LOCUS       NM_001419265            4716 bp    mRNA    linear   ROD 19-FEB-2024
DEFINITION  Rattus norvegicus Eph receptor A8 (Epha8), mRNA.
ACCESSION   NM_001419265 XM_039111297
VERSION     NM_001419265.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4716)
  AUTHORS   Buensuceso,A.V. and Deroo,B.J.
  TITLE     The ephrin signaling pathway regulates morphology and adhesion of
            mouse granulosa cells in vitro
  JOURNAL   Biol Reprod 88 (1), 25 (2013)
   PUBMED   23242526
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4716)
  AUTHORS   Shin,J., Gu,C., Park,E. and Park,S.
  TITLE     Identification of phosphotyrosine binding domain-containing
            proteins as novel downstream targets of the EphA8 signaling
            function
  JOURNAL   Mol Cell Biol 27 (23), 8113-8126 (2007)
   PUBMED   17875921
REFERENCE   3  (bases 1 to 4716)
  AUTHORS   Gu,C., Shim,S., Shin,J., Kim,J., Park,J., Han,K. and Park,S.
  TITLE     The EphA8 receptor induces sustained MAP kinase activation to
            promote neurite outgrowth in neuronal cells
  JOURNAL   Oncogene 24 (26), 4243-4256 (2005)
   PUBMED   15782114
REFERENCE   4  (bases 1 to 4716)
  AUTHORS   Gu,C. and Park,S.
  TITLE     The EphA8 receptor regulates integrin activity through p110gamma
            phosphatidylinositol-3 kinase in a tyrosine kinase
            activity-independent manner
  JOURNAL   Mol Cell Biol 21 (14), 4579-4597 (2001)
   PUBMED   11416136
REFERENCE   5  (bases 1 to 4716)
  AUTHORS   Choi,S. and Park,S.
  TITLE     Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates
            Fyn binding to the Tyr-615 site by enhancing tyrosine kinase
            activity
  JOURNAL   Oncogene 18 (39), 5413-5422 (1999)
   PUBMED   10498895
REFERENCE   6  (bases 1 to 4716)
  AUTHORS   Park,S., Frisen,J. and Barbacid,M.
  TITLE     Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine
            protein kinase receptors
  JOURNAL   EMBO J 16 (11), 3106-3114 (1997)
   PUBMED   9214628
REFERENCE   7  (bases 1 to 4716)
  AUTHORS   Park,S. and Sanchez,M.P.
  TITLE     The Eek receptor, a member of the Eph family of tyrosine protein
            kinases, can be activated by three different Eph family ligands
  JOURNAL   Oncogene 14 (5), 533-542 (1997)
   PUBMED   9053851
REFERENCE   8  (bases 1 to 4716)
  AUTHORS   Chan,J. and Watt,V.M.
  TITLE     eek and erk, new members of the eph subclass of receptor
            protein-tyrosine kinases
  JOURNAL   Oncogene 6 (6), 1057-1061 (1991)
   PUBMED   1648701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000162.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001419265.2.
            
            On Mar 30, 2023 this sequence version replaced XM_039111297.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JACYVU010000162.1  63742608-63742814   c
            208-272             JACYVU010000162.1  63738023-63738087   c
            273-936             JACYVU010000162.1  63731853-63732516   c
            937-1092            JACYVU010000162.1  63726220-63726375   c
            1093-1428           JACYVU010000162.1  63724361-63724696   c
            1429-1553           JACYVU010000162.1  63722240-63722364   c
            1554-1716           JACYVU010000162.1  63721978-63722140   c
            1717-1810           JACYVU010000162.1  63721019-63721112   c
            1811-1878           JACYVU010000162.1  63720560-63720627   c
            1879-2043           JACYVU010000162.1  63719656-63719820   c
            2044-2229           JACYVU010000162.1  63719302-63719487   c
            2230-2291           JACYVU010000162.1  63718988-63719049   c
            2292-2501           JACYVU010000162.1  63718238-63718447   c
            2502-2651           JACYVU010000162.1  63717858-63718007   c
            2652-2842           JACYVU010000162.1  63717582-63717772   c
            2843-3016           JACYVU010000162.1  63717242-63717415   c
            3017-4716           JACYVU010000162.1  63715411-63717110   c
FEATURES             Location/Qualifiers
     source          1..4716
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4716
                     /gene="Epha8"
                     /note="Eph receptor A8"
                     /db_xref="GeneID:60589"
                     /db_xref="RGD:708543"
     exon            1..207
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..3131
                     /gene="Epha8"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-A receptor 8; EPH- and ELK-related
                     kinase; tyrosine-protein kinase receptor EEK"
                     /codon_start=1
                     /product="ephrin type-A receptor 8 precursor"
                     /protein_id="NP_001406194.1"
                     /db_xref="GeneID:60589"
                     /db_xref="RGD:708543"
                     /translation="MAPARARLSPALWVVTAAAAATCVSAGRGEVNLLDTSTIHGDWG
                     WLTYPAHGWDSINEVDESFRPIHTYQVCNVMSPNQNNWLRTSWVPRDGARRVYAEIKF
                     TLRDCNSIPGVLGTCKETFNLHYLESDRDLGASTQESQFLKIDTIAADESFTGADLGV
                     RRLKLNTEVRGVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVT
                     GADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACMACE
                     LGFYKSAPGDQLCARCPPHSHSATPAAQTCRCDLSYYRAALDPPSAACTRPPSAPVNL
                     ISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALSHCEACGSGTRFVPQQTSLA
                     QASLLVANLLAHMNYSFWIEAVNGVSNLSPEPRNAAVVNITTNQAAPSQVVVIRQERA
                     GQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPGTRYM
                     FQVRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVVLLLLLICKKRH
                     CGYSKAFQDSDEEKMHYQNGQAPPPVFLPLNHPPGKLPETQFSAEPHNYEEPGRAGRS
                     FTREIEASRIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLR
                     EAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTILQLVGML
                     KGVGAGMRYLSDLGYIHRDLAARNILVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGK
                     IPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRL
                     PAPMGCPRALHQLMLDCWHKDRAQRPRFSHVVSVLEALVHSPESLRATATVSRCPAPA
                     FARSCFDLRAGGNGNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLHMNAQDVRAL
                     GITLMGHQKKILGSIQTMRSQLSCTQGPRRHL"
     exon            208..272
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            273..936
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1092
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1428
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1553
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1716
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1810
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1878
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2043
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2229
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2291
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2501
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2651
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2842
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..3016
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..4716
                     /gene="Epha8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgggtgc ccgcgtgcgg ctgagccgcg tgtgcgccgg ccggggtgcg ggagaggcag
       61 gagcgcgcca cgcgcggccg ccgggccgag cccgaggagc gcggcgccgc ccggccatgg
      121 cccccgcccg ggcccgcctg tcccccgctc tctgggtcgt cacggccgcg gcggcggcca
      181 cctgcgtgtc cgcggggcgc ggcgaagtga acctgttgga cacatcgacc atccacggag
      241 actggggctg gctcacatat cctgctcatg ggtgggactc catcaacgag gtggacgagt
      301 cctttcggcc catccacacg tatcaggtgt gcaacgtcat gagtcccaac cagaacaact
      361 ggctgcgtac aagctgggtg ccccgtgacg gcgccaggcg tgtctacgcc gagatcaaat
      421 tcaccctgcg tgactgcaat agcattcctg gggtgttggg cacctgcaag gagaccttca
      481 accttcacta cctagagtct gaccgggatc tgggggccag cacacaagag agccagttcc
      541 tcaagattga caccatcgca gcggatgaga gcttcaccgg cgcagatctg ggcgtgcgga
      601 ggctcaagct gaacacggag gtgcgtggcg tgggcccgct cagcaagcgc ggcttctacc
      661 tggccttcca ggacataggt gcctgcctcg ccatcctctc actcagaatc tactacaaga
      721 agtgtcccgc catggtacgc aacctggcgg ccttctcgga ggcggtaacc ggggctgact
      781 cgtcctcgct ggtagaggtt cgaggccagt gtgtgcgaca ctcagaggag cgcgacacac
      841 ccaagatgta ctgcagtgcc gagggcgaat ggctggtgcc catcggcaag tgcgtgtgca
      901 gtgccggcta tgaggagcgg cgcgatgcct gtatggcctg tgagctgggc ttctacaagt
      961 cagcccccgg ggaccagctg tgtgcccgat gcccacccca cagccattct gccacccctg
     1021 cggcccagac ctgccgttgt gacctcagct actaccgtgc ggccttggac ccaccatcgg
     1081 cagcctgcac ccggccaccc tcagcaccgg tgaacctgat ctccagcgtg aacggaactt
     1141 ctgtgaccct ggagtgggcc cctcctctgg acccaggcgg ccgcagtgac atcacctaca
     1201 acgcggtgtg ccgccgctgc ccctgggccc tgagccactg tgaggcttgt gggagtggaa
     1261 ctcgctttgt cccgcaacag acaagcctgg cgcaggccag cctgctggtg gccaacctcc
     1321 tggcccacat gaactactcc ttctggatcg aggcagtcaa cggtgtctcc aacctgagcc
     1381 ccgagccccg caacgctgct gtggtcaaca tcaccacaaa ccaggcagcc ccgtcccagg
     1441 tggtggtgat ccggcaggag cgggctgggc agaccagcgt gtcactcctg tggcaggagc
     1501 cagagcaacc caacggcatc atactggagt acgagatcaa gtactacgag aaggataagg
     1561 agatgcaaag ctactctacc ctcaaggctg tcaccacccg cgccaccgtg tcgggcctca
     1621 aaccaggcac tcgctacatg ttccaggtcc gggcccgcac ctcagcaggc tgtggacgct
     1681 tcagccaggc catggaggtg gagaccggga aacccaggcc ccgctatgac actcggacca
     1741 tcgtctggat ctgcctgaca ctcatcacag gcctggtggt actcctcctg cttctcatct
     1801 gcaagaagag gcactgcggc tatagcaagg cattccagga ctctgatgaa gagaaaatgc
     1861 attaccagaa tggccaagca cccccgcctg tcttcttgcc cttgaaccac cccccgggga
     1921 agctcccaga aacccagttc tcggcagagc cccacaacta tgaggaaccg ggccgtgcag
     1981 gccgaagctt taccagagag atcgaggcct ccaggatcca cattgagaag atcataggct
     2041 cgggggagtc aggagaagta tgctatggga ggctgcaggt gccaggacag cgggatgtgc
     2101 ccgtggccat caaggctctc aaagctggct acacggagag gcagcgccaa gacttcttga
     2161 gagaggcagc catcatggga caattcgatc atcctaacat catccgcctg gagggtgtgg
     2221 tcacccgtgg ccgcctggca atgattgtga ctgagtacat ggaaaatggc tctctggatg
     2281 ccttcctcag gacccacgat ggtcagttca ccatcctgca gctagtgggc atgctcaaag
     2341 gggtgggcgc tggcatgcgc tacctctcgg acctgggcta cattcaccgt gacctggccg
     2401 cccgcaacat cctggtagat ggccgtcttg tgtgcaaggt gtcagacttt gggctctcaa
     2461 gggctctgga ggacgaccct gaggccgcct acaccactgc gggagggaag atccctatcc
     2521 gatggacagc accagaggcc attgccttcc gcactttctc ctcagccagt gatgtgtgga
     2581 gctttggtgt ggtcatgtgg gaggtgctgg cctatggtga acggccctac tggaacatga
     2641 ccaatcagga tgtcatcagc tctgtggaag agggttatag gcttccagcg cccatgggct
     2701 gcccacgtgc cctgcaccaa ctcatgctag actgctggca caaggaccgt gcccagcggc
     2761 ctcgcttctc tcacgtcgtg agcgttctgg aggccctggt ccacagcccc gagagcctta
     2821 gggccacagc tacagtcagc aggtgcccag cccctgcctt tgccaggagc tgctttgacc
     2881 tccgagcagg cggaaatggg aacggggacc tcactgtggg agattggctg gattccatcc
     2941 gaatgggccg gtaccgggac cactttgcag cgggcgggta ctcctccctt ggcatggtgc
     3001 ttcacatgaa cgcccaggat gttcgtgccc tcggcatcac cctcatgggc caccagaaga
     3061 aaatccttgg aagcatccag acaatgaggt cccagctgag ctgcactcag gggccacgcc
     3121 ggcacctctg acccatggcc acttggcact ggtcatacca actgtcaggg gctctgcggg
     3181 gggggggccc ccagcagtca gggtagcccc tgagctctgc cacaggagag tgacagaggt
     3241 caggcacctg ggacaaggac cttggtgctt taagtagaga ggacacctgc cctctggagg
     3301 aaggcacagg accttgtgtc ttctagagcc tggggctcca acaccagacg ccaatggtga
     3361 catcactcgc ctagctgtgg gtgcatgcgt gcatgcatac gggtgacggt gtgggcgtgc
     3421 ccctcgaggc cctggcggtt gatgaaaaca atgcgtaacc atgtctctgt tcccccatta
     3481 ggccccagca cagatgtgtg caggttacca cgcgtgtgct tgtctactag ggcaggagcc
     3541 acgtgtgtat ggccacagat aacacgtcat gaatgaggag gcgtgacaga gtgtgagcga
     3601 cactgcccag ttcccaggac ctgtggggga acgcacagtg cctggcggct ggagcccagg
     3661 ctgcttccga atcataccag caccaggccc accgtccagc ctgggtgaac ccaccatggc
     3721 tgtatctcag gtccgggacg ccttcctact ttgggggctc tgcctggctc ctcctgctac
     3781 tcaataggaa aacagggttc ctggccagtc cctctggccg ccttccgtag aggatcacag
     3841 cagagtgtga gatgccctcg gtgggccgtg actgcctgac cgtcgctctc atggctgtga
     3901 tgcctctttc caatgtctca ctgcccattc ctgctgcccc cctgcccatg ctgggaacag
     3961 gagccccaaa cccacccctt cctgtaccag ataggtatgc ccagagaaaa ggatgccttg
     4021 tctgatgtca catgacaacc aaatttcaga gttgggaccc tcttcccccc cccccaacca
     4081 tggtctattc tccccaaccc cacccaagac agctaggacg ggaggggcct gggagactca
     4141 tcaccacagg ctgatacccc tccccccctt acggcccacc agggtatgta aatgtctttt
     4201 tttctaccat gtcagaatat ttttttccct cactcctgac aatgcaaaaa tggtcttcaa
     4261 agcacataca aagcaccccg ggtgagaacg ccccatccta ggggaggcag ggcccaaaga
     4321 gccccggccc agaggacagg gcggccccct cccctgccca tccctgccca cagccagcac
     4381 agcaccccgc gtgacaccag cactgagccc cctcccttct gcaataatcg ggggcttcag
     4441 ccccacccag gtgccgcggc cagctcctgc gcttctatat attatagtac tatgtagccg
     4501 agctgccctt ccttcctatg gaagtgggaa acatggtcag gacacgaggg gtggggacac
     4561 cttgtcttcc accaccccca ctcacccagt gtctgggctt aggatcctca ggcgaggccc
     4621 ctggggtggg tcccccttgg ggctcctggg gcctctctgt ggttcccatc ctgagtctgg
     4681 aattacttgc gatgagaata aattgtctca tctttg
//
