LOCUS       NM_001104528            4625 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus Eph receptor B1 (Ephb1), mRNA.
ACCESSION   NM_001104528 XM_001059882 XM_001081949 XM_217250
VERSION     NM_001104528.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4625)
  AUTHORS   Omoumi,S., Rashidy-Pour,A., Seyedinia,S.A., Tarahomi,P.,
            Vafaei,A.A. and Raise-Abdullahi,P.
  TITLE     Corticosterone injection into the infralimbic prefrontal cortex
            enhances fear memory extinction: Involvement of GABA receptors and
            the extracellular signal-regulated kinase
  JOURNAL   Physiol Behav 265, 114156 (2023)
   PUBMED   36918107
  REMARK    GeneRIF: Corticosterone injection into the infralimbic prefrontal
            cortex enhances fear memory extinction: Involvement of GABA
            receptors and the extracellular signal-regulated kinase.
REFERENCE   2  (bases 1 to 4625)
  AUTHORS   Li,X., Chen,S., Feng,D., Fu,Y., Wu,H., Lu,J. and Bao,J.
  TITLE     Calcium-sensing receptor promotes calcium oxalate crystal adhesion
            and renal injury in Wistar rats by promoting ROS production and
            subsequent regulation of PS ectropion, OPN, KIM-1, and ERK
            expression
  JOURNAL   Ren Fail 43 (1), 465-476 (2021)
   PUBMED   33678127
  REMARK    GeneRIF: Calcium-sensing receptor promotes calcium oxalate crystal
            adhesion and renal injury in Wistar rats by promoting ROS
            production and subsequent regulation of PS ectropion, OPN, KIM-1,
            and ERK expression.
REFERENCE   3  (bases 1 to 4625)
  AUTHORS   Jin,F., Zhao,L., Hu,Q. and Qi,F.
  TITLE     Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia
            in MPS patients and a rat model of taut band-associated persistent
            muscle pain
  JOURNAL   Mol Pain 16, 1744806920984079 (2020)
   PUBMED   33356837
  REMARK    GeneRIF: Peripheral EphrinB1/EphB1 signalling attenuates muscle
            hyperalgesia in MPS patients and a rat model of taut
            band-associated persistent muscle pain.
REFERENCE   4  (bases 1 to 4625)
  AUTHORS   Zhang,M. and Wang,Z.
  TITLE     Downregulation of miR143/145 gene cluster expression promotes the
            aortic media degeneration process via the TGF-beta1 signaling
            pathway
  JOURNAL   Am J Transl Res 11 (1), 370-378 (2019)
   PUBMED   30787994
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4625)
  AUTHORS   Lim,S.H.
  TITLE     Larch Arabinogalactan Attenuates Myocardial Injury by Inhibiting
            Apoptotic Cascades in a Rat Model of Ischemia-Reperfusion
  JOURNAL   J Med Food 20 (7), 691-699 (2017)
   PUBMED   28622474
REFERENCE   6  (bases 1 to 4625)
  AUTHORS   Stein,E., Lane,A.A., Cerretti,D.P., Schoecklmann,H.O.,
            Schroff,A.D., Van Etten,R.L. and Daniel,T.O.
  TITLE     Eph receptors discriminate specific ligand oligomers to determine
            alternative signaling complexes, attachment, and assembly responses
  JOURNAL   Genes Dev 12 (5), 667-678 (1998)
   PUBMED   9499402
REFERENCE   7  (bases 1 to 4625)
  AUTHORS   Stein,E., Huynh-Do,U., Lane,A.A., Cerretti,D.P. and Daniel,T.O.
  TITLE     Nck recruitment to Eph receptor, EphB1/ELK, couples ligand
            activation to c-Jun kinase
  JOURNAL   J Biol Chem 273 (3), 1303-1308 (1998)
   PUBMED   9430661
REFERENCE   8  (bases 1 to 4625)
  AUTHORS   Cerretti,D.P., Vanden Bos,T., Nelson,N., Kozlosky,C.J., Reddy,P.,
            Maraskovsky,E., Park,L.S., Lyman,S.D., Copeland,N.G., Gilbert,D.J.
            et al.
  TITLE     Isolation of LERK-5: a ligand of the eph-related receptor tyrosine
            kinases
  JOURNAL   Mol Immunol 32 (16), 1197-1205 (1995)
   PUBMED   8559144
REFERENCE   9  (bases 1 to 4625)
  AUTHORS   Lhotak,V., Greer,P., Letwin,K. and Pawson,T.
  TITLE     Characterization of elk, a brain-specific receptor tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (5), 2496-2502 (1991)
   PUBMED   2017163
REFERENCE   10 (bases 1 to 4625)
  AUTHORS   Letwin,K., Yee,S.P. and Pawson,T.
  TITLE     Novel protein-tyrosine kinase cDNAs related to fps/fes and eph
            cloned using anti-phosphotyrosine antibody
  JOURNAL   Oncogene 3 (6), 621-627 (1988)
   PUBMED   2485255
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Sep 14, 2007 this sequence version replaced
            XM_217250.3, XM_001059882.1, XM_001081949.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760384
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4625
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4625
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /note="Eph receptor B1"
                     /db_xref="GeneID:24338"
                     /db_xref="RGD:2556"
     exon            1..326
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..3223
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-B receptor 1; tyrosine-protein kinase
                     receptor EPH-2; Eph receptor B2 (ELK-related protein
                     tyrosine kinase)"
                     /codon_start=1
                     /product="ephrin type-B receptor 1 precursor"
                     /protein_id="NP_001097998.1"
                     /db_xref="GeneID:24338"
                     /db_xref="RGD:2556"
                     /translation="MALDCLLLFLLASAVAAMEETLMDTRTATAELGWTANPASGWEE
                     VSGYDENLNTIRTYQVCNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNV
                     PGSCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNT
                     EVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSL
                     VIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKAGYEPENSVACKACPAGTFK
                     ASQEAEGCSHCPSNSRSPSEASPICTCRTGYYRADFDPPEVACTSVPSGPRNVISIVN
                     ETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECRVS
                     ISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSI
                     TLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRA
                     RTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRK
                     RAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEV
                     IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIR
                     LEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNY
                     VHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAY
                     RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQL
                     MLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFT
                     TVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGVTLAGHQKKILSSIHSM
                     RVQMNQSPSVMA"
     exon            327..391
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            392..1073
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1229
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1565
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1690
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1853
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1962
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2027
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2150
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2398
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2614
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2764
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2958
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3114
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..4625
                     /gene="Ephb1"
                     /gene_synonym="elk; Ephb2; Erk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcgctct ccctcaccct ctctcacaca cgcacgcaca cacccacctc tcccataaac
       61 acacacacac acatgcacac ccacatccac gcgcgcccgc accgccccac gcgcgcacac
      121 tcccgcccac gcccacgccg cgctccgggg agtccggtcc cggccagagc gcgaaaggac
      181 acggagaagc cacccgccgg gagcgcagcg gcgccctggg acgcggcgcg tctccgctgg
      241 ggctcggcct gggggccgct ggccggcgat ggccctggat tgcctgctgc tgttcctcct
      301 ggcatctgca gtggccgcga tggaagaaac attgatggac acaaggactg ccactgcaga
      361 gttgggatgg acggccaacc ctgcctctgg gtgggaagaa gtcagtggct acgatgaaaa
      421 cctgaacacc atccgtactt accaagtgtg caacgtcttt gaacccaacc agaacaactg
      481 gctgcttacc acctttatca acagacgggg cgcccatcgc atctatacag agatgcgctt
      541 cactgtgagg gactgcagca gccttccaaa tgtcccaggc tcctgcaaag agaccttcaa
      601 cttatactac tatgagactg actctgtcat tgccaccaag aagtcagcct tctggtctga
      661 agccccctac ctcaaagttg acaccattgc tgcagatgag agcttctccc aggtggattt
      721 tgggggaagg ttgatgaagg tcaacacaga agtcaggagc tttgggcctc ttactaggaa
      781 tggtttttac ctcgctttcc aggattatgg agcctgtatg tctctacttt ctgtccgtgt
      841 cttcttcaaa aagtgtccca gcattgtgca aaattttgca gtgttcccag aaaccatgac
      901 aggagcagag agcacatctc tggtgattgc tcggggcaca tgcatcccta atgcagaaga
      961 agtggatgtg cccataaaac tctactgcaa tggagatgga gagtggatgg tgcccattgg
     1021 gcgctgcacc tgtaaggctg gctatgaacc tgagaacagc gtggcctgca aggcctgtcc
     1081 tgcgggaacc ttcaaggcca gccaggaagc tgaaggctgc tcccactgcc cctccaacag
     1141 ccgctcccct tcagaggcgt ctcccatctg cacctgccgg actggctatt accgagcaga
     1201 ctttgatccc ccagaagtgg cgtgcactag tgtcccatca ggccctcgaa atgtcatctc
     1261 cattgtgaat gagacatcta tcattctaga gtggcaccct ccaagagaga ccggtgggcg
     1321 agatgatgtg acctacaaca tcatctgcaa gaagtgcaga gcagaccgcc ggagttgctc
     1381 ccgctgcgat gacaatgtgg agtttgtacc cagacagctg ggcttgactg agtgtcgtgt
     1441 ctctatcagt agcctatggg cccacacccc atacactttt gatatccagg ccatcaatgg
     1501 agtctctagc aagagtccct tccccccaca gcatgtctct gtcaacatca ccacaaacca
     1561 agctgccccc tccactgttc ctatcatgca ccaggtcagt gccaccatga ggagcatcac
     1621 cttgtcatgg cctcagccgg agcagcctaa tggcatcatc ctggactatg agatccggta
     1681 ctatgagaag gagcacaatg agttcaactc ttccatggcc aggagccaga ccaacacggc
     1741 acgtatcgat gggctacggc ccggcatggt gtatgtggtc caggtacgag ctcgaaccgt
     1801 ggctggctat ggcaagttca gtggcaagat gtgcttccag actctgacag atgatgatta
     1861 caagtcggag ctgagagagc agctacccct gatcgctggc tctgcagcag ctggggttgt
     1921 atttgttgtg tctctggtgg ctatctccat tgtctgcagc aggaaacgag cttacagcaa
     1981 agaggctgtg tacagtgata aacttcagca ttacagcaca ggccgaggct ccccagggat
     2041 gaagatctac attgacccgt tcacttatga ggaccctaat gaagctgtcc gggagtttgc
     2101 caaggagatt gatgtgtctt ttgtgaaaat tgaagaggtc atcggagcag gggagtttgg
     2161 agaagtgtac aagggccgat tgaagctgcc aggcaagagg gaaatctatg tggccatcaa
     2221 gaccctgaaa gctgggtact cagagaaaca gcgtcgggat tttctgagcg aggcgagcat
     2281 catgggccag tttgaccatc ccaacatcat tcgcctagag ggtgttgtca ccaagagccg
     2341 acctgtcatg atcattacgg agttcatgga gaatggcgct ttagactctt tcctccggca
     2401 aaatgacgga cagttcaccg tgatccagct tgtggggatg ctgaggggca tcgctgctgg
     2461 catgaagtac ctatctgaga tgaattatgt gcaccgggac ctggctgcta ggaacattct
     2521 ggtgaacagc aacctggtgt gcaaagtgtc tgactttggc ctctctcgct acctccagga
     2581 tgacacctca gaccccacct acaccagctc cttgggaggg aagatacctg ttagatggac
     2641 agctccagag gccatcgcct accgcaagtt tacgtcagcc agcgatgtct ggagctacgg
     2701 gattgtcatg tgggaagtaa tgtcatttgg agagagacct tactgggata tgtccaatca
     2761 agatgtcatc aatgccattg agcaggacta ccggctgccc cctcctatgg actgcccagc
     2821 tgccctgcac cagctcatgc tggactgttg gcagaaggat cgaaatagcc ggccccgttt
     2881 tgcagagatc gtcaacaccc tggacaagat gatccggaac ccagctagtc tcaagactgt
     2941 ggcaaccatc accgctgtgc cttcccaacc cctgcttgac cgctctatcc cagacttcac
     3001 ggcctttacc accgtggatg actggctaag tgccatcaaa atggtccagt acagggacag
     3061 cttcctcacc gctggcttca cctccctcca gctggtcacc cagatgacat cagaagacct
     3121 cctgagaata ggggtcacct tggcaggcca tcagaagaag attcttagca gcatccactc
     3181 gatgagggtc cagatgaacc agtcaccgtc ggtaatggca tgagaactcg atgttcctag
     3241 gggaggagag gaatgaaaag gaccagggtc aaaggggaaa cagaggttga ccacggtgga
     3301 atgtgccaga aagatcagct tcttggctga gaaacaactt cccacctgtg aagaatgaac
     3361 tggacctgct gcccatgggc aaccgccatt tctcggccat ggaagtgtgt agaagccgtg
     3421 ggaaaccaaa cgcgtaatga ttgacgataa agacagagaa aggtgatgct aaacagaagc
     3481 gaagctgaaa ccgtatgcgt tgggaaccag ggtgaactca gttcccatct gagagggact
     3541 ggagttcccc gtctgcagga agaaaggaag gaggtggagg gaagagaggg aagccctggg
     3601 ctgtgccatg ctctccctcg ccaatgacat tcttttcttt cctccattcg tactcctccc
     3661 tcagagcccc tcctccctcc cccacatcca tttcccttgc tcatgactca tgtagggaag
     3721 tttcttcaaa ataaaaccca gctcctgagt ctccagatgt cgtctgtcag ttgccaaagg
     3781 actttgctga ccactactgc atggggatcc aaccaatcca attaatgtct tcatattgaa
     3841 gaagaaatgt accttcaatt gaaaaccttg tttttctttt gtttgcattt tctgcaaaaa
     3901 ggaaaaaaaa aaaaagaaac cacaaattgg agagaaaaaa aaaaacacaa atagaaaaac
     3961 ctgtttccgt gtgcgaacgc acacgtatgt gtgtctgcgt tataaaatga ccgtgcttgt
     4021 tcgtgacaga tgcaaacaag aaaaaagaat tgggaaaggt tttggccctg ggaggtctca
     4081 aggggctgga atatgcttgt tggcctggct ttctgcttgg gccactggga agagaaaagg
     4141 gggaggggac gtaaatgaaa gaaaaaaaaa aaagatagtc tctgaagagt ttgcaaatta
     4201 agacaggaaa caggtgagtg gtttggattg gatgcagtgt gggccgttcc agaatgatgc
     4261 tgactgaaga gttactcttt gataagatct gaagaaaagg agagggaaag gatttctgga
     4321 gaatgttctt gcacatcccc ggaaccagcg atttgagagg cggcgaggga gagctctctc
     4381 ttgcccggcc gtggactggc tgagccgcgt ggcatggagg aacagccacg tggcatggag
     4441 gagtgtgtct gtcttgtctg tgtttctctt cgcactcctt cctgcacctc attgttcatt
     4501 gtttgattcg cttttgtaaa ttccacctaa catttaaata ttttttaatt tctcctttga
     4561 ccttaatctc cttgttaatt tcatctgtct aattaaaaag agaagaagca tgtctgggtt
     4621 tacgt
//
