LOCUS       NM_001169137            7700 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus EPH receptor A5 (Epha5), transcript variant 1,
            mRNA.
ACCESSION   NM_001169137 XM_001075222 XM_341201
VERSION     NM_001169137.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7700)
  AUTHORS   Song,H., Zheng,Y., Cai,F., Ma,Y., Yang,J. and Wu,Y.
  TITLE     c-Fos downregulation positively regulates EphA5 expression in a
            congenital hypothyroidism rat model
  JOURNAL   J Mol Histol 49 (2), 147-155 (2018)
   PUBMED   29330744
  REMARK    GeneRIF: c-fos overexpression could upregulate EphA5 expression in
            hippocampal neurons of rats with congenital hypothyroidism.
REFERENCE   2  (bases 1 to 7700)
  AUTHORS   Liu,T.T., Xiao,B., Li,S.Y., Li,G.L., Lu,X.Q. and Liu,W.P.
  TITLE     [Changes in the expression of EphA5/ephrinA5 in the CA3 region of
            the hippocampus in rats with epilepsy and their role in the
            pathogenesis of temporal lobe epilepsy]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 19 (12), 1272-1277 (2017)
   PUBMED   29237529
  REMARK    GeneRIF: Downregulation of ephrinA5 and EphA5 in the CA3 region of
            the hippocampus may participate in the mechanism of mossy fiber
            sprouting and is closely associated with the development and
            progression of epilepsy.
REFERENCE   3  (bases 1 to 7700)
  AUTHORS   Wu,Y., Song,H., Sun,B., Xu,M. and Shi,J.
  TITLE     DNA Methylation of the EphA5 Promoter Is Associated with Rat
            Congenital Hypothyroidism
  JOURNAL   J Mol Neurosci 57 (2), 203-210 (2015)
   PUBMED   26109526
  REMARK    GeneRIF: EphA5 promoter methylation in the hippocampus of rats with
            congenital hypothyroidism is associated with the levels of EphA5
            expression.
REFERENCE   4  (bases 1 to 7700)
  AUTHORS   Szepietowska,B., Horvath,T.L. and Sherwin,R.S.
  TITLE     Role of synaptic plasticity and EphA5-ephrinA5 interaction within
            the ventromedial hypothalamus in response to recurrent hypoglycemia
  JOURNAL   Diabetes 63 (3), 1140-1147 (2014)
   PUBMED   24222347
  REMARK    GeneRIF: changes in ephrinA5/EphA5 interactions and synaptic
            plasticity within the ventromedial hypothalamus may contribute to
            the impairment in glucagon secretion and counterregulatory
            responses caused by recurrent hypoglycemia.
REFERENCE   5  (bases 1 to 7700)
  AUTHORS   Buensuceso,A.V. and Deroo,B.J.
  TITLE     The ephrin signaling pathway regulates morphology and adhesion of
            mouse granulosa cells in vitro
  JOURNAL   Biol Reprod 88 (1), 25 (2013)
   PUBMED   23242526
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7700)
  AUTHORS   Bruce,V., Olivieri,G., Eickelberg,O. and Miescher,G.C.
  TITLE     Functional activation of EphA5 receptor does not promote cell
            proliferation in the aberrant EphA5 expressing human glioblastoma
            U-118 MG cell line
  JOURNAL   Brain Res 821 (1), 169-176 (1999)
   PUBMED   10064801
REFERENCE   7  (bases 1 to 7700)
  AUTHORS   Miescher,G.C., Taylor,V., Olivieri,G., Mindermann,T., Schrock,E.
            and Steck,A.J.
  TITLE     Extensive splice variation and localization of the EHK-1 receptor
            tyrosine kinase in adult human brain and glial tumors
  JOURNAL   Brain Res Mol Brain Res 46 (1-2), 17-24 (1997)
   PUBMED   9191074
REFERENCE   8  (bases 1 to 7700)
  AUTHORS   Winslow,J.W., Moran,P., Valverde,J., Shih,A., Yuan,J.Q., Wong,S.C.,
            Tsai,S.P., Goddard,A., Henzel,W.J., Hefti,F. et al.
  TITLE     Cloning of AL-1, a ligand for an Eph-related tyrosine kinase
            receptor involved in axon bundle formation
  JOURNAL   Neuron 14 (5), 973-981 (1995)
   PUBMED   7748564
REFERENCE   9  (bases 1 to 7700)
  AUTHORS   Taylor,V., Miescher,G.C., Pfarr,S., Honegger,P., Breitschopf,H.,
            Lassmann,H. and Steck,A.J.
  TITLE     Expression and developmental regulation of Ehk-1, a neuronal
            Elk-like receptor tyrosine kinase in brain
  JOURNAL   Neuroscience 63 (1), 163-178 (1994)
   PUBMED   7898646
REFERENCE   10 (bases 1 to 7700)
  AUTHORS   Maisonpierre,P.C., Barrezueta,N.X. and Yancopoulos,G.D.
  TITLE     Ehk-1 and Ehk-2: two novel members of the Eph receptor-like
            tyrosine kinase family with distinctive structures and neuronal
            expression
  JOURNAL   Oncogene 8 (12), 3277-3288 (1993)
   PUBMED   7504232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jun 3, 2021 this sequence version replaced NM_001169137.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               JAXUCZ010000014.1  24008122-24008665
            545-609             JAXUCZ010000014.1  24039990-24040054
            610-1273            JAXUCZ010000014.1  24090212-24090875
            1274-1429           JAXUCZ010000014.1  24209312-24209467
            1430-1765           JAXUCZ010000014.1  24213630-24213965
            1766-1890           JAXUCZ010000014.1  24276690-24276814
            1891-2050           JAXUCZ010000014.1  24282515-24282674
            2051-2153           JAXUCZ010000014.1  24294647-24294749
            2154-2219           JAXUCZ010000014.1  24317360-24317425
            2220-2287           JAXUCZ010000014.1  24326654-24326721
            2288-2413           JAXUCZ010000014.1  24327897-24328022
            2414-2599           JAXUCZ010000014.1  24328682-24328867
            2600-2661           JAXUCZ010000014.1  24344142-24344203
            2662-2871           JAXUCZ010000014.1  24348038-24348247
            2872-3021           JAXUCZ010000014.1  24352190-24352339
            3022-3215           JAXUCZ010000014.1  24358449-24358642
            3216-3371           JAXUCZ010000014.1  24362227-24362382
            3372-7700           JAXUCZ010000014.1  24370520-24374848
FEATURES             Location/Qualifiers
     source          1..7700
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..7700
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /note="EPH receptor A5"
                     /db_xref="GeneID:79208"
                     /db_xref="RGD:620831"
     exon            1..544
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     CDS             358..3477
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ephrin type-A receptor 5; EPH homology kinase
                     1; tyrosine-protein kinase receptor EHK-1; eck-like
                     sequence 1"
                     /codon_start=1
                     /product="ephrin type-A receptor 5 isoform 1 precursor"
                     /protein_id="NP_001162608.1"
                     /db_xref="GeneID:79208"
                     /db_xref="RGD:620831"
                     /translation="MRGSGPRGAGRRRTQGRGGGGDTPRVPASLAGCYSAPLKGPLWT
                     CLLLCAALRTLLASPSNEVNLLDSRTVLGDLGWIAFPKNGWEEIGEVDENYAPIHTYQ
                     VCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFES
                     DDENGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQD
                     VGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDDPPKM
                     HCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHSQTCSKCPPHSYTHEEA
                     STSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVS
                     YYIACKKCNSHAGVCEECGGHVRYLPQQIGLKNTSVMMADLLAHTNYTFEIEAVNGVS
                     DLSPGTRQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKY
                     FEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFA
                     ASNDQSQIPIIAVSVTVGVILLAVMIGFLLSGSCCECGCGRASSLCAVAHPSLIWRCG
                     YSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPTQAVHEFAKEIEASCITIERV
                     IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLSEASIMGQFDHPNIIH
                     LEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGY
                     VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK
                     FTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLML
                     DCWQKDRNSRPKFDDIVNMLDKLIRNPSSLKTLVNASSRVSTLLAEHGSLGSGAYRSV
                     GEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKV
                     QLVNGMVPV"
     exon            545..609
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            610..1273
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1429
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1765
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1890
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2050
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2153
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2219
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2287
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2413
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2599
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2661
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2871
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3021
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3215
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3371
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
     exon            3372..7700
                     /gene="Epha5"
                     /gene_synonym="EHK-1; Els1; Els1."
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaataacagt tctaaaaaag aaagggggac caaaaaacag aaaaaggaaa gtcttaagag
       61 gcaaaggagc gggactcggg accctctgca gacccttgac tcagcccacc caggaccgta
      121 ctagccatcc gaacttctaa ttcatcttat ccaactgaaa gggagggcgg cacaagccag
      181 aagcaaactt cggcggtctc tgcggatctg tgattcccac attgagaggg gtcgagagcc
      241 agaaggcaca ggaccccacc aggaggagga gttccgcgcc tctctcgccc cttccaccaa
      301 gcctgaacct tagactgaac cacgcgggac ctaagaggca gaagagggta gtagaaaatg
      361 cggggctccg ggccccgcgg tgcgggacgc cgacggaccc agggcagagg tggcggcggc
      421 gacacccccc gcgtccctgc ctctctggca ggctgctatt ccgcacctct aaaggggccc
      481 ctctggacgt gccttctcct gtgtgcggcg ctccggaccc ttttggccag ccccagtaac
      541 gaagtgaatt tattggattc gcgcactgtc ctgggagacc ttggatggat tgcttttcca
      601 aagaatgggt gggaagagat tggtgaagtt gatgaaaact atgcccccat ccacacctat
      661 caagtgtgca aagttatgga acagaatcag aataattggc tgttgaccag ttggatctct
      721 aacgaaggtg cttccagaat ttttattgaa ctcaagttta ctctgaggga ttgcaacagc
      781 cttcctggag gactggggac ttgcaaggag acctttaaca tgtattattt tgagtcggat
      841 gatgagaatg ggagaaatat caaagagaac cagtacatca agatcgatac cattgctgct
      901 gatgagagct tcaccgaact tgaccttgga gaccgggtca tgaagctgaa tacggaggtc
      961 agagatgtag gacctctgag caaaaaggga ttttatcttg ctttccaaga tgtcggtgct
     1021 tgcatcgctc tggtttctgt ccgtgtctac tataaaaaat gtccttctgt agttagacat
     1081 ttggctgttt tccctgacac gatcactgga gcagattctt cccagttgct agaggtgtca
     1141 ggctcctgcg tcaaccattc tgtgacagac gatcctccca aaatgcattg cagtgctgaa
     1201 ggggagtggc tggttcccat cgggaaatgc atgtgcaagg ccggatatga agagaaaaat
     1261 ggtacctgtc aagtgtgcag acctgggttc ttcaaagcct ctcctcacag ccagacctgc
     1321 agcaaatgtc cacctcacag ttacacccat gaggaagctt ccacctcttg tgtctgtgaa
     1381 aaggattatt tcaggaggga atctgatccg cccacaatgg catgcacaag acccccctca
     1441 gctcctcgga atgccatctc aaatgttaat gaaactagtg tctttctgga gtggattcct
     1501 cctgctgaca ctggtggacg gaaagatgtg tcctattaca ttgcatgcaa gaagtgcaac
     1561 tcccatgcag gtgtgtgtga ggagtgtggc ggtcatgtca ggtacctccc ccagcaaatc
     1621 ggcctgaaaa atacctctgt catgatggcg gacctccttg ctcacacaaa ctataccttt
     1681 gaaattgagg cagtgaacgg agtttccgac ttgagtccag gcacccggca gtatgtgtct
     1741 gtaaatgtaa ccacgaacca agcagctcct tctccagtca ccaacgtgaa gaaggggaag
     1801 atcgcaaaga acagcatttc tttgtcttgg caagagccag atcgccccaa tgggatcatc
     1861 ctggagtacg aaatcaagta ctttgaaaag gaccaagaga ccagctacac aattatcaag
     1921 tctaaagaga ccactattac ggcagagggc ctgaaacctg cgtctgtgta tgtcttccaa
     1981 attcgagcac gtacagcagc aggctacggc gtcttcagtc gacggtttga gtttgaaacc
     2041 acaccagtgt ttgcagcatc taatgatcaa agccagattc ccatcattgc ggtgtcagtg
     2101 acggtgggag tcatcttgtt ggcagtgatg atcggcttcc tcctcagtgg cagttgctgc
     2161 gaatgtggct gtgggagggc ttcttccctg tgcgctgttg cccatccaag cctaatatgg
     2221 cggtgtggct acagcaaagc aaagcaggat ccagaagagg aaaagatgca ctttcataac
     2281 gggcacatta aactgccagg agtaagaacg tacattgatc cacacaccta cgaagatccc
     2341 actcaagccg ttcatgaatt tgccaaggag atcgaggcct catgcatcac cattgagaga
     2401 gttattggag caggtgaatt tggtgaagtt tgtagtggac gtttgaaact acccggaaaa
     2461 agagaattgc ctgtggctat caaaactctt aaagtaggct acactgaaaa gcagcgcaga
     2521 gattttctga gtgaagcgag tatcatgggg cagtttgatc atccaaacat catccatcta
     2581 gaaggcgttg tgactaaaag taaacctgtg atgatagtga cagagtacat ggagaatggc
     2641 tccttagaca catttttaaa gaaaaacgat ggccagttca ctgtgattca gcttgttggc
     2701 atgctgagag gcatcgctgc aggaatgaag tacctttctg acatgggcta cgtgcacaga
     2761 gaccttgctg ctagaaacat cttaatcaac agtaaccttg tgtgcaaagt gtctgacttt
     2821 ggactttcca gggtgctgga agatgatcct gaggcagcct ataccacaag gggaggcaaa
     2881 attccaatca ggtggactgc tccagaagca atagcttttc gaaagtttac ctctgccagt
     2941 gatgtctgga gctatggaat cgtaatgtgg gaagttgtgt cctatggaga gagaccgtac
     3001 tgggagatga ccaatcagga tgtgatcaag gcagtggaag aaggctaccg cctgccaagc
     3061 cccatggatt gtcctgctgc cctctatcaa ttaatgctgg attgctggca gaaagatcgc
     3121 aacagcaggc ccaagtttga tgacatagtc aacatgctgg ataagctgat acgaaaccca
     3181 agtagtttga agacactggt gaacgcgtca agcagggtat ctactttgtt ggcagaacat
     3241 ggatctttgg ggtctggggc ctacagatca gtaggtgaat ggctagaagc aatcaaaatg
     3301 ggccggtaca cagagatttt catggaaaat ggatacagtt caatggacgc tgtggctcag
     3361 gtgaccttgg aggatttgag acgcctggga gtgactctgg tcggtcacca gaagaagatc
     3421 atgaacagcc ttcaagagat gaaggtgcag ctggtaaacg ggatggtgcc agtgtgaccc
     3481 gcacacgggt cacttctcca agtgaacaac tctgcacttt gtaaacagcc ctaagattta
     3541 ttttaacaga gaaagggaaa tgggtggttc ctaaaccttt gaaggcactt gtctcatcct
     3601 ttgaacttat aatcaacatt ttactaaaat ctccagatct tcttcttaat gtcttcgttt
     3661 ttttcactat gtaaatgtaa cctgcgaaga gagctaacat gagaaacaac atcctataaa
     3721 aacatagtaa ctaaatcttt ctccacttct tccacggaat cttgtacatg aaatatatca
     3781 agacacagaa cctatagaga ctgttaaggc agcccctttc aaaactacca gggatcgact
     3841 tgaaaggaaa agttttaaag ccatgtgtgg gcaaagaaac gctgcatttt actgacgttt
     3901 acttcgagtt ttatttgtct gcataagtgt attggagagc aatatgatta gattatttct
     3961 taaatacagt ttgtaattta aaatggaatt acatgttata agttatagaa aatagtttat
     4021 agacatgttg cccggtcaag gaaaagttca gcacagggtg tatatttatt tttctgtgtt
     4081 atataattta cttttagttg cacttctaga gagtattagg caatgaatgt gtatagactg
     4141 tatagtttgc aatataccga ggaatggact taaattggaa atgtatgtat atgtgtgtgt
     4201 atgtgcgtat gtgtgtgtgt gtttgaatat gtagatggta ttgttctgct tgccttttgt
     4261 atagggtttt aattttggcc tcatacagca aagggtgttc tagactattt tatgggtaag
     4321 aggaatagga agccttagac caaatttcca ctcaagtagg tgtcctttct ctcattttga
     4381 aagcaactaa ttagtttatt taaacagcta atgcctctag attaaattcc ctttggattt
     4441 tacacatacc caacctatgc gtgataaaga agttctcgcc attaatcttt catgtttctt
     4501 ccaaattcga cctttcaaag ttcctgaaaa tatcttctca agctgacaca aagggcacac
     4561 gttgtgtcat agaatgtaga gagttgtgat tgtagtggca tctgtgaaca tccaatccag
     4621 gcagaggtac tcaaaatctc cctgcatgcc ctaaccattt gtagtcactc cccttatgac
     4681 tcattcacag agagtttaat actaagacag cattaaaaag tgaagtaaaa aatgttttgc
     4741 tcagaatttt ctgtttgaac tttgtttctc cttggtaaca gtttgtgcac atcttgtcct
     4801 ccattacagt gaatatgttt ggaaaaacca atggggagta ttttaaaaaa ttagaatttt
     4861 taggtagttt acaatagtcc ttcagtatat tttatatact acatcagaaa agggctgaca
     4921 tttatggaaa atccatgtgg tttattgaaa tgttcactta agtgaccatg atggtaagat
     4981 gaaaaatatt ttatattatt atgctttata aaatctggag aatggtatac aatattttga
     5041 ggagccaaga acttatatca ggactttcac tactgcatgg gaaaaaccat gtgagcagag
     5101 tgagatctac aggggggagg ccagtatttt gtgaggagta cgcctttatt cttactaaga
     5161 tacgtttcac ttcagtattc acccatataa ggaagacaat tggggaactt actatttatc
     5221 tcccaccccc attttttaaa aggagaaata gctccttgat aaataaggaa agatcaaagt
     5281 tgcaaaagga tgtgaagcat ctaaacagtt tttatattat acattgattc ccctctccga
     5341 ataacactga tcccacaatg tgctcaagaa atgtggaagt gacactttca gaaaatacta
     5401 agagtagttt aatactatgt tggtaaaaaa aaatcacaga gagatgtcag tatgaaaata
     5461 catttacata aaatcattga aactaattac tactgtacag ataaattcat tggaatctaa
     5521 gtgatacagt agtactgaga acttcaagac cgaacaaaaa tacaaaacat ttacacatgt
     5581 gtgatttaga gctcgtacaa cgcacaacta tatggacatc aaaaatacat tctaatttgt
     5641 tttctaactt tgtatggtat aattggtaag gtctagctgt tagactgatg atttcatttt
     5701 ttccccatag aatattaggt cacttacttc cctttgcaat tcaagtgtta catttggaga
     5761 gcaattcaga agctctatgg ccacatggcg ttcatccacg cctcaatttg gttgagggtt
     5821 tctaaagact gtcactctga ttttcaaata aacagacctt taaattgtaa gtgctctgtc
     5881 cctcaaagaa gagagagcac ctttctaaaa tatttgttca ccactggata tgtcacccat
     5941 tgaaaagtgc caaactcatc gatcaatgtg agaaatgcag ctggaaggga agccagctct
     6001 cgtacgatgt aacgaggctg ccactcagca caagactggg tacattctca tggtgtggat
     6061 tttcttcttg tggcttcatt tccttactca tggactcccc aaaataaagc ataagattcc
     6121 ataatctcca cacgtataac tgatttgtaa aatgatattt aactggattg tcagaaggaa
     6181 caacggggaa ctttcctatt tgaagtcatt ccgttactgt ggtttatcaa tcataattta
     6241 tacccactct tgccattccc tagcatgtga caattttttc ctctttcaaa tgtatcgatt
     6301 gtatgtgaaa tatagagatg ctgattttca ccgtttaaaa aaaattatga catgcatgtg
     6361 ttttaaattc ctgtgttttg ttaaccaagc cagtgttcta aagtaatagg ttcatgttac
     6421 aatttaaata ggaatatttc atcagaactt cagtgcgtct agacttttgg aatcgtcaca
     6481 aataaaggaa aacacactta gctcttttta tcaaaacagt tctacccact atgtaattaa
     6541 agagctgtaa cttcacatct ccggttaagt ggagcagtta ctgtcggttg agcactgcat
     6601 ttgcatgtct gctgtttaaa ttttacgtgg aagtgaaagg cagtaaagaa gatatttgta
     6661 cacccattga agtgggtttt cagaagcaca atgaaaaata ttcacctttg gaacgtgttc
     6721 tggctgtaat ggtatgttag ataacaaaga gcgtgtggtg tagagactca gtaggtatat
     6781 ggtgttgcat agtagtaaat atctctttct tattttgttc tttctaaaat ctaagtggga
     6841 aagtacatgt gatgatgaaa tatctttgtt taaactttgc cagacgttta acctcaatgt
     6901 aaataaaata taggataata cgatggcggt tgatgatcct aacgaacgaa tgaacagaat
     6961 cagaatggta gctttatttg aaatttgata gctgaacaag tcatcacttt ttttcttctg
     7021 tgcagtagca cagctggtta cattgaatat ttttcctcca ttatgctgtt aattatacag
     7081 taatgtatca ggaaagaaat agataaaaaa aactttctgc ttgtatcttg ttattttctg
     7141 agtcttttca cacatcaacg attgaatgtt cttattcaga atgaccacgt aattgtcgca
     7201 tagaagaagc tgctatttct ttttaaaatg tctgtttata ataaccagac tcaaattcat
     7261 tttctcaatg ttaatagggg aaaaatgttg gcaaaaatac atcccgtctt tgcaagctgg
     7321 gtgctatatt cactgaagtt tgagtggtca attatttgtg aatatttaga ctactgcagt
     7381 tttcgattaa ttatttaaaa gcatatatat actgaatttg taacagtcag agaataaagt
     7441 cagactctgt cctttgtgaa tatgttgatc aacatcacat ggtttcgggc aggtcagaga
     7501 catccatgca gcctgtccga ttctttggta ggcatcagga aatcttgtgt ccctacctca
     7561 gagtgaattc aggaaggatg aacagttttg tattggtttc catctgcgtc tctttgtgct
     7621 ttcagtttgt gtacatgttt tttgtagtgt aagatattaa attttatatt ttttcagaaa
     7681 ataaaaaaca tttgaatata
//
