LOCUS       NM_001271384            7349 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus EPM2A interacting protein 1 (Epm2aip1), mRNA.
ACCESSION   NM_001271384 XM_003754461 XM_236659
VERSION     NM_001271384.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7349)
  AUTHORS   Turnbull,J., Tiberia,E., Pereira,S., Zhao,X., Pencea,N.,
            Wheeler,A.L., Yu,W.Q., Ivovic,A., Naranian,T., Israelian,N.,
            Draginov,A., Piliguian,M., Frankland,P.W., Wang,P., Ackerley,C.A.,
            Giacca,A. and Minassian,B.A.
  TITLE     Deficiency of a glycogen synthase-associated protein, Epm2aip1,
            causes decreased glycogen synthesis and hepatic insulin resistance
  JOURNAL   J Biol Chem 288 (48), 34627-34637 (2013)
   PUBMED   24142699
REFERENCE   2  (bases 1 to 7349)
  AUTHORS   Chan,E.M., Ackerley,C.A., Lohi,H., Ianzano,L., Cortez,M.A.,
            Shannon,P., Scherer,S.W. and Minassian,B.A.
  TITLE     Laforin preferentially binds the neurotoxic starch-like
            polyglucosans, which form in its absence in progressive myoclonus
            epilepsy
  JOURNAL   Hum Mol Genet 13 (11), 1117-1129 (2004)
   PUBMED   15102711
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Sep 21, 2012 this sequence version replaced
            XM_003754461.1, XM_236659.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26360181.2401264.1,
                                        SRR26643299.37529.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7349              JAXUCZ010000008.1  120112265-120119613
FEATURES             Location/Qualifiers
     source          1..7349
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..7349
                     /gene="Epm2aip1"
                     /note="EPM2A interacting protein 1"
                     /db_xref="GeneID:316021"
                     /db_xref="RGD:1310977"
     exon            1..7349
                     /gene="Epm2aip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1934
                     /gene="Epm2aip1"
                     /note="EPM2A (laforin) interacting protein 1"
                     /codon_start=1
                     /product="EPM2A-interacting protein 1"
                     /protein_id="NP_001258313.1"
                     /db_xref="GeneID:316021"
                     /db_xref="RGD:1310977"
                     /translation="MWMTPKRIRMEVDEALVFRPEWTQRYLVVEPAEGDGALCLVCRR
                     LVASTRERDVRRHYEAEHEFYERFVGDEERAALVERLRQGDMSLAAVLTPEERATRAG
                     LGLCRFLALKGRGWGEGDFVHQCMEVLLREVLPDHVGVLEGIDLSPEITRQRILSIDS
                     NLRSQLFNRARDFKAYSLALDDQAFVAYENYLLVFIRGVGRDLEVQEDLLTIINLTHH
                     FSVGALMSAILEALQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNV
                     IHYSGFLHLELLSSYDVDINQIINTISEWVVMIKTRGVRRPEFQSLLTESESEHGERV
                     NGRCLNNWLRRGKTLKLIFSLRKEIEAFLVSVGATTVHFSDKQWLCDFGFLVDIMDYL
                     REISEELQISKVFAAAAFERICTFEDKLSSLQRHMEEVNLTDFPAFSIIVDELKQQFK
                     EDQKIFDPDRYQMVISRLQKDFERHFKDLRFIKKDLELFSNPFSFKPEYAPISVRVEL
                     TKLQGNTDLWNEYRVKDLGQFYAGLSGEAYPIIKGVAYKVASLFDSNQICDKAFAYLT
                     RNQHTLSQPLTDEHLQALFRVATTEMDPRWDDLVRERNDS"
ORIGIN      
        1 gcaccctgct cgggtgatct ggcgcagaac ccaggggggt gcttggcgtt cgtcgggctc
       61 ctccccgttt gctgcggcct cagagctcgg cgttatccct tggcctccgc agaatgtgga
      121 tgacgcccaa gaggattagg atggaagtcg acgaggctct ggtgtttcgg cccgagtgga
      181 cccagcgtta cctggtggtg gagcctgcgg agggtgacgg ggccctgtgc ctggtgtgtc
      241 gccgcctggt cgcctctact cgggaacgcg acgtgaggcg ccactacgaa gccgaacacg
      301 aattctacga acggtttgta ggggacgagg aacgcgcggc cctggtggag cgtctgcggc
      361 agggcgacat gtctttggct gccgttctca ctccggagga gagagctacg cgggcaggcc
      421 tcggcctctg ccgcttcttg gccttgaagg gtcgcggctg gggtgagggt gacttcgttc
      481 accagtgcat ggaggtgttg ctgagagagg tgctgccgga tcacgtcggc gtcctggaag
      541 gcattgattt atctccagag atcacacggc agagaattct gagcattgac agcaacctcc
      601 gtagccagct gtttaaccga gccagggact ttaaggccta ttcccttgct ttggatgacc
      661 aggcttttgt ggcctatgag aactacctgc tggttttcat ccgtggcgtc ggccgcgacc
      721 tggaggtgca agaagatctt ctgaccatta tcaacctgac tcatcacttc agtgttgggg
      781 ctctcatgtc ggcaattctg gaggccctgc agacagcagg gctcagctta cagcgaatgg
      841 ttggactgac cacgacccac accttgagga tgattggcga gaactccgga ctggtctcct
      901 acatgagaga aaaggctgtg agtcccaact gttggaacgt tatccactat tcaggatttc
      961 ttcacttgga actgttgagt tcttacgatg ttgatattaa tcagatcata aataccatct
     1021 ccgaatgggt agtcatgatt aaaaccagag gtgttaggcg gccagagttc cagtctttac
     1081 tgactgagtc tgaatcagag catggagaga gagttaatgg acggtgtttg aacaactggc
     1141 tgagaagagg caaaacgtta aaactaatat tttcgctaag gaaagaaatc gaggcgttct
     1201 tggtttcggt gggggcaaca acagttcatt tctcagacaa gcagtggctt tgtgatttcg
     1261 gtttcttggt agacatcatg gattacctcc gagagatcag tgaagaactg caaatcagta
     1321 aagtctttgc tgctgccgcc tttgaacgca tctgcacctt tgaggataag ctgagctccc
     1381 ttcagagaca tatggaagaa gtaaatctaa cagactttcc tgccttcagc ataatcgttg
     1441 atgaactcaa acagcagttt aaggaagatc aaaaaatatt tgatcctgac aggtatcaaa
     1501 tggtgatctc ccgcctacaa aaagattttg agagacattt caaggacctc aggttcatta
     1561 aaaaggactt ggaacttttc tcaaatccat ttagcttcaa accggaatat gcgcctattt
     1621 ccgtaagagt ggagctaaca aaacttcagg ggaacaccga cctgtggaat gagtacagag
     1681 tcaaagactt gggacagttt tatgctggac tgtctgggga agcttaccca attatcaaag
     1741 gggttgccta taaggtggca tccttatttg atagtaacca aatctgtgat aaggcttttg
     1801 catatttaac tcgaaaccag cacacgttga gccagccact gacggacgag catctccaag
     1861 cgctatttcg agttgccaca actgaaatgg atccccgttg ggatgatctt gtgagagaga
     1921 gaaatgactc ataagccatc gtggtacaag aagaagtcaa tctgaaaagg aaaaattaat
     1981 ttaacttcct ttcacatttc ctcatttgga tggttggaaa gcattgaact tattacagat
     2041 gtccaaactg ataaacattg agatctttct gaagagttac ctttccccat ctcatttggc
     2101 aacatggaac tgacgcataa gaataccacc tttaaaaaac ttagtttaat ggaaaagtca
     2161 ttgcctttta cttttattat aactggtttt caacagattt agtattgata ttgtaagttg
     2221 aactagaagt ctggttttaa aatggtctaa agatgcatgc caaaagtttc agcccttact
     2281 ctgacacagt ggaaagtgta acacatggtt tgaagtggcc aactccgtaa aagtgtattc
     2341 gagtcagttc acagaaactc acatatcaaa ttaagtttct gaaaaggaat agcatataca
     2401 cagtggaggt attttatcta gctaacagaa tttaagatta tttcttaaag catatttctg
     2461 agtctgaagt aaatacaaac cccatcctca cctacccagt ggatggacgg tgacaatacg
     2521 gatggaggaa ggaatcaatt tggtgttgga gcagcaagaa ttattttaag tttctgattt
     2581 aggaggttcc ttactatcag gagttaagaa taaccgacta ttagtggttt gctccttatt
     2641 ttttcacagc cggagcaatt ttttcagctc gtctgtcaaa ggaccatggt aagtatggaa
     2701 tcctgatcac tgccagtcag catttttttc ctgctctaga cagaactttg gtcctatcca
     2761 aacagtaagg gggaaaggac ctttacactt caagatagga gttatgagag gcttgcagct
     2821 tgtttgtctt atctgcatgg gtattaatgt tctctgaaga aactatgctt aagggagaca
     2881 ctttattttg aaatgatgtg ccagattttg ttagctgcag gaaatggatt tactctagaa
     2941 tttaaagctg tcttacacat tgagtagtta agacagtgca taagtaaaat acttaaatct
     3001 aaagaagcaa ccttgtccac agactgtaat aattcctatt tctagagatg ttttgtgctg
     3061 tattgttgtc agatatatta actggaaaag tcaatcttca ggtaaagctc aacgtgtcaa
     3121 cctgatctaa gaacagcact gtgtgtaact catcgtcacg tacaggttac aagctgatgt
     3181 gctgccttct ggcctaaatt ctgcagcaca ttgtgttgtg cattcaagga acctggtgac
     3241 aaccaagatt ttggaaggaa ctgatgctta agccacacga gtctaagaac caaagttaga
     3301 tcagtggttc tcaagcaaag gtagaaaccc ttgcttccag agaacgcagg ggagtgttaa
     3361 ggacaccttt gtagttaccg tatttactgg agagttgtgc tggcatgtaa gccaagaaga
     3421 tttctccttc ctatggtgtt caggcagctt gatgccataa agaatcatcc attccctccc
     3481 aaagtgccag cacctccccc taccaagtat acatcatctt atttcaaaag acagggaaaa
     3541 tctccagtgg aagccgatgg tgcatacttg atagggaagc ctagttctag cagttcagag
     3601 cagaaaagca agtgtcagat tggcattttg cttatccaag aataagctta aatatggaaa
     3661 acacaagtct actgctagtt tcctggtagc ttttgtgtat tgcctttcac agcaaatact
     3721 tcaaatactt tttattattt gagagaatga ttggaagtcc tgaaagctgc ctctactttc
     3781 tatttctagt cccctaagta ttactatctc gtgcattcta tcaagttctt gtgttttgct
     3841 taaggtgatg attagattag tctgcatcct gtaactgctg tgtgagtatg ggggagatag
     3901 aaataagcta aggaattttc tttaattgac cctcagcaat actttgctgt aactagtctt
     3961 attttttgtt tatttgttta aggcagtggt tcttaacctt cctaatgctg caacccttta
     4021 atacagttcc tcgtgttgtg gtgaccccca gccataaaat tatttctttg ctacttcata
     4081 actgtaattt tgctactgtt atgaattgta atgtaaatat ctgatgtgca ggatatctga
     4141 tattcaaccc cacccctacc cccagagggg tcaggaccca tgggttgaga accgctgatt
     4201 taggtgtttt gccgttttct gtatttctgt aagtaattgc agctgcatgg cagttttttt
     4261 cttttcttct tcctttttaa atatatagtt gttactggtc ctgtggtatc tgtgaatata
     4321 gttaaaaata agtgccattt aaaacagtaa ctctgtgtcc ttaactgtcc cttcccattt
     4381 ctctcatttc tactagttca aatatttgct tggccaggct cccatattgc cagccagatc
     4441 actcaagttc agtgttttcc tcagtatttt tcccttcttg aaatcatcct agcattgcag
     4501 agacaccagc tccagtcatt gtagtcacct cttccttaag tatgtctgtc tggtcgcttt
     4561 gtttgctgtt tgttttgttt tcttttaaga ctctcttgcc tcgttctcta cattacttcc
     4621 aagttgatct ctttctatga ctttagttat cacctatatg cagatactcc aaatttttgt
     4681 ctcctgagat ttcctcctaa atcctagttg ctaataattg ctaacactct gctctctcac
     4741 atcttggctc tttctcccaa acctgctctt cctctcactt ttccttcagc agatggcttt
     4801 acagttgccc ttgcctaagc caaaaccagt cagctcactc ttaccgatcc cctcccttca
     4861 gtgctgtcag ggtagataga agacaaactt ctgttcatct tgcagaactt gtcctacata
     4921 tcatgtaaga tgtttcaggg gtctcgtcta ggccaggtat ccacctacat gtactgaaca
     4981 ccctgtcctt tttacttagc atttcttact gtgttttggt cattgctaga ctgaaccaga
     5041 gaagtctaat ccattgattc atctctagtg aatagtagga tgcctggcat ttgaacaaat
     5101 gtttgggcaa ataaatactt gtgtgtttcg ttttgttttg ttttatgaaa ccttcacagt
     5161 cttcatttga ccatcacaga catcctgcct gttcactgaa tagttcttag ccatgtattt
     5221 caaattaaga aatgaaactc accttattcg tgactaggaa tctcattgtt gtgtttcttg
     5281 aatttagtgc agtgcttagc atgtggttca aatattatgt gaatgttgtt aagaaaatag
     5341 attgtaattt accctagtaa actatagtaa tgtcaggatt caaacctagg tgtcctcacg
     5401 aatctactcg ctagtgttaa gtacattcat aatatagtct ttattttaat ttccaaagga
     5461 acccacatac agagggaaga cattggataa ctgcttagat ggaactgaat tcagtaatct
     5521 gaaaattacc ttcattcagt attagagaaa gacaatcctg caaagagtta atgtccattt
     5581 ttccttttgt aggcgtcaac cctaggagaa agtggcatgc tatttagtag ttactttcct
     5641 ttacagatga tttctggctc ttctggaatt taaaagtaag taaacttgtt tctgagaaag
     5701 ctgtcttagc ccttctgact acaaggtccc cggctcattt actttaccat gtggaattcc
     5761 cacatcattt cccaaagaga aaagccccag atgacgtgag ttaacattta gatttgctgt
     5821 attttctccc tttcttgttt catgcctctg aatttcattt ctaggtaaat gagacatttc
     5881 agtctcaagt cagaaagcca aatgcttatt agtgtctttt gttaagccct tttgcccagt
     5941 ttaagagatg aactagtgtc attctcttag ttggacttac cccagtttta ggaagtcaca
     6001 ctaattaact cattcactct gaggtcttgg cagtaggtag gtacagcggt catccagaca
     6061 tttgatcctt gttgcaaaac taggtttttg tcaacctttg ggttaagggt ttctcatttt
     6121 tatctcgtat ttaaaaagtc aattcatcct acactataag tactttttaa atattctata
     6181 tataatttct gccttgaaac cgaccaaata ctgaattcat gtcctgtaca ctttgtctaa
     6241 agcagccagt ggcaaccaca aagtattttt tttcttcttt aataaagagt agatgtcctg
     6301 tcttcatctc aaggggcact tttgcctctc tataatagaa cttgtcccgg tatcattttt
     6361 tttctatctt ccagtagcag tcttcctgag tgcctcccag atagtcacga agcagtttgt
     6421 agtattttag ttctgtatta ggattggtga ggttgccatg agcaggtgaa taactacaaa
     6481 agtctagtgt cccaacagct tgtctgtgac aagctgtctg agctgacaga ctacaatccc
     6541 cacaggccaa gtctgtcttg gctcaccctt ctttgaggaa agtgttacag gagttatagc
     6601 catgtctgtc tatgaactgt catggctgct tccctctata gttgcagact tgagtagttg
     6661 tgacactgtg tgcaatgcaa gctaaaatga ctttttggaa aagttcgttt cctgcttaaa
     6721 attgtcccta cctaccctgg ggctcaggac aaagcagata tactcaatag gggttgactg
     6781 ctcactttgg gaaaagagaa gagaaaattt ggctctgtaa gcccacagct acaccagatt
     6841 tcaagaagtc caaatccctc catacaggtg ggaggaagat gaagtatttg gaagatcact
     6901 ctactggtcc ttattctatt cccctagtta cgtcactcta aatatgtctt tgctttctca
     6961 tcgagataaa agtttacaaa tattaagtgt ccacttgagt ggatttttat attcacctat
     7021 gaatgcacca ctcagatcaa ggtagaacat acttctgtta ctccagtagg tgccgtttgc
     7081 ctctcacaga gagacagttg ctggtctgac ttatattgct tgtcagttag ttttgcctgt
     7141 tttaagtgta tatcaagtgg aactagacac gctgtgctct ctgttctctg tgtctgctat
     7201 agtaatccat ggtgtggatt gtaacagctc atttctcacg cagtgtcaca gtccgtccat
     7261 tgtacaaggt gatccattca atgttgatga atatttggat tgtttccagt ttgtggtcat
     7321 tatgaataaa attgctatta aaagccttg
//
