LOCUS       NM_022587               4125 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ectonucleoside triphosphate diphosphohydrolase 1
            (Entpd1), mRNA.
ACCESSION   NM_022587 XM_006231408 XM_346581
VERSION     NM_022587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4125)
  AUTHORS   Beckenkamp,L.R., Iser,I.C., Onzi,G.R., Fontoura,D.M.S.D.,
            Bertoni,A.P.S., Sevigny,J., Lenz,G. and Wink,M.R.
  TITLE     Characterization of soluble CD39 (SolCD39/NTPDase1) from PiggyBac
            nonviral system as a tool to control the nucleotides level
  JOURNAL   Biochem J 476 (11), 1637-1651 (2019)
   PUBMED   31085558
  REMARK    GeneRIF: PiggyBac transposon system proved to be a fast and
            efficient method to generate cells stably expressing SolCD39,
            producing high amounts of the enzyme from a limited number of cells
            and with high hydrolytic activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4125)
  AUTHORS   Cardoso,A.M., Manfredi,L.H., Zanini,D., Bagatini,M.D.,
            Gutierres,J.M., Carvalho,F., Tremblay,A., Bello-Klein,A.,
            Rubin,M.A., Morsch,V.M., Sevigny,J. and Schetinger,M.R.C.
  TITLE     Physical exercise prevents memory impairment in an animal model of
            hypertension through modulation of CD39 and CD73 activities and A2A
            receptor expression
  JOURNAL   J Hypertens 37 (1), 135-143 (2019)
   PUBMED   30507864
  REMARK    GeneRIF: Studied effect of exercise on memory and cerebral cortex
            physiology of NTPDase-1 (CD39), 5' nucleotidase ecto (CD73), and
            adenosine A2a receptor (A2ar).
REFERENCE   3  (bases 1 to 4125)
  AUTHORS   Doleski,P.H., Adefegha,S.A., Cabral,F.L. and Leal,D.B.
  TITLE     Characterization of E-NTPDase (EC 3.6.1.5) activity in hepatic
            lymphocytes: A different activity profile from peripheral
            lymphocytes
  JOURNAL   Cell Biochem Funct 35 (2), 105-112 (2017)
   PUBMED   28217922
  REMARK    GeneRIF: E-NTPDase activity in hepatic lymphocytes differs from its
            activity profile in peripheral lymphocytes.
REFERENCE   4  (bases 1 to 4125)
  AUTHORS   de Azevedo,M.I., Ferreiro,L., Da Silva,A.S., Tonin,A.A.,
            Ruchel,J.B., Rezer,J.F., Franca,R.T., Zimmermann,C.E., Leal,D.B.,
            Duarte,M.M., Lopes,S.T., Flores,M.M., Fighera,R. and Santurio,J.M.
  TITLE     E-NTPDase and E-ADA activities in rats experimental infected by
            Cryptococcus neoformans
  JOURNAL   Vet Microbiol 174 (1-2), 206-213 (2014)
   PUBMED   25278365
  REMARK    GeneRIF: E-NTPDase and E-ADA activities in rats experimental
            infected by Cryptococcus neoformans are involved in the
            pathogenesis of cryptococcosis.
REFERENCE   5  (bases 1 to 4125)
  AUTHORS   Brisevac,D., Bajic,A., Bjelobaba,I., Milosevic,M., Stojiljkovic,M.,
            Beyer,C., Clarner,T., Kipp,M. and Nedeljkovic,N.
  TITLE     Expression of ecto-nucleoside triphosphate diphosphohydrolase1-3
            (NTPDase1-3) by cortical astrocytes after exposure to
            pro-inflammatory factors in vitro
  JOURNAL   J Mol Neurosci 51 (3), 871-879 (2013)
   PUBMED   23990338
REFERENCE   6  (bases 1 to 4125)
  AUTHORS   Wang,T.F. and Guidotti,G.
  TITLE     Widespread expression of ecto-apyrase (CD39) in the central nervous
            system
  JOURNAL   Brain Res 790 (1-2), 318-322 (1998)
   PUBMED   9593967
REFERENCE   7  (bases 1 to 4125)
  AUTHORS   Kegel,B., Braun,N., Heine,P., Maliszewski,C.R. and Zimmermann,H.
  TITLE     An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in
            rat brain
  JOURNAL   Neuropharmacology 36 (9), 1189-1200 (1997)
   PUBMED   9364474
REFERENCE   8  (bases 1 to 4125)
  AUTHORS   Wang,T.F., Rosenberg,P.A. and Guidotti,G.
  TITLE     Characterization of brain ecto-apyrase: evidence for only one
            ecto-apyrase (CD39) gene
  JOURNAL   Brain Res Mol Brain Res 47 (1-2), 295-302 (1997)
   PUBMED   9221928
REFERENCE   9  (bases 1 to 4125)
  AUTHORS   Kaczmarek,E., Koziak,K., Sevigny,J., Siegel,J.B., Anrather,J.,
            Beaudoin,A.R., Bach,F.H. and Robson,S.C.
  TITLE     Identification and characterization of CD39/vascular ATP
            diphosphohydrolase
  JOURNAL   J Biol Chem 271 (51), 33116-33122 (1996)
   PUBMED   8955160
REFERENCE   10 (bases 1 to 4125)
  AUTHORS   Wang,T.F. and Guidotti,G.
  TITLE     CD39 is an ecto-(Ca2+,Mg2+)-apyrase
  JOURNAL   J Biol Chem 271 (17), 9898-9901 (1996)
   PUBMED   8626624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 28, 2015 this sequence version replaced NM_022587.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.5576.1,
                                           SRR26643299.7159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                JAXUCZ010000001.1  249422864-249422940
            78-205              JAXUCZ010000001.1  249471304-249471431
            206-323             JAXUCZ010000001.1  249479056-249479173
            324-474             JAXUCZ010000001.1  249481777-249481927
            475-634             JAXUCZ010000001.1  249483511-249483670
            635-871             JAXUCZ010000001.1  249484564-249484800
            872-1132            JAXUCZ010000001.1  249485792-249486052
            1133-1252           JAXUCZ010000001.1  249491325-249491444
            1253-1390           JAXUCZ010000001.1  249494405-249494542
            1391-4125           JAXUCZ010000001.1  249499000-249501734
FEATURES             Location/Qualifiers
     source          1..4125
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..4125
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /note="ectonucleoside triphosphate diphosphohydrolase 1"
                     /db_xref="GeneID:64519"
                     /db_xref="RGD:69265"
     exon            1..77
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1597
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /EC_number="3.6.1.5"
                     /note="ecto-apyrase; ATPDase; NTPDase 1; lymphoid cell
                     activation antigen; ecto-ATPase 1; ecto-ATPDase 1;
                     ecto-ATP diphosphohydrolase 1; NTPDase1; nucleoside
                     triphosphate diphosphohydrolase 1"
                     /codon_start=1
                     /product="ectonucleoside triphosphate diphosphohydrolase
                     1"
                     /protein_id="NP_072109.2"
                     /db_xref="GeneID:64519"
                     /db_xref="RGD:69265"
                     /translation="MEDIKDSKVKRFCSKNILIILGFSSVLAVIALIAVGLTQNKPLP
                     ENVKYGIVLDAGSSHTNLYIYKWPAEKENDTGVVQQLEECQVKGPGISKYAQKTDEIA
                     AYLAECMKMSTERIPASKQHQTPVYLGATAGMRLLRMESKQSADEVLAAVSRSLKSYP
                     FDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLNFISDSQKQATFGALDLGGAST
                     QITFVPLNSTLEAPETSLQFRLYGTDYTVYTHSFLCYGKDQALWQKLAQDIQVSSGGI
                     LKDPCFYPGYKKVVNVSELYGTPCTKRFEKKLPFNQFQVQGTGDYEQCHQSILKLFNN
                     SHCPYSQCAFNGVFLPPLQGSFGAFSAFYFVMDFFKKMANDSVSSQEKMTEITKNFCS
                     KPWEEVKASYPTVKEKYLSEYCFSGTYILSLLLQGYNFTGTSWDQIHFMGKIKDSNAG
                     WTLGYMLNLTNMIPAEQPLSPPLPHSTYISLMVLFSLVLVAMVITGLFIFSKPSYFWK
                     EAV"
     exon            78..205
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..323
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..474
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..634
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..871
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1132
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1252
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1390
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..4125
                     /gene="Entpd1"
                     /gene_synonym="ATP-DPH; NTPDase-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaaaaacaa aaacacccaa gacaaacgag ggaagaggaa gaaaacaaaa agctgcccct
       61 tatggaagat ataaaggatt ctaaggtgaa gagattttgc tccaaaaata ttctgatcat
      121 ccttggtttc tcctctgtct tggctgtgat agctttgatt gctgtgggac tgacccagaa
      181 caaaccattg ccagaaaatg ttaagtatgg gattgtgctg gatgccgggt cgtctcacac
      241 caacctgtac atctacaagt ggccggctga gaaggagaat gatacaggag tggtgcagca
      301 gttagaagaa tgccaagtga aaggtcccgg aatctcaaaa tacgctcaga aaacagatga
      361 aatagctgca tatctggctg aatgcatgaa aatgtccact gagcggatac cagcgtccaa
      421 acagcaccag acacccgtgt acctgggagc caccgcgggc atgcgcttgc tcagaatgga
      481 aagcaagcaa tcggcagacg aagtcctggc tgcagtgtcg aggagcctga agagctaccc
      541 ctttgacttc cagggcgcca agatcatcac tgggcaggag gaaggggcct atgggtggat
      601 tactattaac tatctgctgg gcagattcac tcaggaacag agttggctaa acttcatctc
      661 agacagccag aaacaggcaa cctttggcgc tttggatctt ggcggagctt ctacacagat
      721 caccttcgtg cccctaaaca gcactctaga ggccccagaa acctccctgc agttccgtct
      781 ctacggcacg gactacaccg tgtacacaca cagcttcctg tgctatggga aggatcaggc
      841 actctggcag aaactggccc aggacattca ggtttcaagt ggtgggattc tcaaggaccc
      901 gtgcttttac ccaggatata agaaggttgt gaatgtaagc gaactctatg gcactccctg
      961 caccaagaga tttgagaaga agctaccgtt taatcagttt caagtccagg gcactggaga
     1021 ctacgaacag tgccaccaga gcatcctcaa gctcttcaac aacagccact gcccttactc
     1081 ccagtgtgcc ttcaacggtg tcttcttacc acctctccag gggagttttg gggcattttc
     1141 tgctttctac tttgtgatgg acttttttaa gaagatggcg aacgacagtg tctcctctca
     1201 ggagaaaatg actgagataa caaaaaactt ttgctcaaag ccttgggagg aggtaaaggc
     1261 atcttatcct acagtaaagg agaagtacct gagtgaatac tgtttctcgg ggacctacat
     1321 cctgtctctc cttctgcaag gctataactt cacgggaacc tcctgggacc agattcattt
     1381 tatgggcaag atcaaagaca gcaacgcagg gtggactttg ggctacatgc tgaacttgac
     1441 caacatgatc ccagctgaac agccattatc cccgcctctc cctcactcca cctacatcag
     1501 cctcatggtt ctcttctccc tggtcttggt cgccatggtc atcacagggc tgttcatctt
     1561 tagcaagcct tcgtatttct ggaaagaggc agtatagcag gagcagttga aacttgctgg
     1621 ctggagagag aaaacagcct gcccagggag tggattcctc cctgcaaggg gggcctgagt
     1681 cacccttccc tgctcacctg ggacagtcta ggccagcgtg aagcttctga agcttcctga
     1741 ggcctttcct tggggacact caacaccctc ttcctcgagg acttcctggt gagcctctct
     1801 tgccttctcc agttaaccct ctttcttttt tgtcccctgt gcttgggatc acaactttca
     1861 tgatctgtgc ttcataaaag aacaatgtca actttgtctc caagaactaa gagttctgag
     1921 tgtcaccctg cccaagctga gctggctgaa aggcgaaact cagaaaccgt ctcagccata
     1981 gctgtgggac accccctcct ccccaggtct cctaataaag ccatgcagtg ccttcggaga
     2041 gaggagacac atacccatcc aagcctgccc tctgcatagg aggattttct gaagcagatg
     2101 agtatgtgct aacgtaagag tcttcgcaga ggcgcatacg tgcagctaat gtggctctcc
     2161 atccactgaa aataagaacg gaagcaagca attgcccgtt cctgcgtgat gccaaaatgc
     2221 taccatgtag aacacgaagg ccagagatct ttgaagagca gatgcgcaca ttggcattca
     2281 ggggatagat tgtgacgata gtatacacaa ctaggaagaa agccacggct accacccagg
     2341 actgggaaaa tatatcctct aatgcatctt ttagagtttt gtggggtttt taatgttaaa
     2401 atacatataa tataaatctc gccacattta cattcagccc agcaccactg aatagaattt
     2461 agtacattta caatgttata cagcagtcac tattttgcct tcagttatgt gtgtatgtgt
     2521 gggtctgtgc acatgagtac agggaacatg gtggccagaa ggcggcatca gtccttcaga
     2581 gctagtgttt taagcaacca gatgtgagct ggccagttgt gggggctgga aatcaacctg
     2641 gggccctctg ctcttaaccg ctgagttaag aggtcaagtt aacctctcag cctctattcc
     2701 actgttactt aacattctat agccaagaag ttggctgggg acaagacata cactggttgt
     2761 ctcaaaccac aaacctgtcc accgatgtcc aaatagactc tgcaacacag agattgctca
     2821 cggggtttga aagccatgcc acatcttatg gtcccgagac tttgtttagt gaggggaggc
     2881 aggcttttgc tctgtgtttg tatttataca tcaggtgttg ctgcttctcc tcaggagtta
     2941 agaaagtgca caccttattt ccccatttga tggagtgttt tgtgggtagt gaataagtga
     3001 ctgtggatgt atgctatggg aatttaaaga gaccttgtga gtattgactc aagaagtaac
     3061 tgtctggcag aatcgagcac tattgtattc ttgcctcaac tcaaactgtc tctctgtctc
     3121 tgatctggag actgactact tagagaggag agtttccagc aagctaaagc taagtgtcct
     3181 gaatctcgtg ggcagtcgag ccatttttcc gttttatgtc tcttctgcta ttcacagctg
     3241 gacacgctgt cgaaatcgct ggggctgcca ttgactgagc atctgtggtc atgctctccg
     3301 tgcttaggcg catggtgtct tctccttctg ttgtcacaga agtcttctga agaaggtggt
     3361 ccttaccgcc cccagtgccc gtggcagagc tgcattcaaa ctcacatctg cctcgagtct
     3421 tctttttctt ttgtttttga tttttgttat tgttcttttc aagacagggt ttccctgtga
     3481 agctctggcc gtcctggaac tcactatata gaccaggctg gcctcaaact cacagagatc
     3541 caccggcctc tgccctgtgc tgaggattaa aggtgtcacc accacatctg gccatttttt
     3601 tttcttttct aaacaccctt ccaccaccac tgctgccaat atgctggaat tcaaaattac
     3661 aagtttcttc agagaacaaa aatattttta attacatatt tatcttgttg cccaagtttt
     3721 taaccaacca accaagcaca acatccaact caatggagac aattaggtgc cacctaatct
     3781 caattccatt agactgaagg ttaatcccgg ggtcatcttt gggtcctctg gatggggcag
     3841 gccaaataaa atgagtcact accaatattt caatgttggg ttgcccactg gttatagtta
     3901 attattactt atctctagac tttcactcag gactcagaat caggttctgc tagccttgtt
     3961 ccttcaaaag ttggtgattt tttttctacg aacccgatca ggcaaccaat cagcagaagt
     4021 ggcttcattt gcatataaaa atgaaacttt gtgtatgcac atggatgtgt aagagagaga
     4081 aatgtttcaa ttcatctaaa taaacgagta agaaatgtaa cgtga
//
