LOCUS       NM_017002               1794 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus erythropoietin receptor (Epor), mRNA.
ACCESSION   NM_017002
VERSION     NM_017002.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1794)
  AUTHORS   Papic,M., Zivanovic,S., Vucicevic,T., Papic,M.V., Zdravkovic,D.,
            Milivojevic,N., Virijevic,K., Zivanovic,M., Mircic,A., Ljujic,B.,
            Lukic,M.L. and Popovic,M.
  TITLE     Pulpal expression of erythropoietin and erythropoietin receptor
            after direct pulp capping in rat
  JOURNAL   Eur J Oral Sci 130 (5), e12888 (2022)
   PUBMED   35917324
  REMARK    GeneRIF: Pulpal expression of erythropoietin and erythropoietin
            receptor after direct pulp capping in rat.
REFERENCE   2  (bases 1 to 1794)
  AUTHORS   Zhu,L., Huang,L., Wen,Q., Wang,T., Qiao,L. and Jiang,L.
  TITLE     Recombinant human erythropoietin offers neuroprotection through
            inducing endogenous erythropoietin receptor and neuroglobin in a
            neonatal rat model of periventricular white matter damage
  JOURNAL   Neurosci Lett 650, 12-17 (2017)
   PUBMED   28359933
  REMARK    GeneRIF: In conclusion, this study shows that EPOR and Ngb were
            upregulated, and both of them act as important coordinated
            neuroprotectors in rh-EPO treatment of PWMD. However, the two
            proteins exhibit different expression patterns.
REFERENCE   3  (bases 1 to 1794)
  AUTHORS   Zhong,C. and Zhang,X.
  TITLE     Age-associated expression of erythropoietin and its receptor in rat
            spiral ganglion neurons and its association with neuronal apoptosis
            and hearing alterations
  JOURNAL   Mol Med Rep 15 (1), 228-234 (2017)
   PUBMED   27959434
  REMARK    GeneRIF: The present study aimed to determine the expression of
            erythropoietin (EPO) and the EPO receptor (EPOR) in spiral ganglion
            neurons (SGNs) in the inner ear of rats of various ages, and the
            associated neuronal apoptosis and hearing alterations.
REFERENCE   4  (bases 1 to 1794)
  AUTHORS   Liu,F., Wei,W., Ding,J., Chen,Y., Feng,T.T., Ji,L.H. and Shi,J.Y.
  TITLE     [Influence of HIF- 2alpha on the expression of GATA- 1 in bone
            marrow CD71(+) cell of high altitude polycythemia rat model]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 37 (8), 696-701 (2016)
   PUBMED   27587253
REFERENCE   5  (bases 1 to 1794)
  AUTHORS   Hertzberg-Bigelman,E., Barashi,R., Levy,R., Cohen,L.,
            Ben-Shoshan,J., Keren,G. and Entin-Meer,M.
  TITLE     Down-Regulation of Cardiac Erythropoietin Receptor and its
            Downstream Activated Signal Transducer Phospho-STAT-5 in a Rat
            Model of Chronic Kidney Disease
  JOURNAL   Isr Med Assoc J 18 (6), 326-330 (2016)
   PUBMED   27468524
REFERENCE   6  (bases 1 to 1794)
  AUTHORS   Fujita,M., Takahashi,R., Kitada,K., Watanabe,R., Kitazawa,S.,
            Ashoori,F., Liang,P., Saya,H., Serikawa,T. and Maeda,S.
  TITLE     Alternative splicing of the erythropoietin receptor gene correlates
            with erythroid differentiation in rat hematopoietic and leukemic
            cells
  JOURNAL   Cancer Lett 112 (1), 47-55 (1997)
   PUBMED   9029168
REFERENCE   7  (bases 1 to 1794)
  AUTHORS   Longmore,G.D., Pharr,P., Neumann,D. and Lodish,H.F.
  TITLE     Both megakaryocytopoiesis and erythropoiesis are induced in mice
            infected with a retrovirus expressing an oncogenic erythropoietin
            receptor
  JOURNAL   Blood 82 (8), 2386-2395 (1993)
   PUBMED   8400289
REFERENCE   8  (bases 1 to 1794)
  AUTHORS   Masuda,S., Nagao,M., Takahata,K., Konishi,Y., Gallyas,F. Jr.,
            Tabira,T. and Sasaki,R.
  TITLE     Functional erythropoietin receptor of the cells with neural
            characteristics. Comparison with receptor properties of erythroid
            cells
  JOURNAL   J Biol Chem 268 (15), 11208-11216 (1993)
   PUBMED   7684373
REFERENCE   9  (bases 1 to 1794)
  AUTHORS   de la Chapelle,A., Traskelin,A.L. and Juvonen,E.
  TITLE     Truncated erythropoietin receptor causes dominantly inherited
            benign human erythrocytosis
  JOURNAL   Proc Natl Acad Sci U S A 90 (10), 4495-4499 (1993)
   PUBMED   8506290
REFERENCE   10 (bases 1 to 1794)
  AUTHORS   Jones,S.S., D'Andrea,A.D., Haines,L.L. and Wong,G.G.
  TITLE     Human erythropoietin receptor: cloning, expression, and biologic
            characterization
  JOURNAL   Blood 76 (1), 31-35 (1990)
   PUBMED   2163696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089810.1.
            
            On Feb 13, 2005 this sequence version replaced NM_017002.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089810.1, D13566.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132262,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1794
                     /gene="Epor"
                     /note="erythropoietin receptor"
                     /db_xref="GeneID:24336"
                     /db_xref="RGD:2560"
     exon            1..197
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1606
                     /gene="Epor"
                     /note="EPO-R"
                     /codon_start=1
                     /product="erythropoietin receptor precursor"
                     /protein_id="NP_058698.2"
                     /db_xref="GeneID:24336"
                     /db_xref="RGD:2560"
                     /translation="MDQLRVARWPRVSPLCLLLAGAAWASSPSLPDPKFESKAALLAS
                     RGSEELLCFTQRLEDLVCFWEEAANSGMGFNYSFSYQLEGESRKSCRLHQAPTVRGSM
                     RFWCSLPTADTSSFVPLELQVTEASGSPRYHRIIHINEVVLLDAPAGLLARRAEEGSH
                     VVLRWLPPPGAPMTTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFA
                     VRARMAEPSFSGFWSAWSEPASLLTASDLDPLILTLSLILVLISLLLTVLALLSHRRA
                     LRQKIWPGIPSPENEFEGLFTTHKGNFQLWLLQRDGCLWWSPSSPFPEDPPAHLEVLS
                     ERHWGVTQAGDAGAEDKGPLLEPVGSERAQDTYLVLDEWLLPRCPCSENLSGPGDSVD
                     PATMDEGSETSSCPSDLASKPRPEGTSPSSFEYTILDPSSKLLCPRALPPELPPTPPH
                     LKYLYLVVSDSGISTDYSSGGSQGVHGDSSDGPYSHPYENSLVPDTEPLRPSYVACS"
     exon            198..330
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            331..506
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            507..664
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            665..818
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            819..906
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            907..994
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1768
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagaaagag gaaagggaag gggaggtggg gggcaaaaga ggggggctgg agccctgagc
       61 ttcctgaagc tggggctaca tcatggacca actcagggtg gcccgctggc ctcgggttag
      121 ccccctgtgt ctcctacttg ctggggcagc ctgggcatcc tcacccagcc tcccggaccc
      181 caagtttgag agcaaagccg ccctgctggc atcccggggc tccgaagaac ttctatgctt
      241 cacccagcgc ttggaagact tggtgtgttt ctgggaggaa gcggcgaact ccgggatggg
      301 cttcaactac agcttctctt accagctcga aggtgaatca agaaagtcat gtcgcctgca
      361 ccaggcgccc accgtccgcg gctccatgcg tttctggtgt tcactgccga ccgcggacac
      421 gtcgagtttt gtgccactgg agctgcaggt gaccgaggcc tccggatctc ctcgctacca
      481 ccgcatcatc catatcaatg aagtagtgct cctggacgcc cccgcggggc tgctggcgcg
      541 ccgagcagaa gagggcagcc acgtggtgct gcggtggctg ccacctcccg gggctcctat
      601 gaccacccac atccgctacg aggtggacgt gtcagcaggc aaccgggctg gggggacaca
      661 aagggtggag gtcctggaag gccgcactga gtgtgtcctg agcaacctgc ggggcgggac
      721 gcgctacacc ttcgctgttc gagcacgcat ggccgagccg agcttcagcg gattctggag
      781 cgcctggtct gagcccgcgt cgctactgac tgctagcgac ttggaccctc tcatcttgac
      841 gctgtctctc attctcgtcc tcatctcact gttgctgact gtgctggccc tgctgtccca
      901 ccgccgggct ctgcggcaga agatctggcc tggcatccca agcccagaga atgagtttga
      961 gggtctcttc accacccaca agggtaactt ccagctatgg ctgttgcaac gcgatggctg
     1021 tctgtggtgg agcccaagta gccccttccc tgaggatcca cctgcccacc tagaggtcct
     1081 ctcagagcga cactggggag tgactcaggc tggggatgca ggggcagagg acaaggggcc
     1141 cttactggag ccagtgggca gtgagcgggc ccaggacacc tacctggtat tggatgaatg
     1201 gttgctaccc cggtgcccat gcagtgagaa cctctctggg cctggggaca gtgtagaccc
     1261 tgcgactatg gatgaaggtt cagaaacatc ttcctgcccc tctgacttgg cttcaaagcc
     1321 caggccagag ggcacctcgc cttccagctt tgagtacacc atcctggacc ccagctctaa
     1381 gctcctgtgc cctcgggcac tgcctcctga gctacccccc actccacctc acctgaagta
     1441 cctgtacctt gtggtgtccg attccggcat ctcaacagat tacagctcag ggggctccca
     1501 gggagtccac ggggactcat ctgacggccc ctactcccac ccctatgaga atagccttgt
     1561 tccagacaca gagcctctgc ggcccagcta cgtggcctgc tcctaggact ccagcctaca
     1621 gcctgtagtt cctaaaccta caacttcttg aagaggatgg ctgaggccat atttaaagcc
     1681 ctggccctct gcccaggaag tgacagcctt gcaatgttaa gatggatagt tatgtctgta
     1741 tatagaaata tatatatatt gatttttcaa aaaaaaaaaa aaaaaaaaaa aaaa
//
