LOCUS       XM_039111846            4726 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus endothelial PAS domain protein 1
            (Epas1), transcript variant X1, mRNA.
ACCESSION   XM_039111846
VERSION     XM_039111846.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051341.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039111846.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4726
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4726
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /note="endothelial PAS domain protein 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 103 ESTs, 11 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 51 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:29452"
                     /db_xref="RGD:68404"
     CDS             16..2673
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /codon_start=1
                     /product="endothelial PAS domain-containing protein 1
                     isoform X1"
                     /protein_id="XP_038967774.1"
                     /db_xref="GeneID:29452"
                     /db_xref="RGD:68404"
                     /translation="MTAEWRELWEIRGQAGKDWRSSSELRKEKSRDAARCRRSKETEV
                     FYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLY
                     LKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTL
                     KTGSGFGKKNKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVRVYNNCPP
                     HSSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELV
                     GYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQG
                     TVVYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSDDVA
                     LSEKSNYLFTKLKEEPEDLAQLAPTPGDAIISLDFGSQNFDESSTYGKAILPPGQPWA
                     TELRSHSAQSESRSLPAFTVPQAGSPGNATPSATSSSSCSTPSSPEDYYSSLENHLKI
                     EVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQLSPICPEEPLVPESP
                     QPNPQHCFSTMSSIFQPLTPGASQGTFFLDKYPQQLESRKTESEHWPMSTIFFDAGSK
                     GSLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWSVGNQSAEPLGPLPLGTSQL
                     EPPSTPPHVSMFKMRSAKDFGARGPYMMSPAMIALSNKLKLKRQLDYEEPAFQDTSGG
                     DPPGTSSSHLMWKRMKSLMGGTCPLMPDKTVSASMAPDEFTQKSMRGLGQPLRHLPPS
                     QPPSTRSPGENAKSGFPPQCYASPFQDYSPPGAQKGSGVASRLLGPSFEPYLLPELTR
                     YDCEVNVPVPGSSTLLQGRDLLRALDQAT"
ORIGIN      
        1 tccggaatcg aacgcatgac cgcagagtgg cgcgagctgt gggagattcg cggccaggct
       61 ggaaaagact ggcggagcag ctcggagctg aggaaggaga aatcccgaga tgccgcacgg
      121 tgccggcgta gcaaggagac ggaggtcttc tatgaactgg ctcatgagct gccgctgccc
      181 cacagtgtga gctcccacct ggacaaagcc tccatcatgc gcctggccat cagcttcctg
      241 cgaacacata aactcctgtc ttcagtgtgc tctgaaaatg aatctgaagc cgaggctgac
      301 cagcagatgg ataacttgta cctgaaagcc ttggagggct tcattgccgt ggtgacccaa
      361 gacggtgata tgatctttct gtcagaaaac atcagcaagt tcatgggact tacccaggta
      421 gaactaacag gacacagcat ctttgacttc actcatcctt gcgaccacga ggagatccgc
      481 gagaacctga cactcaaaac tggctctggt tttgggaaga agaacaaaga tatgtctacc
      541 gagcgtgact tcttcatgag gatgaagtgt accgtcacca acagaggccg gactgtcaac
      601 cttaagtcgg ccacctggaa ggtcttgcac tgcaccgggc aagtgagagt ctacaacaac
      661 tgcccccctc acagtagcct ctgcggctac aaggagcccc tgctgtcctg cctcatcatc
      721 atgtgtgagc caatccagca cccatcccac atggacatcc ccttggacag caagactttc
      781 ctaagccgcc acagcatgga catgaagttc acctactgtg atgacagaat cttggaactg
      841 gttggttacc accccgagga gctacttggc cgctctgcct atgaattcta ccacgccctg
      901 gactcggaga acatgacaaa aagtcaccag aacttgtgca ccaaggggca agtggtgtct
      961 ggccagtacc ggatgctggc caaacatgga ggatatgtgt ggttggagac ccaggggacc
     1021 gtcgtctaca acccccgcaa cctgcagccc cagtgtatca tgtgtgtcaa ctatgtcctg
     1081 agtgagatag agaagaatga cgtggtgttc tccatggacc agactgaatc cttgttcaag
     1141 ccacacctga tggccatgaa cagcatcttt gacagcagtg acgacgtggc cctatccgag
     1201 aagagcaact acctgttcac caaactgaag gaggagccag aggacctggc ccagctggcc
     1261 cccaccccag gggatgctat tatttctctg gacttcggaa gccagaactt tgatgaatcc
     1321 tcgacctatg gcaaggccat ccttccccca ggccagccgt gggccacaga gctgaggagc
     1381 cacagtgccc agagtgagtc caggagcctg ccagccttca ccgtgcccca ggcaggttcc
     1441 ccagggaatg ccacacccag cgccacaagc agcagcagct gctccacgcc cagcagccct
     1501 gaggattact actcatctct ggagaatcac ttgaagatcg aagtaatcga gaagctcttc
     1561 gccatggaca ccgaggcgaa ggaccagtgc agtactcaga cggacttcaa tgaactggac
     1621 ttggagaccc tggcacccta catccctatg gatggcgagg acttccagct cagccccatc
     1681 tgcccggagg agccactcgt gccggagagc ccccagccca acccccagca ctgtttcagt
     1741 accatgtcaa gcatcttcca gccgctcacc ccgggggcca gccaaggcac cttcttcctt
     1801 gacaagtacc cgcagcagtt ggaaagccgg aagacggagt ccgagcactg gcccatgtct
     1861 accatcttct ttgatgctgg gagcaaaggg tccctgcccc catgctgtgg ccaggccagc
     1921 acccctctct cctctatggg gggcagatct aacactcagt ggcccccaga tccaccatta
     1981 cattttggcc ctacgaagtg gtctgtgggc aatcagagcg ctgaacccct ggggcctctg
     2041 ccactgggga cctcgcagtt ggagcctccc agcaccccgc ctcatgtctc catgttcaag
     2101 atgaggtctg caaaggactt tggggctcga ggcccataca tgatgagccc ggccatgata
     2161 gccctgtcca acaagctgaa gctaaagcgc cagctggact acgaggagcc agccttccaa
     2221 gacacaagtg ggggggaccc tccaggcacc agcagttcac acttgatgtg gaaacgaatg
     2281 aagagcctca tgggcgggac ctgtcctttg atgcctgaca agaccgtcag tgcaagcatg
     2341 gctcctgatg aattcaccca aaaatccatg agaggcctgg gccagccact gagacacctg
     2401 ccaccttccc agccaccatc taccaggagt ccaggagaga acgccaagag tgggttccca
     2461 ccacagtgct atgcctcccc gttccaggac tacagtcctc caggagctca aaaggggtca
     2521 ggagtggcaa gtcgactgct ggggccatcg ttcgagcctt acctgctgcc ggaactgacc
     2581 agatatgact gtgaggtgaa cgtcccagtg cctggaagtt ctacactcct gcaggggaga
     2641 gaccttctca gagctctgga ccaggccacc tgagccaggg cccgtggccg ggcatgtccc
     2701 tgcccagcca tctcgtcctg ccagcttcac ttctgtctgt gttgcaatta ggtatctcta
     2761 acaccagcac acttcttacg agatgtactg gcctggccta ctggccaggc caccaagccg
     2821 tggccttcat ctgacatgct cactttactc tccatgtttt aaaaacacat ggctgtttta
     2881 cctgctatgt tttactgttg atgaaagtgt tctgaaattt tataagatct ccccctccct
     2941 ccctcgaatt acttctaatt tatattcccc aaaggtttct ctctcacatt cagcatccat
     3001 tctaacacgc atggtggctg tcgtctctcc ttagggaggc tttggcttcg ttcaactaaa
     3061 gtgttcttgt ccttgttgcc aaagagaaag gattttcttt ctaagctccg ccgtgggttc
     3121 tccctcttcc tacccccctc tgtcccacac atattgtaaa atttaatgtt tttaaggcca
     3181 acctttgctc cagttttcat acaacttatg taagcgatgt gaagggtcag ctctagggct
     3241 acctgtgaag ccactcggtg acgcttacac agtggcgctt acgtggtggc gttcctaagc
     3301 catttgtccc ccatctcacc ctggggtcca gtggatacat gtttttactc aaaagcaaca
     3361 ctgagttttg ttttgttttt taaagaaaaa ggaaaattta tatctgggtt tagtgtttat
     3421 catatatggg tactttataa tatctaaaag cttagaaatg gagtcctgct cacaaaaatc
     3481 acttctttaa gatcttttta cggctgttaa ctttattctc agtgttctgg acactgtatc
     3541 ctgtgtagta ctcccacggg cctgtactaa ccatcacaga tctctctctc tctctctctc
     3601 tctctctctc tctctctctc tctctctctc tggtgacctt ttgcttttgt gatatgccat
     3661 cggtgtgaca aacagtccca ggagtgaagt cattaaggaa catcgcaagc tatcttctct
     3721 cctcgtgttc tctgtctctt acgtatgtgt gtgctgttgc tgcgtgaggg ctctgacgtc
     3781 ggcgcgtcgt gggcgggaag gaagcgcttt cgctttttct caggcggtgt tgctagccct
     3841 tcaagtgcac tgagctgtgt gactgccagt ctctctcaca tggcacattt gggtgtttcc
     3901 tcggctacca tgaaatggtt ctatcgggaa ttcacaaggc aaggaggaat cacaaatgca
     3961 gcgaccccgg tccttggagc taaactggga gagggtgcca ggtggagggt agcaggtctg
     4021 accagccgta cgccctgcca caaatcacag ttcgcagggc aaatgaccct gcacagccac
     4081 ggtgcagcgc cccctgctgg cgagcggcgg gcagccctcc agggacagcc tctagctgag
     4141 gtcagtcacg tgaagtgaca tgaacaggta gaaagcactg aaaatggtgt tccaagagca
     4201 ctttgtaact cactgagggg gaggggaagc accttttggg tttgtgatac caatcaacat
     4261 aagctgttgt tgactagggt acaataaaac ttttcagtgc acatgaagcc cgtcaggcaa
     4321 gagtgcagtg agcctaaggg acttactgct caaaccaaaa attaactttg aaagtcaatc
     4381 tacctgaaat tacctaggca tggtgttgtt cgcgtcgcac atcggcgcac ggtgtggcct
     4441 gacgcacacg gtgatggaac ttgaagggtt actgacgtgc aaacgctggt atttgatttc
     4501 ctgtgttgtt gcctcagcat taaaggcatt tgtttccctt tgcggtctta ctaaaacact
     4561 ctgagaacta ttccgagttt catagtaatc tttcctgtcc atgtaacaac ttcatgaccg
     4621 ttgctgcatt gtccaattcc tactgacgac attataactg tacggactta actttataag
     4681 gaaatgtatt ttgacactga tatcttatta aagtattctg atccta
//
