LOCUS       NM_053927               4668 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus erythrocyte membrane protein band 4.1-like 3
            (Epb41l3), transcript variant 1, mRNA.
ACCESSION   NM_053927
VERSION     NM_053927.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4668)
  AUTHORS   Li,X., Zhou,F., Jiang,C., Wang,Y., Lu,Y., Yang,F., Wang,N.,
            Yang,H., Zheng,Y. and Zhang,J.
  TITLE     Identification of a DNA methylome profile of esophageal squamous
            cell carcinoma and potential plasma epigenetic biomarkers for early
            diagnosis
  JOURNAL   PLoS One 9 (7), e103162 (2014)
   PUBMED   25050929
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4668)
  AUTHORS   Cifuentes-Diaz,C., Chareyre,F., Garcia,M., Devaux,J., Carnaud,M.,
            Levasseur,G., Niwa-Kawakita,M., Harroch,S., Girault,J.A.,
            Giovannini,M. and Goutebroze,L.
  TITLE     Protein 4.1B contributes to the organization of peripheral
            myelinated axons
  JOURNAL   PLoS One 6 (9), e25043 (2011)
   PUBMED   21966409
  REMARK    GeneRIF: in myelinated axons 4.1B contributes to the stabilization
            of membrane proteins at paranodes, to the clustering of
            juxtaparanodal proteins, and to the regulation of the internodal
            axon caliber.
REFERENCE   3  (bases 1 to 4668)
  AUTHORS   Hoy,J.L., Constable,J.R., Vicini,S., Fu,Z. and Washbourne,P.
  TITLE     SynCAM1 recruits NMDA receptors via protein 4.1B
  JOURNAL   Mol Cell Neurosci 42 (4), 466-483 (2009)
   PUBMED   19796685
REFERENCE   4  (bases 1 to 4668)
  AUTHORS   Tsujiuchi,T., Sugata,E., Masaoka,T., Onishi,M., Fujii,H.,
            Shimizu,K. and Honoki,K.
  TITLE     Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in
            hepatocellular carcinomas induced by N-nitrosodiethylamine in rats
  JOURNAL   Cancer Sci 98 (7), 943-948 (2007)
   PUBMED   17428255
  REMARK    GeneRIF: The 5' upstream region of Tslc1 was methylated in three
            hepatocellular hepatomas in which its expression was reduced, but
            was unmethylated in normal liver tissue. No change in expression
            lever of Dal-1 found in hepatocellular hepatomas.
REFERENCE   5  (bases 1 to 4668)
  AUTHORS   Cavanna,T., Pokorna,E., Vesely,P., Gray,C. and Zicha,D.
  TITLE     Evidence for protein 4.1B acting as a metastasis suppressor
  JOURNAL   J Cell Sci 120 (Pt 4), 606-616 (2007)
   PUBMED   17264155
REFERENCE   6  (bases 1 to 4668)
  AUTHORS   Yu,T., Robb,V.A., Singh,V., Gutmann,D.H. and Newsham,I.F.
  TITLE     The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B
            tumour suppressor interacts with 14-3-3 proteins
  JOURNAL   Biochem J 365 (Pt 3), 783-789 (2002)
   PUBMED   11996670
REFERENCE   7  (bases 1 to 4668)
  AUTHORS   Ohara,R., Yamakawa,H., Nakayama,M. and Ohara,O.
  TITLE     Type II brain 4.1 (4.1B/KIAA0987), a member of the protein 4.1
            family, is localized to neuronal paranodes
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 41-52 (2000)
   PUBMED   11146105
REFERENCE   8  (bases 1 to 4668)
  AUTHORS   Gutmann,D.H., Donahoe,J., Perry,A., Lemke,N., Gorse,K.,
            Kittiniyom,K., Rempel,S.A., Gutierrez,J.A. and Newsham,I.F.
  TITLE     Loss of DAL-1, a protein 4.1-related tumor suppressor, is an
            important early event in the pathogenesis of meningiomas
  JOURNAL   Hum Mol Genet 9 (10), 1495-1500 (2000)
   PUBMED   10888600
REFERENCE   9  (bases 1 to 4668)
  AUTHORS   Yamakawa,H. and Ohara,O.
  TITLE     Comparison of mRNA and protein levels of four members of the
            protein 4.1 family: the type II brain 4.1/4.1B/KIAA0987 is the most
            predominant member of the protein 4.1 family in rat brain
  JOURNAL   Gene 248 (1-2), 137-145 (2000)
   PUBMED   10806359
REFERENCE   10 (bases 1 to 4668)
  AUTHORS   Tran,Y.K., Bogler,O., Gorse,K.M., Wieland,I., Green,M.R. and
            Newsham,I.F.
  TITLE     A novel member of the NF2/ERM/4.1 superfamily with growth
            suppressing properties in lung cancer
  JOURNAL   Cancer Res 59 (1), 35-43 (1999)
   PUBMED   9892180
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Aug 2, 2021 this sequence version replaced NM_053927.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032827.1, SRR26643298.50521.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000009.1  116583260-116583465
            207-409             JAXUCZ010000009.1  116628660-116628862
            410-607             JAXUCZ010000009.1  116630493-116630690
            608-712             JAXUCZ010000009.1  116657692-116657796
            713-755             JAXUCZ010000009.1  116659286-116659328
            756-831             JAXUCZ010000009.1  116663070-116663145
            832-1050            JAXUCZ010000009.1  116665607-116665825
            1051-1138           JAXUCZ010000009.1  116666478-116666565
            1139-1291           JAXUCZ010000009.1  116670629-116670781
            1292-1389           JAXUCZ010000009.1  116674960-116675057
            1390-1565           JAXUCZ010000009.1  116677316-116677491
            1566-1786           JAXUCZ010000009.1  116680575-116680795
            1787-2332           JAXUCZ010000009.1  116683302-116683847
            2333-2386           JAXUCZ010000009.1  116688576-116688629
            2387-2422           JAXUCZ010000009.1  116691175-116691210
            2423-2614           JAXUCZ010000009.1  116692033-116692224
            2615-2737           JAXUCZ010000009.1  116700761-116700883
            2738-3112           JAXUCZ010000009.1  116701439-116701813
            3113-3244           JAXUCZ010000009.1  116703096-116703227
            3245-3343           JAXUCZ010000009.1  116703925-116704023
            3344-3424           JAXUCZ010000009.1  116704519-116704599
            3425-3541           JAXUCZ010000009.1  116704877-116704993
            3542-4668           JAXUCZ010000009.1  116706148-116707274
FEATURES             Location/Qualifiers
     source          1..4668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     gene            1..4668
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /note="erythrocyte membrane protein band 4.1-like 3"
                     /db_xref="GeneID:116724"
                     /db_xref="RGD:71089"
     exon            1..206
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            207..409
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..3535
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /note="isoform 1 is encoded by transcript variant 1;
                     erythrocyte protein band 4.1-like 3; band 4.1-like protein
                     3"
                     /codon_start=1
                     /product="band 4.1-like protein 3 isoform 1"
                     /protein_id="NP_446379.1"
                     /db_xref="GeneID:116724"
                     /db_xref="RGD:71089"
                     /translation="MTTESGSDSESKPDQEAEPQEAAGPQEQAGAQAAPEPAGGNVEE
                     QPGLEQFPEAAAHSTPVKREVSDKDRDFAAAAAKQLEYQQFEDDKLSQKSSSSKLSRS
                     PLKIVKRPKSMQCKVTLLDGSEYGCDVDKRSRGQVLFDKVCEHLNLLEKDYFGLTYRD
                     AENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVS
                     GRLPCSFVTLALLGSYTVQSELGDYDPDECGNDYISEFRFAPNHTKELEDKVIELHKS
                     HRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINR
                     FAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRL
                     LLPEAPPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGA
                     SVNENHEIYMKDSMSAAEVGTGQYATTKVISQTNLITTVTPEKKAEEEHVEEEDRRKK
                     AEEATPVAALRHEGKSPGHGSDSCPLSPPSAHLDPPSPTELRRRCKEKERASPGSAVP
                     RAELSSESDAQGKAYLGDQDVAFSYRQPAGKGTTLFSFSLQLPESFPSLLDEDGYLSF
                     PNLSETNLLPQSWQHFLPIRSPSLLPCFLFIFFFLLSASFSVPYALTLSFPLALCLCF
                     LEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETSATESDQEEDAELKAQELDKT
                     QDELVKHQTNISELKRTFLETSTETALTNEWEKRLSTSPVRLAARQEDAPMIEPLVPE
                     ETKQSSGEKLMDGSEILSLLESARKPTEFIGGVSSTTQSWVQKLETKTETIETEVEPT
                     PHPQPLSTEKVLQETVLVEERHVMNVHASGDASHTARDDVDATESAPADRHSGNGKEG
                     SSVTEAAKEQRGEEADKSAPEQEQPATVSQEEDQVSAIHSSEGLEQKSHFESSTVKVE
                     SISVGSVSPGGVKLETSTKEVPVVHTETKTITYESSQVDPGADLEPGVLMSAQTITSE
                     TTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVT
                     KVVVHKETEITPEDGED"
     exon            410..607
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            608..712
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            713..755
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            756..831
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1050
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1138
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1291
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1389
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1565
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1786
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2332
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2386
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2422
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2614
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2737
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..3112
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3244
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3343
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3424
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3541
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..4668
                     /gene="Epb41l3"
                     /gene_synonym="Epb4.1l3; Kiaa0987"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgaggttg gcctccctcg ctctggtgtc tgggcgtggg ccccgccgca gctccgcgga
       61 gcctccgtgc ctcctgcaaa ggggggcggg ggagccctga gctgcggctt cctcccgcgc
      121 ggagtctcct gcgcaccgcc gagcaggacg ccagcgccag cccggtcccc acgccgcggc
      181 gcgcccggcc ttcgcgtctc ccccagaaca atcaaccatg acaaccgaat caggatcaga
      241 ctcagaatcc aagccagacc aggaggctga gccccaggag gcagcaggac ctcaggagca
      301 agcaggggca caggctgcac ctgagcctgc tggcggaaac gtcgaggagc agccaggact
      361 agagcagttc cctgaagctg ctgcacacag cacgccggtg aagagggagg tcagcgacaa
      421 agaccgggac ttcgccgccg cagctgcgaa acagcttgag tatcagcagt ttgaggacga
      481 taagctctct cagaagtcat ccagcagcaa actctcacgg tccccattga agatcgtgaa
      541 aaggcctaaa agcatgcagt gcaaagtgac gcttctggat ggatctgagt acggctgtga
      601 tgtagataag cgctcccgag gacaagtgct gtttgacaaa gtgtgcgaac atctgaactt
      661 gctagaaaaa gactacttcg gtctcacgta tcgagacgca gagaatcaga agaactggtt
      721 ggaccctgct aaggaaatta aaaagcagat tcgaagtggt gcttggcatt tttcatttaa
      781 tgtgaagttt tacccaccag accctgccca gctatcagaa gatatcacca ggtactacct
      841 ctgcttgcag ctgcgagatg atattgtgtc tggacgccta ccctgttcct tcgtgaccct
      901 cgccctgctg ggctcctaca cagtgcagtc agagcttggg gactatgatc ctgatgaatg
      961 tggaaatgac tacattagcg agttccgctt tgcgccaaac cacacgaaag aactggagga
     1021 taaagtgatc gagctgcaca agagccacag aggaatgacg ccagccgagg cagagatgca
     1081 cttcctggag aatgccaaaa agctctccat gtatggggta gacttacacc acgcaaagga
     1141 ttcggaaggc gtggagatca tgttaggggt ctgtgccagc ggcctgttga tctatcgtga
     1201 ccggcttcga ataaacagat ttgcttggcc caaggtccta aaaatttctt ataaacggaa
     1261 caacttttac attaaaatcc ggccaggaga gtttgaacaa ttcgaaagca ccattggctt
     1321 caagttgccg aaccataggg ctgccaagcg cctctggaaa gtatgtgtgg aacatcatac
     1381 atttttcaga ctactgctac cagaagcacc tccaaagaaa ttcctgacct tgggctccaa
     1441 gttccgctac agtggcagaa cccaggcgca gacgagaaga gccagtgcat tgatagaccg
     1501 cccggcgcct tacttcgaac gctcgtccag caaacgatac accatgtctc gcagcttgga
     1561 tggagcctca gtgaatgaaa accatgaaat atacatgaag gattctatgt ctgctgcaga
     1621 ggttggtaca ggccagtacg ccacaaccaa ggtcatctct cagaccaacc tgatcaccac
     1681 tgtgaccccg gagaaaaagg ctgaggagga gcacgtggag gaagaggaca gaaggaagaa
     1741 ggccgaggaa gccacgcccg tcgcagccct ccggcacgag ggaaagtcac cagggcatgg
     1801 ctctgactca tgtcccctgt cacctccatc agcccatctt gaccctccct ctcccacaga
     1861 gctccgtagg aggtgcaagg agaaagaaag ggcctctcca ggttctgctg tgcctagagc
     1921 agagctgtcc tcggagtctg atgcccaggg gaaggcctac ctaggggacc aagatgtggc
     1981 atttagttac aggcagccgg ctggcaaagg aaccacactg ttttccttct ccttgcagct
     2041 cccagagtca ttcccctcgc tcctagatga agacgggtac ctctctttcc ccaacctgtc
     2101 tgaaaccaac ctcctgcccc agagttggca gcatttcttg cccatccgct cgccctccct
     2161 ccttccctgc ttcctcttca tcttcttctt cctgctgtct gcctccttct cagtaccata
     2221 cgccctcact ctctccttcc ctctggctct gtgcctctgc ttcctggagc ccaaggcggc
     2281 ctccttgagc gcctccctag acaatgaccc gagtgacagt tcagaggaag agactgacag
     2341 tgagcggaca gacactgcgg ctgatggaga gaccagtgcc acagagtcgg accaggagga
     2401 agacgcagag ctcaaggcac aggagctaga taaaactcaa gatgagctgg tgaaacacca
     2461 aaccaatatt agcgaactga aaagaacctt cttagaaacc tctacagaaa ctgccttaac
     2521 aaacgaatgg gaaaagaggc tctccacatc ccccgtgcgg ctggctgcca ggcaggagga
     2581 tgcgcccatg attgagccac ttgtacctga ggagactaaa caatcttctg gggagaagct
     2641 catggatggc tcggagatcc tcagtctatt agagtctgcg aggaaaccca cagagttcat
     2701 aggaggggtt tcatctacta cccagagctg ggtgcagaaa ctggaaacga agactgagac
     2761 cattgaaaca gaggtggaac ccaccccaca ccctcagccc ctcagcacgg agaaggtgtt
     2821 gcaggaaacg gtgctggtag aggagaggca cgtgatgaac gtgcacgcca gtggggacgc
     2881 ttctcacaca gccagggatg atgtggatgc cacagaatca gcacccgcag accgtcacag
     2941 tgggaatggg aaggagggct cttctgtgac agaagcagct aaggaacaga gaggagagga
     3001 ggctgacaag tctgccccgg agcaggaaca accagccact gtctcccagg aggaggatca
     3061 ggtgtcggcc atccactctt ctgagggttt ggaacaaaag tctcattttg agtcgtccac
     3121 tgtgaaggta gaaagcataa gtgtgggcag tgtctctcca ggaggagtga agctagagac
     3181 ctctaccaag gaggtgccag tggtccacac agagacgaaa accatcacgt acgagtcttc
     3241 tcaggtcgat cctggggcag atctggagcc aggtgtgcta atgagcgccc aaacgatcac
     3301 gtctgaaacc acgagtacta ccaccaccac acatatcacc aaaactgtga aaggaggcat
     3361 ttcggagacg aggattgaga agcgaatagt catcacggga gatgccgaca ttgaccatga
     3421 ccaggcgctg gctcaggcaa ttaaagaggc caaagagcag caccccgaca tgtcagtaac
     3481 caaagtagtg gtccataaag agacagaaat cacaccagaa gatggagagg attgaccgca
     3541 ggaataactc agctagcacg tgaacccagt cgtgtaagcc gtcaggaaaa ccggagccta
     3601 tgtgggattc cctcttctaa cccaactgac tcataaccgt ccgtggaaaa ttccgatcca
     3661 ggaaagctga ctttgaccgt tagatgaaag accctggcag agagatcttc ccataataaa
     3721 gcaatccaaa atcagcatca ttaaactgat actgcatgaa gcaacgataa aaaaaaatca
     3781 caaaggagca gcacttttaa ttttcaccaa aatatctccg ttttcaactc tacctgcacg
     3841 ttcataacca acagtgtaag ccgtgatctc atgtaaccca tcgacaactc atgcctttcc
     3901 tagtttatta ttaaaagtct caacaaagtt gcagtttcat agatgacaaa ttctctgttt
     3961 acaataaatg gtaatcaccc tacaatgctg tcagccgtct aggtccttct ggtgtgtcag
     4021 atttacccca gattagatgt gccaataacc aaccttatcc agtaaacaac ttgaatcgtg
     4081 tccttgtcta atctggtttt gttattctcg cccataagca gttacaactc tctgaccctc
     4141 tagaaatgtt taatgcttac aaaccttgct ttatgtctct aatttgctgt aaggtagcat
     4201 tggttttagc acactgatgt ggtttcttct tccacacttg ctctggtctc tattcgaccc
     4261 agaaagattc ccagaattac ctaagcaaac cctcaataat gtaaattatc atttgtgtgg
     4321 gaagaaaata catatttttt gttagtttat aatattatga aaattcactc cagggaatac
     4381 ctgtctggct acctttactt tctgttcttt tttctttttc attgattttt tttttcttct
     4441 tttacttgaa caaaaaggtg ttttatttac aaatctggtc catacttaca atctagttca
     4501 gaaccaagcc ttaaattgta cagaatttcc actgtaatta aaatatttag tgttcagtta
     4561 taaatagcct ccagaaagat atattgtcca ctacactgtc aactgcatca cagcccgtcg
     4621 tgaatgatgt caccgcatcg cgaaataaaa atggcaaatg cattgaaa
//
