LOCUS       NM_001107857            4066 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus Eph receptor B6 (Ephb6), mRNA.
ACCESSION   NM_001107857 XM_001068490 XM_231650
VERSION     NM_001107857.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4066)
  AUTHORS   Mimche,P.N., Brady,L.M., Bray,C.F., Lee,C.M., Thapa,M., King,T.P.,
            Quicke,K., McDermott,C.D., Mimche,S.M., Grakoui,A., Morgan,E.T. and
            Lamb,T.J.
  TITLE     The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in
            mice
  JOURNAL   Hepatology 62 (3), 900-914 (2015)
   PUBMED   25784101
REFERENCE   2  (bases 1 to 4066)
  AUTHORS   Luo,H., Yu,G., Tremblay,J. and Wu,J.
  TITLE     EphB6-null mutation results in compromised T cell function
  JOURNAL   J Clin Invest 114 (12), 1762-1773 (2004)
   PUBMED   15599401
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001068490.1, XM_231650.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..4066
                     /gene="Ephb6"
                     /note="Eph receptor B6"
                     /db_xref="GeneID:312275"
                     /db_xref="RGD:1306163"
     exon            1..642
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            643..714
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            715..915
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     CDS             816..3857
                     /gene="Ephb6"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-B receptor 6; tyrosine-protein
                     kinase-defective receptor EPH-6; serine/arginine
                     repetitive matrix protein 2-like"
                     /codon_start=1
                     /product="ephrin type-B receptor 6 precursor"
                     /protein_id="NP_001101327.1"
                     /db_xref="GeneID:312275"
                     /db_xref="RGD:1306163"
                     /translation="MASENTAGSGSRVAGMVYSLWLLVLGPSVLALEEVLLDTTGETS
                     EIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGLPPGSGQDNWLQTHFVERRGAQR
                     AHIRLHFSVRACSSLGVSGGTCRETFTLYYRQADEPDSPDSISAWHLKRWTKVDTIAA
                     DESFPASSSSSSWAVGPHRTDQRVGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVA
                     VKLFSYTCPSVLRAFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPP
                     RLHCNGEGRWMVAVGGCRCQPGHQPARGDKLCQACPEGSYKALPGNVPCSPCPARSHS
                     PDPAAPVCPCLQGFYRASSDPPEAPCTGPPSAPRELWFEVQGSALMLHWRLPQELGGR
                     GDLLFNVVCKECGGHKEPSSGGMCRRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYIL
                     EVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVMHQVSRAANSITVSWPQPEQTNG
                     NILDYQLRYYDQAEDESHSFTMTSETNTATVTRLSPGHIYGFQVRARTAAGHGPYGGK
                     VYFQTLPQGELSSQLPEKLSLVIGSILGALAFLLLAAITVLAVIFQRKRRGTGYTEQL
                     QQYSSPGLGVKYYIDPSTYDDPCQAIRELAREVDPTYIKIEEVIGAGSFGEVRRGRLQ
                     PRGRREQAVAIQALWAGGAESLKMTFLGRAALLGQFQHPNILRLEGVVTRSRPVMVLT
                     ELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSH
                     LVCKVARLGHSPQGSSSLLRWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERPYWD
                     MSDQEVLNAIEQEFRLPPPPGCPTGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKP
                     DTLQAEGSSGDRPSQALLNPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLSTFSDV
                     AQLSLEDLPGLGITLAGHQKKLLHNIQLLQQHLRQPGSVEV"
     exon            916..980
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1743
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1899
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2250
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2375
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2538
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2653
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2706
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2826
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..3074
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3248
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3398
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3592
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3748
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..4066
                     /gene="Ephb6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgctccgg cgcgagctac aggattttaa acacgccttg cagcggcgcc cactggccac
       61 ctcctcccgg accctaactc gtgcagtcct tctgcccacg tcccctccgc ccgccaggac
      121 ccacgggagg aggccgaccc tcctcagcac acaggcgggc ccagggcgcg cccagcatct
      181 ccactgcacg ccccgctggg gatcgggcgc cgcgcacttg ggtcctaggc ccagagggcg
      241 ggctcggctc ccggaagagg agagccaggg cggcagaagg ggccggagag gggcgggcca
      301 ggctgggagg gacgagaggg ggcgggcccg gctgcgtttg cccagccagc gcttcggagc
      361 agcgggcgtc cgaacccaag agcagagctc agcgactccg atcgtgacac cggcccccgc
      421 acgattcccc agggccccgc ctagggagca gtccctgctt gcagcctcgg gtcctctccc
      481 agaatcccag agactccaag ctgcgagcag acgcgggccg ctgggaagcg aggtcctcag
      541 accagagagg acacgcgcga cgctaggaaa gatctgcgag gtgcagatcc accgcggggg
      601 cctcgggggc gcagacctgc agagctggag gccggcggga aggttggctg ctggaggaca
      661 ggtgcagagt aaatgaagag ctcaaactgg aataactcct tccagacaca aagggaaaca
      721 agcttgtctg tagacaacgg gtcttccgaa aaccacagct gcgcctcaga acagggcagt
      781 ggccgaggca atggtgggag tgccgaagac accgcatggc ttctgagaac acggctgggt
      841 cagggagcag agtggcgggc atggtgtaca gtctatggct cctggttctg gggccctcag
      901 ttctagctct ggaagaggtg ctgctggata ccacaggaga gacctctgag attggctggc
      961 tcacctaccc accaggtggg tgggatgagg tgagtgttct agacgaccag cgccgtctga
     1021 ctcggacctt cgaagcatgc cacgtcgcag ggctccctcc cggttctggg caggacaatt
     1081 ggctacagac acactttgtg gagcggcgag gggcccagag ggcacacatc cgtcttcact
     1141 tctctgtgcg agcctgttcc agcctgggcg tgagtggagg tacctgccga gagaccttca
     1201 ccctttacta ccggcaggct gatgaaccag acagccctga cagtatttcg gcctggcacc
     1261 tcaaacgctg gaccaaagtg gacacaatcg cagcagatga gagcttccct gcctcctctt
     1321 cctcttcctc ctgggctgtg ggaccccaca ggactgatca gcgggtggga ctgcagctga
     1381 atgtcaaaga gcgcagtttt ggtcctctca ctcagcgtgg cttctacgtg gccttccagg
     1441 acacaggggc ctgcctggcc cttgtagcag tcaagctctt ctcctatacc tgtccctccg
     1501 tcctgcgcgc ctttgcctct tttcctgaga cacaggccag cggagctgga ggtgcctcct
     1561 tagtagctgc tgtgggcacc tgtgtagctc atgcggaacc cgaggaggat ggcgtaggag
     1621 gccaggcagg gggcagccca ccaaggttac actgtaatgg ggaaggaagg tggatggtag
     1681 ctgtgggagg ctgtcgctgc cagcctggac accagcctgc tcgtggagac aagctctgcc
     1741 aagcctgccc tgaggggtcc tataaggcac tgcctggaaa tgtcccctgc tcaccgtgtc
     1801 cagcccgcag ccactcccct gaccctgcag ccccagtttg tccctgtctc caaggtttct
     1861 acagggccag ttctgaccca ccagaggctc cctgcactgg tcctccatca gctccccggg
     1921 agctttggtt tgaggttcaa ggctcagcac ttatgctgca ctggcgcctg cctcaggagc
     1981 tgggcggacg aggggacctg ctcttcaatg ttgtgtgcaa ggaatgtgga ggtcacaagg
     2041 agcccagcag tgggggaatg tgtcgccgct gcagggatga ggtgcatttc gacccccgcc
     2101 agaggggcct gaccgagagt cgagtgttag ttggtgggct ccgagcacac gtgccataca
     2161 tcttggaagt gcaggctgtc aatggggtgt ctgagctcag ccctgaccct ccccaggcag
     2221 cagccatcaa tgtcagcacc agccatgaag ttccttctgc agtccctgtg atgcaccagg
     2281 tgagccgggc cgccaacagc atcacagtgt cctggccaca gcctgaacaa acaaatggaa
     2341 acatccttga ctatcagctg cgctactatg accaggcaga agatgaatcc cactccttca
     2401 ccatgaccag tgagactaac actgccactg tgacacggtt gagccctggc cacatttatg
     2461 gcttccaggt tcgagcacgg actgcggctg gccatggccc ctatgggggc aaagtctatt
     2521 ttcagacact gcctcaaggt gagctgtcct cccagcttcc agagaagctg tccttggtga
     2581 ttggttccat cctgggggcc ttggccttcc ttctactggc agccatcact gtactggctg
     2641 tcatcttcca gcggaagcgg cgtgggaccg gctacacaga acaactgcaa cagtacagca
     2701 gcccaggact tggagtgaag tattacattg acccttccac gtatgacgac ccctgccagg
     2761 ccatcagaga gcttgctcga gaggttgacc ctacatatat caagattgag gaagtcattg
     2821 gggcaggttc ctttggagaa gtgcgtcggg gccgactgca accccgggga aggcgggaac
     2881 aggctgtggc tatccaggcc ctgtgggcag ggggtgctga gagcctgaag atgacctttc
     2941 tgggtcgggc agccctgctg ggccagttcc agcaccccaa tatcctgcgc ctggaaggtg
     3001 tagtcactag gagtcggcct gtcatggtgc tgacagaact catggagctt ggtcccctgg
     3061 acagcttcct taggcagcga gagggccagt tcagtagcct gcagctggtg gccatgcagc
     3121 ggggtgtggc tgctgccatg cagtacctgt ccagctttgc ctttgttcac cgagcactct
     3181 cagcccgaag tgtgctagtg aatagccacc tggtgtgtaa ggtggcccgt cttggccaca
     3241 gtcctcaggg ttcaagttcc ttgcttcgct gggcagcccc agaggtcatc acacacggga
     3301 agtacacaac atctagcgat gtctggagct ttggcatact catgtgggaa gtgatgagct
     3361 atggagaacg gccctactgg gacatgagtg accaggaggt actaaatgcg atagagcaag
     3421 agttccggct gcccccacct ccggggtgcc ctactggact acatctgctg atgctagaca
     3481 cttggcagaa ggaccgtgcc cgtcggcctc actttgacca gctcgtagcc gcgtttgaca
     3541 agatgatacg caagcctgat accctccagg ctgaagggag ctccggggac aggccttccc
     3601 aggctcttct gaaccctgtg gccttggact ttccttgcct ggactctccc caggcctggc
     3661 tttcagccat tggactagag tgctaccagg acaacttctc taagtttggt ctttccacct
     3721 tcagtgatgt ggctcagctc agccttgaag acctgccagg cctgggcatc accctagctg
     3781 gccaccagaa gaaactactg cataacatcc agctcctcca gcagcacctg aggcagccag
     3841 gctcggtgga agtgtaaagc ctggtcagca atctgtgagc tgccgctgat gccccaaccc
     3901 agccctggcc atagggtgga ggaggggcgt gtgagactga gccagactct attccagcct
     3961 ccatgcctgc cacattaaac ccagccctct ggacattgca cccccaaatc ctgctcttcc
     4021 aacagcctcc cccatattaa agggaaagaa gggaatttat aagttg
//
