LOCUS       NP_835207                529 aa            linear   ROD 10-OCT-2024
DEFINITION  ectonucleoside triphosphate diphosphohydrolase 3 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_835207
VERSION     NP_835207.1
DBSOURCE    REFSEQ: accession NM_178106.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 529)
  AUTHORS   Grkovic,I., Bjelobaba,I., Mitrovic,N., Lavrnja,I., Drakulic,D.,
            Martinovic,J., Stanojlovic,M., Horvat,A. and Nedeljkovic,N.
  TITLE     Expression of ecto-nucleoside triphosphate diphosphohydrolase3
            (NTPDase3) in the female rat brain during postnatal development
  JOURNAL   J Chem Neuroanat 77, 10-18 (2016)
   PUBMED   27049676
  REMARK    GeneRIF: Prominent enhancement of NTPDase3-ir in the hypothalamus
            coincides with age when animals acquire diurnal rhythms of sleeping
            and feeding, supporting the hypothesis that this enzyme may be
            involved in regulation of homeostatic functions
REFERENCE   2  (residues 1 to 529)
  AUTHORS   Bjelobaba,I., Lavrnja,I., Parabucki,A., Stojkov,D.,
            Stojiljkovic,M., Pekovic,S. and Nedeljkovic,N.
  TITLE     The cortical stab injury induces beading of fibers expressing
            ecto-nucleoside triphosphate diphosphohydrolase 3
  JOURNAL   Neuroscience 170 (1), 107-116 (2010)
   PUBMED   20620196
  REMARK    GeneRIF: Cortical stab injury induces rapid varicose swelling on
            ectonucleoside triphosphate diphosphohydrolase 3-positive nerve
            fibers.
REFERENCE   3  (residues 1 to 529)
  AUTHORS   Zsarnovszky,A., Bartha,T., Frenyo,L.V. and Diano,S.
  TITLE     NTPDases in the neuroendocrine hypothalamus: possible energy
            regulators of the positive gonadotrophin feedback
  JOURNAL   Reprod Biol Endocrinol 7, 63 (2009)
   PUBMED   19527530
  REMARK    GeneRIF: we hypothesize that NTPDase-activity in neurons of the AN
            may play a permissive role in the regulation of the
            estrogen-induced pituitary LH-surge
            Review article
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 529)
  AUTHORS   Kiss,D.S., Zsarnovszky,A., Horvath,K., Gyorffy,A., Bartha,T.,
            Hazai,D., Sotonyi,P., Somogyi,V., Frenyo,L.V. and Diano,S.
  TITLE     Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral
            and lateral hypothalamic area of female rats: morphological
            characterization and functional implications
  JOURNAL   Reprod Biol Endocrinol 7, 31 (2009)
   PUBMED   19383175
  REMARK    GeneRIF: NTPDase3 has a role in the hypothalamus in the regulation
            of purinergic signaling and the tuning of energy supply for
            neurotransmission.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 529)
  AUTHORS   Zebisch,M. and Strater,N.
  TITLE     Characterization of Rat NTPDase1, -2, and -3 ectodomains refolded
            from bacterial inclusion bodies
  JOURNAL   Biochemistry 46 (42), 11945-11956 (2007)
   PUBMED   17910474
  REMARK    GeneRIF: NTPDase3 ectodomain refolded from bacterial inclusion
            bodies was characterized.
REFERENCE   6  (residues 1 to 529)
  AUTHORS   Belcher,S.M., Zsarnovszky,A., Crawford,P.A., Hemani,H., Spurling,L.
            and Kirley,T.L.
  TITLE     Immunolocalization of ecto-nucleoside triphosphate
            diphosphohydrolase 3 in rat brain: implications for modulation of
            multiple homeostatic systems including feeding and sleep-wake
            behaviors
  JOURNAL   Neuroscience 137 (4), 1331-1346 (2006)
   PUBMED   16338080
  REMARK    GeneRIF: NTPDase3, by regulating the extracellular turnover of ATP,
            may modulate feeding, sleep-wake, and other behaviors through
            diverse homeostatic systems.
REFERENCE   7  (residues 1 to 529)
  AUTHORS   Lavoie,E.G., Kukulski,F., Levesque,S.A., Lecka,J. and Sevigny,J.
  TITLE     Cloning and characterization of mouse nucleoside triphosphate
            diphosphohydrolase-3
  JOURNAL   Biochem Pharmacol 67 (10), 1917-1926 (2004)
   PUBMED   15130768
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ437217.1, SRR22582416.909164.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..529
                     /product="ectonucleoside triphosphate diphosphohydrolase 3
                     isoform 1"
                     /EC_number="3.6.1.5"
                     /calculated_mol_wt=58983
     Region          57..468
                     /region_name="ASKHA_NBD_NTPDase3"
                     /note="nucleotide-binding domain (NBD) of ectonucleoside
                     triphosphate diphosphohydrolase 3 (NTPDase3) and similar
                     proteins; cd24112"
                     /db_xref="CDD:466962"
     CDS             1..529
                     /gene="Entpd3"
                     /gene_synonym="NTPDase3"
                     /coded_by="NM_178106.4:244..1833"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="GeneID:316077"
                     /db_xref="RGD:631326"
ORIGIN      
        1 mftvmtrqpc eqagfralsr tpaivtlvvl lvsivvlvtl tliqihhpqv lspglkygiv
       61 ldagssrttv yvyqwpaeke nntgvvsqtf rcsvkgsgis syennpqdap kafedcmlkv
      121 keqvpkhlhe strvylgata gmrllrlqne taahevlesi qsyfksqpfd frgaqiisgq
      181 eegvygwita nyimgnflek nlwhmwvhph gvdttgaldl ggastqisfv seekmepnas
      241 dtvqvslygy tytlythsfq cygrneaekk flamllqsps tdanisnpcy phgysttftm
      301 ghvfgslcte kqrpksynps dtitftgtgd pqlcrekvas vfdfsacqeq dacsfdgiyq
      361 pkvqgpfvaf agfyytasal nlsgsfslts fndsswdfcr htwselpsll prfdetyars
      421 ycfsahyiyh llingykfte atwpqirfek evgnssiaws lgymlsltnq ipagspliql
      481 piqppvfmgv lafftaiall claflfylcs afrtkersen afdqavdsd
//
