LOCUS       NM_021681               5813 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus erythrocyte membrane protein band 4.1-like 1
            (Epb41l1), transcript variant 1, mRNA.
ACCESSION   NM_021681
VERSION     NM_021681.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5813)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5813)
  AUTHORS   Copits,B.A. and Swanson,G.T.
  TITLE     Kainate receptor post-translational modifications differentially
            regulate association with 4.1N to control activity-dependent
            receptor endocytosis
  JOURNAL   J Biol Chem 288 (13), 8952-8965 (2013)
   PUBMED   23400781
  REMARK    GeneRIF: Kainate receptor GluK2a post-translational modifications
            differentially regulate association with 4.1N to control
            activity-dependent receptor endocytosis
REFERENCE   3  (bases 1 to 5813)
  AUTHORS   Fiedler,M.J. and Nathanson,M.H.
  TITLE     The type I inositol 1,4,5-trisphosphate receptor interacts with
            protein 4.1N to mediate neurite formation through intracellular Ca
            waves
  JOURNAL   Neurosignals 19 (2), 75-85 (2011)
   PUBMED   21389686
  REMARK    GeneRIF: Type I inositol 1,4,5-trisphosphate receptor (IP3R1)
            localization via protein 4.1N is necessary for divalent calcium ion
            wave (Ca2+) formation, which in turn mediates neurite formation.
REFERENCE   4  (bases 1 to 5813)
  AUTHORS   Lin,D.T., Makino,Y., Sharma,K., Hayashi,T., Neve,R., Takamiya,K.
            and Huganir,R.L.
  TITLE     Regulation of AMPA receptor extrasynaptic insertion by 4.1N,
            phosphorylation and palmitoylation
  JOURNAL   Nat Neurosci 12 (7), 879-887 (2009)
   PUBMED   19503082
  REMARK    GeneRIF: study describes a previously unknown mechanism that
            governs activity-dependent GluR1 trafficking, reveals an
            interaction between AMPAR palmitoylation and phosphorylation, and
            underscores the importance of 4.1N in AMPAR trafficking and
            synaptic plasticity.
REFERENCE   5  (bases 1 to 5813)
  AUTHORS   Douyard,J., Shen,L., Huganir,R.L. and Rubio,M.E.
  TITLE     Differential neuronal and glial expression of GluR1 AMPA receptor
            subunit and the scaffolding proteins SAP97 and 4.1N during rat
            cerebellar development
  JOURNAL   J Comp Neurol 502 (1), 141-156 (2007)
   PUBMED   17335044
  REMARK    GeneRIF: 4.1N was expressed postsynaptically at the climbing fibers
            synapse at early ages during Purkinje cell dendritic growth; its
            expression changed from neurons to Bergmann glia once these glial
            cells had completed their enwrapping process.
REFERENCE   6  (bases 1 to 5813)
  AUTHORS   Tang,T.S., Tu,H., Chan,E.Y., Maximov,A., Wang,Z., Wellington,C.L.,
            Hayden,M.R. and Bezprozvanny,I.
  TITLE     Huntingtin and huntingtin-associated protein 1 influence neuronal
            calcium signaling mediated by inositol-(1,4,5) triphosphate
            receptor type 1
  JOURNAL   Neuron 39 (2), 227-239 (2003)
   PUBMED   12873381
REFERENCE   7  (bases 1 to 5813)
  AUTHORS   Singh,D. and Lampe,P.D.
  TITLE     Identification of connexin-43 interacting proteins
  JOURNAL   Cell Commun Adhes 10 (4-6), 215-220 (2003)
   PUBMED   14681019
REFERENCE   8  (bases 1 to 5813)
  AUTHORS   Maximov,A., Tang,T.S. and Bezprozvanny,I.
  TITLE     Association of the type 1 inositol (1,4,5)-trisphosphate receptor
            with 4.1N protein in neurons
  JOURNAL   Mol Cell Neurosci 22 (2), 271-283 (2003)
   PUBMED   12676536
REFERENCE   9  (bases 1 to 5813)
  AUTHORS   Binda,A.V., Kabbani,N., Lin,R. and Levenson,R.
  TITLE     D2 and D3 dopamine receptor cell surface localization mediated by
            interaction with protein 4.1N
  JOURNAL   Mol Pharmacol 62 (3), 507-513 (2002)
   PUBMED   12181426
REFERENCE   10 (bases 1 to 5813)
  AUTHORS   Yamakawa,H., Ohara,R., Nakajima,D., Nakayama,M. and Ohara,O.
  TITLE     Molecular characterization of a new member of the protein 4.1
            family (brain 4.1) in rat brain
  JOURNAL   Brain Res Mol Brain Res 70 (2), 197-209 (1999)
   PUBMED   10407168
  REMARK    Erratum:[Brain Res Mol Brain Res 1999 Dec 10;74(1-2):247]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 10, 2021 this sequence version replaced NM_021681.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (L).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript from the reference strain was
            available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               JAXUCZ010000003.1  165444748-165444865
            119-337             JAXUCZ010000003.1  165462356-165462574
            338-502             JAXUCZ010000003.1  165463413-165463577
            503-607             JAXUCZ010000003.1  165464320-165464424
            608-650             JAXUCZ010000003.1  165464949-165464991
            651-726             JAXUCZ010000003.1  165468151-165468226
            727-945             JAXUCZ010000003.1  165472450-165472668
            946-1033            JAXUCZ010000003.1  165474737-165474824
            1034-1186           JAXUCZ010000003.1  165475308-165475460
            1187-1284           JAXUCZ010000003.1  165478029-165478126
            1285-1460           JAXUCZ010000003.1  165478349-165478524
            1461-1609           JAXUCZ010000003.1  165479895-165480043
            1610-1645           JAXUCZ010000003.1  165480937-165480972
            1646-1828           JAXUCZ010000003.1  165483133-165483315
            1829-1927           JAXUCZ010000003.1  165486512-165486610
            1928-3733           JAXUCZ010000003.1  165489969-165491774
            3734-3844           JAXUCZ010000003.1  165492266-165492376
            3845-4252           JAXUCZ010000003.1  165493427-165493834
            4253-4357           JAXUCZ010000003.1  165495475-165495579
            4358-4438           JAXUCZ010000003.1  165499073-165499153
            4439-4525           JAXUCZ010000003.1  165502671-165502757
            4526-4609           JAXUCZ010000003.1  165503695-165503778
            4610-4690           JAXUCZ010000003.1  165505970-165506050
            4691-4807           JAXUCZ010000003.1  165506360-165506476
            4808-5813           JAXUCZ010000003.1  165509491-165510496
FEATURES             Location/Qualifiers
     source          1..5813
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..5813
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /note="erythrocyte membrane protein band 4.1-like 1"
                     /db_xref="GeneID:59317"
                     /db_xref="RGD:71087"
     exon            1..118
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            119..337
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..4816
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /note="isoform L is encoded by transcript variant 1;
                     erythrocyte protein band 4.1-like 1; band 4.1-like protein
                     1-like; neuronal protein 4.1"
                     /codon_start=1
                     /product="band 4.1-like protein 1 isoform L"
                     /protein_id="NP_067713.2"
                     /db_xref="GeneID:59317"
                     /db_xref="RGD:71087"
                     /translation="MTTETGPDSEVKKAQEETPQQPEAAAAVTTPVTPAGHSHPETNS
                     NEKHLTQQDTRPAEQSLDMEEKDYCEADGLSERTTPSKAQKSPQKIAKKFKSATCRVT
                     LLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKK
                     QIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSY
                     AVQAELGDHDTEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLEN
                     AKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNF
                     YIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSK
                     FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGP
                     DGDKREDDAESGGRRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQ
                     ASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKASEAQRIQDTSRQ
                     DLVPGTATGLEMFTQKSLAASPEGSEHWVFIERVYTRPEDLGLLTVAATQRKESGSSL
                     SGILADGRLSKVDILVDKFKVEVATEETVRTRRTSTQQQGKMLASPEDFETVREEDRG
                     GPGEATSTDKLPEGSRLKLRNHGVSNGQLESQVEWGLERPQTWGRPTAAGLGPVQGEV
                     LSPTSDKGGLQSFLLDPAQAEARADSSDETDTSFAERSFCLHYGEKDSEDQLLAPPSE
                     HREEHPDALPGDGTWLELAGVHTENWELKSSDPRASAPGSSQHKDQAHKAPSAEEAWT
                     PRDHGRPDDPQGAAVGQTFEEVWENTQQRLEGELVQPLASVAEDEVPTNMDWMGKTEK
                     SPPARRKKSPPGRGGGVHLDAQACALLRTIPPCVRKPARPDQGSFLPKEKGTVSPPAV
                     EPETEDRETVSPLPVSSGHTEVLAAMEGTSLSPLPPGSRGPSESREFFRDQFPVVLKY
                     IHLPEESPVPKDPHGDRKAPPVASKKPRFVPEGSEEPVLLGELMFPSGKQETSLQDWD
                     QGDSQEDISKTSVANKIRIFETHGAEACRASQGEMRSLPHELPSGASPGQVEQQDNLL
                     DLGFVQLQPPGDLATPTTYHQERCTDPELVSPDSGCETTLEEATGSKSGDAGREDKSS
                     FRRLAPNTPGKGGRLRFASPPGPQRAGLREGSEEKVKPPRPRAPESDTGDEDQDQERD
                     AVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGGAFEDFSRSLPELDRDKS
                     DSETEGLVFARDLKGPSSQEDESGGIEDSPDRGACSTPELPQFESVKAETMTVSSLAI
                     RKKIEPEAMLQSRVSTADSTQVDGGAPAAKDFMTTPPCITTETISTTMENSLKSGKGA
                     AAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRI
                     EKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES"
     exon            338..502
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..607
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..650
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..726
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..945
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1033
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1186
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1284
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1460
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1609
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1645
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1828
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1927
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..3733
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3844
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..4252
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4253..4357
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4358..4438
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4439..4525
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4526..4609
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4610..4690
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4807
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4808..5813
                     /gene="Epb41l1"
                     /gene_synonym="4.1N; Epb4.1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacaggctg ctccgcagag cccgcccgcg ccgccccgcc ccgcggcctg cgggcccgga
       61 ggagccgagg ggaccggccc tcgcccagcc ggccggagat ggggaccccc aggcccagtc
      121 acatgctccc cttcattccg aagcaggcgt gctggtcacc atgacaacag agacaggccc
      181 agattctgag gtgaagaagg ctcaggagga gactccacag cagccagagg ctgctgcagc
      241 tgtgaccacc ccggtgaccc ccgcaggcca cagccaccca gagaccaatt ccaatgagaa
      301 gcatctgacc cagcaggaca caaggcctgc tgaacagagc ctagatatgg aggaaaagga
      361 ttactgtgag gctgatggcc tgtcggagag gactacgccc agtaaggccc agaagtcacc
      421 ccagaagatt gccaagaagt tcaagagtgc cacctgccgc gtcaccctgc ttgatgcctc
      481 tgagtacgag tgtgaggtgg agaagcacgg ccggggccag gtgctgtttg acctggtctg
      541 tgagcacctt aacctcctcg agaaggacta cttcggtctg accttctgcg atgccgacag
      601 ccagaagaat tggctggacc cctccaagga aatcaagaaa cagatccgga gtagcccctg
      661 gaattttgcc ttcacagtga agttctaccc tcctgaccca gcccagctga cagaagacat
      721 cacaaggtac tacctgtgcc tgcagctgag ggcagacatc atcacgggcc gcctgccttg
      781 ctccttcgtc acgcacgccc tgctgggctc ctacgctgtg caggctgaac tgggtgacca
      841 tgataccgag gagcacgtgg gcaactatgt cagcgagctc cgctttgccc caaaccagac
      901 ccgggagctg gaggagagga tcatggagct gcacaagaca tacaggggca tgaccccagg
      961 cgaggcagag atccacttcc tggagaatgc caagaagctc tccatgtatg gagttgatct
     1021 gcaccatgct aaggactctg agggcatcga tatcatgcta ggtgtctgtg ccaatggcct
     1081 gctcatctac cgggaccgcc tgagaatcaa ccgttttgcc tggcccaaga ttctcaagat
     1141 ctcctacaag aggagtaact tctacatcaa gatccgtcct ggggagtatg agcagttcga
     1201 gagcaccatc ggcttcaagc tccctaacca ccgctcagcc aagcggctgt ggaaggtctg
     1261 cattgagcac catacattct tccggctggt gtctccagag cccccaccca agggctttct
     1321 ggtgatgggc tccaagttcc ggtacagtgg gaggacccag gcacagactc gccaagccag
     1381 tgcccttatc gacaggcccg cacccttctt tgagcgttct tccagcaaac gatacaccat
     1441 gtcccggagc cttgatggag ctgagttctc ccgccctgcc tcagtcagtg agaatcacga
     1501 tgcagggcct gacggcgaca agcgggaaga tgatgccgag tcagggggac gtcgatcaga
     1561 ggccgaagaa ggagaggtca ggacccccac taagatcaag gagctgaagc cggagcagga
     1621 aaccacgcca agacacaagc aggagttcct ggacaagcca gaggacgtct tgttgaagca
     1681 ccaggccagc atcaatgaac tcaagaggac cctgaaggag cccaatagca aactgatcca
     1741 ccgggatcga gactgggagc gggagcgcag gctgccctca tcacccgcct ccccctctcc
     1801 caagggcacc cctgagaaag ccagtgaggc ccagaggatc caggacactt ctcggcagga
     1861 cttggtacct ggaacagcaa caggcttgga gatgttcact cagaaaagcc tcgcagcatc
     1921 ccctgagggc tcagagcatt gggtatttat agaaagagtg tacactaggc cagaagacct
     1981 cggcctccta acagtggccg ccacacaacg gaaagaaagt ggatcaagcc tcagtgggat
     2041 ccttgctgac ggcagactct ccaaggtaga cattctggtg gacaagttca aagtcgaagt
     2101 ggccacggaa gaaacagtga gaaccagaag aacaagtact caacagcagg gcaagatgct
     2161 tgcaagtcca gaagactttg agaccgtgag agaggaagac cggggaggtc ccggagaggc
     2221 cacatcaact gacaagcttc ccgagggctc caggctcaag ctcaggaacc acggagtctc
     2281 aaatggtcaa ctagagagcc aagtagaatg gggactggag aggccccaga cctggggaag
     2341 accaacagct gcagggcttg gcccagtgca gggagaggtt ctttctccta catcagacaa
     2401 gggaggactc cagtccttcc tgttggatcc agcccaagcc gaagccagag ctgactcaag
     2461 cgatgagact gacacctcct tcgcagaaag gagcttctgt ctgcactatg gagagaaaga
     2521 ctctgaagac cagcttctcg ccccaccctc agagcacaga gaagagcacc cagatgccct
     2581 tcctggagat gggacctggt tggagctggc aggagtgcac acagagaact gggagctgaa
     2641 gtcctcagac ccaagagctt ctgccccagg ttccagccag cataaagacc aagcccataa
     2701 ggctccctca gcagaagaag cctggactcc cagggaccat ggaagacctg atgaccctca
     2761 gggagctgct gtcggtcaga cttttgaaga ggtctgggaa aacacacagc agaggctaga
     2821 aggagagttg gtccagccac tggccagtgt agctgaagat gaggtcccca caaatatgga
     2881 ctggatggga aagactgaga aaagtccccc agcaagaagg aagaagagcc cccctggtag
     2941 aggaggaggg gtgcacctag acgcccaggc ttgtgccctt ctgaggacca tccctccttg
     3001 tgtcaggaag ccagccaggc cagaccaagg cagcttcctg cccaaagaga aggggacagt
     3061 ttcccctcct gcagtagaac ctgagacaga ggacagggag acagtcagcc ccctgccagt
     3121 ctcctctggt cacactgagg ttctggcagc tatggagggc acctctctaa gcccactacc
     3181 tcctgggtca agggggcctt cagagtccag ggaattcttt agagaccagt tccctgtagt
     3241 tctcaaatat atccatcttc ctgaagagag cccagtaccc aaggacccac acggtgaccg
     3301 caaagcacct ccagttgcca gcaagaagcc caggtttgtc cctgaaggaa gtgaggaacc
     3361 tgtactcctg ggtgaattga tgttcccttc aggaaagcag gagacttcac tccaggactg
     3421 ggaccaaggg gattcccagg aagatattag caagacctca gtggctaaca aaattcggat
     3481 atttgagacc catggagctg aggcttgccg agccagtcag ggtgaaatga ggagccttcc
     3541 acatgagctg ccttcaggag cttccccagg acaggtagaa cagcaagata atcttctaga
     3601 cttgggcttt gtccaactcc agccccctgg ggacttggcc accccaacta cctaccacca
     3661 ggaaagatgc acagacccag agctcgtgtc ccctgattca ggctgtgaaa ccacgctgga
     3721 ggaagctact gggagcaaat ccggagacgc gggcagggaa gacaagagct ccttccgccg
     3781 cttagcgcca aacacccctg gaaagggggg gcgtctgaga ttcgccagcc ctccaggccc
     3841 tcagagagca gggctgaggg agggctcgga ggagaaagtc aaaccgccac gcccacgtgc
     3901 cccagagagt gacacgggag atgaggacca ggaccaggag agggatgcgg tattcttgaa
     3961 ggacaaccac ctggccattg aacgcaaatg ctccagcata acggtcagct ccacgtccag
     4021 cctggaagct gaggtggact tcacggttat tggtgactac cacgggggcg cctttgaaga
     4081 cttctcccga agcctccctg agctcgatcg ggataaaagt gactctgaga cagagggcct
     4141 ggtgttcgcc agggacctca aggggccctc cagccaagag gatgaatctg ggggcatcga
     4201 ggacagcccg gatcgagggg cctgttctac cccagaattg ccccagtttg agtctgtgaa
     4261 agcagaaacc atgaccgtca gcagtctggc aatcaggaag aagatcgagc cagaggccat
     4321 gctgcaaagc agagtctcca ctgcagacag cacccaggtt gatggaggtg ctccagcggc
     4381 gaaagacttc atgacaactc ccccctgcat caccacagag accatctcga ccactatgga
     4441 gaacagtctc aagtccggga agggggcagc tgccatgatc ccaggcccac agacggtggc
     4501 cacggaaatc cgttctcttt caccgatcat cgggaaagat gtcctcacca gcacgtacgg
     4561 cgccaccgcg gaaaccctct caacctccac caccacccat gtcaccaaaa ctgtgaaggg
     4621 agggttttct gagacaagga tcgagaagcg aatcatcatt actggggatg aagatgtcga
     4681 tcaagaccag gctctggctt tggccatcaa ggaagccaaa cttcagcatc cagacatgct
     4741 ggtaaccaaa gctgttgtct atagagaaac agacccatcc ccggaagaga gggacaagaa
     4801 gccacaggaa tcctgacctc tgtgaagaga tgctggcgtg tctggtccaa cccaagccag
     4861 agaatcatta agaaggggcc ttcattctgg attctccgac aataccaaca tcccagctgc
     4921 gacgtactgt cactgacgag agactgggaa gggaaagcat atatatatag atatatagag
     4981 atatagatat atatacagga aacaccgcgt ccttgcaccg ctgctggggc tggcggagca
     5041 gtcagctgat ggccacaacc aacatcggca acaaccttca tttcctttgc aggcaaattg
     5101 aattggtggg aacttttttt tttccttcag gaaaatgtat aacaatcata atctctcgct
     5161 ccccaagccc cttcttctgc aaactacaaa agcagaccga gatgattgta gacattccct
     5221 tgaaccccgg ctgcacagac tccaggatgg atgagcgccc catctgttct ccagcctctg
     5281 ttgctctctc taatgcaaag gaggaaagaa acaagatcgt gtagccaagc cagagaagcc
     5341 acagcagcaa gacacgcaga gtcggctgtt ttccaagaat ggaagtctgc cacacaggga
     5401 ggaggaggag gaggaggagg aggaggagga ggaacactca attgttcttt tctgggtctt
     5461 gacactgggc tgcgaaatcc cctctctgtt cttcggcctc cctgcttcac ccttgacttc
     5521 tactcatcct ctgttcattt tctgtctcgg ctcccctctt cctctctccc caaccctcct
     5581 gttctgtgtc ctggtcctgc cgaggaccac tgcagataac tctcgttgga aggagaagaa
     5641 gctatgagag caaaaggaag tcacgggaag ggaagtagac attgtatgtt tctggtttcc
     5701 catgatagag gtgcagctcg taggagatta tatgactgtg attttaagta tgtatattac
     5761 atgtaacagg aaaacaaaca ttaaaataaa ctgtgctggt aagtatgcag ctg
//
