LOCUS       NM_001033974            2296 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus endosulfine alpha (Ensa), transcript variant 1,
            mRNA.
ACCESSION   NM_001033974
VERSION     NM_001033974.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2296)
  AUTHORS   Mehta,R.I., Tsymbalyuk,N., Ivanova,S., Stokum,J.A., Woo,K.,
            Gerzanich,V. and Simard,J.M.
  TITLE     alpha-Endosulfine (ARPP-19e) Expression in a Rat Model of Stroke
  JOURNAL   J Neuropathol Exp Neurol 76 (10), 898-907 (2017)
   PUBMED   28922851
  REMARK    GeneRIF: This study demonstrated that the alphaEnsa levels are
            significantly upregulated in mammalian brain at various times
            following the onset of ischemia/reperfusion. Protein upregulation
            was detected as early as 2 hours after ischemic onset, with
            sustained upregulation noted subsequently over several days
REFERENCE   2  (bases 1 to 2296)
  AUTHORS   Xiao,L., Ma,Z.L., Li,X., Lin,Q.X., Que,H.P. and Liu,S.J.
  TITLE     cDNA microarray analysis of spinal cord injury and regeneration
            related genes in rat
  JOURNAL   Sheng Li Xue Bao 57 (6), 705-713 (2005)
   PUBMED   16344894
REFERENCE   3  (bases 1 to 2296)
  AUTHORS   Yee,J., Cortes,P., Barnes,J.L., Alviani,R., Biederman,J.I. and
            Szamosfalvi,B.
  TITLE     Rat mesangial alpha-endosulfine
  JOURNAL   Kidney Int 65 (5), 1731-1739 (2004)
   PUBMED   15086912
  REMARK    GeneRIF: ENSA and alpha-endosulfine are expressed in glomeruli and
            mesangial cells, and gene and protein expression are up-regulated
            by a high glucose environment.
REFERENCE   4  (bases 1 to 2296)
  AUTHORS   Dou,J., Cui,C., Dufour,F., Alkon,D.L. and Zhao,W.Q.
  TITLE     Gene expression of alpha-endosulfine in the rat brain: correlative
            changes with aging, learning and stress
  JOURNAL   J Neurochem 87 (5), 1086-1100 (2003)
   PUBMED   14622089
  REMARK    GeneRIF: results suggest that alpha-endosulfine gene expression is
            differentially regulated by distinct brain processes involving
            excitatory neuronal activities
REFERENCE   5  (bases 1 to 2296)
  AUTHORS   Gros,L., Breant,B., Duchene,B., Leroy,C., Fauconnier,G.,
            Bataille,D. and Virsolvy,A.
  TITLE     Localization of alpha-endosulphine in pancreatic somatostatin delta
            cells and expression during rat pancreas development
  JOURNAL   Diabetologia 45 (5), 703-710 (2002)
   PUBMED   12107751
  REMARK    GeneRIF: localization in pancreatic somatostatin delta cells and
            expression during rat pancreas development
REFERENCE   6  (bases 1 to 2296)
  AUTHORS   Dulubova,I., Horiuchi,A., Snyder,G.L., Girault,J.A., Czernik,A.J.,
            Shao,L., Ramabhadran,R., Greengard,P. and Nairn,A.C.
  TITLE     ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated
            phosphoproteins
  JOURNAL   J Neurochem 77 (1), 229-238 (2001)
   PUBMED   11279279
REFERENCE   7  (bases 1 to 2296)
  AUTHORS   Heron,L., Virsolvy,A., Peyrollier,K., Gribble,F.M., Le Cam,A.,
            Ashcroft,F.M. and Bataille,D.
  TITLE     Human alpha-endosulfine, a possible regulator of
            sulfonylurea-sensitive KATP channel: molecular cloning, expression
            and biological properties
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8387-8391 (1998)
   PUBMED   9653196
REFERENCE   8  (bases 1 to 2296)
  AUTHORS   Peyrollier,K., Heron,L., Virsolvy-Vergine,A., Le Cam,A. and
            Bataille,D.
  TITLE     Alpha endosulfine is a novel molecule, structurally related to a
            family of phosphoproteins
  JOURNAL   Biochem Biophys Res Commun 223 (3), 583-586 (1996)
   PUBMED   8687439
REFERENCE   9  (bases 1 to 2296)
  AUTHORS   Virsolvy-Vergine,A., Salazar,G., Sillard,R., Denoroy,L., Mutt,V.
            and Bataille,D.
  TITLE     Endosulfine, endogenous ligand for the sulphonylurea receptor:
            isolation from porcine brain and partial structural determination
            of the alpha form
  JOURNAL   Diabetologia 39 (2), 135-141 (1996)
   PUBMED   8635664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059135.1 and JAXUCZ010000002.1.
            
            On Nov 23, 2013 this sequence version replaced NM_001033974.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059135.1, SRR26643296.6732.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1080              BC059135.1         5-1084
            1081-2296           JAXUCZ010000002.1  185878903-185880118
FEATURES             Location/Qualifiers
     source          1..2296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2296
                     /gene="Ensa"
                     /note="endosulfine alpha"
                     /db_xref="GeneID:60334"
                     /db_xref="RGD:62007"
     exon            1..197
                     /gene="Ensa"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..494
                     /gene="Ensa"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-endosulfine; ARPP-19e"
                     /codon_start=1
                     /product="alpha-endosulfine isoform 1"
                     /protein_id="NP_001029146.1"
                     /db_xref="GeneID:60334"
                     /db_xref="RGD:62007"
                     /translation="MSQKQEEENPAEETGEEKQDTQEKEGILPEKAEEAKLKAKYPSL
                     GQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGADKNLVTGDHIPTPQD
                     LPQRKSSLVTSKLAG"
     exon            198..323
                     /gene="Ensa"
                     /inference="alignment:Splign:2.1.0"
     exon            324..2296
                     /gene="Ensa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgggcttga gccgccattt tgactgagca accatagtga cagtagccgg agcagcagct
       61 caggttgtct ccgtttcccc tcccccttcc cttttccggc tgacttcccg ggcccttcac
      121 tgcacagtcc tggtcctgcc atgtcccaga aacaagaaga agaaaaccct gcggaggaaa
      181 ccggcgagga gaagcaggat acacaggaga aagaaggtat tcttcctgag aaagctgagg
      241 aagcaaagct aaaggccaaa tatccaagcc taggacaaaa gcctggaggc tccgacttcc
      301 tcatgaagag actccagaaa gggcaaaagt actttgactc aggagactac aacatggcca
      361 aagccaagat gaagaacaag cagctaccga gtgcaggagc agacaagaac ctggtgaccg
      421 gtgaccacat ccccacccca caggacctgc cccagagaaa gtcctcgctc gtcaccagca
      481 agcttgcggg gtaacctggg cccctctctt ccccttcctc acccactgga cttttatata
      541 ttgtaggcag ggaattggca cctagtcaga gctcagcttg ctgaccaggg aatacatcct
      601 gctgggggct taggctgaag aggggctctg agctcatgtc tttgggtaaa ttgaaactcg
      661 tataccatca agatagccca gtagacaccc aagagtagga aagactagga atgcagagca
      721 ctgcagcttt tcctgtggtg agaaatgtgg aagatgcgaa ttctcctgct ggaggagcaa
      781 gtccttggac aagctgtctt ggagcagtgt gacaggttca gtgtcccaag gctgagttga
      841 catgttggga aaggtggagt gaaggagacg ctctctgtgc ttctaagtgt gttgtccctt
      901 aggcctctgt gctttgtgtt cccatcatgg atgtttaggg aaccttcaaa ggagagggca
      961 tttgcttgcc tgaaactaca gttgcccacc taacccctct gctgtgttcc tgcaacagtt
     1021 gccctgcttc tcaaggaatg taaagtttaa tggacgttag ctactcatga aaaaaaaaaa
     1081 tggtgtattt tttcttccgc atgttgcttt ttgaaagtat tatgggatat ggaaagagtt
     1141 taggagttgg aatacgtggg ctacagttct tgtcccgctc aacagcacta atgtgtgagc
     1201 ttgaccaggt ctgtagcctt tctggattga ttctgttcct catctgtaaa cagaaggaaa
     1261 cacgtacagg ctaattctaa ctctaaagtc ctacgtctgc cattgtcgta ctggtcatca
     1321 taaaaccaaa attgtggcag gcctgtggct gagccttagc tctgtaaagc tagaagtgct
     1381 acatgggacg agagagagtt cagacttaag ggtcatagct tcagacaaca atctcatagg
     1441 tgtcagcttt tttgagaggg aaaaagaaca aaccaaaaag gctggccctg tacatgtctt
     1501 gactctgccc actttcctgg gtctgccatt gaccctagct gctacaaacc tgctctggca
     1561 gcagatggat gggcctgagg agacagcctc actcgctgtg gcctcacact tcagatgtag
     1621 tcagacacta ggtgtatgtt aggcttggag gaagaaggga cgaaggaagc tggtccccag
     1681 agctcagtgc tgctgccagc tggagcagct ggtccttagc agatgattca tggtggaggc
     1741 tggaaggagg gtgcagggag ggaggcagca gcctgtcttg ctgtgtcatc acgagtttgg
     1801 cctggatctt actgagtgcc acctgctcat catcagcaga gagggccaga atgagaactg
     1861 gtcaaaagag caagttggtg cagtctctct ccccttcaca gatcccagtg ttcccttagg
     1921 ttgtctggcg agtctgtgga tgtgtgttag ggaagagaca tgtaaataca ctcttctcct
     1981 ggctggccac tgctcaggtc tctggccatc gttcagatag ggcagacata ggttggtgag
     2041 gaaggagtgg agagcacagg atccccggtc tccctgaccc ccaaactcct tgactctcat
     2101 ttgtaattgt atataatttt tgtgtttttt gctccatttt ctcatgctgt catccttatc
     2161 agaagtccat gtgggagggg acaaagccga acgtcactgt atagtttctt cagtgtccag
     2221 cctgttgtac atagatatgt catgtcatta tatatataaa tatatatata attttgtacg
     2281 ttttcttcat ctccga
//
