LOCUS       NM_001107858            3248 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus Eph receptor A1 (Epha1), mRNA.
ACCESSION   NM_001107858 XM_001072130 XM_231658
VERSION     NM_001107858.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3248)
  AUTHORS   Chen,G., Wang,Y., Zhou,M., Shi,H., Yu,Z., Zhu,Y. and Yu,F.
  TITLE     EphA1 receptor silencing by small interfering RNA has
            antiangiogenic and antitumor efficacy in hepatocellular carcinoma
  JOURNAL   Oncol Rep 23 (2), 563-570 (2010)
   PUBMED   20043122
REFERENCE   2  (bases 1 to 3248)
  AUTHORS   Yamazaki,T., Masuda,J., Omori,T., Usui,R., Akiyama,H. and Maru,Y.
  TITLE     EphA1 interacts with integrin-linked kinase and regulates cell
            morphology and motility
  JOURNAL   J Cell Sci 122 (Pt 2), 243-255 (2009)
   PUBMED   19118217
REFERENCE   3  (bases 1 to 3248)
  AUTHORS   Masuda,J., Usui,R. and Maru,Y.
  TITLE     Fibronectin type I repeat is a nonactivating ligand for EphA1 and
            inhibits ATF3-dependent angiogenesis
  JOURNAL   J Biol Chem 283 (19), 13148-13155 (2008)
   PUBMED   18308734
  REMARK    GeneRIF: I 12 acquired a higher affinity toward EphA2 with K(d) 18
            nm and inhibited vascular endothelial growth factor-dependent
            angiogenic invasion in a Matrigel plug assay
REFERENCE   4  (bases 1 to 3248)
  AUTHORS   Ogita,H., Kunimoto,S., Kamioka,Y., Sawa,H., Masuda,M. and
            Mochizuki,N.
  TITLE     EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically
            in vascular smooth muscle cells
  JOURNAL   Circ Res 93 (1), 23-31 (2003)
   PUBMED   12775584
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001072130.1, XM_231658.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132271, SAMEA5756307
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..3248
                     /gene="Epha1"
                     /note="Eph receptor A1"
                     /db_xref="GeneID:312279"
                     /db_xref="RGD:1304680"
     exon            1..144
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2993
                     /gene="Epha1"
                     /EC_number="2.7.10.1"
                     /note="ephrin receptor EphA1; ephrin type-A receptor 1"
                     /codon_start=1
                     /product="ephrin type-A receptor 1 precursor"
                     /protein_id="NP_001101328.1"
                     /db_xref="GeneID:312279"
                     /db_xref="RGD:1304680"
                     /translation="MERRWPLGLALLLLLLCAPLPPGARAEEVTLMDTSTAQGELGWL
                     LDPPETGWSEVQQMLNGTPLYMYQDCPIQEGGDTDHWLRSNWIYRGEEASRVHVELQF
                     TVRDCKSFPGGAGPLGCKETFNLFYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDL
                     ASGSVKLNVEHCSLGHLTRRGLYLAFHNPGSCVALVSVRVFYQRCAETVHGLAHFPHT
                     LPGPTGLVEVAGTCLSHAQISLGSSGTPRMHCSPDGEWLVPVGQCQCEPGYEESGGSV
                     GCTACPTGFYRMDMNTLHCLKCPQHSVAESEGSTICTCENGHYRAPGEGPQVACTRPP
                     SAPQNLSFSASGTQLSLRWEPPRDTGGRQDIRYSVECLQCRGIAQDGGPCQPCGKGVH
                     FSPAASGLTASTVQVEGLEPYANYTFTIKSQNRVSGLDSSSPSSASLSINMGQAESLS
                     GLSLKLVKKEPRQLELTWAGSRLQNPGGNLSYELHVLNQDEEWHQMVLEPRVLLTKLQ
                     PDTTYIVRVRTLTPLGPGPFSPDHEFRTSPPVSRSLTGGEIVAIIFGLLLGIALLIGI
                     YVFRSRRGQRQRQQRQRERTTNVDREDKLWLKPYVDLQAYEDPAQGALDFAQELDPAW
                     LIVDTVIGEGEFGEVYRGALRIPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFN
                     HPHILRLEGVITKRKPIMIITEFMENGALDAFLKEREDQLVPGQLVAMLLGIASGMNY
                     LSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEA
                     IAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPL
                     YELMKNCWAYDRARRPHFLQLQAHLEQLLTDPHSLRTIANFDPRVTLRLPSLSGSDGI
                     PYRSVSEWLESIRMKRYILHFRSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSI
                     QGFKD"
     exon            145..212
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..494
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..897
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1053
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1398
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1526
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1677
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1774
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1833
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1959
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2145
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2207
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2414
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2564
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2758
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2914
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3248
                     /gene="Epha1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtccctcg cgacctggcc cagccgtagg ggccgtggtc ccaggtcccg gccggcgcca
       61 tggagcggcg ctggcccctg gggctcgcac tgctgctgct gctgctctgc gccccgctgc
      121 ccccgggggc gcgcgccgag gaagtcactt taatggacac gagcacagca caaggagagt
      181 tgggctggct tctggatccc ccagagactg ggtggagtga ggtgcaacaa atgctgaacg
      241 ggacacccct gtacatgtac caagactgcc caatacagga aggtggagat actgaccact
      301 ggcttcgctc caactggatc taccgaggag aggaagcctc acgtgtccac gtagagctgc
      361 agttcactgt gcgggactgt aaaagtttcc cagggggagc tgggcctctg ggatgcaaag
      421 agaccttcaa ccttttctac atggagagtg accaggatgt gggcattcaa ctccgacggc
      481 ctttgttcca aaaggtaaca actgtggcag cagaccagag cttcaccatc agagacctgg
      541 cctctggctc tgtaaagctg aacgtagagc actgctcctt gggtcacctc acccgccgtg
      601 gtctctacct agctttccac aacccgggat cctgtgtggc gctcgtatct gtaagggtgt
      661 tctaccagcg ctgcgcagag actgtgcatg gcttggccca cttccctcac actctccctg
      721 gacctacagg gttggtagaa gtagctggaa cctgcctctc ccatgcacag atcagcctgg
      781 ggtcctcagg tacaccacgc atgcattgca gccctgatgg cgagtggttg gtgcctgtgg
      841 gtcagtgcca gtgcgagcct ggctatgagg aaagcggtgg aagtgtggga tgcactgcct
      901 gtcctactgg tttctatcga atggacatga atactctcca ctgtctcaag tgcccccaac
      961 atagcgtagc agagtctgag gggtctacca tctgtacctg tgagaatgga cattatcgag
     1021 cccctgggga gggcccccag gtagcatgca cgcgtccccc atcagctccc caaaatctga
     1081 gcttctctgc atcaggcact cagctctccc tacgctggga gcccccaaga gatacagggg
     1141 gacgccaaga tatcagatac agtgtggaat gcttgcagtg tcggggcatt gcacaggatg
     1201 ggggtccctg ccaaccctgt ggaaaaggtg tgcacttttc cccggcagct tccgggctca
     1261 ccgcatctac tgtgcaagtt gaaggcctcg agccttatgc caactacacg tttaccatca
     1321 aatcccagaa cagagtgtcg ggactggaca gttccagccc tagcagcgct tctctcagta
     1381 tcaacatggg gcaagcagag tcactctctg gcctgtcact gaagctggtg aagaaagagc
     1441 cgaggcagct ggagctgact tgggcagggt cccgactcca aaaccctggg gggaatctga
     1501 gctatgagct gcacgtgctg aaccaggatg aagaatggca ccaaatggtg ctggaaccca
     1561 gggtcttgct gacaaaactt cagccagata ccacatacat tgtcagagta cgaacactga
     1621 ccccactggg gcctggccct ttctcccctg accatgagtt ccggacaagc ccaccagttt
     1681 ccagaagcct gactggagga gagattgtgg ccatcatctt tggattgctg cttggaatag
     1741 ctctgctgat cgggatttat gtcttccgtt caaggagagg ccagcgacag agacagcaga
     1801 ggcagcgtga acgcaccacc aatgtcgatc gagaggacaa gctgtggcta aaaccctatg
     1861 tggacctcca ggcctatgag gaccctgcac agggagcctt agactttgcc caggaactgg
     1921 accctgcctg gctgattgtg gacactgtca taggagaagg ggagtttggg gaagtgtatc
     1981 ggggagccct gagaatcccc agccaagact gcaagaccgt ggccattaag accttgaaag
     2041 acacatcccc agatggctac tggtggaatt tccttcgaga agcaactatc atgggccagt
     2101 tcaaccaccc acacattcta cgcctagaag gtgtcatcac gaaaagaaag ccgatcatga
     2161 tcatcacaga atttatggaa aatggagccc ttgatgcctt tctgaaggaa cgggaggacc
     2221 agctagttcc tggtcagcta gtggctatgc ttctgggcat agcatcaggc atgaactacc
     2281 tcagtggcca caattatgtc catagagacc tggctgccag gaacatcttg gtgaatcaga
     2341 acttgtgctg caaggtatct gactttggcc tgacccgcct cctggatgac ttcgatggca
     2401 cctatgaaac ccagggagga aagatcccta tccgttggac agccccagaa gctattgccc
     2461 atcggatctt caccacagcc agtgatgttt ggagctttgg gattgtaatg tgggaggtgt
     2521 tgagttttgg cgacaaaccc tatggggaga tgagcaatca agaggtaatg aaaagcattg
     2581 aggatgggta ccggctgccc cctcctgtgg attgtcctgc ccccctgtat gaactcatga
     2641 agaactgctg ggcttacgac cgtgcccgtc ggccccactt cctccagctg caggcacatc
     2701 tggaacagct gctcacggac ccccattccc taaggacaat tgccaacttt gaccctaggg
     2761 tgaccctacg tctgcccagc ctgagtggct ctgatgggat cccttatcga agtgtctctg
     2821 agtggcttga atccatacgc atgaagcgct acatcctgca cttccgctcg gcaggcctgg
     2881 acaccatgga gtgtgtgctg gagctgacag ccgaggacct gacgcagatg ggaatcacat
     2941 tgccagggca ccagaagcgc attctctgca gtattcaagg atttaaggac tgagcatcca
     3001 ctgaaaagat gttccagccc tctgtccact ccctgggcct ttcctcagcc tacgaaatgt
     3061 aggctattgg tgctgctcct gcccagtcaa tcagaactct gcctttggac caaggagcct
     3121 ttgtttataa agggggtggg tggggtacaa gtgaagggga ctgtgggtgg gtgggtgctg
     3181 gggggagggt ttaatatata tacttacata tgcattatct atttttgtaa ataaacagag
     3241 ttgagttt
//
