LOCUS       NM_178106               3066 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ectonucleoside triphosphate diphosphohydrolase 3
            (Entpd3), mRNA.
ACCESSION   NM_178106
VERSION     NM_178106.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3066)
  AUTHORS   Grkovic,I., Bjelobaba,I., Mitrovic,N., Lavrnja,I., Drakulic,D.,
            Martinovic,J., Stanojlovic,M., Horvat,A. and Nedeljkovic,N.
  TITLE     Expression of ecto-nucleoside triphosphate diphosphohydrolase3
            (NTPDase3) in the female rat brain during postnatal development
  JOURNAL   J Chem Neuroanat 77, 10-18 (2016)
   PUBMED   27049676
  REMARK    GeneRIF: Prominent enhancement of NTPDase3-ir in the hypothalamus
            coincides with age when animals acquire diurnal rhythms of sleeping
            and feeding, supporting the hypothesis that this enzyme may be
            involved in regulation of homeostatic functions
REFERENCE   2  (bases 1 to 3066)
  AUTHORS   Bjelobaba,I., Lavrnja,I., Parabucki,A., Stojkov,D.,
            Stojiljkovic,M., Pekovic,S. and Nedeljkovic,N.
  TITLE     The cortical stab injury induces beading of fibers expressing
            ecto-nucleoside triphosphate diphosphohydrolase 3
  JOURNAL   Neuroscience 170 (1), 107-116 (2010)
   PUBMED   20620196
  REMARK    GeneRIF: Cortical stab injury induces rapid varicose swelling on
            ectonucleoside triphosphate diphosphohydrolase 3-positive nerve
            fibers.
REFERENCE   3  (bases 1 to 3066)
  AUTHORS   Zsarnovszky,A., Bartha,T., Frenyo,L.V. and Diano,S.
  TITLE     NTPDases in the neuroendocrine hypothalamus: possible energy
            regulators of the positive gonadotrophin feedback
  JOURNAL   Reprod Biol Endocrinol 7, 63 (2009)
   PUBMED   19527530
  REMARK    GeneRIF: we hypothesize that NTPDase-activity in neurons of the AN
            may play a permissive role in the regulation of the
            estrogen-induced pituitary LH-surge
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3066)
  AUTHORS   Kiss,D.S., Zsarnovszky,A., Horvath,K., Gyorffy,A., Bartha,T.,
            Hazai,D., Sotonyi,P., Somogyi,V., Frenyo,L.V. and Diano,S.
  TITLE     Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral
            and lateral hypothalamic area of female rats: morphological
            characterization and functional implications
  JOURNAL   Reprod Biol Endocrinol 7, 31 (2009)
   PUBMED   19383175
  REMARK    GeneRIF: NTPDase3 has a role in the hypothalamus in the regulation
            of purinergic signaling and the tuning of energy supply for
            neurotransmission.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3066)
  AUTHORS   Zebisch,M. and Strater,N.
  TITLE     Characterization of Rat NTPDase1, -2, and -3 ectodomains refolded
            from bacterial inclusion bodies
  JOURNAL   Biochemistry 46 (42), 11945-11956 (2007)
   PUBMED   17910474
  REMARK    GeneRIF: NTPDase3 ectodomain refolded from bacterial inclusion
            bodies was characterized.
REFERENCE   6  (bases 1 to 3066)
  AUTHORS   Belcher,S.M., Zsarnovszky,A., Crawford,P.A., Hemani,H., Spurling,L.
            and Kirley,T.L.
  TITLE     Immunolocalization of ecto-nucleoside triphosphate
            diphosphohydrolase 3 in rat brain: implications for modulation of
            multiple homeostatic systems including feeding and sleep-wake
            behaviors
  JOURNAL   Neuroscience 137 (4), 1331-1346 (2006)
   PUBMED   16338080
  REMARK    GeneRIF: NTPDase3, by regulating the extracellular turnover of ATP,
            may modulate feeding, sleep-wake, and other behaviors through
            diverse homeostatic systems.
REFERENCE   7  (bases 1 to 3066)
  AUTHORS   Lavoie,E.G., Kukulski,F., Levesque,S.A., Lecka,J. and Sevigny,J.
  TITLE     Cloning and characterization of mouse nucleoside triphosphate
            diphosphohydrolase-3
  JOURNAL   Biochem Pharmacol 67 (10), 1917-1926 (2004)
   PUBMED   15130768
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_178106.4.
            
            On Nov 27, 2020 this sequence version replaced NM_178106.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ437217.1, SRR26643298.47247.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000008.1  129124709-129124910
            203-254             JAXUCZ010000008.1  129125431-129125482
            255-382             JAXUCZ010000008.1  129129254-129129381
            383-500             JAXUCZ010000008.1  129141354-129141471
            501-651             JAXUCZ010000008.1  129142936-129143086
            652-811             JAXUCZ010000008.1  129145234-129145393
            812-1045            JAXUCZ010000008.1  129146221-129146454
            1046-1318           JAXUCZ010000008.1  129148682-129148954
            1319-1429           JAXUCZ010000008.1  129149134-129149244
            1430-1567           JAXUCZ010000008.1  129150202-129150339
            1568-3066           JAXUCZ010000008.1  129154030-129155528
FEATURES             Location/Qualifiers
     source          1..3066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3066
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /note="ectonucleoside triphosphate diphosphohydrolase 3"
                     /db_xref="GeneID:316077"
                     /db_xref="RGD:631326"
     exon            1..202
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
     exon            203..254
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1804
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /EC_number="3.6.1.5"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase
                     3"
                     /protein_id="NP_835207.1"
                     /db_xref="GeneID:316077"
                     /db_xref="RGD:631326"
                     /translation="MFTVMTRQPCEQAGFRALSRTPAIVTLVVLLVSIVVLVTLTLIQ
                     IHHPQVLSPGLKYGIVLDAGSSRTTVYVYQWPAEKENNTGVVSQTFRCSVKGSGISSY
                     ENNPQDAPKAFEDCMLKVKEQVPKHLHESTRVYLGATAGMRLLRLQNETAAHEVLESI
                     QSYFKSQPFDFRGAQIISGQEEGVYGWITANYIMGNFLEKNLWHMWVHPHGVDTTGAL
                     DLGGASTQISFVSEEKMEPNASDTVQVSLYGYTYTLYTHSFQCYGRNEAEKKFLAMLL
                     QSPSTDANISNPCYPHGYSTTFTMGHVFGSLCTEKQRPKSYNPSDTITFTGTGDPQLC
                     REKVASVFDFSACQEQDACSFDGIYQPKVQGPFVAFAGFYYTASALNLSGSFSLTSFN
                     DSSWDFCRHTWSELPSLLPRFDETYARSYCFSAHYIYHLLINGYKFTEATWPQIRFEK
                     EVGNSSIAWSLGYMLSLTNQIPAGSPLIQLPIQPPVFMGVLAFFTAIALLCLAFLFYL
                     CSAFRTKERSENAFDQAVDSD"
     exon            255..382
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
     exon            383..500
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
     exon            501..651
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
     exon            652..811
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1045
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1318
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1429
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1567
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..3066
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgagcgca gcgcgcaggt aaggtctgga ccggcgcgca ggagtgggat ggagcaggct
       61 gcgggaggct tgaagcaggg agagaaggac ccggcacagc ttcccacaga ggaccgcagg
      121 ctggagccga aacccgggga gctgggcact gtcatctgac aggcacagga caccgcgtca
      181 cgaaacgccc caagacctgc agctcggact gaagatgttt acggtgatga cccgccagcc
      241 ctgtgaacag gcaggcttca gggccctctc gaggactcca gccatcgtca ccttggtggt
      301 cctgcttgtg agcatcgtgg tacttgtgac acttacactc atccagatcc accacccaca
      361 ggttctctct ccagggctga agtatggaat cgtgttggat gccggctctt ccagaaccac
      421 tgtctatgtg tatcagtggc cagcagagaa ggagaataac acaggagtgg tcagccaaac
      481 cttcagatgt agtgtgaaag gctcgggaat ctccagctat gagaataacc cccaagatgc
      541 ccccaaagcc tttgaggact gcatgctaaa ggtcaaggaa caggtcccaa agcatctcca
      601 cgaatccacc cgagtttacc tgggggccac agctgggatg cgcttgctga ggttgcaaaa
      661 tgagacagca gctcatgaag tccttgagag catccaaagc tacttcaagt cccagccttt
      721 tgattttagg ggtgctcaaa tcatttctgg gcaagaggaa ggggtgtatg gatggattac
      781 agccaactat ataatgggaa atttcctgga gaagaacctg tggcacatgt gggtgcaccc
      841 gcacggagta gacaccacag gagccctgga tttgggcggc gcctccaccc agatatcctt
      901 tgtgtcggaa gagaagatgg agccgaacgc cagcgacaca gtgcaggtgt ccttgtacgg
      961 ctacacgtac actctctaca cgcacagttt ccagtgctac ggccggaacg aagcagagaa
     1021 gaagttcctg gcgatgcttc tgcagagccc ttctacagat gccaacatca gcaacccctg
     1081 ctaccctcac ggttacagca ccaccttcac aatgggccac gtgtttggca gcctgtgcac
     1141 ggagaagcag aggccgaaga gctacaaccc cagtgatacc atcaccttca caggaactgg
     1201 tgacccacag ctgtgcaggg agaaggtggc ttctgtgttt gacttcagtg cttgccaaga
     1261 gcaagatgcc tgctcctttg atggcattta ccagcccaag gttcaagggc catttgtggc
     1321 atttgcagga ttctattaca cagccagtgc cctaaacctc tctggaagct tctcccttac
     1381 ctccttcaat gacagcagct gggacttctg cagacacact tggagcgagc tcccgtccct
     1441 gctccccaga tttgatgaga cgtatgcccg gtcctactgc ttctcagccc actacatcta
     1501 ccacttgctc ataaatggat acaaattcac tgaggcaact tggcctcaga tacggtttga
     1561 aaaagaagtg gggaatagca gcatcgcctg gtccctaggc tacatgctca gcttgaccaa
     1621 ccagatccca gctggaagtc cgctgatcca actacccata cagccgccgg tgtttatggg
     1681 agtcctggcc ttcttcacgg ctatcgcctt gctgtgcctg gcatttcttt tctatctatg
     1741 ttcagcattt aggacaaagg agcgctctga gaatgccttt gaccaagcag tggattctga
     1801 ttgaatcttc caagcagcac ctggggcctg aggctgccat aacccaccag agtgacacca
     1861 ggcagggagt gaagtggctg ccaccaggac ctgtcccgtg gttaaatgcc aagatcacgt
     1921 gcctctcagc cactggttcc tgctggagca cctcctggga gtccctcagc cacccagtgg
     1981 gtgttgcctc tgcacccttc gtacccgctt gctgatccat tggaaatcaa ggagacactg
     2041 gcagttggtg tcaagggctt caccctgtct cctccagagg atgttgagag tataatttaa
     2101 ttcggaagga ttgacccagg ctgggtttcc attttctctc cctccgtatt cctcctagca
     2161 agctgcccag gaaggctctg actcagacac ttcaccctgt aggtttgacc tgtagttcct
     2221 ttgcaaggcc ttccagtctt ttagttgagt ggggccctat ctcaagccac tgatactttc
     2281 tcttagcaat ctggtaagca ctaagctccc tgactggtag cttgtagcac ttagcaggga
     2341 agatgatacc ttttgagaca gagtttcatg tagcccattc actatgtagc caagaccact
     2401 cactaagtag ctcttttcct gagggctgcg attatgggtt gtgaggtcct gggggtggaa
     2461 ccccagggct tcatgtatgc taggcaatta ttcgaccagc ctgagtcaca tgcccagcct
     2521 aagaagactc acagccccaa ggacagacgg cctctgtcat gtaggcagaa cctgaagcac
     2581 aaagccacac aggagtccct aagctattag ctattcttat tttggaatgc ccacttggag
     2641 ctctggtcat gactttgcta cttggagtat gtcatccttg tgtaactgcc tccccgctgt
     2701 tccctcttgt aaatcgcacc cagtggactg caccaaggtg ggaggttggg ggtggatccc
     2761 attgacctga caaagctcct gcccaaggtg cctttgggct ataaccatgt cggcgtgtgc
     2821 tttcttccca ctgctcccac aggtatccag gatcctgtcc aaaaaacatc cctacgtttc
     2881 ttcctgcata actgcttccc agcttgactt tggggaaaga aaaggcagtc ttgggaatgt
     2941 ttgcttccaa agtgggatgg gaaaggtctt caaacccagt agctacaagc gacaaatcaa
     3001 tgctgtgcct caaggctggt cgttggctcc atatggaata aactattatt tttattttgc
     3061 aatatg
//
