LOCUS       NP_058698                507 aa            linear   ROD 29-JUL-2024
DEFINITION  erythropoietin receptor precursor [Rattus norvegicus].
ACCESSION   NP_058698
VERSION     NP_058698.2
DBSOURCE    REFSEQ: accession NM_017002.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 507)
  AUTHORS   Papic,M., Zivanovic,S., Vucicevic,T., Papic,M.V., Zdravkovic,D.,
            Milivojevic,N., Virijevic,K., Zivanovic,M., Mircic,A., Ljujic,B.,
            Lukic,M.L. and Popovic,M.
  TITLE     Pulpal expression of erythropoietin and erythropoietin receptor
            after direct pulp capping in rat
  JOURNAL   Eur J Oral Sci 130 (5), e12888 (2022)
   PUBMED   35917324
  REMARK    GeneRIF: Pulpal expression of erythropoietin and erythropoietin
            receptor after direct pulp capping in rat.
REFERENCE   2  (residues 1 to 507)
  AUTHORS   Zhu,L., Huang,L., Wen,Q., Wang,T., Qiao,L. and Jiang,L.
  TITLE     Recombinant human erythropoietin offers neuroprotection through
            inducing endogenous erythropoietin receptor and neuroglobin in a
            neonatal rat model of periventricular white matter damage
  JOURNAL   Neurosci Lett 650, 12-17 (2017)
   PUBMED   28359933
  REMARK    GeneRIF: In conclusion, this study shows that EPOR and Ngb were
            upregulated, and both of them act as important coordinated
            neuroprotectors in rh-EPO treatment of PWMD. However, the two
            proteins exhibit different expression patterns.
REFERENCE   3  (residues 1 to 507)
  AUTHORS   Zhong,C. and Zhang,X.
  TITLE     Age-associated expression of erythropoietin and its receptor in rat
            spiral ganglion neurons and its association with neuronal apoptosis
            and hearing alterations
  JOURNAL   Mol Med Rep 15 (1), 228-234 (2017)
   PUBMED   27959434
  REMARK    GeneRIF: The present study aimed to determine the expression of
            erythropoietin (EPO) and the EPO receptor (EPOR) in spiral ganglion
            neurons (SGNs) in the inner ear of rats of various ages, and the
            associated neuronal apoptosis and hearing alterations.
REFERENCE   4  (residues 1 to 507)
  AUTHORS   Liu,F., Wei,W., Ding,J., Chen,Y., Feng,T.T., Ji,L.H. and Shi,J.Y.
  TITLE     [Influence of HIF- 2alpha on the expression of GATA- 1 in bone
            marrow CD71(+) cell of high altitude polycythemia rat model]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 37 (8), 696-701 (2016)
   PUBMED   27587253
REFERENCE   5  (residues 1 to 507)
  AUTHORS   Hertzberg-Bigelman,E., Barashi,R., Levy,R., Cohen,L.,
            Ben-Shoshan,J., Keren,G. and Entin-Meer,M.
  TITLE     Down-Regulation of Cardiac Erythropoietin Receptor and its
            Downstream Activated Signal Transducer Phospho-STAT-5 in a Rat
            Model of Chronic Kidney Disease
  JOURNAL   Isr Med Assoc J 18 (6), 326-330 (2016)
   PUBMED   27468524
REFERENCE   6  (residues 1 to 507)
  AUTHORS   Fujita,M., Takahashi,R., Kitada,K., Watanabe,R., Kitazawa,S.,
            Ashoori,F., Liang,P., Saya,H., Serikawa,T. and Maeda,S.
  TITLE     Alternative splicing of the erythropoietin receptor gene correlates
            with erythroid differentiation in rat hematopoietic and leukemic
            cells
  JOURNAL   Cancer Lett 112 (1), 47-55 (1997)
   PUBMED   9029168
REFERENCE   7  (residues 1 to 507)
  AUTHORS   Longmore,G.D., Pharr,P., Neumann,D. and Lodish,H.F.
  TITLE     Both megakaryocytopoiesis and erythropoiesis are induced in mice
            infected with a retrovirus expressing an oncogenic erythropoietin
            receptor
  JOURNAL   Blood 82 (8), 2386-2395 (1993)
   PUBMED   8400289
REFERENCE   8  (residues 1 to 507)
  AUTHORS   Masuda,S., Nagao,M., Takahata,K., Konishi,Y., Gallyas,F. Jr.,
            Tabira,T. and Sasaki,R.
  TITLE     Functional erythropoietin receptor of the cells with neural
            characteristics. Comparison with receptor properties of erythroid
            cells
  JOURNAL   J Biol Chem 268 (15), 11208-11216 (1993)
   PUBMED   7684373
REFERENCE   9  (residues 1 to 507)
  AUTHORS   de la Chapelle,A., Traskelin,A.L. and Juvonen,E.
  TITLE     Truncated erythropoietin receptor causes dominantly inherited
            benign human erythrocytosis
  JOURNAL   Proc Natl Acad Sci U S A 90 (10), 4495-4499 (1993)
   PUBMED   8506290
REFERENCE   10 (residues 1 to 507)
  AUTHORS   Jones,S.S., D'Andrea,A.D., Haines,L.L. and Wong,G.G.
  TITLE     Human erythropoietin receptor: cloning, expression, and biologic
            characterization
  JOURNAL   Blood 76 (1), 31-35 (1990)
   PUBMED   2163696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089810.1.
            
            On Feb 13, 2005 this sequence version replaced NP_058698.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089810.1, D13566.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132262,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     Protein         1..507
                     /product="erythropoietin receptor precursor"
                     /note="EPO-R"
                     /calculated_mol_wt=52776
     sig_peptide     1..24
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
                     /calculated_mol_wt=2723
     mat_peptide     25..507
                     /product="Erythropoietin receptor. /id=PRO_0000010871"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07303.1)"
                     /calculated_mol_wt=52776
     Region          37..139
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cl21522"
                     /db_xref="CDD:473895"
     Site            75
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
     Site            116
                     /site_type="other"
                     /note="Required for ligand binding.
                     /evidence=ECO:0000250|UniProtKB:P19235; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
     Region          145..243
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          232..236
                     /region_name="WSXWS motif.
                     /evidence=ECO:0000250|UniProtKB:P14753"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07303.1)"
     Site            order(232..233,235..236)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            250..272
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07303.1)"
     Region          281..289
                     /region_name="Box 1 motif.
                     /evidence=ECO:0000250|UniProtKB:P16310"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07303.1)"
     Site            367
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK2.
                     /evidence=ECO:0000250|UniProtKB:P14753; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
     Region          384..423
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07303.1)"
     Site            425
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK2.
                     /evidence=ECO:0000250|UniProtKB:P14753; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
     Region          451..456
                     /region_name="ITIM motif.
                     /evidence=ECO:0000250|UniProtKB:P14753"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07303.1)"
     Site            453
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK2.
                     /evidence=ECO:0000250|UniProtKB:P14753; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
     Site            455
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK2.
                     /evidence=ECO:0000250|UniProtKB:P14753; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
     Region          466..507
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q07303.1)"
     Site            467
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK2.
                     /evidence=ECO:0000250|UniProtKB:P14753; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
     Site            484
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK2.
                     /evidence=ECO:0000250|UniProtKB:P14753; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
     Site            488
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK2.
                     /evidence=ECO:0000250|UniProtKB:P14753; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
     Site            503
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK2.
                     /evidence=ECO:0000250|UniProtKB:P14753; propagated from
                     UniProtKB/Swiss-Prot (Q07303.1)"
     CDS             1..507
                     /gene="Epor"
                     /coded_by="NM_017002.2:83..1606"
                     /db_xref="GeneID:24336"
                     /db_xref="RGD:2560"
ORIGIN      
        1 mdqlrvarwp rvsplcllla gaawasspsl pdpkfeskaa llasrgseel lcftqrledl
       61 vcfweeaans gmgfnysfsy qlegesrksc rlhqaptvrg smrfwcslpt adtssfvple
      121 lqvteasgsp ryhriihine vvlldapagl larraeegsh vvlrwlpppg apmtthirye
      181 vdvsagnrag gtqrvevleg rtecvlsnlr ggtrytfavr armaepsfsg fwsawsepas
      241 lltasdldpl iltlslilvl isllltvlal lshrralrqk iwpgipspen efeglftthk
      301 gnfqlwllqr dgclwwspss pfpedppahl evlserhwgv tqagdagaed kgpllepvgs
      361 eraqdtylvl dewllprcpc senlsgpgds vdpatmdegs etsscpsdla skprpegtsp
      421 ssfeytildp sskllcpral ppelpptpph lkylylvvsd sgistdyssg gsqgvhgdss
      481 dgpyshpyen slvpdteplr psyvacs
//
