LOCUS       NM_001033565            1737 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ectonucleoside triphosphate diphosphohydrolase 8
            (Entpd8), mRNA.
ACCESSION   NM_001033565
VERSION     NM_001033565.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1737)
  AUTHORS   Fausther,M., Lecka,J., Kukulski,F., Levesque,S.A., Pelletier,J.,
            Zimmermann,H., Dranoff,J.A. and Sevigny,J.
  TITLE     Cloning, purification, and identification of the liver canalicular
            ecto-ATPase as NTPDase8
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 292 (3), G785-G795 (2007)
   PUBMED   17095758
  REMARK    GeneRIF: NTPDase8 is the canalicular ecto-ATPase/ATPDase and is
            responsible for the main hepatic NTPDase activity.
REFERENCE   2  (bases 1 to 1737)
  AUTHORS   Knowles,A.F. and Li,C.
  TITLE     Molecular cloning and characterization of expressed human
            ecto-nucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) and
            its soluble extracellular domain
  JOURNAL   Biochemistry 45 (23), 7323-7333 (2006)
   PUBMED   16752921
REFERENCE   3  (bases 1 to 1737)
  AUTHORS   Kukulski,F., Levesque,S.A., Lavoie,E.G., Lecka,J., Bigonnesse,F.,
            Knowles,A.F., Robson,S.C., Kirley,T.L. and Sevigny,J.
  TITLE     Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3
            and 8
  JOURNAL   Purinergic Signal 1 (2), 193-204 (2005)
   PUBMED   18404504
  REMARK    Erratum:[Purinergic Signal. 2005 Jul 29;1(3):293]
REFERENCE   4  (bases 1 to 1737)
  AUTHORS   Bigonnesse,F., Levesque,S.A., Kukulski,F., Lecka,J., Robson,S.C.,
            Fernandes,M.J. and Sevigny,J.
  TITLE     Cloning and characterization of mouse nucleoside triphosphate
            diphosphohydrolase-8
  JOURNAL   Biochemistry 43 (18), 5511-5519 (2004)
   PUBMED   15122917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001033565.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY536920.1, SRR26643288.12631.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000003.1  28288080-28288210
            132-249             JAXUCZ010000003.1  28288299-28288416
            250-400             JAXUCZ010000003.1  28289222-28289372
            401-560             JAXUCZ010000003.1  28289498-28289657
            561-788             JAXUCZ010000003.1  28289770-28289997
            789-1052            JAXUCZ010000003.1  28290097-28290360
            1053-1163           JAXUCZ010000003.1  28290546-28290656
            1164-1298           JAXUCZ010000003.1  28292788-28292922
            1299-1737           JAXUCZ010000003.1  28293021-28293459
FEATURES             Location/Qualifiers
     source          1..1737
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1737
                     /gene="Entpd8"
                     /note="ectonucleoside triphosphate diphosphohydrolase 8"
                     /db_xref="GeneID:613267"
                     /db_xref="RGD:1561793"
     exon            1..131
                     /gene="Entpd8"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1490
                     /gene="Entpd8"
                     /EC_number="3.6.1.5"
                     /note="NTPDase8; NTPDase 8; E-NTPDase 8"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase
                     8"
                     /protein_id="NP_001028737.2"
                     /db_xref="GeneID:613267"
                     /db_xref="RGD:1561793"
                     /translation="MRLSWKERVFMVLLGVAAASGLTMLILILVKATNVLLPADTKFG
                     ILFDAGSSHTSLFVYQWPANKEKDTGVVSQALACQVEGPGISSYTSDPTQAGESLKSC
                     LQEALALIPQTQHPVTPTFLGATAGMRLLSQKNSSQAQDILAAVSQTLSRAPVDFWGA
                     RILAGQDEGAFGWITVNYVLGMLLKYSSGQWILPEDGTLVGALDLGGASTQISFVPQG
                     PILDQSTQVTFRLYGANYSVYTHSYLCFGRDQILRRLLAELVQSSQVARVRHPCYHSG
                     YQATLSLASLYDSPCVHTPDSLNYTQNLTVEGIGNPGNCVAALRGLFNFSSCKGQEDC
                     AFNGVYQPPVHGQFYAFSNFYYTFQFLNLTSRQPLNIVNDTIWKFCQKPWRLVEDSYP
                     GQERWLRDYCASGLYILVLLLEGYKFSEETWPNIQFQKQAGGTDIGWTLGFMLNLTGM
                     IPAEALTQWRAQSYSIWIAGVVFAVLTLVAILGAAAVQLFWTQD"
     exon            132..249
                     /gene="Entpd8"
                     /inference="alignment:Splign:2.1.0"
     exon            250..400
                     /gene="Entpd8"
                     /inference="alignment:Splign:2.1.0"
     exon            401..560
                     /gene="Entpd8"
                     /inference="alignment:Splign:2.1.0"
     exon            561..788
                     /gene="Entpd8"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1052
                     /gene="Entpd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1163
                     /gene="Entpd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1298
                     /gene="Entpd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1737
                     /gene="Entpd8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaccatgag actttcctgg aaggaacggg tcttcatggt cctgttggga gttgcagcag
       61 cttctggcct caccatgctc atcctcatcc tggtgaaagc aaccaatgtt ctcctgcctg
      121 cagacaccaa gtttgggatc ctgtttgacg ccggctcctc ccacacatca ctgtttgtgt
      181 accagtggcc agcaaacaag gagaaggaca caggagtggt cagccaggcc ctggcttgcc
      241 aggtagaagg accgggaatc tcttcctaca cctctgaccc gacacaggct ggggagagcc
      301 tgaagagctg cctgcaggag gcgctggcac tgatcccaca gacccagcat ccagtgacgc
      361 ccacattcct gggggccaca gcaggaatga ggctgctcag ccagaagaac agctctcagg
      421 ctcaagacat cctagctgca gtctcccaga cactgagcag ggctccggtg gacttttggg
      481 gagccaggat cctggctggg caggatgaag gtgcctttgg ttggatcact gtcaactacg
      541 tcctgggaat gctcctgaag tattcgtctg gacaatggat cctgcctgaa gatgggacgc
      601 tagttggtgc tctggacctt ggcggggcct ccacgcagat cagctttgtg cctcagggcc
      661 ccatcctgga ccagagcacc caggttacct tccgcctgta cggcgccaat tacagtgtct
      721 acactcacag ctacctctgc tttgggcggg accagatcct aagaaggctc ctggctgaac
      781 tggtacagag cagccaggta gcccgggtca gacacccatg ctaccacagt ggctaccagg
      841 ccacactgtc actggcttcc ttgtatgatt caccctgcgt ccacactcca gattccctga
      901 actacaccca gaacctcaca gttgaaggga taggcaaccc tgggaactgt gtggcagccc
      961 tccggggtct cttcaacttc tccagctgta agggccaaga ggattgtgct ttcaatggag
     1021 tctaccagcc tcccgtgcat ggccagttct atgcattttc caacttttac tacaccttcc
     1081 agttcctcaa cctcacctcc aggcagccac tgaacatcgt caatgacact atctggaagt
     1141 tctgtcagaa accctggaga ctggtggaag acagctaccc tgggcaggag cgctggctac
     1201 gggactactg tgcctcaggc ctatacatcc tcgtgttgct gctggagggc tacaaattca
     1261 gtgaggagac ctggcccaac atccagttcc agaagcaggc aggcggcacg gacattggct
     1321 ggacactggg cttcatgctg aacctgacag gcatgatccc agctgaggcg ctgacccagt
     1381 ggcgggctca gagctacagc atctggatag ctggagtagt gtttgcagtg ctgaccctcg
     1441 tggccattct tggggcagct gcagtccagc tcttctggac ccaggactag gtagaaacaa
     1501 agctgatggc gatgtctaaa gcagaaaaag tcgatggtga caacacggct gtttgtgttg
     1561 tcaccacagg accttctgag cacatcctag acgcctgccc tcatgagccc ctgacacttg
     1621 agggctccag tctgctgagc aggccaggag agccacttgc tgacagtgct gactcctctg
     1681 tgccctcagg gcggcactgt ccatggggac tgttagttgc cccagggata gaaacaa
//
