LOCUS       NM_053498               2458 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus ectonucleoside triphosphate diphosphohydrolase 6
            (Entpd6), transcript variant 1, mRNA.
ACCESSION   NM_053498
VERSION     NM_053498.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2458)
  AUTHORS   O'Keeffe,M.G., Thorne,P.R., Housley,G.D., Robson,S.C. and
            Vlajkovic,S.M.
  TITLE     Hair cell specific NTPDase6 immunolocalisation in vestibular end
            organs: potential role of purinergic signaling in vestibular
            sensory transduction
  JOURNAL   J Vestib Res 22 (5-6), 213-219 (2012)
   PUBMED   23302703
  REMARK    GeneRIF: NTPDase6 immunolocalisation in the vestibular end organ
            could be linked to the regulation of P2 receptor signalling and
            sensory transduction, including maintenance of vestibular hair
            bundles.
REFERENCE   2  (bases 1 to 2458)
  AUTHORS   Ivanenkov,V.V., Murphy-Piedmonte,D.M. and Kirley,T.L.
  TITLE     Bacterial expression, characterization, and disulfide bond
            determination of soluble human NTPDase6 (CD39L2) nucleotidase:
            implications for structure and function
  JOURNAL   Biochemistry 42 (40), 11726-11735 (2003)
   PUBMED   14529283
REFERENCE   3  (bases 1 to 2458)
  AUTHORS   Hicks-Berger,C.A., Chadwick,B.P., Frischauf,A.M. and Kirley,T.L.
  TITLE     Expression and characterization of soluble and membrane-bound human
            nucleoside triphosphate diphosphohydrolase 6 (CD39L2)
  JOURNAL   J Biol Chem 275 (44), 34041-34045 (2000)
   PUBMED   10948193
REFERENCE   4  (bases 1 to 2458)
  AUTHORS   Braun,N., Fengler,S., Ebeling,C., Servos,J. and Zimmermann,H.
  TITLE     Sequencing, functional expression and characterization of rat
            NTPDase6, a nucleoside diphosphatase and novel member of the
            ecto-nucleoside triphosphate diphosphohydrolase family
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 639-647 (2000)
   PUBMED   11042118
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ277748.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ277748.1, SRR8487231.76011.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132287, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2458
                     /gene="Entpd6"
                     /note="ectonucleoside triphosphate diphosphohydrolase 6"
                     /db_xref="GeneID:85260"
                     /db_xref="RGD:619725"
     exon            1..96
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            97..420
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1496
                     /gene="Entpd6"
                     /EC_number="3.6.1.6"
                     /function="ecto-nucleoside triphosphate
                     diphosphohydrolase"
                     /note="NTPDase 6; CD39 antigen-like 2"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase
                     6"
                     /protein_id="NP_445950.1"
                     /db_xref="GeneID:85260"
                     /db_xref="RGD:619725"
                     /translation="MRKIPNHGTLRMTKVAYPLGLCVGLFIYVAYIKWHRASAAQAFF
                     TIAGAASGVRWTQQAFSSPDSATRGHEVFYGIMFDAGSTGTRIHVFQFARPPGETPTL
                     THETFKALKPGLSAYADDVEKSAQGIQELLNVAKQHIPYDFWKATPLVLKATAGLRLL
                     PGEKAQKLLQKVKEVFKASPFLVGDDCVSIMNGTDEGVSAWITVNFLTGSLKTPGSSS
                     VGMLDLGGGSTQITFLPRVEGTLQASPPGHLTALQMFNRTFKLYSYSYLGLGLMSARL
                     AILGGVEGKPAEDDKELVSPCLSPRFRGKWEHAEVTYRISGQKAVGLYELCASRVSEV
                     LRNKVHRTEEAQHVDFYAFSYYYDLAASFGLIDAEKGGSLVVGDFEIAAKYVCRTLET
                     QPPSSPFACMDLTYISLLLHEFGFPGDKVLKLARKIDNVETSWALGAIFHYIDSLKRQ
                     KVPAL"
     exon            421..497
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            498..641
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            642..717
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            718..753
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            754..842
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            843..922
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            923..987
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1089
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1227
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1284
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1397
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..2441
                     /gene="Entpd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcggctaag gtctggttcc acgcgttgag gctctgttga cgcggactgg cgctggagag
       61 ccaagcgctc ggtgtgtggt cgctgtctgc ctccagcacc ggctacatag tccctagcag
      121 actgagaaat gagaaaaata ccaaaccatg ggaccttgcg gatgacgaag gtggcgtatc
      181 ccctgggact gtgcgtgggc ctgttcatct atgttgccta tatcaagtgg caccgggcct
      241 ccgccgccca ggccttcttc accattgctg gggctgcctc aggagtgcgg tggacccaac
      301 aggccttcag ctctccagac tcagccacac gtggtcacga ggtcttctat gggatcatgt
      361 ttgatgccgg gagtaccggc acccgcatcc acgtcttcca gtttgcccgg ccacctggag
      421 aaactcccac cttgacccac gaaaccttca aagctctgaa gcctgggctt tctgcgtatg
      481 ccgatgatgt tgaaaagagc gcccaaggga tccaggagct tctgaatgtc gccaagcaac
      541 acattccata cgacttctgg aaggccaccc ctctggttct caaggccaca gctggtctgc
      601 gcctgctgcc gggagaaaag gctcagaagt tgctgcaaaa ggtgaaggag gtgtttaagg
      661 catcaccctt ccttgtaggg gatgactgtg tttccatcat gaatggcaca gatgaaggtg
      721 tttcggcttg gatcactgtc aacttcctga caggcagtct gaagacccca ggaagcagca
      781 gtgtgggcat gctggacttg ggcggaggat ccactcagat caccttcctc ccacgtgtcg
      841 agggtaccct gcaggcctcc ccacccggcc acctgacagc gctgcagatg tttaacagga
      901 ctttcaagct gtattcctac agctacctgg ggctgggact gatgtcggca cgactggcta
      961 tcttgggtgg tgtggagggg aaacctgctg aggatgacaa ggaactggtc agcccctgtc
     1021 tgtctccccg gttcagagga aagtgggagc atgcggaggt cacctataga atttcaggac
     1081 agaaggcagt gggcctctac gagctgtgtg ccagcagggt atcagaagtc ctccgcaata
     1141 aagtacacag gacagaagag gcgcagcacg tggacttcta tgcgttttcc tactactacg
     1201 accttgctgc cagctttggc cttatagatg cagagaaagg aggcagcctt gtagttggag
     1261 actttgagat agcagccaag tatgtctgcc gcactctgga gacacagcct ccaagcagcc
     1321 cctttgcttg catggacctc acctacatca gcctcctgct ccacgagttt ggttttcccg
     1381 gggacaaggt actgaagctg gctcggaaaa ttgacaatgt tgaaaccagc tgggctctgg
     1441 gggctatttt tcattacatc gactccctga agagacagaa ggttcctgcc ttgtagcagc
     1501 ctcgaactag tccccaccct agccagattt ccgaggctcc caactccacg gacccctcta
     1561 tcttggaagt gacaccatcc ttgaggagcc tgcatctggt tgagacccgc ctctgtgcct
     1621 gcagtgtcat ctcctgcaga tttgcctggg acatgaccca tgtactggct ctgctacacc
     1681 acactagctg gggcagggcc agggtaggaa tgctgcctgg cctgaggcca tctccctgtc
     1741 ttacccccaa atgggcgggg agccagctgg ggcccagggc acatgctaag gtagagacgc
     1801 agccctgctc ttatcccgtc cgtgtgcagg attgtggctg cttttgtgtg tttctgtgac
     1861 ttgagtcttg ttttgtctcc cagcccccgt tccctcatga gttgggcctc tctgccttcc
     1921 cagagtttgg cgagatgaag taactggccc aaacgcagtg caaggggagc acattttgag
     1981 tgtggccatc tcttcctcgg gatagacgtg aagttacctg gaggtttgct gtcccacctt
     2041 tggatggtat agcattcatt gatgtgggga cattgagtag gaaggagatg gggcagtgcc
     2101 tctttataga cctttgcaga gcatgtgggt gtgagcagag ctatgagaat gttcagggct
     2161 gcgtgctcaa gtactacctt gcaagctgtg agcgctgtac gttaaaactg agcccctctt
     2221 ctggacacag cggtgtcccc gtgaatgtat tactgctatg agccacttgc agaccagtgg
     2281 ggcaggttag aaagctcagc cctagaacca gactacccct caccccaccc tccttactcg
     2341 gctgcagctg gcttccccgt ggtcccctca gtgaatgtac agttcataga gtaagctgag
     2401 ccaccaccgt tcaactccaa ataaaggttt acaagggttt caaaaaaaaa aaaaaaaa
//
