LOCUS       NM_001012466            1970 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase
            7 (Enpp7), mRNA.
ACCESSION   NM_001012466 XM_221184
VERSION     NM_001012466.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1970)
  AUTHORS   Gorelik,A., Liu,F., Illes,K. and Nagar,B.
  TITLE     Crystal structure of the human alkaline sphingomyelinase provides
            insights into substrate recognition
  JOURNAL   J Biol Chem 292 (17), 7087-7094 (2017)
   PUBMED   28292932
REFERENCE   2  (bases 1 to 1970)
  AUTHORS   Duan,R.D., Verkade,H.J., Cheng,Y., Havinga,R. and Nilsson,A.
  TITLE     Effects of bile diversion in rats on intestinal sphingomyelinases
            and ceramidase
  JOURNAL   Biochim Biophys Acta 1771 (2), 196-201 (2007)
   PUBMED   17204455
  REMARK    GeneRIF: The presence of bile salts is important for maintaining
            high intraluminal levels of Alk-SMase and N-CDase, two key enzymes
            for hydrolysis of sphingomyelin in the gut.
REFERENCE   3  (bases 1 to 1970)
  AUTHORS   Wu,J., Nilsson,A., Jonsson,B.A., Stenstad,H., Agace,W., Cheng,Y.
            and Duan,R.D.
  TITLE     Intestinal alkaline sphingomyelinase hydrolyses and inactivates
            platelet-activating factor by a phospholipase C activity
  JOURNAL   Biochem J 394 (Pt 1), 299-308 (2006)
   PUBMED   16255717
  REMARK    GeneRIF: Alkaline sphingomyelinase hydrolyses and inactivates PAF
            by a phospholipase C activity, a novel function by which it may
            counteract the development of intestinal inflammation and colon
            cancer.
REFERENCE   4  (bases 1 to 1970)
  AUTHORS   Wu,J., Cheng,Y., Palmberg,C., Bergman,T., Nilsson,A. and Duan,R.D.
  TITLE     Cloning of alkaline sphingomyelinase from rat intestinal mucosa and
            adjusting of the hypothetical protein XP_221184 in GenBank
  JOURNAL   Biochim Biophys Acta 1687 (1-3), 94-102 (2005)
   PUBMED   15708357
  REMARK    GeneRIF: Results describe the cloning of rat alkaline
            sphingomyelinase from rat intestine, comparison to the human
            sequence, adjustment of the putative protein in GenBank, and
            confirmation of the specific expression of the gene in the small
            intestine.
REFERENCE   5  (bases 1 to 1970)
  AUTHORS   Wu,J., Liu,F., Nilsson,A. and Duan,R.D.
  TITLE     Pancreatic trypsin cleaves intestinal alkaline sphingomyelinase
            from mucosa and enhances the sphingomyelinase activity
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 287 (5), G967-G973 (2004)
   PUBMED   15205117
REFERENCE   6  (bases 1 to 1970)
  AUTHORS   Duan,R.D., Bergman,T., Xu,N., Wu,J., Cheng,Y., Duan,J.,
            Nelander,S., Palmberg,C. and Nilsson,A.
  TITLE     Identification of human intestinal alkaline sphingomyelinase as a
            novel ecto-enzyme related to the nucleotide phosphodiesterase
            family
  JOURNAL   J Biol Chem 278 (40), 38528-38536 (2003)
   PUBMED   12885774
REFERENCE   7  (bases 1 to 1970)
  AUTHORS   Duan,R.D., Cheng,Y., Hansen,G., Hertervig,E., Liu,J.J., Syk,I.,
            Sjostrom,H. and Nilsson,A.
  TITLE     Purification, localization, and expression of human intestinal
            alkaline sphingomyelinase
  JOURNAL   J Lipid Res 44 (6), 1241-1250 (2003)
   PUBMED   12671034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1 and AY568760.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001012466.3.
            
            On Mar 9, 2021 this sequence version replaced NM_001012466.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY568760.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132301,
                                           SAMD00155309 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JACYVU010000220.1  61067027-61067139
            114-134             AY568760.1         60-80
            135-304             JACYVU010000220.1  61067164-61067333
            305-319             JACYVU010000220.1  61067636-61067650
            320-352             AY568760.1         266-298
            353-450             JACYVU010000220.1  61067686-61067783
            451-531             JACYVU010000220.1  61069089-61069169
            532-534             AY568760.1         478-480
            535-738             JACYVU010000220.1  61069172-61069375
            739-740             AY568760.1         685-686
            741-835             JACYVU010000220.1  61069379-61069473
            836-919             AY568760.1         782-865
            920-1077            JACYVU010000220.1  61069557-61069714
            1078-1261           JACYVU010000220.1  61070885-61071068
            1262-1267           AY568760.1         1208-1213
            1268-1297           JACYVU010000220.1  61071076-61071105
            1298-1970           JACYVU010000220.1  61071371-61072043
FEATURES             Location/Qualifiers
     source          1..1970
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1970
                     /gene="Enpp7"
                     /gene_synonym="E-NPP 7"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 7"
                     /db_xref="GeneID:303729"
                     /db_xref="RGD:1359324"
     exon            1..304
                     /gene="Enpp7"
                     /gene_synonym="E-NPP 7"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1374
                     /gene="Enpp7"
                     /gene_synonym="E-NPP 7"
                     /EC_number="3.1.4.12"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 7; NPP-7; E-NPP7; alk-SMase; intestinal
                     alkaline sphingomyelinase; alkaline sphingomyelin
                     phosphodiesterase; sphingomyelinase, intestinal alkaline"
                     /codon_start=1
                     /product="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 7 precursor"
                     /protein_id="NP_001012484.2"
                     /db_xref="GeneID:303729"
                     /db_xref="RGD:1359324"
                     /translation="MGHSAVLLSVALVILPACVTGGPVQRQQRHKLLLVSFDGFRWNY
                     DQDVETPNLDSMAQEGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTN
                     KVRLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEG
                     VLHNYKNETEWRANVDTVMKWFTEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQV
                     DRTVGYLRDSIKRHHLTDSLNLIITSDHGMTTVNKKASDLVEFHKFPNFTFRDIEFEL
                     LDYGPNGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKTFHYANNPRITSLLMYSD
                     LGYVIHGRVNVQFNNGEHGFDNQDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCQ
                     LLGIVPEPNDGHPGVLQPMLRSGSPLSRQHHLVVVLMGILTGLAKVV"
     exon            305..450
                     /gene="Enpp7"
                     /gene_synonym="E-NPP 7"
                     /inference="alignment:Splign:2.1.0"
     exon            451..1077
                     /gene="Enpp7"
                     /gene_synonym="E-NPP 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1297
                     /gene="Enpp7"
                     /gene_synonym="E-NPP 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1970
                     /gene="Enpp7"
                     /gene_synonym="E-NPP 7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccactcc tggtccgagc tgtctgtgcc acctgtctgt ctgagagcca ggccatgggg
       61 cactcagctg tcctcctctc tgtggctcta gtcatcctcc cagcttgtgt gactgggggt
      121 cctgtccaaa ggcagcagcg gcataagctt ctccttgtat ccttcgatgg cttccgctgg
      181 aactatgacc aagacgtgga aacccctaac ctggactcca tggctcagga aggagtgaaa
      241 gctcgataca tgactcctgc cttcgtcacc atgaccagcc cctgccactt tacactggtc
      301 accggcaaat acatcgagaa ccatggggtg gtccacaaca tgttctataa caccaccaac
      361 aaggtgaggc tgccctacca tgccacgctc gggatccaga ggtggtggga taatggcagc
      421 atacccatct ggatcacagc ccagaggcag ggcttaaaaa ctggctcctt cttctaccct
      481 ggtgggaacg taacctacca aggagaggcc gtgacgatga gccggaagga aggcgtctta
      541 cacaattaca aaaacgagac agagtggagg gcaaatgtgg acacggtgat gaagtggttc
      601 acggaggagg atgtgtccct ggtcactctc tactttgggg agccagactc cactggccac
      661 aagtatggcc ctgagtccca ggagaggaag gacatggtga aacaggtaga caggacggtg
      721 ggctacctcc gggacagcat caagcgccac cacctcacag acagcctcaa cctgataatc
      781 acctcggacc acggcatgac gaccgtcaac aagaaggcca gcgacctggt cgagttccac
      841 aagttcccca acttcacctt cagggacatt gagttcgaac tcttggacta cgggcccaac
      901 gggatgctga tccccaagga agggatgctg gagaaggtat acagtgtcct caaggatgcc
      961 caccccaggc tgcatgtgta caagaaggag gacttcccga agacctttca ctacgccaac
     1021 aaccccagga tcacatccct gctcatgtac agtgacctcg gctatgtcat tcatgggaga
     1081 gtgaacgtcc agttcaacaa tggtgagcat ggtttcgaca accaagacat ggacatgaag
     1141 accatcttcc gggctgtggg tcccagcttc aaggcaggct tggaagtgga gcccttcgag
     1201 agcgtccatg tgtacgagct catgtgtcag ctgctgggca ttgtgcccga gcccaacgat
     1261 gggcatccag gcgtcctgca acccatgctc cggtcaggat ctccgctcag caggcagcac
     1321 cacttggtgg tggtgttgat ggggatccta acgggtctgg ccaaggtcgt ataatgcccc
     1381 atcacttgac gaagatcgga ggcccagaag gagaggaggc tcaaaggatg aaactgagac
     1441 tgttttcctg cttctcagcc tgaagttcct gccccacagg gcaccctccc agatcctcac
     1501 ccttttccct ctgccacttc acccactccc acctccaact cgggagccag aacatggctt
     1561 ctggattctt caagctggta tctccagcaa gtgtggaagc cagagaagta ctcctaaggt
     1621 ccttccagcg caggcttgga ggacatctct gcagacaggc catcataccc ctgcaacaat
     1681 cacactgctc cccatgcctc cctagccttt acccagagcc acccactcct tcctgctgcc
     1741 atccaattgc cccaggtgca gacctcaaac ttcacagaga actggtttga ggagaactgc
     1801 aaggctagct ggttttggaa tgcaccagga gccagtcatc actctgagga catcccggca
     1861 tgaccgggtg acaagatcag cctggttttg tggtcctgtg ccattacaac ccttggccag
     1921 ggcagaaggt tattgtactc ttctagaaac ataaaacagg agctcactca
//
