LOCUS       NM_023090               3453 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus endothelial PAS domain protein 1 (Epas1), mRNA.
ACCESSION   NM_023090
VERSION     NM_023090.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3453)
  AUTHORS   Zhang,J., Hu,Y., Wang,Z., Wu,X., Yang,C. and Yang,H.
  TITLE     Hypoxia-inducible factor expression is related to apoptosis and
            cartilage degradation in temporomandibular joint osteoarthritis
  JOURNAL   BMC Musculoskelet Disord 23 (1), 583 (2022)
   PUBMED   35710352
  REMARK    GeneRIF: Hypoxia-inducible factor expression is related to
            apoptosis and cartilage degradation in temporomandibular joint
            osteoarthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3453)
  AUTHORS   Che,X., Park,N.R., Jin,X., Jung,Y.K., Han,M.S., Park,C.Y.,
            Chun,J.S., Kim,S.G., Jin,J., Kim,H.J., Lian,J.B., Stein,J.L.,
            Stein,G.S. and Choi,J.Y.
  TITLE     Hypoxia-inducible factor 2alpha is a novel inhibitor of chondrocyte
            maturation
  JOURNAL   J Cell Physiol 236 (10), 6963-6973 (2021)
   PUBMED   33748969
  REMARK    GeneRIF: Hypoxia-inducible factor 2alpha is a novel inhibitor of
            chondrocyte maturation.
REFERENCE   3  (bases 1 to 3453)
  AUTHORS   Feng,G.W., Liu,X., Qi,Q., Wang,S.J., Yang,C.T., Zuo,M. and
            Zhang,G.Z.
  TITLE     Skin Ultrastructure and the Changes of HIF-2alpha, H-FABP
            Expression in the Myocardium of Electric Shock Death Rats
  JOURNAL   Fa Yi Xue Za Zhi 37 (2), 158-165 (2021)
   PUBMED   34142475
  REMARK    GeneRIF: Skin Ultrastructure and the Changes of HIF-2alpha, H-FABP
            Expression in the Myocardium of Electric Shock Death Rats.
REFERENCE   4  (bases 1 to 3453)
  AUTHORS   Wu,J.W., Hu,H., Li,D. and Ma,L.K.
  TITLE     Hypoxia-inducible factor 2-alpha-dependent induction of IL-6
            protects the heart from ischemia/reperfusion injury
  JOURNAL   Aging (Albany NY) 13 (3), 3443-3458 (2021)
   PUBMED   33428604
  REMARK    GeneRIF: Hypoxia-inducible factor 2-alpha-dependent induction of
            IL-6 protects the heart from ischemia/reperfusion injury.
REFERENCE   5  (bases 1 to 3453)
  AUTHORS   Coelho,N.R., Tomkiewicz,C., Correia,M.J., Goncalves-Dias,C.,
            Barouki,R., Pereira,S.A., Coumoul,X. and Monteiro,E.C.
  TITLE     First evidence of aryl hydrocarbon receptor as a druggable target
            in hypertension induced by chronic intermittent hypoxia
  JOURNAL   Pharmacol Res 159, 104869 (2020)
   PUBMED   32416216
REFERENCE   6  (bases 1 to 3453)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Jain,S. and Bradfield,C.A.
  TITLE     The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally
            active complexes with circadian and hypoxia factors
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5474-5479 (1998)
   PUBMED   9576906
REFERENCE   7  (bases 1 to 3453)
  AUTHORS   Ladoux,A. and Frelin,C.
  TITLE     Cardiac expressions of HIF-1 alpha and HLF/EPAS, two basic loop
            helix/PAS domain transcription factors involved in adaptative
            responses to hypoxic stresses
  JOURNAL   Biochem Biophys Res Commun 240 (3), 552-556 (1997)
   PUBMED   9398602
REFERENCE   8  (bases 1 to 3453)
  AUTHORS   Ema,M., Taya,S., Yokotani,N., Sogawa,K., Matsuda,Y. and
            Fujii-Kuriyama,Y.
  TITLE     A novel bHLH-PAS factor with close sequence similarity to
            hypoxia-inducible factor 1alpha regulates the VEGF expression and
            is potentially involved in lung and vascular development
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4273-4278 (1997)
   PUBMED   9113979
REFERENCE   9  (bases 1 to 3453)
  AUTHORS   Hogenesch,J.B., Chan,W.K., Jackiw,V.H., Brown,R.C., Gu,Y.Z.,
            Pray-Grant,M., Perdew,G.H. and Bradfield,C.A.
  TITLE     Characterization of a subset of the basic-helix-loop-helix-PAS
            superfamily that interacts with components of the dioxin signaling
            pathway
  JOURNAL   J Biol Chem 272 (13), 8581-8593 (1997)
   PUBMED   9079689
REFERENCE   10 (bases 1 to 3453)
  AUTHORS   Tian,H., McKnight,S.L. and Russell,D.W.
  TITLE     Endothelial PAS domain protein 1 (EPAS1), a transcription factor
            selectively expressed in endothelial cells
  JOURNAL   Genes Dev 11 (1), 72-82 (1997)
   PUBMED   9000051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 26, 2021 this sequence version replaced NM_023090.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ277828.1, SRR26643291.17114.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-579               JAXUCZ010000006.1  13624151-13624729   c
            580-770             JAXUCZ010000006.1  13581445-13581635   c
            771-922             JAXUCZ010000006.1  13570848-13570999   c
            923-1007            JAXUCZ010000006.1  13570333-13570417   c
            1008-1126           JAXUCZ010000006.1  13566752-13566870   c
            1127-1332           JAXUCZ010000006.1  13566432-13566637   c
            1333-1439           JAXUCZ010000006.1  13558198-13558304   c
            1440-1587           JAXUCZ010000006.1  13552858-13553005   c
            1588-1802           JAXUCZ010000006.1  13552072-13552286   c
            1803-1993           JAXUCZ010000006.1  13550902-13551092   c
            1994-2104           JAXUCZ010000006.1  13550130-13550240   c
            2105-2610           JAXUCZ010000006.1  13548686-13549191   c
            2611-2737           JAXUCZ010000006.1  13547770-13547896   c
            2738-2852           JAXUCZ010000006.1  13547479-13547593   c
            2853-3026           JAXUCZ010000006.1  13547113-13547286   c
            3027-3453           JAXUCZ010000006.1  13545030-13545456   c
FEATURES             Location/Qualifiers
     source          1..3453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..3453
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /note="endothelial PAS domain protein 1"
                     /db_xref="GeneID:29452"
                     /db_xref="RGD:68404"
     exon            1..579
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             554..3178
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /function="transcription factor"
                     /note="EPAS-1; HIF2-alpha; HIF-2-alpha; hypoxia-inducible
                     factor 2-alpha; hypoxia inducible factor 2a; hypoxia
                     inducible factor 2, alpha subunit"
                     /codon_start=1
                     /product="endothelial PAS domain-containing protein 1"
                     /protein_id="NP_075578.2"
                     /db_xref="GeneID:29452"
                     /db_xref="RGD:68404"
                     /translation="MTADKEKKRSSSELRKEKSRDAARCRRSKETEVFYELAHELPLP
                     HSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVV
                     TQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLKTGSGFGKKNK
                     DMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVRVYNNCPPHSSLCGYKEPL
                     LSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELVGYHPEELLGRS
                     AYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVVYNPRNLQP
                     QCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSDDVALSEKSNYLFTK
                     LKEEPEDLAQLAPTPGDAIISLDFGSQNFDESSTYGKAILPPGQPWATELRSHSAQSE
                     SRSLPAFTVPQAGSPGNATPSATSSSSCSTPSSPEDYYSSLENHLKIEVIEKLFAMDT
                     EAKDQCSTQTDFNELDLETLAPYIPMDGEDFQLSPICPEEPLVPESPQPNPQHCFSTM
                     SSIFQPLTPGASQGTFFLDKYPQQLESRKTESEHWPMSTIFFDAGSKGSLPPCCGQAS
                     TPLSSMGGRSNTQWPPDPPLHFGPTKWSVGNQSAEPLGPLPLGTSQLEPPSTPPHVSM
                     FKMRSAKDFGARGPYMMSPAMIALSNKLKLKRQLDYEEPAFQDTSGGDPPGTSSSHLM
                     WKRMKSLMGGTCPLMPDKTVSASMAPDEFTQKSMRGLGQPLRHLPPSQPPSTRSPGEN
                     AKSGFPPQCYASPFQDYSPPGAQKGSGVASRLLGPSFEPYLLPELTRYDCEVNVPVPG
                     SSTLLQGRDLLRALDQAT"
     exon            580..770
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            771..922
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1007
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1126
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1332
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1439
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1587
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1802
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1993
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2104
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2610
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2737
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2852
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3026
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3453
                     /gene="Epas1"
                     /gene_synonym="HIF-2 alpha; HIF2 alpha; Hif2a; HLF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacattcga gagcggccgg tgtacagctc cggagtccgc tgcgctccgc tccagctctc
       61 ctgaggcggc cgtacaatcc tcggcagtgt cctgagactg tatggtcatc tcagcggccg
      121 cactcgcctg ctcccggatt ttttccaacc tgctctcttc gagccacttt tttttttttt
      181 ttttttggtt ggttggtttt gttttgtcag atcccagaaa agtgactcca gttcggggat
      241 aaacggaact tcaggtccct tgtcgctgct ctcttttggc gtcttgcaac ctcctcccat
      301 tcctttcccc agccccgcct cctcctgcag gttcctcccc gtcacccctc tcctccctcc
      361 tcctcagcac ctagccagcc gtccgcaaac ttccacctga ttgtgcggga ctctcggacc
      421 tgcgagcact gaagacctgt ctcacctgcc ggggcgacag agagctgcgg agggccacag
      481 caaagagagc ggctgcagcc cctacggggt taaggaaccc aggtgctccg ggtgtcggag
      541 ggccgcggcg acaatgacag ctgacaagga gaagaaaagg agcagctcgg agctgaggaa
      601 ggagaaatcc cgagatgccg cacggtgccg gcgtagcaag gagacggagg tcttctatga
      661 actggctcat gagctgccgc tgccccacag tgtgagctcc cacctggaca aagcctccat
      721 catgcgcctg gccatcagct tcctgcgaac acataaactc ctgtcttcag tgtgctctga
      781 aaatgaatct gaagccgagg ctgaccagca gatggataac ttgtacctga aagccttgga
      841 gggcttcatt gccgtggtga cccaagacgg tgatatgatc tttctgtcag aaaacatcag
      901 caagttcatg ggacttaccc aggtagaact aacaggacac agcatctttg acttcactca
      961 tccttgcgac cacgaggaga tccgcgagaa cctgacactc aaaactggct ctggttttgg
     1021 gaagaagaac aaagatatgt ctaccgagcg tgacttcttc atgaggatga agtgtaccgt
     1081 caccaacaga ggccggactg tcaaccttaa gtcggccacc tggaaggtct tgcactgcac
     1141 cgggcaagtg agagtctaca acaactgccc ccctcacagt agcctctgcg gctacaagga
     1201 gcccctgctg tcctgcctca tcatcatgtg tgagccaatc cagcacccat cccacatgga
     1261 catccccttg gacagcaaga ctttcctaag ccgccacagc atggacatga agttcaccta
     1321 ctgtgatgac agaatcttgg aactggttgg ttaccacccc gaggagctac ttggccgctc
     1381 tgcctatgaa ttctaccacg ccctggactc ggagaacatg acaaaaagtc accagaactt
     1441 gtgcaccaag gggcaagtgg tgtctggcca gtaccggatg ctggccaaac atggaggata
     1501 tgtgtggttg gagacccagg ggaccgtcgt ctacaacccc cgcaacctgc agccccagtg
     1561 tatcatgtgt gtcaactatg tcctgagtga gatagagaag aatgacgtgg tgttctccat
     1621 ggaccagact gaatccttgt tcaagccaca cctgatggcc atgaacagca tctttgacag
     1681 cagtgacgac gtggccctat ccgagaagag caactacctg ttcaccaaac tgaaggagga
     1741 gccagaggac ctggcccagc tggcccccac cccaggggat gctattattt ctctggactt
     1801 cggaagccag aactttgatg aatcctcgac ctatggcaag gccatccttc ccccaggcca
     1861 gccgtgggcc acagagctga ggagccacag tgcccagagt gagtccagga gcctgccagc
     1921 cttcaccgtg ccccaggcag gttccccagg gaatgccaca cccagcgcca caagcagcag
     1981 cagctgctcc acgcccagca gccctgagga ttactactca tctctggaga atcacttgaa
     2041 gatcgaagta atcgagaagc tcttcgccat ggacaccgag gcgaaggacc agtgcagtac
     2101 tcagacggac ttcaatgaac tggacttgga gaccctggca ccctacatcc ctatggatgg
     2161 cgaggacttc cagctcagcc ccatctgccc ggaggagcca ctcgtgccgg agagccccca
     2221 gcccaacccc cagcactgtt tcagtaccat gtcaagcatc ttccagccgc tcaccccggg
     2281 ggccagccaa ggcaccttct tccttgacaa gtacccgcag cagttggaaa gccggaagac
     2341 ggagtccgag cactggccca tgtctaccat cttctttgat gctgggagca aagggtccct
     2401 gcccccatgc tgtggccagg ccagcacccc tctctcctct atggggggca gatctaacac
     2461 tcagtggccc ccagatccac cattacattt tggccctacg aagtggtctg tgggcaatca
     2521 gagcgctgaa cccctggggc ctctgccact ggggacctcg cagttggagc ctcccagcac
     2581 cccgcctcat gtctccatgt tcaagatgag gtctgcaaag gactttgggg ctcgaggccc
     2641 atacatgatg agcccggcca tgatagccct gtccaacaag ctgaagctaa agcgccagct
     2701 ggactacgag gagccagcct tccaagacac aagtgggggg gaccctccag gcaccagcag
     2761 ttcacacttg atgtggaaac gaatgaagag cctcatgggc gggacctgtc ctttgatgcc
     2821 tgacaagacc gtcagtgcaa gcatggctcc tgatgaattc acccaaaaat ccatgagagg
     2881 cctgggccag ccactgagac acctgccacc ttcccagcca ccatctacca ggagtccagg
     2941 agagaacgcc aagagtgggt tcccaccaca gtgctatgcc tccccgttcc aggactacag
     3001 tcctccagga gctcaaaagg ggtcaggagt ggcaagtcga ctgctggggc catcgttcga
     3061 gccttacctg ctgccggaac tgaccagata tgactgtgag gtgaacgtcc cagtgcctgg
     3121 aagttctaca ctcctgcagg ggagagacct tctcagagct ctggaccagg ccacctgagc
     3181 cagggcccgt ggccgggcat gtccctgccc agccatctcg tcctgccagc ttcacttctg
     3241 tctgtgttgc aattaggtat ctctaacacc agcacacttc ttacgagatg tactggcctg
     3301 gcctactggc caggccacca agccgtggcc ttcatctgac atgctcactt tactctccat
     3361 gttttaaaaa cacatggctg ttttacctgc tatgttttac tgttgatgaa agtgttctga
     3421 aattttataa gatctccccc tccctccctc gaa
//
