LOCUS       NM_001415078            4865 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase
            6 (Enpp6), mRNA.
ACCESSION   NM_001415078 XM_006253156
VERSION     NM_001415078.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4865)
  AUTHORS   Morita,J., Kano,K., Kato,K., Takita,H., Sakagami,H., Yamamoto,Y.,
            Mihara,E., Ueda,H., Sato,T., Tokuyama,H., Arai,H., Asou,H.,
            Takagi,J., Ishitani,R., Nishimasu,H., Nureki,O. and Aoki,J.
  TITLE     Structure and biological function of ENPP6, a choline-specific
            glycerophosphodiester-phosphodiesterase
  JOURNAL   Sci Rep 6, 20995 (2016)
   PUBMED   26888014
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4865)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 4865)
  AUTHORS   Sakagami,H., Aoki,J., Natori,Y., Nishikawa,K., Kakehi,Y., Natori,Y.
            and Arai,H.
  TITLE     Biochemical and molecular characterization of a novel
            choline-specific glycerophosphodiester phosphodiesterase belonging
            to the nucleotide pyrophosphatase/phosphodiesterase family
  JOURNAL   J Biol Chem 280 (24), 23084-23093 (2005)
   PUBMED   15788404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Dec 21, 2022 this sequence version replaced XM_006253156.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.32735.1,
                                           SRR26643429.50568.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               JAXUCZ010000016.1  52026435-52026728   c
            295-474             JAXUCZ010000016.1  51973281-51973460   c
            475-586             JAXUCZ010000016.1  51950128-51950239   c
            587-728             JAXUCZ010000016.1  51929324-51929465   c
            729-908             JAXUCZ010000016.1  51928746-51928925   c
            909-1046            JAXUCZ010000016.1  51925877-51926014   c
            1047-1170           JAXUCZ010000016.1  51906821-51906944   c
            1171-4865           JAXUCZ010000016.1  51898557-51902251   c
FEATURES             Location/Qualifiers
     source          1..4865
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..4865
                     /gene="Enpp6"
                     /gene_synonym="E-NPP 6"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 6"
                     /db_xref="GeneID:306460"
                     /db_xref="RGD:1311645"
     exon            1..294
                     /gene="Enpp6"
                     /gene_synonym="E-NPP 6"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1376
                     /gene="Enpp6"
                     /gene_synonym="E-NPP 6"
                     /EC_number="3.1.4.38"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 6; NPP-6; E-NPP6; ectonucleotide
                     pyrophosphatase/phosphodiesterase family member 6-like;
                     choline-specific glycerophosphodiester phosphodiesterase;
                     GPC-Cpde; glycerophosphocholine cholinephosphodiesterase
                     ENPP6"
                     /codon_start=1
                     /product="glycerophosphocholine cholinephosphodiesterase
                     ENPP6 precursor"
                     /protein_id="NP_001402007.1"
                     /db_xref="GeneID:306460"
                     /db_xref="RGD:1311645"
                     /translation="MAGKLWTFLLLFGFSWVWPASAHRKLLVLLLDGFRSDYISEDAL
                     ASLPGFREIVNRGVKVDYLTPDFPSLSYPNYYTLMTGRHCEVHQMIGNYMWDPRTNKS
                     FDIGVNRDSLMPLWWNGSEPLWITLMKARRKVYMYYWPGCEVEILGVRPTYCLEYKNV
                     PTDINFANAVSDALDSLKSGRADLAAIYHERIDVEGHHYGPSSPQRKDALKAVDTVLK
                     YMTQWIQERGLQNDLNVILFSDHGMTDIFWMDKVIELSKYISLDDLQQVKDQGPVVSL
                     WPVPEKHSEIYHKLRTVEHMTVYEKEAIPNRFYYKKGKFVSPLTLVADEGWFIAESRE
                     ALPFWMNSTGKREGWQHGWHGYDNELMDMRGIFLAFGPDFKSNFRAAPIRSVDVYNIM
                     CNVVGITPLPNNGSWSRVVCMLKSQTSSSPSIPPNSCALVLILLLYFV"
     exon            295..474
                     /gene="Enpp6"
                     /gene_synonym="E-NPP 6"
                     /inference="alignment:Splign:2.1.0"
     exon            475..586
                     /gene="Enpp6"
                     /gene_synonym="E-NPP 6"
                     /inference="alignment:Splign:2.1.0"
     exon            587..728
                     /gene="Enpp6"
                     /gene_synonym="E-NPP 6"
                     /inference="alignment:Splign:2.1.0"
     exon            729..908
                     /gene="Enpp6"
                     /gene_synonym="E-NPP 6"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1046
                     /gene="Enpp6"
                     /gene_synonym="E-NPP 6"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1170
                     /gene="Enpp6"
                     /gene_synonym="E-NPP 6"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..4865
                     /gene="Enpp6"
                     /gene_synonym="E-NPP 6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctttgca agggcacagc tgtgccagct cactccagca gactcctggc agcatggcag
       61 gaaagctctg gaccttcctg ctgctgtttg ggttcagctg ggtttggcca gcttctgccc
      121 accggaagct cctggtgttg ctcctggatg gttttcgctc agactacatc agtgaggatg
      181 ccctggcatc cttgcctggt ttcagagaga tcgtgaacag aggagtcaaa gtggattact
      241 tgactccaga cttccccagc ctctcctatc ccaattacta caccctcatg accggccgcc
      301 actgtgaggt ccaccagatg atcgggaact acatgtggga tcccagaacc aacaagtcat
      361 tcgacatcgg ggtcaaccga gacagcctga tgcccctctg gtggaatggg tcagaaccct
      421 tgtggatcac tctgatgaaa gccaggagga aggtctacat gtactactgg ccaggctgtg
      481 aagttgagat tcttggtgtc agaccaactt attgcctaga atacaaaaat gtcccaacag
      541 acatcaactt tgcgaatgca gttagcgatg ctctcgactc attaaagagt ggccgagcgg
      601 atctagcagc catataccac gaacgcattg atgtagaagg ccatcactat ggcccctcat
      661 cacctcagag aaaagatgct ctcaaagctg tggacactgt cctgaagtat atgacccagt
      721 ggattcagga acgaggcttg cagaatgacc taaacgtcat ccttttctca gaccatggga
      781 tgactgacat cttctggatg gataaagtga ttgagttgag caaatacatc agcctggatg
      841 acctgcagca agtgaaggac caagggcccg ttgtgagcct gtggcccgtc ccagaaaaac
      901 actctgagat atatcacaaa ctccgcaccg tagaacacat gacagtgtat gagaaagaag
      961 caatacccaa caggttctat tacaagaaag ggaaatttgt ctctcctttg accttggtgg
     1021 ctgatgaagg gtggttcata gcagagagtc gagaggcgct tccgttttgg atgaacagca
     1081 ccggcaagcg cgaaggctgg cagcacggat ggcatggata tgacaacgag ctcatggaca
     1141 tgagagggat cttcctggcc ttcggacctg atttcaagtc gaacttcaga gctgctccaa
     1201 tcagatctgt ggatgtctac aacatcatgt gtaatgtcgt aggcatcacc ccactgccca
     1261 acaatgggtc ctggtccagg gtggtatgca tgctgaagag tcaaaccagc tcgtctccat
     1321 ccatcccgcc gaacagttgt gcgctggtct tgattctcct cttatacttt gtatagctcg
     1381 ccatagggct cattccaaag cactcctcca acatggagta gttttcattt tccttatgaa
     1441 taatagctct attaacacaa tcaaggccat taaagttgta aacatattat tcttggatga
     1501 tcctacacac aaatgtctgt ctgttcttat actttgtttt acctaaaatg tataaatttt
     1561 atcctctcat tcaccacaca gttttctgct ctgttcacac attcttactg aagacgaatg
     1621 gtgagagcca cggtcagccc atgcaacagc caaacattaa atggataagc tgcggtcatc
     1681 ctggacccct ctcatcctgc ctcaccctgt gaagcaggct ctctgtgctc tgtccacatc
     1741 taatggctca aacctgggga tctgcagcca ttattttgta tttccttttt tattccagat
     1801 agagactatc tccaggaaag cagtatgtgt tgtctgtttc tgccccaatg cctgatgtgg
     1861 gttttctttt taaaataaca caatcttaga aagcacatag gccagtcgag atcataacca
     1921 attaaagcat caaaaccaat tagacaactc atagaaatgg caggagccac gactcctctc
     1981 aaaatccaag aacagaataa tttccccctt ttattgaacg gcaagtttta aagttctata
     2041 taacttcaca cacactctct catgccataa agcctttcaa accacaggcc ctgaacatta
     2101 acatacacca atcatctgcc tgcctgtgac cactaacttc ctgctgctac tctttagcag
     2161 ggtacatgcc tgatctgtca gtaaaggctt ggaaagaaga acggtctgag taataataat
     2221 aggatcatca gaaatttaac tcattgttag gaatggcaat atatcaaatg caagtttcat
     2281 acttcagtag ttcagaagaa aacttgtata acaagggctg attatatttt taaacaatta
     2341 gaagtgtgcc tacacacaca cacaccccac acacacactt gcacatgaac atacacatgc
     2401 acacatgcat atgccatgta tactcacatg tacacacatg cacagacaca aacatataat
     2461 gcatatatgc ttacacataa acacacactc gtgtgccagc atacacacat actcacagag
     2521 tccgccacat ataacggtta gacttagaat ttttatcttc tttatgacga gaaagcaaga
     2581 cacattcaaa agaatttgaa ttttgaattt ttccattttc tcagcttgct gttatgccat
     2641 gtgacattgt ctcaggaggc tggccagaag cagccacaaa gcgcaactcc caaccagcca
     2701 catgatcctg ggtgtaacca tcaacatctc agagcacatt gtgctgctaa agtatgaggg
     2761 tctgtaggat ggtgcatgaa attcatgttg actgaataat attttcgatt tatgataggt
     2821 ttattggcat gcaaccccat catatgttga ggagattaag aatcctgttg ctttgcattt
     2881 gaaatgagtt agcactaaat gggtcactca aagtgacact aaaagtgaac taaaagttca
     2941 cagaaggagg aagtctttat ttggtgcttg ccctgggggg aatggctctt aatagcccca
     3001 gagtttggta aagacgaagt tgctagtgtc ttgaattatt aaagcaaaag atcactgctt
     3061 aaaaaaattg ctgagtttat cctcacaaaa gatttctaag gatttaggta atgtgtcttt
     3121 aaagctccaa caaaccatgg aatcaactgg gaaggaggca aatcagcctt tgttgtgtgg
     3181 ttgaaagcaa attagtgctt tcagaacact gatagctgct gagacagaca tccattgttc
     3241 aaagttttct tttccctgaa agaatggtgt tttgttgaat tccaggaagc agggttgact
     3301 tcctctttag aagaaggatt tctgagacac attcaaatga ttaaattaaa agctaatcgt
     3361 caacatcacg agggaataag atcggacaca atgttgcatc tttttttttt ttttctggtt
     3421 cttcctttca ctcaccctta ggcagcctta ggttgtacaa caaagcctca ggtatctacc
     3481 taacacagta tagtttctcc caaagtaatg ctcagtagat gaatgagaaa aagataccaa
     3541 aggaatcttg tgtggaggca aataataaaa tttagggtgg gaaaaaaaaa aaggtctttt
     3601 gcctgaaaac aatgtataga ttctgacgac ataaatagtt ggctgtaatt acctcccttt
     3661 tagttttgct ttaaagtcta atttttctcc agttaacatc tcccacccac tattaaccct
     3721 gcatagcctc tgagactcag tgagagacag tatgttcctg gtgccacggc tgtagacttc
     3781 actttctcta aacatggcgt tcagtagaag taagatgttc gaggaatacg aacacacgtg
     3841 cttccttttt aagtttcctg agactttcct gctaatccca ggaggaagat agctgggtgg
     3901 acctaccact gagaaacgaa agggatggtc tttaaattaa agatgacact aagagctcct
     3961 ttctctaccc atgtgcctca tctccaggat ccaatttaat taaattctaa agacctaacc
     4021 ataaactaca aaaggtccag ggaattcttg caagcctaga agggtcttaa attataaagg
     4081 cccagttctc ttcgctttaa aggagacttt ggaaatccat atcaggcccc agttcaacca
     4141 cagagagtac cttgcaaccc ctcccaaagt tgcagaggca gggcctcaga caacacttgt
     4201 aagtcataat aatgaaggtt tgggcttgct ccaaggagaa gtggggtttg cttcaattct
     4261 ggagtatctg aatcctgaga gagctatttc gtaagtagcc agttcttttg gggctcatca
     4321 gctgacattg gccaccgacc aaccccatat ggatcaagcc tccatccctc caacaccaaa
     4381 gaggaggtct caaagctctt aaggaggaag aaacttggag agagagagag agagagagag
     4441 agagagagag agagagagaa ggcaggtagc ttggtttcca aatgccctcc ttgtggctct
     4501 aagagccccg atggtgctat caaaccaact tggaccatgt tcaagaagaa cggctcctct
     4561 ttggtggaat tttctaagtt tccgcgtttg tgtaaatgtc aagagatttc caagtgtgat
     4621 tttcatttta cctttataag caacctgtga tggaccaaag tcagctgcta taaataattc
     4681 actacagaaa aggcgatcat tagccaaggc ccactggcta ttaaaggttt tgaaacttgg
     4741 tttttagttc atactaaaga gagtacgtgt cgcttaaaaa tcataaaatg tcacctagta
     4801 caatgtctta aatgtttata ttttgaatga aaaaaaaaga ataaatgtca acaggaagac
     4861 ttaaa
//
