LOCUS       NM_001414988            4151 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus Eph receptor B3 (Ephb3), mRNA.
ACCESSION   NM_001414988 XM_006248561
VERSION     NM_001414988.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4151)
  AUTHORS   Huang,H., Chen,L., Yuan,J., Zhang,H., Yang,J., Xu,Z. and Chen,Y.
  TITLE     Role and mechanism of EphB3 in epileptic seizures and
            epileptogenesis through Kalirin
  JOURNAL   Mol Cell Neurosci 128, 103915 (2024)
   PUBMED   38143048
  REMARK    GeneRIF: Role and mechanism of EphB3 in epileptic seizures and
            epileptogenesis through Kalirin.
REFERENCE   2  (bases 1 to 4151)
  AUTHORS   Huang,H., Li,R., Yuan,J., Zhou,X., Liu,X., Ou,S., Xu,T. and Chen,Y.
  TITLE     Up-regulated ephrinB3/EphB3 expression in intractable temporal lobe
            epilepsy patients and pilocarpine induced experimental epilepsy rat
            model
  JOURNAL   Brain Res 1639, 1-12 (2016)
   PUBMED   26930615
  REMARK    GeneRIF: Study found up-regulated expression of ephrinB3/EphB3 in
            intractable temporal lobe epilepsy patients and experimental
            temporal lobe epilepsy rats, which suggested that ephrinB3/EphB3
            might be involved in the pathogenesis of temporal lobe epilepsy
REFERENCE   3  (bases 1 to 4151)
  AUTHORS   Mimche,P.N., Brady,L.M., Bray,C.F., Lee,C.M., Thapa,M., King,T.P.,
            Quicke,K., McDermott,C.D., Mimche,S.M., Grakoui,A., Morgan,E.T. and
            Lamb,T.J.
  TITLE     The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in
            mice
  JOURNAL   Hepatology 62 (3), 900-914 (2015)
   PUBMED   25784101
REFERENCE   4  (bases 1 to 4151)
  AUTHORS   Lin,B., Yin,T., Wu,Y.I., Inoue,T. and Levchenko,A.
  TITLE     Interplay between chemotaxis and contact inhibition of locomotion
            determines exploratory cell migration
  JOURNAL   Nat Commun 6, 6619 (2015)
   PUBMED   25851023
  REMARK    GeneRIF: Breast cancer cell motility is regulated in part by Ephb3
            signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4151)
  AUTHORS   Garcia-Ceca,J., Jimenez,E., Alfaro,D., Cejalvo,T., Chumley,M.J.,
            Henkemeyer,M., Munoz,J.J. and Zapata,A.G.
  TITLE     On the role of Eph signalling in thymus histogenesis; EphB2/B3 and
            the organizing of the thymic epithelial network
  JOURNAL   Int J Dev Biol 53 (7), 971-982 (2009)
   PUBMED   19598115
REFERENCE   6  (bases 1 to 4151)
  AUTHORS   Birgbauer,E., Oster,S.F., Severin,C.G. and Sretavan,D.W.
  TITLE     Retinal axon growth cones respond to EphB extracellular domains as
            inhibitory axon guidance cues
  JOURNAL   Development 128 (15), 3041-3048 (2001)
   PUBMED   11532925
REFERENCE   7  (bases 1 to 4151)
  AUTHORS   Cowan,C.A., Yokoyama,N., Bianchi,L.M., Henkemeyer,M. and
            Fritzsch,B.
  TITLE     EphB2 guides axons at the midline and is necessary for normal
            vestibular function
  JOURNAL   Neuron 26 (2), 417-430 (2000)
   PUBMED   10839360
REFERENCE   8  (bases 1 to 4151)
  AUTHORS   Adams,R.H., Wilkinson,G.A., Weiss,C., Diella,F., Gale,N.W.,
            Deutsch,U., Risau,W. and Klein,R.
  TITLE     Roles of ephrinB ligands and EphB receptors in cardiovascular
            development: demarcation of arterial/venous domains, vascular
            morphogenesis, and sprouting angiogenesis
  JOURNAL   Genes Dev 13 (3), 295-306 (1999)
   PUBMED   9990854
REFERENCE   9  (bases 1 to 4151)
  AUTHORS   Orioli,D., Henkemeyer,M., Lemke,G., Klein,R. and Pawson,T.
  TITLE     Sek4 and Nuk receptors cooperate in guidance of commissural axons
            and in palate formation
  JOURNAL   EMBO J 15 (22), 6035-6049 (1996)
   PUBMED   8947026
REFERENCE   10 (bases 1 to 4151)
  AUTHORS   Bohme,B., Holtrich,U., Wolf,G., Luzius,H., Grzeschik,K.H.,
            Strebhardt,K. and Rubsamen-Waigmann,H.
  TITLE     PCR mediated detection of a new human receptor-tyrosine-kinase, HEK
            2
  JOURNAL   Oncogene 8 (10), 2857-2862 (1993)
   PUBMED   8397371
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 20, 2022 this sequence version replaced XM_006248561.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.48865.1,
                                           SRR26643288.46239.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               JAXUCZ010000011.1  93363295-93363775   c
            482-546             JAXUCZ010000011.1  93355573-93355637   c
            547-1219            JAXUCZ010000011.1  93353569-93354241   c
            1220-1375           JAXUCZ010000011.1  93351143-93351298   c
            1376-1726           JAXUCZ010000011.1  93350114-93350464   c
            1727-1851           JAXUCZ010000011.1  93349862-93349986   c
            1852-2011           JAXUCZ010000011.1  93349525-93349684   c
            2012-2120           JAXUCZ010000011.1  93349328-93349436   c
            2121-2173           JAXUCZ010000011.1  93348947-93348999   c
            2174-2296           JAXUCZ010000011.1  93347912-93348034   c
            2297-2544           JAXUCZ010000011.1  93347559-93347806   c
            2545-2760           JAXUCZ010000011.1  93346902-93347117   c
            2761-2910           JAXUCZ010000011.1  93346635-93346784   c
            2911-3104           JAXUCZ010000011.1  93346351-93346544   c
            3105-3260           JAXUCZ010000011.1  93346100-93346255   c
            3261-4151           JAXUCZ010000011.1  93345098-93345988   c
FEATURES             Location/Qualifiers
     source          1..4151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..4151
                     /gene="Ephb3"
                     /note="Eph receptor B3"
                     /db_xref="GeneID:287989"
                     /db_xref="RGD:1305602"
     exon            1..481
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..3369
                     /gene="Ephb3"
                     /EC_number="2.7.10.1"
                     /note="EPH-like tyrosine kinase-2; ephrin type-B receptor
                     3"
                     /codon_start=1
                     /product="ephrin type-B receptor 3 precursor"
                     /protein_id="NP_001401917.1"
                     /db_xref="GeneID:287989"
                     /db_xref="RGD:1305602"
                     /translation="MAGARPPPGLLPLLAPLLLPLLLPAGCRALEETLMDTKWVTSEL
                     AWTSHPESGWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRREVQRVYVELK
                     FTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSR
                     LDAGRVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETL
                     TGAEPTSLVIAPGTCIANAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKETQC
                     RACPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDTADSACTTVPSP
                     PRGVISNVNETSLILEWSEPRDLGGRDDLLYNVICKKCRGSSGAGGPATCSRCDDNVE
                     FEPRQLGLTERRVHISHLLAHTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSE
                     VPTLHLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSKGIASTVTSQKNSVQLDGL
                     QPDARYVVQVRARTVAGYGQYSRPAEFETTSERGSGAQQLQEQLPLIVGSTVAGFVFM
                     VVVVVIALVCLRKQRQGPDAEYTEKLQQYVAPRMKVYIDPFTYEDPNEAVREFAKEID
                     VSCVKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMG
                     QFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAG
                     MKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIR
                     WTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPM
                     DCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVIASAPSGMSQPLLDR
                     TVPDYTTFTTVGDWLDAIKMGRYKESFVGAGFASFDLVAQMTAEDLLRIGVTLAGHQK
                     KILSSIQDMRLQMNQTLPVQV"
     exon            482..546
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            547..1219
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1375
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1726
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1851
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2011
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2120
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2173
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2296
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2544
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2760
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2910
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3104
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3260
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..4151
                     /gene="Ephb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagtgagt acgtgagcgg agcagtctga taccggctcc taccccggac ggcgcgctca
       61 ccgggagccc gggatccgag ctcggcctca gtggactgtg ccccgagaac cgcgaccatc
      121 tgcgccctct gcctcccgag tcatcgggca tcaagccacc cagcgccccg gatcctcctg
      181 gaccggtccg tccagattcc cgcgggaacg acctgccggc atctaccctg agtaccgggt
      241 tgggcgacac ctcagataca gagccgcccg tctgctttgc gccccctccc tgccgggatc
      301 tcttggactg tgcgcgagcc ttcttcctca ggcgccccca gccccgccgg cgcggcccgg
      361 ctcggcgccc cccgagcgct ccgggctatg gccggagccc gcccgccgcc ggggcttctg
      421 ccgctgctcg ctccgctgct gctgccgctg ctgctgcccg ccggctgccg ggcgctggaa
      481 gagactctca tggacacgaa atgggtgacg tccgagctgg catggacatc tcatccagag
      541 agtgggtggg aagaagtgag cggctacgat gaagccatga atcctatccg cacgtatcag
      601 gtgtgtaacg tgcgcgagtc cagccagaac aactggctgc ggaccggttt catctggcgg
      661 cgggaagtcc agcgcgtcta cgtggagctg aagtttaccg tgagagattg caacagcatc
      721 cccaacatcc ctggctcctg caaggaaacc ttcaaccttt tttactacga ggctgatagc
      781 gatgtggcgt cagcctcctc tcccttctgg atggagaacc cctacgtgaa agtggacacc
      841 attgcgccag atgagagctt ctcgcggcta gacgctgggc gcgttaacac caaagtgcgc
      901 agcttcgggc cgctttccaa agccggcttc tacttggcct tccaggacca gggtgcctgc
      961 atgtcactca tctctgtgcg cgccttctac aagaagtgtg catccaccac tgcaggcttc
     1021 gcactcttcc ccgagaccct cacgggggct gagcccactt cgctggtcat tgcccctggc
     1081 acctgcatcg ctaacgctgt ggaggtgtct gtaccgctca agctctactg caatggcgac
     1141 ggggagtgga tggtgcccgt tggtgcctgc acctgcgcta ctggccatga gccagccgcc
     1201 aaggagaccc agtgccgcgc ctgtccccct gggagctaca aggcaaagca aggagagggg
     1261 ccctgcctcc cctgtccccc caatagccgc accacctcgc cggctgccag catctgcacc
     1321 tgtcacaata atttctaccg cgcagactca gacacagcgg acagcgcctg caccacggtg
     1381 ccgtctcccc cccggggtgt gatctccaat gtgaatgaga cctcgctgat cctcgagtgg
     1441 agtgagcccc gggaccttgg cggacgagat gacctccttt ataatgttat ctgtaagaag
     1501 tgccgtggca gctctggggc tggaggtccg gcgacctgtt cacgctgtga tgacaacgtg
     1561 gagttcgagc cccgacagct gggcctgacc gagcgccggg tccacatcag ccacctgttg
     1621 gcccacaccc gctacacctt tgaggtgcag gctgtcaacg gcgtctctgg caaaagccct
     1681 ttgccgcccc gctatgcagc tgtgaatatc accaccaacc aggccgcccc atcagaagtg
     1741 cctacgctcc acttgcacag cagttcaggg agcagcctga ccctgtcctg ggcacccccg
     1801 gagcggccta acggagtcat cttggactat gagatgaagt actttgagaa gagtaaaggc
     1861 atcgcctcca ctgtcaccag ccagaagaac tctgtacaac tggacggact gcagcccgac
     1921 gcccgctatg tagttcaggt ccgggctcgc acagtagcag gttacggaca gtatagccgc
     1981 ccagctgagt ttgagaccac gagtgaaaga ggctcagggg cccagcagct tcaagagcag
     2041 cttcccctaa ttgtgggatc caccgtagct ggctttgtct tcatggtggt cgtcgtggtc
     2101 attgctcttg tctgcctcag gaagcagcgc cagggccctg atgcagaata cacggagaag
     2161 ttgcagcaat acgttgcccc caggatgaaa gtttacattg acccctttac ctacgaggat
     2221 cccaatgagg ccgtccgaga gttcgccaag gagatcgatg tgtcctgcgt caagatcgag
     2281 gaggtgattg gagctgggga gtttggggaa gtgtgccggg gtcggctgaa actgcccggc
     2341 cgccgggagg tgttcgtggc catcaagaca ctgaaggtgg gatacacgga gaggcagcgg
     2401 cgggacttcc tgagtgaggc ttccatcatg ggtcaatttg accatccaaa tataatccgt
     2461 ctagagggcg tggtcaccaa aagtcgtcca gtcatgatcc tcactgagtt catggagaac
     2521 tgtgccctgg actccttcct acggctcaat gacgggcagt tcacagtcat ccagcttgtg
     2581 ggcatgttgc gtggcattgc tgccggcatg aagtacttgt ctgagatgaa ctacgtgcac
     2641 cgtgacctcg ctgcccgcaa catccttgtc aacagtaact tggtctgcaa agtatctgac
     2701 tttgggctct cccgcttcct ggaggacgac ccctcagacc ccacctacac cagctccctg
     2761 ggtgggaaga tccctatccg ttggaccgcc ccagaggcca tagcctatcg gaagttcacg
     2821 tctgccagcg atgtctggag ctacgggatc gtcatgtggg aggtcatgag ctacggagag
     2881 cgaccatact gggacatgag caaccaggat gtcatcaatg ccgtagagca agactatcgg
     2941 ttaccacccc ccatggactg ccccacggcg ctgcaccagc tcatgctgga ctgttgggtg
     3001 cgggaccgga acctcaggcc caagttctcc caaatcgtca acacgctaga caagcttatc
     3061 cgcaatgctg ccagcctcaa ggtcatcgcc agtgccccat ctggcatgtc ccagcccctc
     3121 ctagaccgca cggtcccaga ttatacgacc ttcacgacgg tgggcgactg gctagatgcc
     3181 atcaagatgg ggaggtataa agagagcttc gtcggtgcgg gttttgcctc ctttgacctg
     3241 gtggcccaga tgactgcaga agatctgcta aggatcgggg tcactttggc cggccaccag
     3301 aagaagatcc tcagcagtat ccaggacatg cggctgcaga tgaaccagac actgcccgtg
     3361 caggtctgac gctcagctcc agcgaggggc gtggcccccc gggactgcac aaggattctg
     3421 accagccagc tggacttttg gatacctggc ctttggctgt ggcccagaag acagaagttc
     3481 gggggagaac cctagctgtg acttctccaa gcctgtgctc cctcccagga agtgtgcccc
     3541 aaacctcttc atattgaaga tggattagaa gagggggtga tatcccctcc ccagatgcct
     3601 cagggcccag gcctgcctgc tctccagtcg gggatcttca caactcagat ttggttgtgc
     3661 ttcagtagtg gaggtcctgg tagggtcggg tggggataag cctgggttct tcaggcccca
     3721 gccctggcag gggtctgacc ccagcaggta agcagagagt actccctccc caggaagtgg
     3781 aggaggggac tctgggaatg gggaaatatg gtgccccatc ctgaagccgg ctggtacctc
     3841 cagtttgcac agggacttgt tgggggctga gggccctgcc tacccttggt gctgtcataa
     3901 aagggcaggc gggagcaggc tgagaagcag cctgtgcctc ccagagactg actcagagag
     3961 ccagagacgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgaaagacg
     4021 ggggtggggt atgtatgcgt gtgttgtgca catgcttgcc tgcacagaga gcatgagtgt
     4081 gtacaagctt agccctgtgc cctgtagtgg ggccagctgg gcagacagcg aaataaaagg
     4141 caataagttg a
//
