LOCUS       NM_138541               1460 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus epithelial cell adhesion molecule (Epcam), mRNA.
ACCESSION   NM_138541
VERSION     NM_138541.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1460)
  AUTHORS   Poon,C.E., Madawala,R.J., Day,M.L. and Murphy,C.R.
  TITLE     EpCAM is decreased but is still present in uterine epithelial cells
            during early pregnancy in the rat: potential mechanism for
            maintenance of mucosal integrity during implantation
  JOURNAL   Cell Tissue Res 359 (2), 655-664 (2015)
   PUBMED   25367431
  REMARK    GeneRIF: These results suggest that, prior to implantation, EpCAM
            mediates intercellular adhesion in the uterine epithelium.
REFERENCE   2  (bases 1 to 1460)
  AUTHORS   Guo,Z., Li,L.Q., Jiang,J.H., Ou,C., Zeng,L.X. and Xiang,B.D.
  TITLE     Cancer stem cell markers correlate with early recurrence and
            survival in hepatocellular carcinoma
  JOURNAL   World J Gastroenterol 20 (8), 2098-2106 (2014)
   PUBMED   24616575
REFERENCE   3  (bases 1 to 1460)
  AUTHORS   Thuma,F. and Zoller,M.
  TITLE     EpCAM-associated claudin-7 supports lymphatic spread and drug
            resistance in rat pancreatic cancer
  JOURNAL   Int J Cancer 133 (4), 855-866 (2013)
   PUBMED   23390083
  REMARK    GeneRIF: cld7 supports tumorigenic features of EpC by provoking EpC
            cleavage and thereby its cotranscription factor activity
REFERENCE   4  (bases 1 to 1460)
  AUTHORS   Kang,J.S.
  TITLE     Increased expression of epithelial cell adhesion molecule (EpCAM)
            in rat hepatic tumors induced by diethylnitrosamine
  JOURNAL   Asian Pac J Cancer Prev 13 (8), 3627-3630 (2012)
   PUBMED   23098445
  REMARK    GeneRIF: EpCAM overexpression is asociated with hepatic tumors.
REFERENCE   5  (bases 1 to 1460)
  AUTHORS   Ng,V.Y., Ang,S.N., Chan,J.X. and Choo,A.B.
  TITLE     Characterization of epithelial cell adhesion molecule as a surface
            marker on undifferentiated human embryonic stem cells
  JOURNAL   Stem Cells 28 (1), 29-35 (2010)
   PUBMED   19785009
REFERENCE   6  (bases 1 to 1460)
  AUTHORS   Munz,M., Zeidler,R. and Gires,O.
  TITLE     The tumour-associated antigen EpCAM upregulates the fatty acid
            binding protein E-FABP
  JOURNAL   Cancer Lett 225 (1), 151-157 (2005)
   PUBMED   15922867
REFERENCE   7  (bases 1 to 1460)
  AUTHORS   Munz,M., Kieu,C., Mack,B., Schmitt,B., Zeidler,R. and Gires,O.
  TITLE     The carcinoma-associated antigen EpCAM upregulates c-myc and
            induces cell proliferation
  JOURNAL   Oncogene 23 (34), 5748-5758 (2004)
   PUBMED   15195135
REFERENCE   8  (bases 1 to 1460)
  AUTHORS   van Niel,G., Raposo,G., Candalh,C., Boussac,M., Hershberg,R.,
            Cerf-Bensussan,N. and Heyman,M.
  TITLE     Intestinal epithelial cells secrete exosome-like vesicles
  JOURNAL   Gastroenterology 121 (2), 337-349 (2001)
   PUBMED   11487543
REFERENCE   9  (bases 1 to 1460)
  AUTHORS   Wurfel,J., Rosel,M., Seiter,S., Claas,C., Herlevsen,M., Weth,R. and
            Zoller,M.
  TITLE     Metastasis-association of the rat ortholog of the human epithelial
            glycoprotein antigen EGP314
  JOURNAL   Oncogene 18 (14), 2323-2334 (1999)
   PUBMED   10327052
REFERENCE   10 (bases 1 to 1460)
  AUTHORS   Litvinov,S.V., Balzar,M., Winter,M.J., Bakker,H.A., Briaire-de
            Bruijn,I.H., Prins,F., Fleuren,G.J. and Warnaar,S.O.
  TITLE     Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell
            interactions mediated by classic cadherins
  JOURNAL   J Cell Biol 139 (5), 1337-1348 (1997)
   PUBMED   9382878
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138541.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            55 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001044.1, BC061787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000006.1  12649536-12649678   c
            144-251             JAXUCZ010000006.1  12646141-12646248   c
            252-492             JAXUCZ010000006.1  12645653-12645893   c
            493-558             JAXUCZ010000006.1  12644486-12644551   c
            559-622             JAXUCZ010000006.1  12643698-12643761   c
            623-724             JAXUCZ010000006.1  12642131-12642232   c
            725-928             JAXUCZ010000006.1  12639547-12639750   c
            929-973             JAXUCZ010000006.1  12635742-12635786   c
            974-1460            JAXUCZ010000006.1  12633715-12634201   c
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1460
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /note="epithelial cell adhesion molecule"
                     /db_xref="GeneID:171577"
                     /db_xref="RGD:621365"
     exon            1..143
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1015
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /note="ep-CAM; epithelial glycoprotein 314;
                     tumor-associated calcium signal transducer 1"
                     /codon_start=1
                     /product="epithelial cell adhesion molecule precursor"
                     /protein_id="NP_612550.1"
                     /db_xref="GeneID:171577"
                     /db_xref="RGD:621365"
                     /translation="MAPPKALAFGLLLAVVTATLAAAQKDCVCNNYKLTSRCYENENG
                     ECQCTSYGTQNTVICSKLASKCLVMKAEMTHSKSGRRMKPEGAIQNNDGLYDPECDEQ
                     GLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERAQPYNFE
                     SLHTALQDTFASRYMLNPKFIKSIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEK
                     DVKGESLFHSSKSMDLRVNGELLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVV
                     VLAVIAGIVVLVISTRKRSAKYEKAEIKEMGEIHRELNA"
     exon            144..251
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..492
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..558
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..622
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..724
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..928
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..973
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1460
                     /gene="Epcam"
                     /gene_synonym="Egp314; Tacstd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgcgact gtccctggag ccgtcccgcg cctcagaccc gcgagtcccc gccgctccgc
       61 gcgcagtatg gcgcccccca aggccctcgc gttcgggctc ctgctcgcgg tggtcacggc
      121 gacgctggcc gcagctcaga aagactgtgt ctgtaacaac tacaagctga cgtcacggtg
      181 ctatgagaat gagaatggtg aatgccagtg tacttcctat gggacacaaa atactgtcat
      241 ttgctccaaa ctggcatcca agtgcttggt gatgaaggcg gagatgactc acagcaagtc
      301 tgggaggagg atgaaacccg agggggcgat ccagaacaac gacggtctgt atgatcccga
      361 gtgtgacgag caagggctct tcaaagccaa gcagtgcaac ggcaccgcca cgtgctggtg
      421 cgtgaacacc gcgggtgtcc ggagaaccga caaggacacg gagatcacgt gctccgagag
      481 agtgaggacc tactggatca tcattgagct caaacacaaa gaaagagcac agccttataa
      541 cttcgagagt ttgcatactg cacttcagga cacatttgca tctcgataca tgctgaatcc
      601 gaaatttatc aaaagtatta tgtatgagaa taatgttatc actattgatt tgatgcaaaa
      661 ctcttctcag aagactcaag atgatgtgga catagctgat gtggcttact attttgagaa
      721 agatgtaaag ggggagtcct tgttccattc atctaagagc atggacctga gggtgaacgg
      781 ggagctcctc gatctggacc ccgggcagac tctgatttac tacgtcgatg aaaaggcccc
      841 ggagttttcc atgcagggcc tcacggctgg gatcatcgcc gtcattgtcg tggtggtgtt
      901 agcagtcatt gcggggattg ttgtcctggt tatatctaca aggaagagat cagcaaaata
      961 tgagaaggct gagataaagg agatgggtga gatacacaga gagctcaatg cctaaccaac
     1021 catgccgtgt gctgcactga ggagggagcc accggacgga aatggcgaag aactcaggtt
     1081 gcaaacggat agacctgggg aggatggaga cctttcgagg gtcactgctt tgttagctaa
     1141 gctcacacat ttgtaacagt gaaatttgta ctcataaata caagcagctt gacattggca
     1201 ttaacaatct taaaattaga cgagtgtctt acacatgcag gtctggcgtg gaactcagaa
     1261 cttagcctgc caagatagga gagcttatgc ttattgttga agtgtgtgtg tgtgtgtgtg
     1321 tgtgtgtgtg tgtgtgtcat aaacagccca cagtagaata cgatgactac tctcattttt
     1381 gtgattaaag ctgcccttct acacactgag tcttgtacat aataaacgtt ttttaatgaa
     1441 ataaaacatt tttaaactga
//
