LOCUS       NM_172030               1900 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ectonucleoside triphosphate diphosphohydrolase 2
            (Entpd2), mRNA.
ACCESSION   NM_172030
VERSION     NM_172030.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Maesawa,S., Yokoyama,T., Sakanoue,W., Yamamoto,Y., Hirakawa,M.,
            Shiraishi,H., Sato,K. and Saino,T.
  TITLE     ADP-mediated Modulation of Intracellular Calcium Responses in
            Chromaffin Cells: The Role of Ectonucleoside Triphosphate
            Diphosphohydrolase 2 on Rat Adrenal Medulla Function
  JOURNAL   J Histochem Cytochem 72 (1), 41-60 (2024)
   PUBMED   38158780
  REMARK    GeneRIF: ADP-mediated Modulation of Intracellular Calcium Responses
            in Chromaffin Cells: The Role of Ectonucleoside Triphosphate
            Diphosphohydrolase 2 on Rat Adrenal Medulla Function.
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Dragic,M., Mihajlovic,K., Adzic,M., Jakovljevic,M., Kontic,M.Z.,
            Mitrovic,N., Laketa,D., Lavrnja,I., Kipp,M., Grkovic,I. and
            Nedeljkovic,N.
  TITLE     Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2
            (NTPDase2) Is Negatively Regulated Under Neuroinflammatory
            Conditions In Vivo and In Vitro
  JOURNAL   ASN Neuro 14, 17590914221102068 (2022)
   PUBMED   35593054
  REMARK    GeneRIF: Expression of Ectonucleoside Triphosphate
            Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under
            Neuroinflammatory Conditions In Vivo and In Vitro.
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Brisevac,D., Adzic,M., Laketa,D., Parabucki,A., Milosevic,M.,
            Lavrnja,I., Bjelobaba,I., Sevigny,J., Kipp,M. and Nedeljkovic,N.
  TITLE     Extracellular ATP Selectively Upregulates Ecto-Nucleoside
            Triphosphate Diphosphohydrolase 2 and Ecto-5'-Nucleotidase by Rat
            Cortical Astrocytes In Vitro
  JOURNAL   J Mol Neurosci 57 (3), 452-462 (2015)
   PUBMED   26080748
  REMARK    GeneRIF: At the transcriptional level, extracellular ATP
            upregulated expression of NTPDase1, NTPDase2, NPP2, and eN, while,
            at translational and functional levels, these were paralleled only
            by the induction of NTPDase2 and ecto-5'-nucleotidase.
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Brisevac,D., Bajic,A., Bjelobaba,I., Milosevic,M., Stojiljkovic,M.,
            Beyer,C., Clarner,T., Kipp,M. and Nedeljkovic,N.
  TITLE     Expression of ecto-nucleoside triphosphate diphosphohydrolase1-3
            (NTPDase1-3) by cortical astrocytes after exposure to
            pro-inflammatory factors in vitro
  JOURNAL   J Mol Neurosci 51 (3), 871-879 (2013)
   PUBMED   23990338
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Zebisch,M., Krauss,M., Schafer,P., Lauble,P. and Strater,N.
  TITLE     Crystallographic snapshots along the reaction pathway of nucleoside
            triphosphate diphosphohydrolases
  JOURNAL   Structure 21 (8), 1460-1475 (2013)
   PUBMED   23830739
  REMARK    GeneRIF: Apo and complex structures of the rat NTPDase2
            extracellular domain and Legionella pneumophila NTPDase1.
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Sevigny,J., Sundberg,C., Braun,N., Guckelberger,O., Csizmadia,E.,
            Qawi,I., Imai,M., Zimmermann,H. and Robson,S.C.
  TITLE     Differential catalytic properties and vascular topography of murine
            nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and
            NTPDase2 have implications for thromboregulation
  JOURNAL   Blood 99 (8), 2801-2809 (2002)
   PUBMED   11929769
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Lu,Q., Porter,L.D., Cui,X. and Sanborn,B.M.
  TITLE     Ecto-ATPase mRNA is regulated by FSH in Sertoli cells
  JOURNAL   J Androl 22 (2), 289-301 (2001)
   PUBMED   11229804
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Vlajkovic,S.M., Housley,G.D., Greenwood,D. and Thorne,P.R.
  TITLE     Evidence for alternative splicing of ecto-ATPase associated with
            termination of purinergic transmission
  JOURNAL   Brain Res Mol Brain Res 73 (1-2), 85-92 (1999)
   PUBMED   10581401
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Mateo,J., Harden,T.K. and Boyer,J.L.
  TITLE     Functional expression of a cDNA encoding a human ecto-ATPase
  JOURNAL   Br J Pharmacol 128 (2), 396-402 (1999)
   PUBMED   10510450
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Kegel,B., Braun,N., Heine,P., Maliszewski,C.R. and Zimmermann,H.
  TITLE     An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in
            rat brain
  JOURNAL   Neuropharmacology 36 (9), 1189-1200 (1997)
   PUBMED   9364474
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF276940.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_172030.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF276940.1, BC086558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1900
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /note="ectonucleoside triphosphate diphosphohydrolase 2"
                     /db_xref="GeneID:64467"
                     /db_xref="RGD:69266"
     exon            1..118
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1489
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /EC_number="3.6.1.-"
                     /note="NTPDase 2; ecto-ATPase 2; ecto-ATPDase 2; ecto-ATP
                     diphosphohydrolase 2; testicular ecto-ATPase; CD39
                     antigen-like 1; nucleoside triphosphate diphosphohydrolase
                     2"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase
                     2"
                     /protein_id="NP_742027.1"
                     /db_xref="GeneID:64467"
                     /db_xref="RGD:69266"
                     /translation="MAGKLVSLVPPLLLAAAGLAGLLLLCVPTQDVREPPALKYGIVL
                     DAGSSHTSMFVYKWPADKENDTGIVGQHSSCDVQGGGISSYANDPSKAGQSLVRCLEQ
                     ALRDVPRDRHASTPLYLGATAGMRLLNLTSPEATARVLEAVTQTLTQYPFDFRGARIL
                     SGQDEGVFGWVTANYLLENFIKYGWVGRWIRPRKGTLGAMDLGGASTQITFETTSPSE
                     DPGNEVHLRLYGQHYRVYTHSFLCYGRDQILLRLLASALQIHRFHPCWPKGYSTQVLL
                     QEVYQSPCTMGQRPRAFNGSAIVSLSGTSNATLCRDLVSRLFNISSCPFSQCSFNGVF
                     QPPVTGNFIAFSAFYYTVDFLTTVMGLPVGTLKQLEEATEITCNQTWTELQARVPGQK
                     TRLADYCAVAMFIHQLLSRGYHFDERSFREVVFQKKAADTAVGWALGYMLNFTNLIPA
                     DLPGLRKGTHFSSWVALLLLFTVLILAALVLLLRQVRSAKSPGAL"
     exon            119..236
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /inference="alignment:Splign:2.1.0"
     exon            237..387
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..547
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /inference="alignment:Splign:2.1.0"
     exon            548..775
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..1030
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1150
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1285
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1886
                     /gene="Entpd2"
                     /gene_synonym="Cd39l1; NTPDase2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggctgga aagttggtgt cactggtgcc acccctgctg ctggctgccg cgggcctcgc
       61 cggccttctg ctactttgcg tccctaccca agacgtccgg gagccgcccg ccctcaagta
      121 cggcattgtc ctggatgcgg gctcttcaca cacatccatg tttgtctaca agtggccagc
      181 ggacaaggag aatgacacag gcatcgtggg ccagcacagc tcttgtgatg ttcaaggtgg
      241 tggcatctcc agctatgcaa atgacccctc taaggcaggc cagagtctgg tccgatgcct
      301 tgagcaggcc cttcgggatg tacccagaga cagacatgct agcacaccac tctacctggg
      361 agctacagca ggcatgcgcc tgctcaacct gaccagccca gaggccacag ccagggtgct
      421 tgaggcagtg acacagacgc tcacacagta cccctttgac ttccgtggtg ctcgcatcct
      481 ctcgggacag gatgaagggg tgtttggctg ggtgactgcc aactacctgc tggagaactt
      541 catcaagtat ggctgggtgg gccggtggat acggccaagg aagggaacac tgggggccat
      601 ggaccttggg ggtgcttcga cacagatcac ctttgagaca accagtccct ctgaagatcc
      661 aggcaacgag gttcatttgc gactctatgg ccagcattac cgcgtttaca cacatagctt
      721 cctctgctat ggccgagacc agattctcct gaggcttctg gccagtgccc tccagatcca
      781 tcgcttccac ccctgctggc caaagggcta ctctacccaa gtgctgctcc aggaagtcta
      841 ccagtcgcca tgcacgatgg gtcagcgtcc ccgggccttc aatggcagtg ccatcgtcag
      901 cctgtcagga accagcaatg ctaccctgtg tcgtgacctc gtctctcggc tcttcaacat
      961 ctcctcctgc cccttttccc aatgctcctt caatggggtc ttccagcctc ccgtgactgg
     1021 aaacttcata gccttttctg ctttctacta tactgtggac ttcctgacaa cagtgatggg
     1081 gctgcctgtg ggaaccctga agcagctgga ggaagccaca gagatcacct gcaaccagac
     1141 atggactgaa cttcaggccc gagtgccagg acaaaagacc cgcctggctg actactgtgc
     1201 tgtagccatg ttcatacatc agcttctgag ccgtggttac cacttcgatg agcgctcctt
     1261 cagagaagtg gtcttccaaa agaaggctgc agacacggct gtcggctggg cgctgggcta
     1321 catgctgaat ttcactaacc tgattcctgc cgacctcccc ggactacgca agggcaccca
     1381 cttcagctcc tgggtcgctc tcctgctgct cttcacagtc ctgatcttgg cggcgctggt
     1441 cctgctcctg cgccaggtgc gttctgccaa gtctccaggc gccctctagg ggtgaactgg
     1501 gagcctctcc caactcccta ctatccctcc cttccagagg gcatctctga ccctgaagca
     1561 gcctggaaac caacgttccc tatctacatt cacagaaagc ctacgtgggc agccctgagt
     1621 tctcaattaa tcctcctctc tcttcctagg atgtcaggtc tcagcctgtg actcagggtg
     1681 aggtccattc ggagtgggac ttttgttctg atcttcaggg ccctgggaac tttctgtctg
     1741 ggcctttaga aaggcaggca ccagagccta caggctggga gtcagttcca tgcctacttg
     1801 taaaaacttt tgtaataaaa gatttctcct agagcagcga agtgttccta gggcggggca
     1861 cccttggtcg cctgttctgc cttccaaaaa aaaaaaaaaa
//
