LOCUS       NM_001309462            3761 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus enhancer of polycomb homolog 1 (Epc1), mRNA.
ACCESSION   NM_001309462 XM_002725273 XM_002728490
VERSION     NM_001309462.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3761)
  AUTHORS   Joung,H., Kwon,J.S., Kim,J.R., Shin,S., Kang,W., Ahn,Y., Kook,H.
            and Kee,H.J.
  TITLE     Enhancer of polycomb1 lessens neointima formation by potentiation
            of myocardin-induced smooth muscle differentiation
  JOURNAL   Atherosclerosis 222 (1), 84-91 (2012)
   PUBMED   22398275
REFERENCE   2  (bases 1 to 3761)
  AUTHORS   Watanabe,S. and Peterson,C.L.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
REFERENCE   3  (bases 1 to 3761)
  AUTHORS   Kim,J.R., Kee,H.J., Kim,J.Y., Joung,H., Nam,K.I., Eom,G.H.,
            Choe,N., Kim,H.S., Kim,J.C., Kook,H., Seo,S.B. and Kook,H.
  TITLE     Enhancer of polycomb1 acts on serum response factor to regulate
            skeletal muscle differentiation
  JOURNAL   J Biol Chem 284 (24), 16308-16316 (2009)
   PUBMED   19359245
REFERENCE   4  (bases 1 to 3761)
  AUTHORS   Kee,H.J., Kim,J.R., Nam,K.I., Park,H.Y., Shin,S., Kim,J.C.,
            Shimono,Y., Takahashi,M., Jeong,M.H., Kim,N., Kim,K.K. and Kook,H.
  TITLE     Enhancer of polycomb1, a novel homeodomain only protein-binding
            partner, induces skeletal muscle differentiation
  JOURNAL   J Biol Chem 282 (10), 7700-7709 (2007)
   PUBMED   17192267
REFERENCE   5  (bases 1 to 3761)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   6  (bases 1 to 3761)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   7  (bases 1 to 3761)
  AUTHORS   Shimono,Y., Murakami,H., Hasegawa,Y. and Takahashi,M.
  TITLE     RET finger protein is a transcriptional repressor and interacts
            with enhancer of polycomb that has dual transcriptional functions
  JOURNAL   J Biol Chem 275 (50), 39411-39419 (2000)
   PUBMED   10976108
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before Jun 5, 2015 this sequence version replaced
            XM_002728490.4, XM_002725273.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.52672.1,
                                           SRR26360190.2396814.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000017.1  59289309-59289519   c
            212-371             JAXUCZ010000017.1  59227275-59227434   c
            372-517             JAXUCZ010000017.1  59217436-59217581   c
            518-724             JAXUCZ010000017.1  59216418-59216624   c
            725-873             JAXUCZ010000017.1  59215735-59215883   c
            874-1033            JAXUCZ010000017.1  59214542-59214701   c
            1034-1207           JAXUCZ010000017.1  59212691-59212864   c
            1208-1297           JAXUCZ010000017.1  59212521-59212610   c
            1298-1446           JAXUCZ010000017.1  59212296-59212444   c
            1447-1799           JAXUCZ010000017.1  59211110-59211462   c
            1800-1918           JAXUCZ010000017.1  59204344-59204462   c
            1919-2060           JAXUCZ010000017.1  59202724-59202865   c
            2061-2424           JAXUCZ010000017.1  59202259-59202622   c
            2425-3761           JAXUCZ010000017.1  59198513-59199849   c
FEATURES             Location/Qualifiers
     source          1..3761
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..3761
                     /gene="Epc1"
                     /note="enhancer of polycomb homolog 1"
                     /db_xref="GeneID:100362678"
                     /db_xref="RGD:2324280"
     exon            1..211
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2497
                     /gene="Epc1"
                     /codon_start=1
                     /product="enhancer of polycomb homolog 1"
                     /protein_id="NP_001296391.1"
                     /db_xref="GeneID:100362678"
                     /db_xref="RGD:2324280"
                     /translation="MEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEF
                     KMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPVQFEEMIDRLEKGSGQ
                     QPVSLQEAKLLLKEDDELIREVYEYWIKKRKTCRGPSLIPSVKQEKRDGSSTNDPYVA
                     FRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEI
                     MEKRYNLGDYSGEIMSEVMAQRQPVKPTYAIPIIPITNSSQFKHQDVTDAKEFKVNKQ
                     DKADLIRPKRKYEKKPKVLPSSAAAPQQPSPAALPGFSAKDLNQYDFPSSDEEPLSQV
                     LSGSSEAEEENDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLT
                     TLTVPQRCLGFARRRVGRGGRVLLDRAHSDYDSMFHHLDLDMLSSPQPSPVNQFANTS
                     ETNTSDRPSSKDLSQILVDIKSCRWRHFRPRTPSLPDSDSGELSSRKLHRSISRAGPA
                     QPGAHTCSASTQSRSSSGSTHCAFTAEQYQQHQQQLALMQQQQLAQTQQQQANSSSST
                     AAPQGFVSKTLDSASAQFAASALMTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLH
                     LSSTTPTALVHTSPSTAGSTLLQPSNITQTSGSHSALSHQVTAANSATTQVLFGNNIR
                     LTVPSSVPTVNSIAPINARHIPRTLSAVPPSALKLAAAANCQVSKVPSSSSVDSVPRE
                     NHESEKPALNNIADNTVAMEVT"
     exon            212..371
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..517
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..724
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..873
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1033
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1207
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1297
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1446
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1799
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1918
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2060
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2424
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..3761
                     /gene="Epc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attccccccg acgccctcgg atcctgcggc tgcccgcccc gctccgcgcc ctccatggac
       61 gaaagtctca cttttgattt accaaatatt ttcaggatgt ttgaagaccc gtacgctgcc
      121 cggaggctgt tttttctgga cagcccagac ctcagcctat attgttacaa tttttttttg
      181 agagctagct gctgctttgc ctacaccgat ggaacaccat cttcagcggg ctatctctgc
      241 acagcaggtg tacggcgaga agcgggataa catggttatt ccagttcctg aagcagaaag
      301 taacatcgct tactatgagt ccatataccc tggggagttc aagatgccaa agcagctcat
      361 tcacatacag cctttcagct tggacgctga gcagcctgat tacgacctgg attctgagga
      421 tgaagtcttt gtgaataaac tgaagaagaa aatggacatc tgcccagtgc agtttgagga
      481 gatgattgac cggttagaaa aaggcagcgg tcagcagcca gtcagtctgc aggaagccaa
      541 actacttcta aaagaagatg atgagttaat tagagaagtt tatgaatact ggattaaaaa
      601 gaggaaaacc tgccgggggc catcacttat cccgtcggta aaacaggaaa aacgagatgg
      661 ttctagcaca aatgatcctt atgtggcttt tagaagacga actgagaaaa tgcaaactcg
      721 aaaaaatcgc aaaaacgatg aagcctccta tgagaaaatg cttaagctgc gccgggatct
      781 cagccgggct gtcaccatcc tggagatgat caagagacgt gagaaaagta aacgggagct
      841 gctgcacctg acactggaga ttatggagaa gaggtataat ttaggtgact acagtggaga
      901 gatcatgtct gaggtcatgg cacagagaca gccagtgaag cctacctatg ccatccccat
      961 catcccgatt actaacagca gccagttcaa acaccaggac gtcacggatg cgaaggagtt
     1021 caaagttaac aagcaagata aggctgatct tattcggccg aagcgcaaat atgaaaagaa
     1081 gcccaaagtc ttaccgtcgt ctgctgccgc accccagcag ccaagtcctg ctgcactgcc
     1141 aggcttcagt gctaaagact taaaccagta cgacttcccc agctcagatg aagagcctct
     1201 gtcacaggtt ttgtctggct cttcagaagc tgaggaagag aatgaccctg atggcccttt
     1261 cgctttccgt aggaaagcag gctgtcagta ctatgctcct catttagacc aaactggcaa
     1321 ctggccctgg actagcccta aagatggagg cctgggggat gtgcgatata gatattgctt
     1381 aactactctc accgtacccc agaggtgtct tggatttgca cgaagacggg tcgggcgcgg
     1441 tggaagggtc ttgctggaca gagcgcattc agactatgac agtatgtttc accacctgga
     1501 tctggacatg ctttcctcac cacaaccttc tccagtcaat cagtttgcca atacctcaga
     1561 aaccaatacc tcggacagac cttcctctaa agacctcagt cagatactag tcgatatcaa
     1621 atcatgtaga tggcggcact ttaggccccg gacaccatcc cttcctgaca gtgacagtgg
     1681 tgagctctcc agtagaaagt tacacagaag tataagtcga gcaggaccag cgcagcctgg
     1741 ggcccacacg tgcagcgcct ccacacagag cagaagtagc agtggctcga cacactgtgc
     1801 atttacagcc gagcagtacc agcagcacca gcagcaactg gcactcatgc agcagcagca
     1861 gcttgcacaa actcagcagc agcaagcaaa tagcagttcc tccaccgccg ctccacaggg
     1921 ttttgtttct aagacgttgg attctgccag tgcacagttc gctgcttctg ctttaatgac
     1981 gtcagaacag ctgatgggat tcaagatgaa ggatgatgtg gtgcttggga ttggggtgaa
     2041 tggcgtcctt cccgcctcag gagtatacaa gggcttgcac ctcagcagca ctacaccaac
     2101 ggcgcttgta catacgagtc cttcgaccgc aggttcaacc ttgttacagc cttcaaatat
     2161 tacacagact tcgggttccc acagcgcact gagtcaccaa gtaactgctg ccaactctgc
     2221 aacaactcag gttctgtttg ggaacaacat ccgattaact gtcccctcat ctgtccccac
     2281 tgtcaactct atcgccccaa taaacgcacg gcatatacct aggactttaa gtgctgttcc
     2341 gccatctgcc ttaaagctgg ctgctgcagc aaactgtcaa gtttccaagg tcccctcctc
     2401 atcctctgta gattcagttc caagggaaaa tcatgaatca gaaaagccag cactgaacaa
     2461 catagcagac aacacagtag caatggaggt gacgtagctt cctgggagca ggactgcatc
     2521 ctggggacat ggtcaggtgc tatgcatcag agcgttggaa cgcagggagg atggagtgcg
     2581 taggcggttc cgtggcagct gtggggactc ggcagcactg cgcacctctc gtgcttcaac
     2641 ctttcttttc ttattgttaa taggaaaaaa tcaacatctg taaattaaga atacagcaat
     2701 tatctgtaca gtactgcata tttgtaatac ccttgtatat atgttacttg aatacagaac
     2761 tgttcatttg tgatgctttg cacttggggg cggggggtgg ggggtaactg caacaagagt
     2821 gtgagctgtg agattgtgta gctggtgtca tcacatcatg tgcatggtgc ggaacctgct
     2881 gtctctattt attgtgccgt gtttacaggt tttgtacact gtaccctcat tggttcctgt
     2941 gctgtagtaa atgtgttagg tagctgtgga ctccttggta ttttgtaaat ggtataacat
     3001 aacttggttc cctctgggtc cttgagtttt ctgtgtatca tgtgaaaaaa aaaatggtga
     3061 catacataca gaattttaca aaaaaaaaaa aggcatcagt tttttaaaac ggggaatgta
     3121 ctgttcaatg gggatcttcc tggtctacta gcattaggat gcgcaacaag ctaaaaatga
     3181 agtctcttga attctcccat ccccgcctgc ctgcaagctt gggcagccct ggtacttaaa
     3241 gcactaatgt tatgttgctg ccctacaaac agcccagtcg tcccatttcc ttccacacca
     3301 aaaagtgtta aatcaagtac acaaacggag tccttacaac tggagtttat gttgtcttgc
     3361 ccttttttta gcacaaaaag atgtactttt atattgtgga attgtttaaa gacttcattc
     3421 tttacttgtt cttacagaaa ggatataggg gagaagaatg ctgtccgtgt atcgtcattc
     3481 cagtttgtaa aacagccagc cagctttttc cttttaagat tctccagaag gctgcgaggc
     3541 cagaaccaca aatatcgggt gccttccttt ggaaatattt gacctctctt ctgtgaagag
     3601 aatggtactt accagactac tactgctttg ttagtaccga agtctgaatg cccagtccaa
     3661 tggcagacat atgttatcct taaggttttt aatcccacct ggaaacattg tgatagaatt
     3721 ctcacaaaat aaacccaggg cattacatgt tgacaaacta a
//
