LOCUS       NM_001399558            5172 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus erythrocyte membrane protein band 4.1 (Epb41),
            mRNA.
ACCESSION   NM_001399558 XM_232771
VERSION     NM_001399558.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5172)
  AUTHORS   Papal,S., Cortese,M., Legendre,K., Sorusch,N., Dragavon,J.,
            Sahly,I., Shorte,S., Wolfrum,U., Petit,C. and El-Amraoui,A.
  TITLE     The giant spectrin betaV couples the molecular motors to
            phototransduction and Usher syndrome type I proteins along their
            trafficking route
  JOURNAL   Hum Mol Genet 22 (18), 3773-3788 (2013)
   PUBMED   23704327
REFERENCE   2  (bases 1 to 5172)
  AUTHORS   Kiyomitsu,T. and Cheeseman,I.M.
  TITLE     Cortical dynein and asymmetric membrane elongation coordinately
            position the spindle in anaphase
  JOURNAL   Cell 154 (2), 391-402 (2013)
   PUBMED   23870127
  REMARK    Erratum:[Cell. 2013 Sep 12;154(6):1401]
REFERENCE   3  (bases 1 to 5172)
  AUTHORS   Liu,C., Weng,H., Chen,L., Yang,S., Wang,H., Debnath,G., Guo,X.,
            Wu,L., Mohandas,N. and An,X.
  TITLE     Impaired intestinal calcium absorption in protein 4.1R-deficient
            mice due to altered expression of plasma membrane calcium ATPase 1b
            (PMCA1b)
  JOURNAL   J Biol Chem 288 (16), 11407-11415 (2013)
   PUBMED   23460639
REFERENCE   4  (bases 1 to 5172)
  AUTHORS   Korsgren,C. and Lux,S.E.
  TITLE     The carboxyterminal EF domain of erythroid alpha-spectrin is
            necessary for optimal spectrin-actin binding
  JOURNAL   Blood 116 (14), 2600-2607 (2010)
   PUBMED   20585040
REFERENCE   5  (bases 1 to 5172)
  AUTHORS   Trevino,M.A., Rodriguez-Rodriguez,M., Correas,I., Marcilla,M.,
            Albar,J.P., Rico,M., Jimenez,M.A. and Bruix,M.
  TITLE     NMR characterisation of the minimal interacting regions of
            centrosomal proteins 4.1R and NuMA1: effect of phosphorylation
  JOURNAL   BMC Biochem 11, 7 (2010)
   PUBMED   20109190
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5172)
  AUTHORS   Walensky,L.D., Shi,Z.T., Blackshaw,S., DeVries,A.C., Demas,G.E.,
            Gascard,P., Nelson,R.J., Conboy,J.G., Rubin,E.M., Snyder,S.H. and
            Mohandas,N.
  TITLE     Neurobehavioral deficits in mice lacking the erythrocyte membrane
            cytoskeletal protein 4.1
  JOURNAL   Curr Biol 8 (23), 1269-1272 (1998)
   PUBMED   9822582
REFERENCE   7  (bases 1 to 5172)
  AUTHORS   Menegoz,M., Gaspar,P., Le Bert,M., Galvez,T., Burgaya,F.,
            Palfrey,C., Ezan,P., Arnos,F. and Girault,J.A.
  TITLE     Paranodin, a glycoprotein of neuronal paranodal membranes
  JOURNAL   Neuron 19 (2), 319-331 (1997)
   PUBMED   9292722
REFERENCE   8  (bases 1 to 5172)
  AUTHORS   Dalla Venezia,N., Gilsanz,F., Alloisio,N., Ducluzeau,M.T.,
            Benz,E.J. Jr. and Delaunay,J.
  TITLE     Homozygous 4.1(-) hereditary elliptocytosis associated with a point
            mutation in the downstream initiation codon of protein 4.1 gene
  JOURNAL   J Clin Invest 90 (5), 1713-1717 (1992)
   PUBMED   1430200
REFERENCE   9  (bases 1 to 5172)
  AUTHORS   Mische,S.M., Mooseker,M.S. and Morrow,J.S.
  TITLE     Erythrocyte adducin: a calmodulin-regulated actin-bundling protein
            that stimulates spectrin-actin binding
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2837-2845 (1987)
   PUBMED   3693401
REFERENCE   10 (bases 1 to 5172)
  AUTHORS   Tchernia,G., Mohandas,N. and Shohet,S.B.
  TITLE     Deficiency of skeletal membrane protein band 4.1 in homozygous
            hereditary elliptocytosis. Implications for erythrocyte membrane
            stability
  JOURNAL   J Clin Invest 68 (2), 454-460 (1981)
   PUBMED   6894932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 12, 2022 this sequence version replaced XM_232771.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103731.1, SRR26643429.21106.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               JAXUCZ010000005.1  149521782-149521993 c
            213-686             JAXUCZ010000005.1  149478322-149478795 c
            687-896             JAXUCZ010000005.1  149474437-149474646 c
            897-1001            JAXUCZ010000005.1  149470847-149470951 c
            1002-1044           JAXUCZ010000005.1  149468056-149468098 c
            1045-1120           JAXUCZ010000005.1  149461702-149461777 c
            1121-1339           JAXUCZ010000005.1  149460355-149460573 c
            1340-1427           JAXUCZ010000005.1  149452545-149452632 c
            1428-1580           JAXUCZ010000005.1  149448715-149448867 c
            1581-1678           JAXUCZ010000005.1  149445720-149445817 c
            1679-1851           JAXUCZ010000005.1  149444871-149445043 c
            1852-2036           JAXUCZ010000005.1  149437574-149437758 c
            2037-2099           JAXUCZ010000005.1  149432910-149432972 c
            2100-2276           JAXUCZ010000005.1  149427998-149428174 c
            2277-2405           JAXUCZ010000005.1  149407370-149407498 c
            2406-2507           JAXUCZ010000005.1  149399960-149400061 c
            2508-2588           JAXUCZ010000005.1  149398731-149398811 c
            2589-2693           JAXUCZ010000005.1  149396958-149397062 c
            2694-5172           JAXUCZ010000005.1  149394096-149396574 c
FEATURES             Location/Qualifiers
     source          1..5172
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..5172
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /note="erythrocyte membrane protein band 4.1"
                     /db_xref="GeneID:313052"
                     /db_xref="RGD:1564762"
     exon            1..212
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            213..686
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2687
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /note="erythrocyte protein band 4.1"
                     /codon_start=1
                     /product="protein 4.1"
                     /protein_id="NP_001386487.1"
                     /db_xref="GeneID:313052"
                     /db_xref="RGD:1564762"
                     /translation="MTTEKSLAAEAENSQHQKEEGEGATNSGQQESQLEEASQAAAAE
                     GSNQGEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLLSSFLKRPKSQVSEEEGREV
                     ESEREKGEGEQKETELGTSLDEDVILKAPIAAPEPELKTDPSLDLHSLSSIETQPAQE
                     EHREDPDSETKEGEGIEECSGTEVKEDPESRAEREPETSQKPIRRHRNMHCKVSLLDD
                     TVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAVWDSTTSKTWLDSAKEIKKQVRG
                     VPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTVQS
                     ELGDYDPELHGVDYVSDFKLAPNQTRELEEKVMELHKSYRSMTPAQADLEFLENAKKL
                     SMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKI
                     RPGEQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTLPKSKFLALGSKFRY
                     SGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAAESTDRSPRPTSAPAIAQS
                     QVMEGPGAPAKKAPKEAVKVEEKRGEEPAEPEPEPTEAWKKKRERLDGENIYIRHSNL
                     MLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQVP
                     TGDGPPLVKTQTVTISDTANAVKSEIPTKDVPIVHTETKTITYEAAQTEDSNGDLDPG
                     VLLTAQTITSETTSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKE
                     AKEQHPDMSVTKVVVHQETEISEE"
     exon            687..896
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1001
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1044
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1120
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1339
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1427
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1580
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1678
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1851
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2036
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2099
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2276
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2405
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2507
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2588
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2693
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..5172
                     /gene="Epb41"
                     /gene_synonym="Epb4.1; RGD1564762"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggaaaggc gggagggcgc gcgccggggc tgctcgctcg ctcgctttct ccctcgctcc
       61 ctccctccgc cggcgggttt agtcagctag cctgcagccc gccagccccg gagccgcaga
      121 gggccggagc ctcggacgcc ggcgccgcct cctgctattg ttcgtccggc tgaagctacg
      181 gctggcgccg gagccccggc tgggaacccc ggaacatcat gacgacagag aagagtttag
      241 cggctgaagc cgagaattct cagcaccaga aggaagaagg tgagggagcc acaaactcag
      301 gccagcaaga aagtcagctg gaggaggctt cccaagcggc agcagctgag ggcagtaatc
      361 agggtgagca gaagctgaaa gcgtccaatg gggacacccc aacacatgaa gacttgacca
      421 agaacaagga gcggacatca gaaagcagag gcctgtcgcg actgctctcc tcattcctca
      481 aaaggcccaa gtctcaggtc tctgaagaag aaggccgaga agtagagtcg gagagagaga
      541 aaggcgaagg agaacaaaag gagacggaac tgggaaccag cctcgatgaa gacgtcattt
      601 taaaagcccc cattgcagct cctgaacctg agctcaaaac agacccatct ttggatctcc
      661 attcattaag cagtatagaa acacagccag ctcaggagga acacagagag gacccggatt
      721 cggaaacgaa ggaaggagaa gggattgagg agtgctctgg aacggaggtg aaagaggacc
      781 cagaatcaag agcagagaga gagcccgaga cctcccagaa gcccatcagg agacacagga
      841 acatgcattg caaggtctcc ctgttggacg acacagtcta cgaatgcgtt gtggagaaac
      901 acgctaaggg acaagacctg cttaagcgag tatgtgaaca cctcaacctg ttggaagaag
      961 actactttgg tttagccgtg tgggacagca caacctccaa gacatggctg gattctgcca
     1021 aagaaataaa aaagcaggtt cgaggtgttc cttggaattt tacatttaat gtgaagtttt
     1081 atccacctga cccagcacag ttaacagaag acataacaag gtactactta tgtcttcagc
     1141 tgcggcagga catcgttgct ggacgtctgc cctgttcctt tgcaacgtta gccctcctcg
     1201 ggtcttacac tgtgcagtcg gagctgggag actacgaccc agagctccat ggcgtggatt
     1261 atgttagcga ctttaaactg gctccaaatc agaccaggga acttgaagag aaggtcatgg
     1321 agttgcataa atcatacagg tccatgactc cagctcaggc tgacttggaa tttcttgaga
     1381 atgccaaaaa gttgtccatg tatggagttg atcttcataa agcaaaggac ttggagggag
     1441 tggatatcat cctaggagtc tgctctagtg gccttttggt ttacaaagat aagttgagaa
     1501 ttaaccgttt cccttggccc aaagtgctaa agatttctta caaacgtagc agctttttca
     1561 tcaagatccg gcctggagag caagagcatt atgaaagcac cattggcttc aagcttccca
     1621 gctatcgagc agctaagaaa ctatggaaag tctgtgtgga gcaccacacg tttttcagac
     1681 tgacctctac agacaccctt cccaaaagca agttccttgc cctgggatcc aaatttcgat
     1741 acagtggccg gactcaagca cagaccaggc aagccagtgc cctgattgat aggcctgctc
     1801 cacactttga gcggacagca agcaaacggg catccaggag cctcgatgga gcagcagctg
     1861 ccgagtccac agaccgaagc cctcgaccca cctctgcccc agccattgct cagagtcagg
     1921 tcatggaagg gccgggagca cctgccaaga aagcaccaaa ggaagccgtg aaggttgaag
     1981 agaagcgggg agaagagcca gctgagcccg agcctgagcc cacagaagct tggaagaaaa
     2041 agagagagag actagatggt gaaaacattt atatcagaca tagcaattta atgttggagg
     2101 atttagacaa gagtcaagaa gagatcaaga agcatcatgc cagcatcagt gaactgaaaa
     2161 agaactttat ggaatcagta cccgaaccac ggcccagcga gtgggacaag cgcttgtcca
     2221 cacactcacc cttccggact cttaacatca acgggcaagt ccctaccgga gatggacctc
     2281 ccctggtgaa gactcaaact gtcaccatct cagatactgc caatgctgtg aaaagtgaaa
     2341 tcccaaccaa agatgtcccg attgtccaca cggagaccaa gaccatcacc tatgaagctg
     2401 cccagactga ggacagcaat ggggacttag accctggagt cttgctgaca gcccagacca
     2461 tcacatctga gaccacaagt agcacaacca cgacacagat taccaagact gtaaaagggg
     2521 ggatttccga gacccggatc gagaagagaa ttgtaatcac aggagacgct gatatcgacc
     2581 atgatcaggt cctcgtccaa gccatcaagg aggccaagga acagcaccca gacatgtcag
     2641 tgaccaaggt ggtcgtccac caggagaccg agatctctga ggagtgagct cagggactgt
     2701 cctgcccatc cccacctgtc cccatccaag agaaaccagc atgtaataaa gaagccagcc
     2761 tgcagcagac ttcagactct gaagactgct ccacaccaca aaaaaaccaa cttcattttc
     2821 tattcagaat ttataccaag agactcttct agacgccacg gatgttctct atattgtgat
     2881 acagaaactg ccaacttttg gctctatgaa ctgtttttaa gacactttga ttttttacgg
     2941 ggtggtcggt aacctctcaa cctagcctct cctcactcat ttccaacaca gaccctgaca
     3001 ggatccacag acttctccaa gaccctccag agaccctgcc agcagttaga ggacagagcc
     3061 agctcagtgg gacaccctgc tcctccctca gcttcatgcc ctctggatga cacaaaaact
     3121 tcatacacca gtgaatgtca agcaaggcaa atgccctggt cacagacccc agaaacgtga
     3181 cctcccatcg cagggtgttt gaggcacagc tcttcttttc cctgagcgcg tgatgtcacc
     3241 cccatctgtt tggagcttct ttaagtcaaa gagatcacct gtcttagagc tgatactgtg
     3301 accatttaat gtgtctgtgg ccttcacctc cccagctgct ctgtccctca ctggaaaaag
     3361 cagctttgtc gagtgcttcc caggtcccac ctcaggagac cagaactcat ggaaaaatta
     3421 ggcactgttg gctaaaagtg ccaatggaac atttttagtt gtagtttggg gaagaaaagt
     3481 taatgaggtt ttaaaaatca ggtcttgtcg ctcggggagc ctgcttcacc caggggagtg
     3541 gcacctttac ctcagtcgga tccagtaagg aggcttccag ccccagccta ggcccctccc
     3601 acctggcatg gtaagggaca gtggctcagg gaagagggtg cgttctagga cctttctgtg
     3661 gcaggcccga ggatgccctc tagaagccag ggtatttccc gtctcctggt ggccatccct
     3721 ggtcaaggtg ggtgtgaacc agctctgctc atcccccact cactgcctga ggagtctgcc
     3781 aggttttgag agcttgattt catggtgggt tttggattta gttcccgttc cctttccctt
     3841 ttttaaaaat actggttttg aaaagggagc ctgatgtccc caactagtag tgagaattgg
     3901 gggacctttc ctccccctca aacagggcct ctgtaatcct ccagctaact tcctacaaac
     3961 atctgcctgg aagattagta gaatcctgga atgaacttca tgagggttga cagcagggcc
     4021 actggccgca ctggctgggg gctgaagggg agtgagcaaa gtcagaagcc acagcagcct
     4081 cctggccgac cgctcctcat acaaacgcag cgatttgaac tggttttgtg tgcagttttc
     4141 ttttagctct cttgagacca ttgccaatgg cagcttgctt taaggaggga gagccccggt
     4201 gggagagggg caggctcggg ttccactctc agaagtaaac tgcagtctag gactgagccg
     4261 gagaaggctg ggctgcaggg ggtgggttag catggactct agctaccccc aggctctgaa
     4321 aaggaggagc agcaggagga gcctgcccat agccctgcgc catcccctca ggacctcaga
     4381 cctggttacc tgaactctgc ccctctgctg ctgcctctgt ctggaaattg gaccagagtt
     4441 ctgataccct gcagcctcct cccactcctt tgctggctct ggcaacatat cctgggatat
     4501 ggttgttgtt tggattttct ttctttctgc agttgtgtga agaacaggct ctgtccaggt
     4561 agaaggagtg aggggggagg ggagtcccat ctccagggtc agagacttgg caggactttt
     4621 cccaaagtga ctcaggcaca ccacagtaac aatcccaact gcagttttat ttttacttca
     4681 gaagtagatt tccttcaaac cacatgagat ctctgccacc cacccacaaa gcaagcccta
     4741 tattcctaaa ctgagggctc aaggaggctg actccggggg ccctccccaa ggccagcagt
     4801 gtattcgggg tctgggagcc ctggcccact ttgaggaatg gagctggggc tacagcctgg
     4861 ccagcaccct gatgctcatg ggaaatacca gccctaggct ggttgttttt acaaatctct
     4921 cagatatatt attttcatga caaaaatgaa ggagctttgt aaattttttt aaaattatga
     4981 atcatatcaa gtagttgttt acatttgaca aaataggaac tatgccggcg gagtccagcc
     5041 gaaaaacccc tcccttaggt gagataggca gtaactgggc ctgctgtctg cgcctttgta
     5101 gtgacagatg tggctgtagt gtttaggtaa gtgtttggtc ttgcttcttg tatggcattt
     5161 ttcaataaac tt
//
