LOCUS       XP_038936215            2413 aa            linear   ROD 22-FEB-2024
DEFINITION  histone acetyltransferase p300 isoform X1 [Rattus norvegicus].
ACCESSION   XP_038936215
VERSION     XP_038936215.1
DBLINK      BioProject: PRJNA1074393
DBSOURCE    REFSEQ: accession XM_039080287.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086025) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2413
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     Protein         1..2413
                     /product="histone acetyltransferase p300 isoform X1"
                     /calculated_mol_wt=263452
     Region          88..>323
                     /region_name="Med15"
                     /note="ARC105 or Med15 subunit of Mediator complex
                     non-fungal; pfam09606"
                     /db_xref="CDD:312941"
     Region          348..415
                     /region_name="zf-TAZ"
                     /note="TAZ zinc finger; pfam02135"
                     /db_xref="CDD:460457"
     Region          567..647
                     /region_name="KIX"
                     /note="KIX domain; pfam02172"
                     /db_xref="CDD:366953"
     Region          <647..797
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          <659..1075
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1049..1156
                     /region_name="Bromo_cbp_like"
                     /note="Bromodomain, cbp_like subfamily. Cbp (CREB binding
                     protein or CREBBP) is an acetyltransferase acting on
                     histone, which gives a specific tag for transcriptional
                     activation and also acetylates non-histone proteins.
                     CREBBP binds specifically to...; cd05495"
                     /db_xref="CDD:99927"
     Site            order(1077,1084,1087,1126,1130,1136)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99927"
     Region          1168..1240
                     /region_name="RING_CBP-p300"
                     /note="atypical RING domain found in CREB-binding protein
                     and p300 histone acetyltransferases; cd15802"
                     /db_xref="CDD:276805"
     Site            order(1168,1171..1172,1238,1240)
                     /site_type="other"
                     /note="HAT interface [polypeptide binding]"
                     /db_xref="CDD:276805"
     Region          1241..1275
                     /region_name="PHD_p300"
                     /note="PHD finger found in histone acetyltransferase p300;
                     cd15646"
                     /db_xref="CDD:277116"
     Site            order(1241..1245,1249,1268)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277116"
     Region          1304..1610
                     /region_name="HAT_KAT11"
                     /note="Histone acetylation protein; pfam08214"
                     /db_xref="CDD:400497"
     Region          1666..1706
                     /region_name="ZZ_CBP"
                     /note="Zinc finger, ZZ type. Zinc finger present in
                     CBP/p300 and related proteins. The ZZ motif coordinates
                     two zinc ions and most likely participates in ligand
                     binding or molecular scaffolding. CREB-binding protein
                     (CBP) is a large multidomain protein that...; cd02337"
                     /db_xref="CDD:239077"
     Site            order(1668,1671,1681,1684,1690,1693,1699,1701)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239077"
     Site            order(1668,1671,1690,1693)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239077"
     Site            order(1669,1678,1680,1686,1688)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239077"
     Site            order(1679,1694,1703,1706)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239077"
     Site            order(1681,1684,1699,1701)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239077"
     Region          1733..1801
                     /region_name="zf-TAZ"
                     /note="TAZ zinc finger; pfam02135"
                     /db_xref="CDD:460457"
     Region          1956..>2335
                     /region_name="Med15"
                     /note="ARC105 or Med15 subunit of Mediator complex
                     non-fungal; pfam09606"
                     /db_xref="CDD:312941"
     Region          1989..2095
                     /region_name="Creb_binding"
                     /note="Creb binding; pfam09030"
                     /db_xref="CDD:462659"
     CDS             1..2413
                     /gene="Ep300"
                     /coded_by="XM_039080287.2:971..8212"
                     /db_xref="GeneID:170915"
                     /db_xref="RGD:620036"
ORIGIN      
        1 maenvvepgp psakrpklss palsasasdg tdfgslfdle hdlpdelins telgltnggd
       61 isqlqtslgi vqdaaskhkq lsellrsgss pnlnmgvggp gqvmasqaqq nspglslins
      121 mvkspmaqtg ltspnmgmgs sgpnqgptqs tagmmnspvn qpamgmntgm nagmnpgmla
      181 agngqgimpn qvmngsigag rgrpnmqypn agmgnagsll teplqqgspq mggqpglrgp
      241 qshkmgmmsn ptpygspytq nsgqqigasg lglqiqtktv lpnnlspfam dkkavtgggm
      301 pnmgqqptps vqqpglvnpv apgmgsgaht adpekrkliq qqlvlllhah kcqrreqang
      361 evrqcnlphc rtmknvlnhm thcqsgkscq vahcassrqi ishwknctrh dcpvclplkn
      421 agdkrnqqsi ltgapvglgn psslgvgqqs tpslstvsqi dpssieraya alglpyqvnq
      481 ippqppvqak nqqsqpsgqs pqgmrsmnnm saspmgvngg vgvqtpnlls dsmlhstins
      541 qnpmmnenas vaslgplpta aqpsstgirk qwheditqdl rnhlvhklvq aifptpdpaa
      601 lkdrrmenlv ayarkvegdm yesannraey yhllaekiyk iqkeleekrr trlqkqnmlp
      661 sapgmvpvpm ntapnmgqqp tgmttngplp dpsmirgsvp nqmmprmtpq pglnqfgqmn
      721 ipqppigprq psplqhhgql aqsgslnppm gygprmqqts gqnqflsqtq fpsqgmnvtn
      781 mplapsssqa pvsqaqmsss scpvnspimp pgsqgshihc ptlpqqahqn spspvpsrtp
      841 tphhtppsig tqqpaataip apvptppamp pgaqpqslrp psrqtptppt hlppqvqpsl
      901 pvppadqsqp qprsqqstaa svptptapll ppqpptplsq pavsvegqvs nppstsstev
      961 nsqtipekqp sqevkmevkm dvdqpepada qpddtkeaka edgkveptet eergpelkte
     1021 vkeeedqpst saaqsspapg qskkkifkpe elrqalmptl ealyrqdpes lpfrqpvdpq
     1081 llgipdyfdi vkspmdlsti krkldtgqyq epwqyiddiw lmfnnawlyn rktsrvykyc
     1141 sklsevfeqe idpvmqslgy ccgrklefsp qtlccygkql ctiprdatyy syqnryhfce
     1201 kcfneiqges vslgddpsqp qttinkeqfs krkndtldpe lfvectecgr kmhqicvlhh
     1261 eviwpsgfvc dgclkktart rkenkfsakr lpstrlgtfl enrvndflrr qnhpesgevt
     1321 vrvvhasdkt vevkpgmkar fvdsgemaes fpyrtkalfa feeidgvdlc ffgmhvqeyg
     1381 sdcpppnqrr vyisyldsvh ffrpkclrta vyheiligyl eyvkklgytt ghiwacppse
     1441 gddyifhchp pdqkipkpkr lqewykkmld kavserivhd ykdilkqate drltsakelp
     1501 yfegdfwpnv leesikeleq eeeerkreen tsnestdvtk gdsknakkkn nkktsknkss
     1561 lsrgnkkkpg vpnvsndlsq klyatmekhk evffvirlia cpapnslppi vdpdplipcd
     1621 lmdgrdaflt lardkhlefs slrraqwstm cmlvelhtqs qdrfvytcne ckhhvetrwh
     1681 ctvcedydlc itcyntknhd hkmeklglgl ddesnnqqaa atqspgdsrr lsiqrciqsl
     1741 vhacqcrnan cslpscqkmk rvvqhtkgck rktnggcpic kqlialccyh akhcqenkcp
     1801 vpfclnikqk lrqqqlqhrl qqaqmlrrrm asmqrtgvag qqqglpsptp atpttptgqq
     1861 patpqtpqpq ptsqpqptpp nnmtpylprt qtagpvsqgk aagqvtpptp pqtaqpplpg
     1921 pppaavemam qiqraaetqr qmahvqifqr piqhqmapma pmgmnpppma rgpgghldpg
     1981 mgpagmqqqp pwaqggmpqp qqmqsgmprp ammsvaqhgq plnmapqpgl gqvgvsplkp
     2041 gtvsqqalqn llrtlrspss plqqqqvlsi lhanpqllaa fikqraakya nsnpqplpgq
     2101 pgmpqgqpgl qpptmpgqqg vhsnpalqnm npmqagvqra glpqqqpqqq lqppmggmsp
     2161 qaqqmnmnhn tmpsqfrdil rrqmmqqqga gpgigpgman hnqfqqpqgi gyppqqqqqq
     2221 qqqrmqhhmq qmqqgnmgqm gqlpqalgae agaslqayqq rllqqqmgsp aqpnpmspqq
     2281 hmlpnqaqsp hlqgqqipns lsnqvrspqp vpsprpqsqp phsspsprmq pqpsphhvsp
     2341 qtssphpglv aaqaanpmeq ghfaspdqns mlsqlasnpg manlhgasat dlglsadsad
     2401 lssnlsqstl dih
//
