LOCUS       NP_001101327            1013 aa            linear   ROD 02-JUN-2024
DEFINITION  ephrin type-B receptor 6 precursor [Rattus norvegicus].
ACCESSION   NP_001101327 XP_001068490 XP_231650
VERSION     NP_001101327.1
DBSOURCE    REFSEQ: accession NM_001107857.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1013)
  AUTHORS   Mimche,P.N., Brady,L.M., Bray,C.F., Lee,C.M., Thapa,M., King,T.P.,
            Quicke,K., McDermott,C.D., Mimche,S.M., Grakoui,A., Morgan,E.T. and
            Lamb,T.J.
  TITLE     The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in
            mice
  JOURNAL   Hepatology 62 (3), 900-914 (2015)
   PUBMED   25784101
REFERENCE   2  (residues 1 to 1013)
  AUTHORS   Luo,H., Yu,G., Tremblay,J. and Wu,J.
  TITLE     EphB6-null mutation results in compromised T cell function
  JOURNAL   J Clin Invest 114 (12), 1762-1773 (2004)
   PUBMED   15599401
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001068490.1, XP_231650.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1013
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     Protein         1..1013
                     /product="ephrin type-B receptor 6 precursor"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-B receptor 6; tyrosine-protein
                     kinase-defective receptor EPH-6; serine/arginine
                     repetitive matrix protein 2-like"
                     /calculated_mol_wt=107194
     sig_peptide     1..31
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3138
     mat_peptide     32..1013
                     /product="Ephrin type-B receptor 6. /id=PRO_0000042113"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0K7.3)"
                     /calculated_mol_wt=107194
     Region          33..225
                     /region_name="EphR_LBD_B6"
                     /note="Ligand Binding Domain of Ephrin type-B Receptor 6;
                     cd10475"
                     /db_xref="CDD:198443"
     Site            order(45,57..60,62..63,68,70,73,110,112,164,184..186,
                     213..215,217)
                     /site_type="other"
                     /note="ephrin binding site [polypeptide binding]"
                     /db_xref="CDD:198443"
     Region          294..361
                     /region_name="TNFRSF"
                     /note="Tumor necrosis factor receptor superfamily
                     (TNFRSF); cd00185"
                     /db_xref="CDD:276900"
     Region          311..342
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276900"
     Site            order(364,444,457)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          365..463
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(458..459,461..462)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            472
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C0K7.3)"
     Site            order(480,544,559)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          481..563
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(560..561,563..564)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            591..611
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0K7.3)"
     Region          604..659
                     /region_name="EphA2_TM"
                     /note="Ephrin type-A receptor 2 transmembrane domain;
                     pfam14575"
                     /db_xref="CDD:464211"
     Region          657..911
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(668..671,674,676,692,694,724,740..743,787,791..792,
                     794,804..805)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          937..1005
                     /region_name="SAM_EPH-B6"
                     /note="SAM domain of EPH-B6 subfamily of tyrosine kinase
                     receptors; cd09555"
                     /db_xref="CDD:188954"
     Site            order(957,990)
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:188954"
     Region          1011..1013
                     /region_name="PDZ-binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C0K7.3)"
     CDS             1..1013
                     /gene="Ephb6"
                     /coded_by="NM_001107857.1:816..3857"
                     /db_xref="GeneID:312275"
                     /db_xref="RGD:1306163"
ORIGIN      
        1 masentagsg srvagmvysl wllvlgpsvl aleevlldtt getseigwlt yppggwdevs
       61 vlddqrrltr tfeachvagl ppgsgqdnwl qthfverrga qrahirlhfs vracsslgvs
      121 ggtcretftl yyrqadepds pdsisawhlk rwtkvdtiaa desfpassss sswavgphrt
      181 dqrvglqlnv kersfgpltq rgfyvafqdt gaclalvavk lfsytcpsvl rafasfpetq
      241 asgaggaslv aavgtcvaha epeedgvggq aggspprlhc ngegrwmvav ggcrcqpghq
      301 pargdklcqa cpegsykalp gnvpcspcpa rshspdpaap vcpclqgfyr assdppeapc
      361 tgppsaprel wfevqgsalm lhwrlpqelg grgdllfnvv ckecgghkep ssggmcrrcr
      421 devhfdprqr gltesrvlvg glrahvpyil evqavngvse lspdppqaaa invstshevp
      481 savpvmhqvs raansitvsw pqpeqtngni ldyqlryydq aedeshsftm tsetntatvt
      541 rlspghiygf qvrartaagh gpyggkvyfq tlpqgelssq lpeklslvig silgalafll
      601 laaitvlavi fqrkrrgtgy teqlqqyssp glgvkyyidp styddpcqai relarevdpt
      661 yikieeviga gsfgevrrgr lqprgrreqa vaiqalwagg aeslkmtflg raallgqfqh
      721 pnilrlegvv trsrpvmvlt elmelgplds flrqregqfs slqlvamqrg vaaamqylss
      781 fafvhralsa rsvlvnshlv ckvarlghsp qgsssllrwa apevithgky ttssdvwsfg
      841 ilmwevmsyg erpywdmsdq evlnaieqef rlppppgcpt glhllmldtw qkdrarrphf
      901 dqlvaafdkm irkpdtlqae gssgdrpsqa llnpvaldfp cldspqawls aiglecyqdn
      961 fskfglstfs dvaqlsledl pglgitlagh qkkllhniql lqqhlrqpgs vev
//
