LOCUS       NM_199394               1798 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus ectonucleoside triphosphate diphosphohydrolase 5
            (Entpd5), mRNA.
ACCESSION   NM_199394 XM_234411
VERSION     NM_199394.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Baldissarelli,J., Santi,A., Schmatz,R., Zanini,D., Cardoso,A.M.,
            Abadalla,F.H., Thome,G.R., Murussi,C., Polachini,C.R.N.,
            Delenogare,D.P., Loro,V.L., Morsch,V.M. and Schetinger,M.R.C.
  TITLE     Quercetin changes purinergic enzyme activities and oxidative
            profile in platelets of rats with hypothyroidism
  JOURNAL   Biomed Pharmacother 84, 1849-1857 (2016)
   PUBMED   27832996
  REMARK    GeneRIF: Quercetin decreases NTPDase, 5'-nucleotidase and adenosine
            deaminase activities in blood platelets of hypothyroid rats, and
            improves the oxidative profile to reduce platelet aggregation.
REFERENCE   2  (bases 1 to 1798)
  AUTHORS   Fang,M., Shen,Z., Huang,S., Zhao,L., Chen,S., Mak,T.W. and Wang,X.
  TITLE     The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg
            effect, and proliferation in the PTEN pathway
  JOURNAL   Cell 143 (5), 711-724 (2010)
   PUBMED   21074248
REFERENCE   3  (bases 1 to 1798)
  AUTHORS   Murphy-Piedmonte,D.M., Crawford,P.A. and Kirley,T.L.
  TITLE     Bacterial expression, folding, purification and characterization of
            soluble NTPDase5 (CD39L4) ecto-nucleotidase
  JOURNAL   Biochim Biophys Acta 1747 (2), 251-259 (2005)
   PUBMED   15698960
REFERENCE   4  (bases 1 to 1798)
  AUTHORS   Solanas,M., Escrich,E., Rouzaut,A., Costa,I., Martinez,A. and
            Notario,V.
  TITLE     Deregulated expression of the PCPH proto-oncogene in rat mammary
            tumors induced with 7,12-dimethylbenz[a]anthracene
  JOURNAL   Mol Carcinog 33 (4), 219-227 (2002)
   PUBMED   11933075
  REMARK    GeneRIF: the expression of of PCPH in benign and malignant mammary
            tumors (PCPH)
REFERENCE   5  (bases 1 to 1798)
  AUTHORS   Mulero,J.J., Yeung,G., Nelken,S.T., Bright,J.M., McGowan,D.W. and
            Ford,J.E.
  TITLE     Biochemical characterization of CD39L4
  JOURNAL   Biochemistry 39 (42), 12924-12928 (2000)
   PUBMED   11041857
REFERENCE   6  (bases 1 to 1798)
  AUTHORS   Mulero,J.J., Yeung,G., Nelken,S.T. and Ford,J.E.
  TITLE     CD39-L4 is a secreted human apyrase, specific for the hydrolysis of
            nucleoside diphosphates
  JOURNAL   J Biol Chem 274 (29), 20064-20067 (1999)
   PUBMED   10400613
REFERENCE   7  (bases 1 to 1798)
  AUTHORS   Trombetta,E.S. and Helenius,A.
  TITLE     Glycoprotein reglucosylation and nucleotide sugar utilization in
            the secretory pathway: identification of a nucleoside diphosphatase
            in the endoplasmic reticulum
  JOURNAL   EMBO J 18 (12), 3282-3292 (1999)
   PUBMED   10369669
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_199394.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062044.1, SRR26643297.23306.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                JAXUCZ010000006.1  109783052-109783121 c
            71-143              JAXUCZ010000006.1  109773251-109773323 c
            144-423             JAXUCZ010000006.1  109770611-109770890 c
            424-503             JAXUCZ010000006.1  109769150-109769229 c
            504-647             JAXUCZ010000006.1  109766945-109767088 c
            648-723             JAXUCZ010000006.1  109762983-109763058 c
            724-759             JAXUCZ010000006.1  109762731-109762766 c
            760-848             JAXUCZ010000006.1  109762159-109762247 c
            849-928             JAXUCZ010000006.1  109761815-109761894 c
            929-990             JAXUCZ010000006.1  109761160-109761221 c
            991-1092            JAXUCZ010000006.1  109760242-109760343 c
            1093-1233           JAXUCZ010000006.1  109758656-109758796 c
            1234-1290           JAXUCZ010000006.1  109756679-109756735 c
            1291-1406           JAXUCZ010000006.1  109755312-109755427 c
            1407-1798           JAXUCZ010000006.1  109753187-109753578 c
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..1798
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /note="ectonucleoside triphosphate diphosphohydrolase 5"
                     /db_xref="GeneID:314312"
                     /db_xref="RGD:735219"
     exon            1..70
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            71..143
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            144..423
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1493
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /EC_number="3.6.1.6"
                     /note="NTPDase 5; GDPase ENTPD5; UDPase ENTPD5;
                     uridine-diphosphatase ENTPD5; guanosine-diphosphatase
                     ENTPD5"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase 5
                     precursor"
                     /protein_id="NP_955426.2"
                     /db_xref="GeneID:314312"
                     /db_xref="RGD:735219"
                     /translation="MATSWASVFMLIIAYVGGTVFYREQQTWFEGVFLSSMCPVNVSA
                     GTFYGIMFDAGSTGTRIHVYTFVQRTSGQLPFLEGEIFDSVKPGLSAFVDQPKQGAET
                     VQELLEVAKDSIPRSHWKRTPVVLKATAGLRLLPEQKAQTLLLEVEEIFKNSPFLVPD
                     DSVSIMDGSYEGILAWVTVNFLTGQLHGRGQETVGTLDLGGASTQITFLPQLEKTLEQ
                     TPKGYLASFEMFNSTFKLYTHSYLGFGLKAARLATLGALEAEGTDGHTFRSACLPRWL
                     EAEWIFGGVKYQYGGNQEGEMGFEPCYAEVRRVVQGKLHQPEEIRGSSFYAFSYYYDR
                     AAETHLIDYEKGGVLKVEDFERKAREVCDNLESFSSGSPFLCMDLSYITALLKDGFGF
                     EDGTLLQLTKKVNNIETGWALGATFHLLQSLGITS"
     exon            424..503
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            504..647
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            648..723
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            724..759
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            760..848
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            849..928
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            929..990
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1092
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1233
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1290
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1406
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1798
                     /gene="Entpd5"
                     /gene_synonym="Pcph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcttggttg acacagaaat gaagagtatc ttggctgaat attcaagcag aggcgatcat
       61 tatgaccctg ctttttaaat tggcctacaa gaccagccta cttgctataa aagaagaatc
      121 tgccaaaggg agggctttac agacctccac aggggtgtga gcagcactgc ttcagcaaca
      181 gagcctcagg tccacatcgt gggaagagta tggccacgtc ctgggcgtcc gtcttcatgc
      241 tgatcatagc ctatgttggt ggcactgtct tctacagaga acagcagact tggtttgagg
      301 gtgtcttctt gtcttccatg tgccccgtta atgtcagtgc cggcaccttt tatggaatca
      361 tgtttgatgc gggcagcact ggaactcgga ttcacgttta cacctttgtg cagagaacat
      421 caggacagct cccctttctg gaaggtgaaa tttttgattc tgtgaagccg ggactttctg
      481 cttttgtgga tcaacccaaa cagggtgctg agactgttca agaactctta gaggtggcca
      541 aggactcaat ccccagaagt cactggaagc ggacgccagt ggttctgaag gcaacggctg
      601 gactgcgatt gctgccagaa cagaaagccc agaccctgct cttggaggta gaggagatct
      661 tcaagaattc acctttcctg gtcccggatg acagcgttag catcatggat gggtcctatg
      721 aaggcatatt agcttgggtt accgtgaact ttctaacagg tcagctgcat ggccgtggcc
      781 aggagactgt ggggaccctt gacctggggg gtgcctccac ccaaatcacg tttctaccgc
      841 agttggagaa aaccctggaa caaacaccta agggctacct cgcttccttt gagatgttta
      901 acagcacttt taagctctat acacatagtt acttgggatt tggactgaaa gctgcaagac
      961 tagcgactct gggagctctg gaagcagaag ggactgatgg acatactttc cgaagtgcct
     1021 gtttaccaag atggttggaa gcagagtgga tctttggggg tgtgaaatat cagtatggtg
     1081 gtaaccaaga aggggagatg ggctttgagc cctgctatgc agaagtgcgg agggtagttc
     1141 aaggaaaact tcaccagcca gaagagattc gaggaagctc cttttatgct ttctcctact
     1201 attatgatcg agctgccgag acacacttga ttgattatga aaaggggggt gttttgaagg
     1261 ttgaagattt tgaaagaaaa gccagggaag tgtgtgacaa cttggagagc ttctcctcag
     1321 gcagtccttt cctctgcatg gacctcagtt acatcacagc cttattgaaa gatggctttg
     1381 gctttgagga tggcaccctc ttacagctca caaagaaagt gaacaacata gagactggtt
     1441 gggccttggg agccaccttt cacctgctcc agtccctggg tatcaccagc tgaggcgaag
     1501 cacgtcctct gaaacctgcg tttctgaaca cttgttttta caggaaggag tggactcaga
     1561 cattttctga ccttctctgg gaaaagcctg gaccgaaacc tgttaactgg ctttattagg
     1621 agggaggggt ttgtagatga gtcctgccct tgagcctagc gatttgggct tagctaattt
     1681 tgcacatcta atgtgaatga ctccctaacc acttggtggg catatagctg gtaccagagt
     1741 gtaaatcttt tgagattctt tgttaagtta cagagtcctg caaagaaaaa aaaaaaaa
//
