LOCUS       NM_031564               3078 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus Eph receptor A3 (Epha3), mRNA.
ACCESSION   NM_031564 XM_346414
VERSION     NM_031564.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3078)
  AUTHORS   Li,M., Yang,C., Liu,X., Yuan,L., Zhang,F., Wang,M., Miao,D., Gu,X.,
            Jiang,S., Cui,B., Tong,J. and Yu,Z.
  TITLE     EphA3 promotes malignant transformation of colorectal epithelial
            cells by upregulating oncogenic pathways
  JOURNAL   Cancer Lett 383 (2), 195-203 (2016)
   PUBMED   27721017
  REMARK    GeneRIF: EphA3 promotes malignant transformation of colorectal
            epithelial cells by upregulating oncogenic signaling pathways.
REFERENCE   2  (bases 1 to 3078)
  AUTHORS   Buensuceso,A.V. and Deroo,B.J.
  TITLE     The ephrin signaling pathway regulates morphology and adhesion of
            mouse granulosa cells in vitro
  JOURNAL   Biol Reprod 88 (1), 25 (2013)
   PUBMED   23242526
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3078)
  AUTHORS   Brennaman,L.H., Zhang,X., Guan,H., Triplett,J.W., Brown,A.,
            Demyanenko,G.P., Manis,P.B., Landmesser,L. and Maness,P.F.
  TITLE     Polysialylated NCAM and ephrinA/EphA regulate synaptic development
            of GABAergic interneurons in prefrontal cortex
  JOURNAL   Cereb Cortex 23 (1), 162-177 (2013)
   PUBMED   22275477
REFERENCE   4  (bases 1 to 3078)
  AUTHORS   Wang,L., Klein,R., Zheng,B. and Marquardt,T.
  TITLE     Anatomical coupling of sensory and motor nerve trajectory via axon
            tracking
  JOURNAL   Neuron 71 (2), 263-277 (2011)
   PUBMED   21791286
REFERENCE   5  (bases 1 to 3078)
  AUTHORS   Nievergall,E., Janes,P.W., Stegmayer,C., Vail,M.E., Haj,F.G.,
            Teng,S.W., Neel,B.G., Bastiaens,P.I. and Lackmann,M.
  TITLE     PTP1B regulates Eph receptor function and trafficking
  JOURNAL   J Cell Biol 191 (6), 1189-1203 (2010)
   PUBMED   21135139
REFERENCE   6  (bases 1 to 3078)
  AUTHORS   Cheng,N., Brantley,D., Fang,W.B., Liu,H., Fanslow,W.,
            Cerretti,D.P., Bussell,K.N., Reith,A., Jackson,D. and Chen,J.
  TITLE     Inhibition of VEGF-dependent multistage carcinogenesis by soluble
            EphA receptors
  JOURNAL   Neoplasia 5 (5), 445-456 (2003)
   PUBMED   14670182
REFERENCE   7  (bases 1 to 3078)
  AUTHORS   Yang,J., Kim,O., Wu,J. and Qiu,Y.
  TITLE     Interaction between tyrosine kinase Etk and a RUN domain- and FYVE
            domain-containing protein RUFY1. A possible role of ETK in
            regulation of vesicle trafficking
  JOURNAL   J Biol Chem 277 (33), 30219-30226 (2002)
   PUBMED   11877430
REFERENCE   8  (bases 1 to 3078)
  AUTHORS   Munoz,J.J., Alonso-C,L.M., Sacedon,R., Crompton,T., Vicente,A.,
            Jimenez,E., Varas,A. and Zapata,A.G.
  TITLE     Expression and function of the Eph A receptors and their ligands
            ephrins A in the rat thymus
  JOURNAL   J Immunol 169 (1), 177-184 (2002)
   PUBMED   12077243
REFERENCE   9  (bases 1 to 3078)
  AUTHORS   Lawrenson,I.D., Wimmer-Kleikamp,S.H., Lock,P., Schoenwaelder,S.M.,
            Down,M., Boyd,A.W., Alewood,P.F. and Lackmann,M.
  TITLE     Ephrin-A5 induces rounding, blebbing and de-adhesion of
            EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated
            signalling
  JOURNAL   J Cell Sci 115 (Pt 5), 1059-1072 (2002)
   PUBMED   11870224
REFERENCE   10 (bases 1 to 3078)
  AUTHORS   Li,Y.Y., McTiernan,C.F. and Feldman,A.M.
  TITLE     IL-1 beta alters the expression of the receptor tyrosine kinase
            gene r-EphA3 in neonatal rat cardiomyocytes
  JOURNAL   Am J Physiol 274 (1), H331-H341 (1998)
   PUBMED   9458884
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031564.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69278.1, SRR26643298.65815.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000011.1  14920304-14920425   c
            123-187             JAXUCZ010000011.1  14901810-14901874   c
            188-848             JAXUCZ010000011.1  14833138-14833798   c
            849-1004            JAXUCZ010000011.1  14697927-14698082   c
            1005-1340           JAXUCZ010000011.1  14696699-14697034   c
            1341-1465           JAXUCZ010000011.1  14650061-14650185   c
            1466-1628           JAXUCZ010000011.1  14648173-14648335   c
            1629-1731           JAXUCZ010000011.1  14641648-14641750   c
            1732-1799           JAXUCZ010000011.1  14640395-14640462   c
            1800-1925           JAXUCZ010000011.1  14636318-14636443   c
            1926-2111           JAXUCZ010000011.1  14633571-14633756   c
            2112-2173           JAXUCZ010000011.1  14624378-14624439   c
            2174-2383           JAXUCZ010000011.1  14622830-14623039   c
            2384-2533           JAXUCZ010000011.1  14610181-14610330   c
            2534-2727           JAXUCZ010000011.1  14608249-14608442   c
            2728-2883           JAXUCZ010000011.1  14593738-14593893   c
            2884-3078           JAXUCZ010000011.1  14587541-14587735   c
FEATURES             Location/Qualifiers
     source          1..3078
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11p12"
     gene            1..3078
                     /gene="Epha3"
                     /note="Eph receptor A3"
                     /db_xref="GeneID:29210"
                     /db_xref="RGD:68389"
     exon            1..122
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2989
                     /gene="Epha3"
                     /EC_number="2.7.10.1"
                     /note="ephrin type-A receptor 3; tyrosine-protein kinase
                     TYRO4; tyrosine-protein kinase receptor REK4; EK4; rEK4;
                     EPH-like kinase 4"
                     /codon_start=1
                     /product="ephrin type-A receptor 3 precursor"
                     /protein_id="NP_113752.2"
                     /db_xref="GeneID:29210"
                     /db_xref="RGD:68389"
                     /translation="MDCHLSILILLGCCVLSCSRELSPQPSNEVNLLDSKTIQGELGW
                     ISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFT
                     LRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFLEHQFTKIDTIAADESFTQMDLGDR
                     ILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPM
                     DSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCTCNAGYEERGFICQACRPG
                     FYKALDGVAKCTKCPPHSSTQEDGSMNCRCENNYFRAEKDPPSMACTRPPSAPRNVIS
                     NINETSVILDWSWPLDTGGRKDITFNIICKKCGWNVRQCEPCSPNVRFLPRQLGLTNT
                     TVTVTDLLAHTNYTFEIDAINGVSELSSPPRQFAAVSITTNQAAPSPVMTIKKDRTSR
                     NSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTTYVFQ
                     IRARTAAGYGTNSRKFEFETSPDSFSISGENSHVVMIAISAAVAIIVLTVVTYVLVGR
                     FCGYHKSKHSSDEKRLHFGNGHLRLPGLRTYVDPHTYEDPTQAVHEFAKELDATNIAI
                     DKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN
                     IIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSD
                     MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA
                     YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQ
                     LMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDIATF
                     HTTGDWLNGMRTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKA
                     LETQSKNGPVPV"
     exon            123..187
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            188..848
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1004
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1340
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1465
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1628
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1731
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1799
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1925
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2111
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2173
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2383
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2533
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2727
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2883
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3078
                     /gene="Epha3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatgctcct ctcactgccc ggtgcaccag caacatggat tgtcacctct ccatcctcat
       61 cctgctcggc tgctgcgtcc tcagctgctc cagggaactg agtccacagc cttccaacga
      121 agttaatcta ctagattcaa aaacgattca aggagagctg ggctggatct cctacccatc
      181 ccacgggtgg gaagagatca gtggtgttga tgagcattac acaccaatca ggacttacca
      241 ggtatgcaat gtcatggatc acagccaaaa taattggctg aggacaaact gggtgccgag
      301 aaactcagct cagaagatct atgtggagct aaagttcaca ctgcgggact gtaacagcat
      361 tccattggtt ttggggacgt gcaaggagac ctttaacctg tactacatgg agtctgatga
      421 tgatcacggt gtcaaattcc tagagcatca gtttacaaag attgacacca tcgccgctga
      481 tgaaagtttc actcaaatgg atctcgggga ccgcattcta aaactcaaca ctgagattag
      541 agaagtggga ccagtcaata aaaaggggtt ttatttggcc tttcaagatg ttggtgcttg
      601 tgttgccttg gtgtctgtga gagtgtactt caaaaagtgc ccatttacag tgaagaatct
      661 ggctatgttt ccagacacag tgcccatgga ctcccagtcc ttggtggagg ttaggggctc
      721 ttgtgtcaat aattccaagg aggaggaccc tcccaggatg tactgcagta cagaaggtga
      781 atggctggtc cccattggca agtgcacttg caatgctggg tatgaagaac gagggttcat
      841 atgccaagct tgtcggccag gcttctacaa ggctttggat ggtgttgcca agtgtactaa
      901 gtgcccacca cacagctcaa cccaagaaga tggttcaatg aactgcaggt gtgagaataa
      961 ttatttccgg gcagaaaaag accctccatc catggcttgt acccgacctc catccgcacc
     1021 aagaaatgtt atctctaaca taaatgagac ctcggttatc ctggactgga gctggcccct
     1081 ggacacagga ggccggaagg atattacctt caacatcata tgtaaaaaat gtgggtggaa
     1141 tgtcaggcag tgcgagccat gcagccccaa cgtccgcttc ctccctcgtc agcttggact
     1201 caccaacacc acggtgacag tgacagacct cctggcacat actaactaca cctttgagat
     1261 tgatgccatt aatggagtgt cagagctgag ctcgccaccg agacagtttg ccgccgtcag
     1321 catcacaact aatcaggctg ctccatcacc agttatgaca attaagaaag atcggacttc
     1381 cagaaacagt atctctttat cttggcaaga accagaacat ccaaatggaa ttatacttga
     1441 ctacgaggtc aaatactatg aaaagcagga gcaagagacg agttatacca ttttgagggc
     1501 aagaggcaca aatgttacta tcagtagcct caagccagat actacttacg tattccaaat
     1561 ccgagctcga acagcagcag gatacggaac caacagccgc aaatttgaat ttgaaactag
     1621 tccagactcc ttctccatct ctggtgaaaa cagtcatgtg gtgatgatcg cgatttcagc
     1681 tgctgtggcc atcattgtcc tcactgttgt cacctacgtt ttggtcggga gattttgtgg
     1741 ctatcacaag tcaaaacaca gttcagatga gaagcgcctt cactttggga atgggcactt
     1801 aagacttcca ggtctcagga catatgttga tccacataca tatgaagacc ctacacaagc
     1861 agttcatgag tttgcgaaag aattggatgc caccaacata gccatcgaca aagttgttgg
     1921 agcaggtgaa tttggagaag tttgcagtgg tcgcttaaaa cttccttcaa aaaaagagat
     1981 ttcagtggct atcaagaccc tgaaagtggg ctacacggag aagcagagga gagactttct
     2041 aggagaagca agcatcatgg gacagtttga ccaccccaac atcatccgac tggaaggagt
     2101 tgtcactaaa agtaagccag tgatgattgt cacagaatac atggagaatg gttccctgga
     2161 cagtttctta cgtaaacatg atgcccagtt tacagtcatc cagctcgtgg gaatgctccg
     2221 tgggatagca tctggtatga agtacctctc agatatgggc tatgtccacc gcgaccttgc
     2281 tgctcggaac atcttgatca acagtaactt ggtgtgcaaa gtctctgact tcggactttc
     2341 tcgagtgttg gaagatgacc ctgaagctgc ttacaccacc agaggaggaa agataccaat
     2401 aaggtggaca tcaccagaag caattgccta ccgcaagttc acatcagcca gcgatgtatg
     2461 gagttacggg attgtactct gggaagtgat gtcttacgga gaaaggccgt attgggagat
     2521 gtccaatcag gatgtaatta aggccgtgga tgagggctat cgcctgccac ctcccatgga
     2581 ctgcccagct gccctgtatc agttgatgtt ggactgctgg cagaaagaca ggaacaacag
     2641 acccaagttt gagcagatcg tcagcattct ggacaagctc atccggaatc caggcagtct
     2701 gaagatcatc actagcgcgg ctgcaaggcc atcaaacctt cttctggacc aaagcaatgt
     2761 cgatattgct acgttccaca caacaggtga ttggcttaac ggtatgagga cagcacactg
     2821 taaggaaatc ttcacgggtg tggagtacag ctcctgtgac accattgcca agatctccac
     2881 agatgacatg aaaaaggttg gtgttactgt ggttgggcca cagaagaaga tcatcagttc
     2941 cattaaagct ctagaaacac aatctaagaa tggtccagtt cccgtgtaaa gtactggaag
     3001 gatgtgagga aagggaagat gcagcgtcat ccagcaaaca gatagaaatg gtggagctgc
     3061 tgctgaaagc tccaagtc
//
