LOCUS       NM_001108977            3911 bp    mRNA    linear   ROD 08-NOV-2023
DEFINITION  Rattus norvegicus Eph receptor A2 (Epha2), mRNA.
ACCESSION   NM_001108977 XM_001072610 XM_345596
VERSION     NM_001108977.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3911)
  AUTHORS   Ren L, Zhu X, Tan J, Lv X, Wang J and Hua F.
  TITLE     MiR-210 promotes bone formation in ovariectomized rats by
            regulating osteogenic/adipogenic differentiation of bone marrow
            mesenchymal stem cells through downregulation of EPHA2
  JOURNAL   J Orthop Surg Res 18 (1), 811 (2023)
   PUBMED   37904187
  REMARK    GeneRIF: MiR-210 promotes bone formation in ovariectomized rats by
            regulating osteogenic/adipogenic differentiation of bone marrow
            mesenchymal stem cells through downregulation of EPHA2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3911)
  AUTHORS   Han X, Zhu Y, Shen L, Zhou Y, Pang L, Zhou W, Gu H, Han K, Yang Y,
            Jiang C, Xie J, Zhang C and Ding L.
  TITLE     PTIP Inhibits Cell Invasion in Esophageal Squamous Cell Carcinoma
            via Modulation of EphA2 Expression
  JOURNAL   Front Oncol 11, 629916 (2021)
   PUBMED   33833989
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3911)
  AUTHORS   Zhao Y, Li W, Song J, Zhang M, Huang T and Wei X.
  TITLE     High expression of EphA2 led to secondary injury by destruction of
            BBB integrity though the ROCK pathway after diffuse axonal injury
  JOURNAL   Neurosci Lett 736, 135234 (2020)
   PUBMED   32721428
  REMARK    GeneRIF: High expression of EphA2 led to secondary injury by
            destruction of BBB integrity though the ROCK pathway after diffuse
            axonal injury.
REFERENCE   4  (bases 1 to 3911)
  AUTHORS   Feng G, Sun B, Liu HX, Liu QH, Zhao L and Wang TL.
  TITLE     EphA2 antagonism alleviates LPS-induced acute lung injury via
            Nrf2/HO-1, TLR4/MyD88 and RhoA/ROCK pathways
  JOURNAL   Int Immunopharmacol 72, 176-185 (2019)
   PUBMED   30986645
  REMARK    GeneRIF: Our data indicate that EphA2 receptor plays an essential
            role in LPS-induced acute lung injury (ALI) and EphA2 antagonism
            has protective effects against LPS-induced ALI via Nrf2/HO-1,
            TLR4/MyD88 and RhoA/ROCK pathways.  These results suggest that
            antagonism of EphA2 may be an effective therapeutic strategy for
            the treatment of ALI.
REFERENCE   5  (bases 1 to 3911)
  AUTHORS   Li G, Huang M, Cai Y, Ke Y, Yang Y and Sun X.
  TITLE     miR-141 inhibits glioma vasculogenic mimicry by controlling EphA2
            expression
  JOURNAL   Mol Med Rep 18 (2), 1395-1404 (2018)
   PUBMED   29901110
  REMARK    GeneRIF: miR-141 inhibits glioma neovascularization by controlling
            EphA2 expression.
REFERENCE   6  (bases 1 to 3911)
  AUTHORS   Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R and
            Sugimura H.
  TITLE     Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2
  JOURNAL   EMBO J 23 (5), 1075-1088 (2004)
   PUBMED   14988728
REFERENCE   7  (bases 1 to 3911)
  AUTHORS   Dobrzanski P, Hunter K, Jones-Bolin S, Chang H, Robinson C,
            Pritchard S, Zhao H and Ruggeri B.
  TITLE     Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist
  JOURNAL   Cancer Res 64 (3), 910-919 (2004)
   PUBMED   14871820
REFERENCE   8  (bases 1 to 3911)
  AUTHORS   Biervert C, Horvath E and Fahrig T.
  TITLE     Semiquantitative expression analysis of ephrine-receptor tyrosine
            kinase mRNA's in a rat model of traumatic brain injury
  JOURNAL   Neurosci Lett 315 (1-2), 25-28 (2001)
   PUBMED   11711206
REFERENCE   9  (bases 1 to 3911)
  AUTHORS   Naruse-Nakajima C, Asano M and Iwakura Y.
  TITLE     Involvement of EphA2 in the formation of the tail notochord via
            interaction with ephrinA1
  JOURNAL   Mech Dev 102 (1-2), 95-105 (2001)
   PUBMED   11287184
REFERENCE   10 (bases 1 to 3911)
  AUTHORS   Miao H, Burnett E, Kinch M, Simon E and Wang B.
  TITLE     Activation of EphA2 kinase suppresses integrin function and causes
            focal-adhesion-kinase dephosphorylation
  JOURNAL   Nat Cell Biol 2 (2), 62-69 (2000)
   PUBMED   10655584
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345596.3, XM_001072610.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3911
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3911
                     /gene="Epha2"
                     /note="Eph receptor A2"
                     /db_xref="GeneID:366492"
                     /db_xref="RGD:1307204"
     exon            1..192
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..3044
                     /gene="Epha2"
                     /EC_number="2.7.10.1"
                     /note="ephrin receptor EphA2; ephrin type-A receptor 2"
                     /codon_start=1
                     /product="ephrin type-A receptor 2 precursor"
                     /protein_id="NP_001102447.1"
                     /db_xref="GeneID:366492"
                     /db_xref="RGD:1307204"
                     /translation="MKLRAAGFCLALLWGCALAAAAAQGKEVVLLDFAAMKGELGWLT
                     HPYGKGWDLMQNIMNDMPIYMYSVCNVVSGDQDNWLRTNWVYREEAERIFIELKFTVR
                     DCNSFPGGASSCKETFNLYYAESDVDYGTNFQKRQFTKIDTIAPDEITVSSDFEARNV
                     KLNVEERMVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPEMLQSLARFPETIAVAV
                     SDAQPLATVAGTCVDHAVVPYGGEGPLMHCTVDGEWLVPIGQCLCQEGYEKVEDACQA
                     CSPGFFKSEASESPCLQCPEHTLPSTEGATSCQCEEGYFRAPEDPLSMPCTRPPSAPH
                     YLTAIGMGAKVELRWTAPQDTGGRKDIVYSVTCEQCWPESGECGSCEASVQYSEPPQA
                     LTRTSVTVSDLEPHMNYTFTVEARNGVSDLVNSRSFRTASVSINQTEPPKVRLEDRST
                     TSLSVAWSIPVPQQSRVWKYEVTYRKKGDANSYNVHRTDGFSVTLDGLAPGTTYLVQV
                     QALTQEGQGAGSKVHEFQTLSTEGSATMAVIGGVAVGVVLLLVLAGIGFFIHRRRRNL
                     RARQSSEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVSRQKVIGAGE
                     FGEVYKGTLKSSSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGV
                     VSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIASGMKYLANMNYVHRD
                     LAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSA
                     SDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQ
                     QERSRRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWL
                     ESIKMQQYTEHFMVAGYTAIEKVVQMSNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNT
                     VGIPI"
     exon            193..260
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..936
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1092
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1425
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1541
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1695
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1795
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1851
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1977
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2166
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2228
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2438
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2588
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2782
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2938
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3911
                     /gene="Epha2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attaaggact tggggcagga gggcagaagt tgtctgtggc gagcgggtag gagcgagaca
       61 tccgggccgg cgtgtggaca gcagggatcg cggggagcga ggggtgcagc atgaagcttc
      121 gggcagccgg tttctgcctg gccctgttgt ggggttgcgc gctggcggcc gcggcggcac
      181 agggaaaaga agttgttttg ctggacttcg cagcaatgaa gggggaactc ggctggctca
      241 cacaccccta cggaaaaggg tgggacctga tgcaaaacat catgaatgac atgcctatct
      301 acatgtactc cgtgtgcaat gtggtgtctg gcgaccagga caactggctc cgtaccaact
      361 gggtgtaccg ggaggaggcc gagcgcatct ttattgagct caagttcacc gtgcgagact
      421 gcaatagctt tccgggtggc gccagctcct gcaaagagac cttcaacctc tactatgcag
      481 agtcagacgt ggactatggc accaacttcc agaagcgcca gttcaccaag atcgacacca
      541 tcgcccctga cgagatcacg gtcagcagtg acttcgaggc tcgcaatgtc aagctgaatg
      601 tggaggagcg catggtgggg ccccttaccc ggaagggctt ctacctggcc ttccaggaca
      661 tcggtgcctg tgtggcattg ctctctgttc gtgtctacta caagaagtgt cccgagatgc
      721 ttcagagctt ggcccgcttc cctgagacca ttgctgtcgc cgtctcagat gcacagcccc
      781 tggccacggt ggccggtacc tgcgtggacc acgctgtggt gccttatggg ggcgaggggc
      841 ctctcatgca ctgcacggtg gatggtgagt ggctggtgcc tatcgggcag tgcctgtgcc
      901 aagaaggcta cgagaaggtg gaggacgcct gccaagcctg ttctccagga ttcttcaagt
      961 ctgaggcatc tgagagccct tgcctgcagt gtccggagca taccctgcca tccactgagg
     1021 gtgccacctc ctgccagtgt gaagaaggct atttcagggc acctgaggac ccactgtcca
     1081 tgccctgcac acgtccaccc tctgcccccc actacctcac ggccatcggc atgggtgcca
     1141 aagtagaact gcgttggacg gccccccagg acaccggtgg gcgcaaggac atcgtctaca
     1201 gcgtcacttg cgaacagtgc tggccagagt ccggcgagtg tgggtcctgt gaggccagtg
     1261 tgcaatactc agaaccacct caggccctga cccgcacgag tgtgacagtc agcgacctgg
     1321 agcctcacat gaactatacc ttcactgtcg aagcccgcaa tggcgtctca gacctggtga
     1381 atagccgaag cttccggact gccagtgtca gcattaacca aacagagccc cccaaggtga
     1441 gactggagga ccgaagcacc acctccctga gtgtcgcctg gagcatcccg gtgccacagc
     1501 agagccgtgt gtggaagtac gaagtcacct accgcaagaa gggggatgcc aatagctaca
     1561 atgtgcaccg tacagacggc ttctccgtga ccctggatgg ccttgctccc ggtactacat
     1621 acctggtgca ggtgcaggcg ctgacgcagg agggccaggg cgccggcagc aaagtgcacg
     1681 agttccagac gctgtccacg gaaggatctg ccaccatggc ggtgatcggc ggtgtggctg
     1741 ttggcgttgt cctgctccta gtgttagcgg gaattggctt cttcatccat cgaaggagga
     1801 ggaacctgcg ggcccgtcag tcctctgagg acgtctactt ttccaagtca gaacaactaa
     1861 agcccctgaa gacatatgtg gatcctcaca cttacgaaga ccccaaccag gccgtgctca
     1921 agtttaccac cgagatccac ccatcctgtg tctccaggca gaaggtcatt ggagcaggag
     1981 agtttggaga ggtatataaa gggacgctga agtcctcctc tgggaagaag gagataccgg
     2041 tggctatcaa gacgctgaaa gccggctaca ctgagaagca gcgggtggac ttcctaagtg
     2101 aagccagcat catgggccag ttcagccatc acaatatcat ccgcctggag ggcgttgtct
     2161 ctaaatacaa acccatgatg attatcacag agtacatgga gaatggagcg ctagacaagt
     2221 tccttaggga gaaggacggc gagttcagcg tactgcagct cgtgggcatg cttcggggca
     2281 tcgcgtctgg catgaagtac ctggccaaca tgaactacgt gcaccgggac ctggccgccc
     2341 gcaacatcct tgtcaacagt aacctggtat gcaaggtgtc cgattttggc ctgtcgcgtg
     2401 tgctggagga tgaccctgag gccacctaca ccactagtgg cggcaagatt cctattcgat
     2461 ggacagcccc agaagccatt tcctaccgca agttcacctc agccagtgat gtgtggagct
     2521 atggaattgt catgtgggag gtgatgacgt acggagagcg gccctattgg gagctgtcaa
     2581 accatgaggt catgaaagcc atcaacgatg gcttccggct ccccacgccc atggactgcc
     2641 cctcagccat ctaccaactc atgatgcaat gctggcagca agagcgctcc cgccggccca
     2701 agtttgctga cattgttagc atcttggaca agctcatccg agcccccgac tccctcaaga
     2761 ccctggctga cttcgatccc cgagtgtcca ttcggctacc cagcaccagc ggctcagagg
     2821 gagtcccctt ccggacggtg tctgagtggc tggaaagcat caaaatgcaa cagtatacgg
     2881 aacacttcat ggtagctggc tacacggcca tcgagaaagt ggtgcagatg tccaatgatg
     2941 acatcaaaag gatcggagtg cgtcttcctg gccaccagaa gcgcattgcc tacagcctgc
     3001 tgggactcaa agaccaagtg aacacagtgg ggattcctat ctgagtctga tggggcctcg
     3061 tgcccacctt gaccaacaat acttgaagag ccacagtggt ctccctaccg acctggtgct
     3121 gggccactgg aactttattt atttctgact tcctcgtcga cacctccctg aggactctgc
     3181 gagggggact cttgaatgac accctggcat gagccgggga acgcctggtc agggttcctt
     3241 tccccctgca aaggacccag ctaagcactt agcaggttgt cattgcactc ccagcatccc
     3301 ctgaggctgg agtttggcca agactgtcga tatccacgag gggagtttcc aaactgacct
     3361 ccccgtcttt tctccccaag aagccacctc aagagctgag gctaagcact aagcccagga
     3421 ccatatgact agggcactgt aagccccacc tctagttaga gggtaggttt tggacttggc
     3481 tgggtggggc cacaacaatc tcccagtgcc ttctacagac ccagggctct gccctctgcc
     3541 ctcgagggcc agtttcttgc tttcctaggg ccctctcagg atgcttggct gtgttgaggt
     3601 tttttttaaa tatatatttt atacttgtgg aaagaatgag tgtgtggcag ggaccttgcc
     3661 agggctgggg acagaggata ccctgcaaca gacattcccg ggctgaggcc tggccgactt
     3721 gtaggagact taccacccag ccaccccgtc tctagcccct ttggacaact gtcgctgtca
     3781 gtgttacaga tctgtgttat tgggtggttt ttgtttttgt ttttggaacc ttaacttatt
     3841 attatttttt tttatattta ttgttagaaa atgacttatt tctgctccag aataaagttg
     3901 cagatggttc a
//
