LOCUS       NM_001127319            4762 bp    mRNA    linear   ROD 27-FEB-2024
DEFINITION  Rattus norvegicus Eph receptor B2 (Ephb2), mRNA.
ACCESSION   NM_001127319 XM_001069612 XM_233574
VERSION     NM_001127319.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4762)
  AUTHORS   Duan,G.B., Wang,J.W., Sun,H.H., Dong,Z.Y., Zhang,Y., Wang,Z.X.,
            Chen,Y., Chen,Y., Huang,Y. and Xu,S.C.
  TITLE     Overexpression of EphB2 in the basolateral amygdala is crucial for
            inducing visceral pain sensitization in rats subjected to water
            avoidance stress
  JOURNAL   CNS Neurosci Ther 30 (2), e14611 (2024)
   PUBMED   38353051
  REMARK    GeneRIF: Overexpression of EphB2 in the basolateral amygdala is
            crucial for inducing visceral pain sensitization in rats subjected
            to water avoidance stress.
REFERENCE   2  (bases 1 to 4762)
  AUTHORS   Bodin,R., Paille,V., Oullier,T., Durand,T., Aubert,P., Le
            Berre-Scoul,C., Hulin,P., Neunlist,M. and Cisse,M.
  TITLE     The ephrin receptor EphB2 regulates the connectivity and activity
            of enteric neurons
  JOURNAL   J Biol Chem 297 (5), 101300 (2021)
   PUBMED   34648765
  REMARK    GeneRIF: The ephrin receptor EphB2 regulates the connectivity and
            activity of enteric neurons.
REFERENCE   3  (bases 1 to 4762)
  AUTHORS   Wu,J., Lu,B., Yang,R., Chen,Y., Chen,X. and Li,Y.
  TITLE     EphB2 knockdown decreases the formation of astroglial-fibrotic
            scars to promote nerve regeneration after spinal cord injury in
            rats
  JOURNAL   CNS Neurosci Ther 27 (6), 714-724 (2021)
   PUBMED   33794069
  REMARK    GeneRIF: EphB2 knockdown decreases the formation of
            astroglial-fibrotic scars to promote nerve regeneration after
            spinal cord injury in rats.
REFERENCE   4  (bases 1 to 4762)
  AUTHORS   Sun,C.L., Li,C.W., He,N., Tang,Y.Z., Li,X.L., Xue,F.S. and Ni,J.X.
  TITLE     Blockade of Erythropoietin-Producing Human Hepatocellular Carcinoma
            Receptor B1 in Spinal Dorsal Horn Alleviates Visceral Pain in Rats
  JOURNAL   Pain Res Manag 2021, 7582494 (2021)
   PUBMED   33880135
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4762)
  AUTHORS   Yu,T., Chu,S., Liu,X., Li,J., Chen,Q., Xu,M., Wu,H., Li,M.,
            Dong,Y., Zhu,F., Zhou,H., Hu,D. and Fan,H.
  TITLE     Extracellular vesicles derived from EphB2-overexpressing bone
            marrow mesenchymal stem cells ameliorate DSS-induced colitis by
            modulating immune balance
  JOURNAL   Stem Cell Res Ther 12 (1), 181 (2021)
   PUBMED   33722292
  REMARK    GeneRIF: Extracellular vesicles derived from EphB2-overexpressing
            bone marrow mesenchymal stem cells ameliorate DSS-induced colitis
            by modulating immune balance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4762)
  AUTHORS   Cowan,C.A., Yokoyama,N., Bianchi,L.M., Henkemeyer,M. and
            Fritzsch,B.
  TITLE     EphB2 guides axons at the midline and is necessary for normal
            vestibular function
  JOURNAL   Neuron 26 (2), 417-430 (2000)
   PUBMED   10839360
REFERENCE   7  (bases 1 to 4762)
  AUTHORS   Adams,R.H., Wilkinson,G.A., Weiss,C., Diella,F., Gale,N.W.,
            Deutsch,U., Risau,W. and Klein,R.
  TITLE     Roles of ephrinB ligands and EphB receptors in cardiovascular
            development: demarcation of arterial/venous domains, vascular
            morphogenesis, and sprouting angiogenesis
  JOURNAL   Genes Dev 13 (3), 295-306 (1999)
   PUBMED   9990854
REFERENCE   8  (bases 1 to 4762)
  AUTHORS   Torres,R., Firestein,B.L., Dong,H., Staudinger,J., Olson,E.N.,
            Huganir,R.L., Bredt,D.S., Gale,N.W. and Yancopoulos,G.D.
  TITLE     PDZ proteins bind, cluster, and synaptically colocalize with Eph
            receptors and their ephrin ligands
  JOURNAL   Neuron 21 (6), 1453-1463 (1998)
   PUBMED   9883737
REFERENCE   9  (bases 1 to 4762)
  AUTHORS   Orioli,D., Henkemeyer,M., Lemke,G., Klein,R. and Pawson,T.
  TITLE     Sek4 and Nuk receptors cooperate in guidance of commissural axons
            and in palate formation
  JOURNAL   EMBO J 15 (22), 6035-6049 (1996)
   PUBMED   8947026
REFERENCE   10 (bases 1 to 4762)
  AUTHORS   Henkemeyer,M., Orioli,D., Henderson,J.T., Saxton,T.M., Roder,J.,
            Pawson,T. and Klein,R.
  TITLE     Nuk controls pathfinding of commissural axons in the mammalian
            central nervous system
  JOURNAL   Cell 86 (1), 35-46 (1996)
   PUBMED   8689685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000162.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001127319.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001127319.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JACYVU010000162.1  63626068-63626288   c
            222-286             JACYVU010000162.1  63565197-63565261   c
            287-971             JACYVU010000162.1  63561441-63562125   c
            972-1127            JACYVU010000162.1  63485398-63485553   c
            1128-1463           JACYVU010000162.1  63483429-63483764   c
            1464-1588           JACYVU010000162.1  63472670-63472794   c
            1589-1751           JACYVU010000162.1  63464131-63464293   c
            1752-1860           JACYVU010000162.1  63462002-63462110   c
            1861-1925           JACYVU010000162.1  63461183-63461247   c
            1926-2048           JACYVU010000162.1  63452717-63452839   c
            2049-2296           JACYVU010000162.1  63452001-63452248   c
            2297-2512           JACYVU010000162.1  63450924-63451139   c
            2513-2662           JACYVU010000162.1  63450289-63450438   c
            2663-2856           JACYVU010000162.1  63448228-63448421   c
            2857-3012           JACYVU010000162.1  63447156-63447311   c
            3013-4762           JACYVU010000162.1  63444913-63446662   c
FEATURES             Location/Qualifiers
     source          1..4762
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4762
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /note="Eph receptor B2"
                     /db_xref="GeneID:313633"
                     /db_xref="RGD:1564232"
     exon            1..221
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..3121
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-B receptor 2; ephrin type-B receptor
                     2-like"
                     /codon_start=1
                     /product="ephrin type-B receptor 2 precursor"
                     /protein_id="NP_001120791.2"
                     /db_xref="GeneID:313633"
                     /db_xref="RGD:1564232"
                     /translation="MAVRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWE
                     EVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPS
                     VPGSCKETFNLYYYEADFDLATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKIN
                     TEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKCPRVIQNGAIFQETLSGAESTS
                     LVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGT
                     FKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISS
                     VNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPR
                     IYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVD
                     SITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQV
                     RARTVAGYGRYSGKMYFQTMTEAEYQTSIKEKLPLIVGSSAAGVVFVIAVVVIAIVCN
                     RRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIE
                     QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNV
                     IHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM
                     NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAI
                     QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALH
                     QLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTS
                     FNTVDEWLEAIKMGQYKESFTNAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQ
                     VMRAQMNQIQSVEV"
     exon            222..286
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            287..971
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1127
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1463
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1588
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1751
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1860
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1925
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2048
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2296
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2512
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2662
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2856
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..3012
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..4762
                     /gene="Ephb2"
                     /gene_synonym="RGD1564232"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggctgga tggctcattc tgctggctgc gcggcggcgg cggctcgtgt gtgtgtgcgc
       61 cgcgccccgc cgctccccgc cggccccccg agcccggggc gcgcgctcca gcccgggggt
      121 ccccgcggcg ccgcggcccg aggctccggg cagcgtagca atggccgtgc gcaggctggg
      181 ggccgcgctg ctgctgctgc cgctgctagc cgccgtggaa gaaacactga tggactctac
      241 tacagcaacg gctgagctgg gctggatggt acatccccca tcagggtggg aagaggtgag
      301 cggctacgat gagaacatga acactatccg tacctaccag gtgtgcaatg tctttgagtc
      361 aagccagaac aactggctac ggaccaaatt catccggcgc cgcggcgccc accgcatcca
      421 cgtggagatg aagttctcgg tgcgtgactg tagcagcatt cccagcgtgc ccggctcctg
      481 caaggagacc ttcaacctct actactatga ggctgatttt gacttagcca ccaagacctt
      541 tcccaactgg atggagaatc cgtgggtgaa ggtggacacc attgcggctg atgagagctt
      601 ttcccaggtg gatctgggtg gccgcgtcat gaaaatcaac actgaggtgc gaagcttcgg
      661 tcccgtgtcc cgcaatggtt tctacctggc cttccaggac tacggcggct gtatgtccct
      721 cattgcggtg cgcgtcttct accggaagtg cccccgagtc atccagaatg gtgccatctt
      781 ccaggagaca ctgtcggggg ctgagagcac ctcactggta gctgctcggg gcagctgcat
      841 cgccaacgct gaagaagtgg atgtacccat caaactctac tgtaacgggg acggcgaatg
      901 gctggtgccc atcggtcgct gcatgtgcaa ggcgggcttc gaggctgtgg agaacggtac
      961 cgtctgccga ggttgtccat caggaacctt caaggccaac caaggggatg aagcctgtac
     1021 ccactgtccc atcaacagcc gtaccacctc cgagggtgcc accaactgtg tgtgccgtaa
     1081 cggctactac agggctgacc tggacccctt agacatgcct tgcacaacca tcccctctgc
     1141 gccccaggct gtgatctcca gtgtcaacga gacgtccctc atgctagagt ggaccccgcc
     1201 acgagactcg gggggccgtg aggaccttgt ttataacatc atctgcaaga gctgtggctc
     1261 aggccggggt gcctgcacgc gctgtggaga caatgtgcag tacgcacccc gccagctagg
     1321 cctgaccgag ccacgcatct acatcagtga cctgctggca cacacacagt acaccttcga
     1381 gatccaggcc gtgaatggtg tcaccgacca gagtcccttc tcacctcagt tcgcctctgt
     1441 gaacatcacc accaaccaag cagcaccgtc ggccgtgtcc atcatgcacc aggtgagccg
     1501 caccgtggac agcatcaccc tgtcgtggtc ccagccagac cagcccaacg gtgtgatcct
     1561 ggactatgaa ctacagtact atgagaagga gctcagtgag tacaacgcca cagccataaa
     1621 aagccccacc aacacagtca ctgtgcaggg cctcaaagcc ggcgccatct atgtcttcca
     1681 ggtgcgggca cgcaccgtcg caggctatgg gcgttacagt ggcaagatgt acttccaaac
     1741 catgacagaa gccgagtacc agaccagcat caaggaaaag ctgcccctca tcgtcggctc
     1801 ctccgctgcc ggcgtagtct tcgtcatcgc cgtggtcgtc attgccatcg tatgtaacag
     1861 acgggggttt gagcgtgccg actcagaata cacggacaag ctgcagcact acaccagcgg
     1921 ccacatgacc ccaggcatga agatctatat tgaccctttc acctatgaag atcctaatga
     1981 ggcagtgcgg gagtttgcca aggaaatcga catctcctgt gtcaagattg agcaggtgat
     2041 tggagcaggg gaatttggtg aggtctgcag tggccacttg aagctgccag ggaagagaga
     2101 gatctttgta gccatcaaga ccctcaagtc aggatacaca gagaaacagc gccgggactt
     2161 cctgagtgag gcatccatca tgggccagtt cgaccacccc aatgtcatcc acctggaagg
     2221 ggttgtcacc aagagcacac ctgtcatgat catcactgaa ttcatggaga acggttccct
     2281 ggactccttc ctccggcaaa acgatgggca gttcacggtc atccaactgg tgggcatgct
     2341 gaggggcatc gcagctggca tgaagtacct ggcggacatg aactatgtgc accgggacct
     2401 tgctgcacgc aacatccttg tcaatagcaa cctggtgtgc aaggtgtctg acttcgggct
     2461 ctcacgcttc ctggaggacg acacatctga ccccacctac accagcgctc tgggtgggaa
     2521 gatccccatc cgttggacag caccggaagc catccagtac cggaaattca cctcagccag
     2581 tgatgtgtgg agctatggca ttgtcatgtg ggaggtgatg tcctacgggg agcgacccta
     2641 ctgggacatg accaaccaag acgtaatcaa tgccatcgag caggactacc ggctacctcc
     2701 gcccatggac tgccccagcg cgctgcacca gctcatgctg gattgctggc agaaggaccg
     2761 caaccaccgg cccaagttcg gccagatcgt caacacgctg gacaagatga tccgaaaccc
     2821 caacagcctc aaagctatgg cgcccctgtc ctctggtatc aacctgccac tactggaccg
     2881 cacgataccc gactacacca gctttaacac agtggatgag tggctggagg ccatcaagat
     2941 gggccagtac aaggagagct ttaccaacgc cggcttcacc tcttttgacg tcgtatctca
     3001 gatgatgatg gaggacattc tccgggttgg ggtcactcta gctggccacc agaaaaaaat
     3061 cctgaacagt atccaggtga tgcgggccca gatgaaccag atccagtcgg tagaggtttg
     3121 atggtcgcct gcctcggctc tcctcgtcct ccatgcgccc ctaagcccct tacgtcggtc
     3181 cccctgctgc tctgtccact gcaaggtcag ccacctgcca gcaggccaca ggcaacagga
     3241 agaaccaagc agcactccag tcaagccgtc accaagaacc catgcaagtc aaaggaagga
     3301 aaagggaatg ggggggacac gcacctagat ctgggagggg gcgggacagg caagaaacgt
     3361 ttgttcaaag aggattctca taagaagagt gatggttctt aggggagaaa agcaaaaagg
     3421 cttgggagac ccacatggcc tgtcccggtg gaggccaaaa gcattttctc tccaactcct
     3481 tctgggaagg ttgagctggt cagagccaag ggggaaaaaa aaatgcttcc aggaacatta
     3541 acatggaggg aagaggtggg ccaccctcct tgcctggcct tggctgtttc ttggagcatc
     3601 actaatggcc cagtcccagg cacaaggggc agagagacag gcagtcgccc caaataagct
     3661 ctggggaagt ccattccagt cgccaccggc agacagaaca gttctgtctt gggagccggt
     3721 ttcaaaaact ccgagggact tttcttctgc taatggttca ggaggcgaca cacagaggag
     3781 ctcctggcct tccggatcac actgaacagg ccagatcttc ctgaggacag ccacccaggt
     3841 ctgcagcccc acaaggccct gccctgcacg ggtgcccgct cctgccctgc tgcaggtgac
     3901 tgtcttgagc ctcgactgcc actgagaagc attctcttgc atctgggttt gtttacagca
     3961 attcgtggac ttgggggtat tttgatcagg ggtggttttg gtctgggagg gtttgtttgt
     4021 tgggtttttt taaatgacaa tgaagagaca ctttgacatt tcctaccttt tgaggacttg
     4081 atccttctcc aggaagaagg tgctttctgc ttactgactt aggcaataca ccaagggcaa
     4141 gattttatat gcacatttct ggatttttat acgcttttca ttgacaccct tccctccccg
     4201 cacctgctgc caggcctcac caaagccaac tgtcacaggg ccacctgggc cattcagaga
     4261 cctcagtggg tctgggggaa tggagggagc cgcaccaaca cccccccccc ccccgcattg
     4321 gaccccagac tgagtgaggc agatgagggc ttcctctgca ggaagtcctc tcttcctccc
     4381 tgcacattcc catgctctct gccctgttct atctggtact tcccaggcac agaggcccct
     4441 tcaggttcct gggtgctctc cgatggccaa aacccaattt cacctctggg agcctggacc
     4501 aggctaccca ggaagtcagg accctgatca ttcactgtga caccctagcc ctccaagggt
     4561 accccgggag accatgtgac tctctctccc actccttctc cctacccccc acccccgcct
     4621 ttgcccaggt ctgaaggtct tggccagagg aatatcatca gtcaggggtc tggcctcaga
     4681 ctctcctgtg agcaaaagca ggagacccga gcagaacaat cggttagtga attgaacgga
     4741 aataaatgct ttagttataa aa
//
