LOCUS       NM_001007625            2243 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ependymin related 1 (Epdr1), transcript variant
            1, mRNA.
ACCESSION   NM_001007625 XM_225426
VERSION     NM_001007625.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2243)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   2  (bases 1 to 2243)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 2243)
  AUTHORS   Della Valle,M.C., Sleat,D.E., Sohar,I., Wen,T., Pintar,J.E.,
            Jadot,M. and Lobel,P.
  TITLE     Demonstration of lysosomal localization for the mammalian
            ependymin-related protein using classical approaches combined with
            a novel density shift method
  JOURNAL   J Biol Chem 281 (46), 35436-35445 (2006)
   PUBMED   16954209
  REMARK    GeneRIF: A novel density shift method was used to demonstrate that
            EPDR resides in the lysosome.
REFERENCE   4  (bases 1 to 2243)
  AUTHORS   Gregorio-King,C.C., McLeod,J.L., Collier,F.M., Collier,G.R.,
            Bolton,K.A., Van Der Meer,G.J., Apostolopoulos,J. and Kirkland,M.A.
  TITLE     MERP1: a mammalian ependymin-related protein gene differentially
            expressed in hematopoietic cells
  JOURNAL   Gene 286 (2), 249-257 (2002)
   PUBMED   11943480
REFERENCE   5  (bases 1 to 2243)
  AUTHORS   Apostolopoulos,J., Sparrow,R.L., McLeod,J.L., Collier,F.M.,
            Darcy,P.K., Slater,H.R., Ngu,C., Gregorio-King,C.C. and
            Kirkland,M.A.
  TITLE     Identification and characterization of a novel family of mammalian
            ependymin-related proteins (MERPs) in hematopoietic,
            nonhematopoietic, and malignant tissues
  JOURNAL   DNA Cell Biol 20 (10), 625-635 (2001)
   PUBMED   11749721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Mar 14, 2022 this sequence version replaced NM_001007625.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083701.1, SRR22399489.1158435.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-521               JAXUCZ010000017.1  50029591-50030111
            522-730             JAXUCZ010000017.1  50051512-50051720
            731-2243            JAXUCZ010000017.1  50052742-50054254
FEATURES             Location/Qualifiers
     source          1..2243
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q11"
     gene            1..2243
                     /gene="Epdr1"
                     /gene_synonym="Epdr2; MERP2"
                     /note="ependymin related 1"
                     /db_xref="GeneID:291180"
                     /db_xref="RGD:1359161"
     exon            1..521
                     /gene="Epdr1"
                     /gene_synonym="Epdr2; MERP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..927
                     /gene="Epdr1"
                     /gene_synonym="Epdr2; MERP2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; upregulated in colorectal cancer gene 1
                     protein; mammalian ependymin-related protein 1; MERP-1;
                     ependymin related protein 1"
                     /codon_start=1
                     /product="mammalian ependymin-related protein 1 isoform 1
                     precursor"
                     /protein_id="NP_001007626.1"
                     /db_xref="GeneID:291180"
                     /db_xref="RGD:1359161"
                     /translation="MLTRAPRRLVQGPRETWLLGGLWVWILCGLGMAGSPGTPQPCQA
                     PQQWEGRQVLYQQSSGHNSRALVSYDGLNQRVRVLDERKALIPCKRLFEYILLYKDGV
                     MFQIEQATKLCAKIPLAEPWDPLDIPQNSTFEDQYSIGGPQEQIMVQEWSDRRTARSY
                     ETWIGVYTAKDCYPVQETFIRNYTVVLSTRFFDVQLGIKDPSVFTPPSTCQTAQPEKM
                     KENCSL"
     exon            522..730
                     /gene="Epdr1"
                     /gene_synonym="Epdr2; MERP2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..2243
                     /gene="Epdr1"
                     /gene_synonym="Epdr2; MERP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcgttagt aagcctcggt cagggcagaa agagctctgg gcgattcaca cacggctacc
       61 ccagactcgg acccccaagc cggaagcctc taaaaccgaa aattggaaaa tcggaaaatc
      121 aggagaggcc agggctcctg agctggtccc agagcacatc ttccaccagc gctcagacaa
      181 cgcgcgtgac tctcccacgc cgggcctcgg ctccctccca ggtttggctg acccggaggg
      241 ccgcgaatca cgatgctcac acgcgctccc cgccgcctgg tccaggggcc ccgggagacc
      301 tggctgcttg gcggcctctg ggtctggata ttgtgcggcc tggggatggc gggctccccg
      361 ggaaccccgc agccatgcca ggcgccccag cagtgggagg gacgtcaggt tctgtaccag
      421 cagagcagcg ggcacaacag ccgcgccctg gtgtcctacg atggtctcaa ccagcgcgtg
      481 cgggtgctgg acgaaaggaa ggcgctgatc ccctgcaaga gattatttga atacatttta
      541 ctctataagg atggagtgat gtttcagatt gaacaagcca ccaaactgtg tgcaaagata
      601 cccttggcag aaccctggga tcctctcgac attccccaga attctacctt tgaagatcag
      661 tactctatcg gagggcctca ggagcagatc atggtccagg aatggtctga caggaggaca
      721 gccagatcct atgaaacctg gattggcgtt tatacagcca aggattgcta cccggtccag
      781 gagaccttca ttaggaacta cactgtggtc ctgtccactc ggttctttga tgtgcagttg
      841 ggcattaaag acccctctgt gttcacccca ccaagcacgt gccagacagc acagccagag
      901 aagatgaaag agaactgctc cctgtgaatt tccatgagcg gaagccacga cctcagctct
      961 tagggacttt gtgtggaaat ggactagagg ccagttggaa agcaactcgt cacgagaagc
     1021 aaagctagtt ttaggaagat aaaccctatg tggacttgct tgtcatctga ctgtggctgc
     1081 tcagctctat ttttggaagg aacctgggtt atcctttctg tgtgcaggtg tgtagtcagt
     1141 gctgtagggt aggacggggt gaaggtgggg tcggcacaag gagtttgcct ctgcagagtg
     1201 aaccttttat tattgccaat aagattgaaa gtgataataa gatatagtat aatttttttc
     1261 agttctctcc ttacaaagaa agtcccttgc ttgtgtgcac tagggtagtg acagttccca
     1321 ctgaccccac acctgcctct ggctactatg agatgaccct ttaagattct ttccaagctt
     1381 aaattttgtc acatggccca ccggatgtag atattctgca aggaagtaga aacttgtaat
     1441 gcaaagcaat gttgcctctg aagggaaaag aagttttaag cgggaggctt agacaatctt
     1501 agtatcttca tgtgagatga agtccgagcc gtgtgtggtg ctttgtgtgc aagagtactg
     1561 actgctgtgc tgaaactatg tcttttctag cgggcaaaca ggcttgcaaa acagcactga
     1621 attgggaggc ccccaagtaa ggcctaggat tctctgctac tctaatcctt taagtagtaa
     1681 atgcactagg ctaatagctc tcgccttgcc tttctggaaa ctctctgtct atatgactac
     1741 tgctcacgct tccaacatca gctcacatgt gccccctgtg agctgctcca atgcctgaat
     1801 tcattgcacc ttacagcttg gcatgccttg ctcacaatac tcagtatgct gcgtgaggat
     1861 ttcctgatta ctggaaacta acctctgtta tcctgggtaa gaatcccttg agttacgggt
     1921 atcgtgttct gtttacttta atatctccag caccaagcaa gtgcctggca cgtagtccgt
     1981 gccccaaaca tttgcagaga ggagctcatc agctctgtca gtgtttagtt ttctcatcta
     2041 ttaaacaggg ttggtttttc tggttgctag ggagacttgt actaatgcaa cctactgttc
     2101 tagattcttt atcaccgtgt ttcatttgac cacgtatcac cttttgttat caagagaaat
     2161 gtgtgaagct tgctttatgc tgtagccatc tatattgtaa tttatctcta tacaattaaa
     2221 caaatttatt gacaccctac aaa
//
