelial cells
  JOURNAL   BMC Res Notes 9, 278 (2016)
   PUBMED   27206504
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 4488)
  AUTHORS   Szabo,S., Wogenstein,K.L., Osterreicher,C.H., Guldiken,N., Chen,Y.,
            Doler,C., Wiche,G., Boor,P., Haybaeck,J., Strnad,P. and Fuchs,P.
  TITLE     Epiplakin attenuates experimental mouse liver injury by chaperoning
            keratin reorganization
  JOURNAL   J Hepatol 62 (6), 1357-1366 (2015)
   PUBMED   25617501
REFERENCE   3  (residues 1 to 4488)
  AUTHORS   Wogenstein,K.L., Szabo,S., Lunova,M., Wiche,G., Haybaeck,J.,
            Strnad,P., Boor,P., Wagner,M. and Fuchs,P.
  TITLE     Epiplakin deficiency aggravates murine caerulein-induced acute
            pancreatitis and favors the formation of acinar keratin granules
  JOURNAL   PLoS One 9 (9), e108323 (2014)
   PUBMED   25232867
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 4488)
  AUTHORS   Kokado,M., Okada,Y., Goto,M., Ishikawa,K., Miyamoto,T.,
            Yamanaka,O., Fujiwara,S. and Saika,S.
  TITLE     Increased fragility, impaired differentiation, and acceleration of
            migration of corneal epithelium of epiplakin-null mice
  JOURNAL   Invest Ophthalmol Vis Sci 54 (5), 3780-3789 (2013)
   PUBMED   23599337
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 4488)
  AUTHORS   Shimada,H., Nambu-Niibori,A., Wilson-Morifuji,M., Mizuguchi,S.,
            Araki,N., Sumiyoshi,H., Sato,M., Mezaki,Y., Senoo,H., Ishikawa,K.,
            Hatano,Y., Okamoto,O. and Fujiwara,S.
  TITLE     Epiplakin modifies the motility of the HeLa cells and accumulates
            at the outer surfaces of 3-D cell clusters
  JOURNAL   J Dermatol 40 (4), 249-258 (2013)
   PUBMED   23398049
REFERENCE   6  (residues 1 to 4488)
  AUTHORS   Spazierer,D., Raberger,J., Gross,K., Fuchs,P. and Wiche,G.
  TITLE     Stress-induced recruitment of epiplakin to keratin networks
            increases their resistance to hyperphosphorylation-induced
            disruption
  JOURNAL   J Cell Sci 121 (Pt 6), 825-833 (2008)
   PUBMED   18285451
REFERENCE   7  (residues 1 to 4488)
  AUTHORS   Wang,W., Sumiyoshi,H., Yoshioka,H. and Fujiwara,S.
  TITLE     Interactions between epiplakin and intermediate filaments
  JOURNAL   J Dermatol 33 (8), 518-527 (2006)
   PUBMED   16923132
  REMARK    Erratum:[J Dermatol. 2006 Sep;33(9):654]
REFERENCE   8  (residues 1 to 4488)
  AUTHORS   Goto,M., Sumiyoshi,H., Sakai,T., Fassler,R., Ohashi,S., Adachi,E.,
            Yoshioka,H. and Fujiwara,S.
  TITLE     Elimination of epiplakin by gene targeting results in acceleration
            of keratinocyte migration in mice
  JOURNAL   Mol Cell Biol 26 (2), 548-558 (2006)
   PUBMED   16382146
REFERENCE   9  (residues 1 to 4488)
  AUTHORS   Jang,S.I., Kalinin,A., Takahashi,K., Marekov,L.N. and Steinert,P.M.
  TITLE     Characterization of human epiplakin: RNAi-mediated epiplakin
            depletion leads to the disruption of keratin and vimentin IF
            networks
  JOURNAL   J Cell Sci 118 (Pt 4), 781-793 (2005)
   PUBMED   15671067
REFERENCE   10 (residues 1 to 4488)
  AUTHORS   Spazierer,D., Fuchs,P., Proll,V., Janda,L., Oehler,S., Fischer,I.,
            Hauptmann,R. and Wiche,G.
  TITLE     Epiplakin gene analysis in mouse reveals a single exon encoding a
            725-kDa protein with expression restricted to epithelial tissues
  JOURNAL   J Biol Chem 278 (34), 31657-31666 (2003)
   PUBMED   12791695
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 30, 2021 this sequence version replaced XP_017450878.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2189011.1,
                                           SRR26360172.2963346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4488
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     Protein         1..4488
                     /product="epiplakin"
                     /note="epiplakin 1, pseudogene 1"
                     /calculated_mol_wt=495231
     Region          81..119
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          118..151
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          157..195
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          325..363
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          362..394
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          401..439
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          613..651
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          651..689
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          727..765
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          977..1009
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          1047..1085
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          1287..1325
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          1363..1401
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          1575..1612
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          1612..1650
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          1648..1685
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          1688..1726
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          1944..1976
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          1975..2011
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          2014..2048
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2227..2270
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2270..2308
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2307..2338
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          2346..2384
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2742..2785
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2785..2823
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          2822..2853
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          2861..2899
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          3257..3300
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          3300..3338
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          3337..3368
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          3376..3414
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          3772..3815
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          3815..3853
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          3852..3883
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          3891..3929
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          4287..4330
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          4330..4368
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     Region          4367..4398
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Region          4406..4444
                     /region_name="Plectin"
                     /note="Plectin repeat; pfam00681"
                     /db_xref="CDD:459901"
     CDS             1..4488
                     /gene="Eppk1"
                     /gene_synonym="Eppk1-ps1"
                     /coded_by="NM_001398964.1:141..13607"
                     /db_xref="GeneID:680860"
                     /db_xref="RGD:1587023"
ORIGIN      
        1 mngqapphdv vvangtekli vpkimknqse astpsrpqak aalpttarsi agvyveasgq
       61 tlsiydamkq gllptglgvt lleaqaatgg lmdlaqgqll pvsealrrgl vglelkekll
      121 aaeravtgyp dpyggeklsl fqairkevvd ktlgwrllea qlatgglvdp tqgvqvapel
      181 acqqglldke twlslmesep smgtlgfsdp ntleqlpysv llgrcvldps sglpllplkt
      241 tfhtlagaas aamlleagvl neetvrglqe gtlvvsdvgt rpevqryleg tgglagvvll
      301 pgghkksffq atvehslskg ialqlleaqa atrtlvhpst gqrlwveeav ktglvgpdlh
      361 eqllvaeqav tgyydpfsss riplfqamkk glvdqplalr lldaqvatgg licparrfrl
      421 pleaalrfgc ldeetrqrls qtmgfsdptt hdrlhyeqll alsvtdpetg laflpllgms
      481 hanepqglpf idhctrhvls kattsvsvgr yqgrpvslwe llfseavpvk qramlaqkhq
      541 ngalsveala aelksivqqa aatakvtfag lrdtvtpgel lkaeiinqdl feqlergqts
      601 ardvgsldsv qrylqgtgci aglllpdsqe rlriyearsk gllrpgtali lleaqaatgf
      661 iidpkenkry sveealragv igldvyakll saeravtgyt dpysgeqisl fqamqreliv
      721 rdhgirllea qiatggvidp vhshrvpvdv ayqrgyfdqm lnsilldpsd dtkgffdpnt
      781 henltylqll ercihdsetg lhllplsgtr pqlvdsstrq afqnllisvk ygrfrgqrvs
      841 awelinseyf kedwrrqllr rcqqrkitle qvtqllekem rrwadvtlpa lqgqvtayql
      901 leahiinqel ldqvltgtvs pdallhmsdv rrylqgsgtv ggvllqpsnq rislyqamkq
      961 kllapsvala lleaqaatga itdpcsmqtl svdeavcrgv vgaevyhklk qaehsitgyr
     1021 dpfsgktvsl fgamkkglvp veqatrllea qvstggvvdp tthlhlpmsv avqrgcidqe
     1081 mevalsrspe tfptpdgrgh asyaqlleqc lqdepsglhl lpltedapsv ptdtqiqesl
     1141 qalagtedgl slwdsltsch fteeqrngfl edvrvgktsv sqlqdivrsw vqtakllara
     1201 ritvpgpqge vpavwlrdag iitqetleal aqgvqspdev aeqpavkacl wgtgcvagvl
     1261 lqpsgtklsi aqavrdgllp aglgqqllea qvasgflvnp ltnqrlsvhd avkaglvgve
     1321 lseqlrqver avtgysdpfs ggllslwqak ekglvsqsea fpllqvqlat ggvvdpvhrv
     1381 hlpqavaykl glldeqtsqa ltatgeenkl ffdpnsrekv tyqqlkelcv ldadtglwll
     1441 plpqdtvlev ddhtavalra mkvpinmgrf qghsvslwdl lhseyvgaek rrelvalccs
     1501 graaalrqvi smvttlveaa ekqppqatfk glrkqvsagd lfrsqlitkq tldelnqgkr
     1561 tveevtemds vrrsleggnf iagvlirdtk ekmsipealr rhilrpgtal vlleaqaatg
     1621 fiidpvenrk ltveqafqag mfgketytkl lsaeravtgy tdpytgeqis lfqamqrdli
     1681 vrdhgirlle aqiatggiid pvhshrvpvd vayqrgyfne emnrvladps ddtkgffdpn
     1741 thenltylql lercvedpet glymleivkk geiyvyidea trqvlrsrtm kmhigkfagq
     1801 tvsvwdllss qyftegrkrk llreyraqni glekllevit stvedtekqs qifkvpgihg
     1861 dvtavelfns gildkrtlda lhsgergrqd lcqlehikiy legtnciagv tapltqkvms
     1921 fykaskeeli pagfaaqlle aqaatgylmd pcsrrrlcvd eaiaaglvge dlrerlvsae
     1981 kaakgyedpa tgetlplfqa mekklvgree alrllevqva tggvidplhr hripldvacq
     2041 rgclcediiv liadqkhmrr rfvdpntqek vtyqelqdrc rkeeksgwal fpvvkdkkdm
     2101 dyvdeatkra leaeqvevtv gryrgqkpsv wellnseyfs eekkielvri ykedtaralq
     2161 kvvklilkii adkegrsrql wfrglrtqvt aeellraavi trktledlee gratvdqiee
     2221 tedvkrylkg tsciagilvp vqgepgrqek msiyqamwkg llrpgtalvl leaqaatgfi
     2281 idpvhnrrls veeavaagvv ggeiqeklla aeravtgytd pytgeqislf qamqrdlivk
     2341 dhgirlleaq iatggvidpv hshrvpvdva ykrgyfdeem nsiladpgdd tkgffdpnth
     2401 enltylqllr rcvrdpetgf ymlqlagkgs svyhvsedlr ralrearvsp gtvdfqgqsi
     2461 svwellfyre vpeslrqdll rryqagglsv qdvsttltsl lartkegspr adpqgtlgka
     2521 tmevkrghlr ghevpvwdvl tsnyvsrdtr kellaqfssg altlpmlkrr lttiieetee
     2581 tqesqaghsv tslkqqesaa gssgayadkg eagdstdsar qqqeqtlraa tmqvrrgqfr
     2641 dqpvsvwkvl fssylsetrr eellsqhlag rlgvnelisi lvqvieetee rlsrvslpgl
     2701 rrqvtvselg ntgildpdtm relaqgtrti devtemdsvk rylkgtscia gilvpvqgep
     2761 grqekmsiyq amwkgllrpg talvlleaqa atgfiidpvh nrrlsveeav aagvvggeiq
     2821 ekllaaerav tgytdpytge qislfqamqr dlivkdhgir lleaqiatgg vidpvhshrv
     2881 pvdvaykrgy fdeemnsila dpgddtkgff dpnthenlty lqllrrcvrd petgfymlql
     2941 agkgssvyhv sedlrralre arvspgtvdf qgqsisvwel lfyrevpesl rqdllrryqa
     3001 gglsvqdvst tltsllartk egspradpqg tlgkatmevk rghlrghevp vwdvltsnyv
     3061 srdtrkella qfssgaltlp mlkrrlttii eeteetqesq aghsvtslkq qesaagssga
     3121 yadkgeagds tdsarqqqeq tlraatmqvr rgqfrdqpvs vwkvlfssyl setrreells
     3181 qhlagrlgvn elisilvqvi eeteerlsrv slpglrrqvt vselgntgil dpdtmrelaq
     3241 gtrtidevte mdsvkrylkg tsciagilvp vqgepgrqek msiyqamwkg llrpgtalvl
     3301 leaqaatgfi idpvhnrrls veeavaagvv ggeiqeklla aeravtgytd pytgeqislf
     3361 qamqrdlivk dhgirlleaq iatggvidpv hshrvpvdva ykrgyfdeem nsiladpgdd
     3421 tkgffdpnth enltylqllr rcvrdpetgf ymlqlagkgs svyhvsedlr ralrearvsp
     3481 gtvdfqgqsi svwellfyre vpeslrqdll rryqagglsv qdvsttltsl lartkegspr
     3541 adpqgtlgka tmevkrghlr ghevpvwdvl tsnyvsrdtr kellaqfssg altlpmlkrr
     3601 lttiieetee tqesqaghsv tslkqqesaa gssgayadkg eagdstdsar qqqeqtlraa
     3661 tmqvrrgqfr dqpvsvwkvl fssylsetrr eellsqhlag rlgvnelisi lvqvieetee
     3721 rlsrvslpgl rrqvtvselg ntgildpdtm relaqgtrti devtemdsvk rylkgtscia
     3781 gilvpvqgep grqekmsiyq amwkgllrpg talvlleaqa atgfiidpvh nrrlsveeav
     3841 aagvvggeiq ekllaaerav tgytdpytge qislfqamqr dlivkdhgir lleaqiatgg
     3901 vidpvhshrv pvdvaykrgy fdeemnsila dpgddtkgff dpnthenlty lqllrrcvrd
     3961 petgfymlql agkgssvyhv sedlrralre arvspgtvdf qgqsisvwel lfyrevpesl
     4021 rqdllrryqa gglsvqdvst tltsllartk egspradpqg tlgkatmevk rghlrghevp
     4081 vwdvltsnyv srdtrkella qfssgaltlp mlkrrlttii eeteetqesq aghsvtslkq
     4141 qesaagssga yadkgeagds tdsarqqqeq tlraatmqvr rgqfrdqpvs vwkvlfssyl
     4201 setrreells qhlagrlgvn elisilvqvi eeteerlsrv sfpglrrqvt aselsitgil
     4261 dpdtmrelaq gtrtidevte mdsvkrylkg tsciagilvp vqgepgrqek msiyqamwkg
     4321 llrpgtalvl leaqaatgfi idpvhnrrls veeavaegvv ggeireklls aeravtgytd
     4381 pytgeqislf qamqrdlivk nhgirlleaq iatggvidpv hshrvpvdva ykrgyfdeem
     4441 nsiladpgdd tkgffdpnth enltylqllq ratvepetgl lflsllkg
//
