LOCUS       NP_001401917             993 aa            linear   ROD 01-APR-2024
DEFINITION  ephrin type-B receptor 3 precursor [Rattus norvegicus].
ACCESSION   NP_001401917 XP_006248623
VERSION     NP_001401917.1
DBSOURCE    REFSEQ: accession NM_001414988.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 993)
  AUTHORS   Huang,H., Chen,L., Yuan,J., Zhang,H., Yang,J., Xu,Z. and Chen,Y.
  TITLE     Role and mechanism of EphB3 in epileptic seizures and
            epileptogenesis through Kalirin
  JOURNAL   Mol Cell Neurosci 128, 103915 (2024)
   PUBMED   38143048
  REMARK    GeneRIF: Role and mechanism of EphB3 in epileptic seizures and
            epileptogenesis through Kalirin.
REFERENCE   2  (residues 1 to 993)
  AUTHORS   Huang,H., Li,R., Yuan,J., Zhou,X., Liu,X., Ou,S., Xu,T. and Chen,Y.
  TITLE     Up-regulated ephrinB3/EphB3 expression in intractable temporal lobe
            epilepsy patients and pilocarpine induced experimental epilepsy rat
            model
  JOURNAL   Brain Res 1639, 1-12 (2016)
   PUBMED   26930615
  REMARK    GeneRIF: Study found up-regulated expression of ephrinB3/EphB3 in
            intractable temporal lobe epilepsy patients and experimental
            temporal lobe epilepsy rats, which suggested that ephrinB3/EphB3
            might be involved in the pathogenesis of temporal lobe epilepsy
REFERENCE   3  (residues 1 to 993)
  AUTHORS   Mimche,P.N., Brady,L.M., Bray,C.F., Lee,C.M., Thapa,M., King,T.P.,
            Quicke,K., McDermott,C.D., Mimche,S.M., Grakoui,A., Morgan,E.T. and
            Lamb,T.J.
  TITLE     The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in
            mice
  JOURNAL   Hepatology 62 (3), 900-914 (2015)
   PUBMED   25784101
REFERENCE   4  (residues 1 to 993)
  AUTHORS   Lin,B., Yin,T., Wu,Y.I., Inoue,T. and Levchenko,A.
  TITLE     Interplay between chemotaxis and contact inhibition of locomotion
            determines exploratory cell migration
  JOURNAL   Nat Commun 6, 6619 (2015)
   PUBMED   25851023
  REMARK    GeneRIF: Breast cancer cell motility is regulated in part by Ephb3
            signaling.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 993)
  AUTHORS   Garcia-Ceca,J., Jimenez,E., Alfaro,D., Cejalvo,T., Chumley,M.J.,
            Henkemeyer,M., Munoz,J.J. and Zapata,A.G.
  TITLE     On the role of Eph signalling in thymus histogenesis; EphB2/B3 and
            the organizing of the thymic epithelial network
  JOURNAL   Int J Dev Biol 53 (7), 971-982 (2009)
   PUBMED   19598115
REFERENCE   6  (residues 1 to 993)
  AUTHORS   Birgbauer,E., Oster,S.F., Severin,C.G. and Sretavan,D.W.
  TITLE     Retinal axon growth cones respond to EphB extracellular domains as
            inhibitory axon guidance cues
  JOURNAL   Development 128 (15), 3041-3048 (2001)
   PUBMED   11532925
REFERENCE   7  (residues 1 to 993)
  AUTHORS   Cowan,C.A., Yokoyama,N., Bianchi,L.M., Henkemeyer,M. and
            Fritzsch,B.
  TITLE     EphB2 guides axons at the midline and is necessary for normal
            vestibular function
  JOURNAL   Neuron 26 (2), 417-430 (2000)
   PUBMED   10839360
REFERENCE   8  (residues 1 to 993)
  AUTHORS   Adams,R.H., Wilkinson,G.A., Weiss,C., Diella,F., Gale,N.W.,
            Deutsch,U., Risau,W. and Klein,R.
  TITLE     Roles of ephrinB ligands and EphB receptors in cardiovascular
            development: demarcation of arterial/venous domains, vascular
            morphogenesis, and sprouting angiogenesis
  JOURNAL   Genes Dev 13 (3), 295-306 (1999)
   PUBMED   9990854
REFERENCE   9  (residues 1 to 993)
  AUTHORS   Orioli,D., Henkemeyer,M., Lemke,G., Klein,R. and Pawson,T.
  TITLE     Sek4 and Nuk receptors cooperate in guidance of commissural axons
            and in palate formation
  JOURNAL   EMBO J 15 (22), 6035-6049 (1996)
   PUBMED   8947026
REFERENCE   10 (residues 1 to 993)
  AUTHORS   Bohme,B., Holtrich,U., Wolf,G., Luzius,H., Grzeschik,K.H.,
            Strebhardt,K. and Rubsamen-Waigmann,H.
  TITLE     PCR mediated detection of a new human receptor-tyrosine-kinase, HEK
            2
  JOURNAL   Oncogene 8 (10), 2857-2862 (1993)
   PUBMED   8397371
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 20, 2022 this sequence version replaced XP_006248623.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.48865.1,
                                           SRR26643288.46239.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..993
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     Protein         1..993
                     /product="ephrin type-B receptor 3 precursor"
                     /EC_number="2.7.10.1"
                     /note="EPH-like tyrosine kinase-2; ephrin type-B receptor
                     3"
                     /calculated_mol_wt=106897
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2903
     Region          31..203
                     /region_name="EphR_LBD_B3"
                     /note="Ligand Binding Domain of Ephrin type-B Receptor 3;
                     cd10478"
                     /db_xref="CDD:198446"
     Site            order(39..41,43,55..58,60,64,66,68,71,104..106,110,112,
                     158,160,162..163,165..166,191,193,195)
                     /site_type="other"
                     /note="ephrin binding site [polypeptide binding]"
                     /db_xref="CDD:198446"
     Region          264..308
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Site            order(332,412,428)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          333..431
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(429..430,432..433)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <468..537
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(526..527,529..530)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          555..625
                     /region_name="EphA2_TM"
                     /note="Ephrin type-A receptor 2 transmembrane domain;
                     pfam14575"
                     /db_xref="CDD:464211"
     Region          623..891
                     /region_name="PTKc_EphR_B"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Class EphB Ephrin Receptors; cd05065"
                     /db_xref="CDD:173638"
     Site            order(634..638,642,658,660,706..707,709,713,753,757..758,
                     760,771,792..796,805,839)
                     /site_type="active"
                     /db_xref="CDD:173638"
     Site            order(634..636,638,642,658,660,706..707,709,713,758,760,
                     771)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173638"
     Site            order(753,757,792..796,805,839)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173638"
     Site            770..798
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173638"
     Region          917..985
                     /region_name="SAM_superfamily"
                     /note="SAM (Sterile alpha motif); cl15755"
                     /db_xref="CDD:472832"
     CDS             1..993
                     /gene="Ephb3"
                     /coded_by="NM_001414988.1:388..3369"
                     /db_xref="GeneID:287989"
                     /db_xref="RGD:1305602"
ORIGIN      
        1 magarpppgl lpllaplllp lllpagcral eetlmdtkwv tselawtshp esgweevsgy
       61 deamnpirty qvcnvressq nnwlrtgfiw rrevqrvyve lkftvrdcns ipnipgscke
      121 tfnlfyyead sdvasasspf wmenpyvkvd tiapdesfsr ldagrvntkv rsfgplskag
      181 fylafqdqga cmslisvraf ykkcasttag falfpetltg aeptslviap gtcianavev
      241 svplklycng dgewmvpvga ctcatghepa aketqcracp pgsykakqge gpclpcppns
      301 rttspaasic tchnnfyrad sdtadsactt vpspprgvis nvnetslile wseprdlggr
      361 ddllynvick kcrgssgagg patcsrcddn vefeprqlgl terrvhishl lahtrytfev
      421 qavngvsgks plppryaavn ittnqaapse vptlhlhsss gssltlswap perpngvild
      481 yemkyfeksk giastvtsqk nsvqldglqp daryvvqvra rtvagygqys rpaefettse
      541 rgsgaqqlqe qlplivgstv agfvfmvvvv vialvclrkq rqgpdaeyte klqqyvaprm
      601 kvyidpftye dpneavrefa keidvscvki eevigagefg evcrgrlklp grrevfvaik
      661 tlkvgyterq rrdflseasi mgqfdhpnii rlegvvtksr pvmiltefme ncaldsflrl
      721 ndgqftviql vgmlrgiaag mkylsemnyv hrdlaarnil vnsnlvckvs dfglsrfled
      781 dpsdptytss lggkipirwt apeaiayrkf tsasdvwsyg ivmwevmsyg erpywdmsnq
      841 dvinaveqdy rlpppmdcpt alhqlmldcw vrdrnlrpkf sqivntldkl irnaaslkvi
      901 asapsgmsqp lldrtvpdyt tfttvgdwld aikmgrykes fvgagfasfd lvaqmtaedl
      961 lrigvtlagh qkkilssiqd mrlqmnqtlp vqv
//
