LOCUS       NP_001406194            1004 aa            linear   ROD 03-APR-2024
DEFINITION  ephrin type-A receptor 8 precursor [Rattus norvegicus].
ACCESSION   NP_001406194 XP_038967225
VERSION     NP_001406194.1
DBSOURCE    REFSEQ: accession NM_001419265.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1004)
  AUTHORS   Buensuceso,A.V. and Deroo,B.J.
  TITLE     The ephrin signaling pathway regulates morphology and adhesion of
            mouse granulosa cells in vitro
  JOURNAL   Biol Reprod 88 (1), 25 (2013)
   PUBMED   23242526
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1004)
  AUTHORS   Shin,J., Gu,C., Park,E. and Park,S.
  TITLE     Identification of phosphotyrosine binding domain-containing
            proteins as novel downstream targets of the EphA8 signaling
            function
  JOURNAL   Mol Cell Biol 27 (23), 8113-8126 (2007)
   PUBMED   17875921
REFERENCE   3  (residues 1 to 1004)
  AUTHORS   Gu,C., Shim,S., Shin,J., Kim,J., Park,J., Han,K. and Park,S.
  TITLE     The EphA8 receptor induces sustained MAP kinase activation to
            promote neurite outgrowth in neuronal cells
  JOURNAL   Oncogene 24 (26), 4243-4256 (2005)
   PUBMED   15782114
REFERENCE   4  (residues 1 to 1004)
  AUTHORS   Gu,C. and Park,S.
  TITLE     The EphA8 receptor regulates integrin activity through p110gamma
            phosphatidylinositol-3 kinase in a tyrosine kinase
            activity-independent manner
  JOURNAL   Mol Cell Biol 21 (14), 4579-4597 (2001)
   PUBMED   11416136
REFERENCE   5  (residues 1 to 1004)
  AUTHORS   Choi,S. and Park,S.
  TITLE     Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates
            Fyn binding to the Tyr-615 site by enhancing tyrosine kinase
            activity
  JOURNAL   Oncogene 18 (39), 5413-5422 (1999)
   PUBMED   10498895
REFERENCE   6  (residues 1 to 1004)
  AUTHORS   Park,S., Frisen,J. and Barbacid,M.
  TITLE     Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine
            protein kinase receptors
  JOURNAL   EMBO J 16 (11), 3106-3114 (1997)
   PUBMED   9214628
REFERENCE   7  (residues 1 to 1004)
  AUTHORS   Park,S. and Sanchez,M.P.
  TITLE     The Eek receptor, a member of the Eph family of tyrosine protein
            kinases, can be activated by three different Eph family ligands
  JOURNAL   Oncogene 14 (5), 533-542 (1997)
   PUBMED   9053851
REFERENCE   8  (residues 1 to 1004)
  AUTHORS   Chan,J. and Watt,V.M.
  TITLE     eek and erk, new members of the eph subclass of receptor
            protein-tyrosine kinases
  JOURNAL   Oncogene 6 (6), 1057-1061 (1991)
   PUBMED   1648701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 30, 2023 this sequence version replaced XP_038967225.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     Protein         1..1004
                     /product="ephrin type-A receptor 8 precursor"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-A receptor 8; EPH- and ELK-related
                     kinase; tyrosine-protein kinase receptor EEK"
                     /calculated_mol_wt=108292
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2556
     Region          30..202
                     /region_name="EphR_LBD"
                     /note="Ligand Binding Domain of Ephrin Receptors; cl02704"
                     /db_xref="CDD:470656"
     Site            order(42,54..57,59..60,65,67,70,103,105,153,161..163,
                     190..192,194)
                     /site_type="other"
                     /note="ephrin binding site [polypeptide binding]"
                     /db_xref="CDD:198454"
     Region          <325..>518
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          439..530
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,503,518)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(519..520,522..523)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <561..631
                     /region_name="EphA2_TM"
                     /note="Ephrin type-A receptor 2 transmembrane domain;
                     pfam14575"
                     /db_xref="CDD:464211"
     Region          629..895
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(640..643,646,648,664,666,696,712..715,759,763..764,
                     766,776..777)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270651"
     Region          932..994
                     /region_name="SAM_EPH-A8"
                     /note="SAM domain of EPH-A8 subfamily of tyrosine kinase
                     receptors; cd09550"
                     /db_xref="CDD:188949"
     Site            order(946,979)
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:188949"
     CDS             1..1004
                     /gene="Epha8"
                     /coded_by="NM_001419265.2:117..3131"
                     /db_xref="GeneID:60589"
                     /db_xref="RGD:708543"
ORIGIN      
        1 mapararlsp alwvvtaaaa atcvsagrge vnlldtstih gdwgwltypa hgwdsinevd
       61 esfrpihtyq vcnvmspnqn nwlrtswvpr dgarrvyaei kftlrdcnsi pgvlgtcket
      121 fnlhylesdr dlgastqesq flkidtiaad esftgadlgv rrlklntevr gvgplskrgf
      181 ylafqdigac lailslriyy kkcpamvrnl aafseavtga dssslvevrg qcvrhseerd
      241 tpkmycsaeg ewlvpigkcv csagyeerrd acmacelgfy ksapgdqlca rcpphshsat
      301 paaqtcrcdl syyraaldpp saactrppsa pvnlissvng tsvtlewapp ldpggrsdit
      361 ynavcrrcpw alshceacgs gtrfvpqqts laqasllvan llahmnysfw ieavngvsnl
      421 speprnaavv nittnqaaps qvvvirqera gqtsvsllwq epeqpngiil eyeikyyekd
      481 kemqsystlk avttratvsg lkpgtrymfq vrartsagcg rfsqamevet gkprprydtr
      541 tivwicltli tglvvlllll ickkrhcgys kafqdsdeek mhyqngqapp pvflplnhpp
      601 gklpetqfsa ephnyeepgr agrsftreie asrihiekii gsgesgevcy grlqvpgqrd
      661 vpvaikalka gyterqrqdf lreaaimgqf dhpniirleg vvtrgrlami vteymengsl
      721 daflrthdgq ftilqlvgml kgvgagmryl sdlgyihrdl aarnilvdgr lvckvsdfgl
      781 sraleddpea ayttaggkip irwtapeaia frtfssasdv wsfgvvmwev laygerpywn
      841 mtnqdvissv eegyrlpapm gcpralhqlm ldcwhkdraq rprfshvvsv lealvhspes
      901 lratatvsrc papafarscf dlraggngng dltvgdwlds irmgryrdhf aaggysslgm
      961 vlhmnaqdvr algitlmghq kkilgsiqtm rsqlsctqgp rrhl
//
