LOCUS       NM_017001               1378 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus erythropoietin (Epo), mRNA.
ACCESSION   NM_017001
VERSION     NM_017001.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1378)
  AUTHORS   Jin,X., Jin,W., Li,G., Zheng,J. and Xu,X.
  TITLE     Erythropoietin alleviates lung ischemia-reperfusion injury by
            activating the FGF23/FGFR4/ERK signaling pathway
  JOURNAL   PeerJ 12, e17123 (2024)
   PUBMED   38560469
  REMARK    GeneRIF: Erythropoietin alleviates lung ischemia-reperfusion injury
            by activating the FGF23/FGFR4/ERK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1378)
  AUTHORS   Shan,W., Wang,J., Cheng,R., Xuan,Y. and Yin,Z.
  TITLE     Erythropoietin alleviates astrocyte pyroptosis by targeting the
            miR-325-3p/Gsdmd axis in rat spinal cord injury
  JOURNAL   Inflammopharmacology 32 (1), 523-536 (2024)
   PUBMED   37578618
  REMARK    GeneRIF: Erythropoietin alleviates astrocyte pyroptosis by
            targeting the miR-325-3p/Gsdmd axis in rat spinal cord injury.
REFERENCE   3  (bases 1 to 1378)
  AUTHORS   Papic,M., Zivanovic,S., Vucicevic,T., Papic,M.V., Zdravkovic,D.,
            Milivojevic,N., Virijevic,K., Zivanovic,M., Mircic,A., Ljujic,B.,
            Lukic,M.L. and Popovic,M.
  TITLE     Pulpal expression of erythropoietin and erythropoietin receptor
            after direct pulp capping in rat
  JOURNAL   Eur J Oral Sci 130 (5), e12888 (2022)
   PUBMED   35917324
  REMARK    GeneRIF: Pulpal expression of erythropoietin and erythropoietin
            receptor after direct pulp capping in rat.
REFERENCE   4  (bases 1 to 1378)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1378)
  AUTHORS   Dang,J.Z., Tu,Y.F., Wang,J. and Yang,Y.J.
  TITLE     Carbamylated Erythropoietin Alleviates Kidney Damage in Diabetic
            Rats by Suppressing Oxidative Stress
  JOURNAL   Curr Med Sci 41 (3), 513-521 (2021)
   PUBMED   34129202
  REMARK    GeneRIF: Carbamylated Erythropoietin Alleviates Kidney Damage in
            Diabetic Rats by Suppressing Oxidative Stress.
REFERENCE   6  (bases 1 to 1378)
  AUTHORS   Okajima,Y., Matsumura,I., Nishiura,T., Hashimoto,K., Yoshida,H.,
            Ishikawa,J., Wakao,H., Yoshimura,A., Kanakura,Y., Tomiyama,Y. and
            Matsuzawa,Y.
  TITLE     Insulin-like growth factor-I augments erythropoietin-induced
            proliferation through enhanced tyrosine phosphorylation of STAT5
  JOURNAL   J Biol Chem 273 (36), 22877-22883 (1998)
   PUBMED   9722506
REFERENCE   7  (bases 1 to 1378)
  AUTHORS   Frede,S., Fandrey,J., Pagel,H., Hellwig,T. and Jelkmann,W.
  TITLE     Erythropoietin gene expression is suppressed after
            lipopolysaccharide or interleukin-1 beta injections in rats
  JOURNAL   Am J Physiol 273 (3 Pt 2), R1067-R1071 (1997)
   PUBMED   9321887
REFERENCE   8  (bases 1 to 1378)
  AUTHORS   Jelkmann,W., Pagel,H., Hellwig,T. and Fandrey,J.
  TITLE     Effects of antioxidant vitamins on renal and hepatic erythropoietin
            production
  JOURNAL   Kidney Int 51 (2), 497-501 (1997)
   PUBMED   9027729
REFERENCE   9  (bases 1 to 1378)
  AUTHORS   Wen,D., Boissel,J.P., Tracy,T.E., Gruninger,R.H., Mulcahy,L.S.,
            Czelusniak,J., Goodman,M. and Bunn,H.F.
  TITLE     Erythropoietin structure-function relationships: high degree of
            sequence homology among mammals
  JOURNAL   Blood 82 (5), 1507-1516 (1993)
   PUBMED   8364201
REFERENCE   10 (bases 1 to 1378)
  AUTHORS   Nagao,M., Suga,H., Okano,M., Masuda,S., Narita,H., Ikura,K. and
            Sasaki,R.
  TITLE     Nucleotide sequence of rat erythropoietin
  JOURNAL   Biochim Biophys Acta 1171 (1), 99-102 (1992)
   PUBMED   1420369
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10763.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000012.1  24841285-24841319
            36-178              JAXUCZ010000012.1  24841883-24842025
            179-265             JAXUCZ010000012.1  24842499-24842585
            266-445             JAXUCZ010000012.1  24842856-24843035
            446-1378            JAXUCZ010000012.1  24843793-24844725
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1378
                     /gene="Epo"
                     /note="erythropoietin"
                     /db_xref="GeneID:24335"
                     /db_xref="RGD:2559"
     exon            1..35
                     /gene="Epo"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..601
                     /gene="Epo"
                     /codon_start=1
                     /product="erythropoietin precursor"
                     /protein_id="NP_058697.1"
                     /db_xref="GeneID:24335"
                     /db_xref="RGD:2559"
                     /translation="MGVPERPTLLLLLSLLLIPLGLPVLCAPPRLICDSRVLERYILE
                     AKEAENVTMGCAEGPRLSENITVPDTKVNFYAWKRMKVEEQAVEVWQGLSLLSEAILQ
                     AQALQANSSQPPESLQLHIDKAISGLRSLTSLLRVLGAQKELMSPPDATQAAPLRTLT
                     ADTFCKLFRVYSNFLRGKLKLYTGEACRRGDR"
     exon            36..178
                     /gene="Epo"
                     /inference="alignment:Splign:2.1.0"
     exon            179..265
                     /gene="Epo"
                     /inference="alignment:Splign:2.1.0"
     exon            266..445
                     /gene="Epo"
                     /inference="alignment:Splign:2.1.0"
     exon            446..1378
                     /gene="Epo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcagcag ccaggcgcgg agatgggggt gcccgaacgt cccaccctgc tgcttttact
       61 atccttgcta ctgattcctc tgggcctccc agtcctctgc gctcccccac gcctcatttg
      121 cgacagtcgc gttctggaga ggtacatctt ggaggccaag gaggcagaaa atgtcacaat
      181 gggctgtgca gaaggtccca gactgagtga gaatattacc gtcccagata ccaaagtcaa
      241 cttctacgct tggaaaagaa tgaaggtgga agaacaggct gtagaagttt ggcaaggcct
      301 gtctctgctc tcagaagcca tcctgcaggc ccaggctctg caggccaatt cctcccagcc
      361 accagagagt cttcagcttc atatagacaa agccatcagt gggctacgta gcctcacttc
      421 actgcttcgg gtgctgggag ctcagaagga attgatgtcg cctccagacg ccacccaagc
      481 cgctccactc cgaacactca cagcggatac tttctgcaag ctcttccggg tctactccaa
      541 cttcctccgg gggaaactga agctgtacac gggggaggcc tgcaggagag gggacaggtg
      601 acctgccact gccgtgtacc cgccaactcg ctcaccgtca ctgtgtcacg ccaaccctcc
      661 accactccca accctcatca aacggggttg tttgttacct tcttaccggc ctgtcctacg
      721 gacactccag cagtgatatt ctgggggcca gaagaacttc ccagagctcc attctgagcc
      781 tgaggcccca gagcaggaga gactgagaga accagctcgg atttgtttag ttttcgttga
      841 gacaggaagg tctcacatag cccaggctgg cctggaactc gctatgtagt caaggacgac
      901 gtcgttgaac tcatgacctt tctgcttcca tttcttgagt gctgagatta caaatgccct
      961 ggccctattt acggggtgct ggacgtggaa gctggggctt cctgatgcga tgtgagtgag
     1021 cttccagagg ctgacttaga actcaggggc agagacagcc aaactcatct agtgccctgc
     1081 cggaactgta atccacgcca gccacctccc ccccccccac acacacaggg caagctttgg
     1141 gctccaatct ttgtggcatc tacgaagaac acagggcctg gagaatgtag ggggcaagac
     1201 atggattctt taggtctcat agggtttccc cagacagcac gggccctgca ctggacaaca
     1261 gagggtcacg aagccatgaa gacagaatgg ccactgactc tcagctttca tgggagggaa
     1321 ggggtttgag gttttgtgtc ttttaaaaaa taccactggc aacagccgaa atcaccaa
//
