LOCUS       NM_001106892            4648 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase
            4 (Enpp4), mRNA.
ACCESSION   NM_001106892 XM_001068428 XM_236955
VERSION     NM_001106892.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4648)
  AUTHORS   Albright,R.A., Chang,W.C., Robert,D., Ornstein,D.L., Cao,W.,
            Liu,L., Redick,M.E., Young,J.I., De La Cruz,E.M. and Braddock,D.T.
  TITLE     NPP4 is a procoagulant enzyme on the surface of vascular
            endothelium
  JOURNAL   Blood 120 (22), 4432-4440 (2012)
   PUBMED   22995898
REFERENCE   2  (bases 1 to 4648)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 4648)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            [WARNING] On Jul 30, 2024 this sequence was replaced by
            NM_001106892.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001106892.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643296.23793.1, SRR26360176.1600641.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               JAXUCZ010000009.1  24386571-24386764
            195-1052            JAXUCZ010000009.1  24389822-24390679
            1053-1223           JAXUCZ010000009.1  24391000-24391170
            1224-4648           JAXUCZ010000009.1  24392824-24396248
FEATURES             Location/Qualifiers
     source          1..4648
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..4648
                     /gene="Enpp4"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 4"
                     /db_xref="GeneID:301261"
                     /db_xref="RGD:1308689"
     exon            1..194
                     /gene="Enpp4"
                     /inference="alignment:Splign:2.1.0"
     exon            195..1052
                     /gene="Enpp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1591
                     /gene="Enpp4"
                     /EC_number="3.6.1.29"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 4; bis(5'-adenosyl)-triphosphatase ENPP4"
                     /codon_start=1
                     /product="bis(5'-adenosyl)-triphosphatase ENPP4 precursor"
                     /protein_id="NP_001100362.1"
                     /db_xref="GeneID:301261"
                     /db_xref="RGD:1308689"
                     /translation="MKLLVILSFWGLVAGYRGNSSYSSAPQLLLVSFDGFRADYLNNY
                     DLPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDDVTKKHF
                     SESNDKDPFWWNGAVPIWVTNQLQENRSSAAAMWPGTDVSIHNVTPSYFMNYSSSVPF
                     EERLNNVATWLSSSNPPVTFATLYWEEPDVSGHKYGPEDKFNMRRVLKEVDGLIGDLV
                     QKLKALGLWESLNVIITSDHGMAQCSENRRIYLDTCINHSDYSVIDLTPVAAILPKIN
                     VTEVYNKLKHCNPHMTVYLKEAIPNRFYYQHSDRIQPILLVADEGWTIALNTSSSKLG
                     DHGYDNSLPSMHPFLAAHGPAFRKGYRQSTINTVDIYPMMCYILGLKPHPNNGTFSHS
                     KCLLVDQWCINLPEAIGIVVSALLALTVLTGLIIFMQNRASASRPFSRLQLHEDDDDD
                     PLIE"
     exon            1053..1223
                     /gene="Enpp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..4648
                     /gene="Enpp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctccgcc cgcgtccgcc gagcccacaa gtaccccgga gcgcgcggtt ccgctatcgc
       61 cgagttccgc gcgccggacc gaagtggcgg cggaggcggg tgagtcctga agggaaatgc
      121 cactcccttc ccgagctcgc cgagggcgga gggtagagac tgggagagtt tctggtccct
      181 tctcctcccg cggcgggtcc cagctgctgt gtccaacgtg ttcaatatga agttactagt
      241 aattctttca ttttggggac ttgttgctgg ctacagaggt aactcttcct atagctcggc
      301 acctcagtta cttctggtat cctttgatgg ctttagagct gactacctga acaactatga
      361 ccttcctcac ctccagaact ttatcaaaga aggtgtcttg gtggaacacg ttaaaaatgt
      421 ttttatcaca aaaacatttc caaaccacta cagcattgtg acaggcttat atgaggaaag
      481 ccatggcatt gtggccaact ccatgtatga tgacgtcaca aagaaacatt tttctgaatc
      541 caatgataag gatccgtttt ggtggaatgg ggcagtgcct atttgggtga ccaatcagct
      601 tcaggaaaac agatcaagtg ctgctgctat gtggcctggt actgatgtgt ccattcataa
      661 tgtcacacct tcctatttta tgaattacag cagctcagtg ccctttgagg agagactaaa
      721 taacgttgcc acatggctca gcagttccaa cccaccagtc acctttgcaa cgctctattg
      781 ggaagaaccg gatgtaagcg gccacaaata cgggcctgaa gataaattca acatgcgtcg
      841 ggtattgaaa gaagtagatg gccttattgg tgatcttgtc caaaagctca aggcgttagg
      901 actgtgggaa agtcttaatg tgatcattac aagcgatcat gggatggctc agtgctctga
      961 gaacaggcgg atatatttgg atacctgcat caaccattca gactatagtg tcatagactt
     1021 aacccctgtg gctgcgattc ttcccaaaat aaatgtaaca gaggtttata acaaactgaa
     1081 acactgtaac cctcacatga ctgtttatct caaagaagct atccctaaca gattttacta
     1141 ccaacacagc gatcggattc agcccattct tttggttgct gatgaaggct ggacaatcgc
     1201 actgaacacg tcatcgtcaa aattaggtga ccatggctat gacaattcac tgcccagcat
     1261 gcatccgttt ctcgctgccc atgggcctgc cttcaggaaa ggctacaggc agagcaccat
     1321 caacactgtg gatatttacc caatgatgtg ctacatcctg ggactgaaac cacatcccaa
     1381 caacggaacc ttcagccatt ccaagtgcct gttagtggac cagtggtgca tcaacctccc
     1441 agaagccatt gggattgtcg ttagtgcact attggcatta accgtgctaa caggcctcat
     1501 aatcttcatg cagaacagag cgtctgcatc ccgtccattc tcccgcctac agctgcacga
     1561 agatgatgat gatgatcctt taattgagtg acccactgtg tcttaactca tttctaaact
     1621 aaggatccat gcaaggagtg agtggtatta tagccataaa aaggtatatt tccaaagaca
     1681 agacagacat ggcaaaatct ctctggggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1741 tgtgtgtgtg tgtgtgtgtg tgtgttgtta tgttgcctat gcaaataacc ctgatagtaa
     1801 tagagtcact ggtaaatcag ttcaaaccgc ctgtttccat aacaaatcta gcctttgaga
     1861 gaatactctg agcttgcctg cctgcctgct tcccttcctt cctcccttcc ttcctccctt
     1921 ccttccttct ttccttgctt tcttcttcct tcttcctttc ttccttcttt tcagtgaaat
     1981 atatctttaa gggaaaatat accagaattt aataggcacg cttttctaac atgtttatat
     2041 atttgtaaat gacacaaaac tatttatgta atttgttcat tttgtgtatc ccggagaaaa
     2101 tgttgcatat atttttatat ttgtctttaa tgagtgtgtg tccctagaaa acctttgaag
     2161 taggaaattc tgtgatagtt aataaaactg attagccaca tagcataact atagcataca
     2221 aagaaatcac tttaaataaa gctgctaaga acaaacaaaa cccaaggaag actatgtaat
     2281 ataaagtctg agcttgataa agtccgtaag cgattggcgc ctcagaagtt gagtgtggag
     2341 ctgggcgggg cggtgcacac ctgtaggaag ggtgaggcag aagggcctag aggtggagtc
     2401 cagctcggac tgcatagcaa tactcgagtt ttgtttgttc acttgtttgc tttagttaca
     2461 gttttagata ctattgttaa taaggagttt caaagaaaat agagaaaaaa tgttctctgt
     2521 gtttaactct tctgggtaag ttgtgtgtgc cagtgtgttt gtatgagtgg atgtgcagac
     2581 gccatatgac atgtaaaggg gctgggctct gtgccagaac acagctgtcg ggaacgattc
     2641 tgctcaaggc aaggctactt cttgcagacc ttatgtgcat acttaatatc acaattaaaa
     2701 tattgtattt tttgttacaa ttttcaactc tcacgtttgt tggaagtatc aaatgctgca
     2761 ggaaaaaata tgacccaagt atacagctgc aaggtcagga cttttgtatt gacctttgag
     2821 gctcttgagt gtgccttcca tgcagtcgag tgggaacaca tgtaccgtgg aggttagcgt
     2881 cttccccccg gcagtggccg tgtgctaagg gcggagcact ccagccctgc actgctggct
     2941 tctcacctga ctcctcctaa gcccgagaac caaagagctg ttgtgaagca ctgatatcat
     3001 ccgtcccctc catagcgggg tcctcagaac cggagctatt aggacaacca gcctatgtgg
     3061 tgtccgttaa acggcagacc acagcttcgt gttactggtg tgttctccag cattctgaca
     3121 acgtaaagca aacttggtca ttgctcttca gaggcaagat ggagctacac tgaggatccc
     3181 tgtggacgac acttgtcagt cgtcttagat ttattgcact gctgtggctc actgcaaatt
     3241 tccttaaagt ttggtgtctg gtgcctcatt gttttggggt ttcaagaggc atatctgtac
     3301 ataatctatg ctcctggcca cagaatggct gttttaagaa caggatagga ctggttttgc
     3361 tcataaatgt tctgatctat tttgttacac gcaatcgtga tactaagggg tcaagagttg
     3421 acccagtaaa acagtagaga aactcgtgct tatttcaatt tccatgtaag gaaataacaa
     3481 gtaaactgcc accttcactt tgagagaaaa tgactggagc atttttgaac tgtctcccag
     3541 cagagttgaa gataccttag ttcctacagt ggtgtggatc ccagcgactg ccttacctcg
     3601 actgcacctt atacttggtg tctgcctcta gaatagaagg tttaaaaggg tgggagagga
     3661 agggatgccc tttcagtgtc ttagccctgt gcaacacatg tatttatttt gtattttact
     3721 ctgttctcag aataccaaaa ctaggtaaaa ttttataaag cacttatttg gaagacaaga
     3781 atagtattta tttaatcaaa tagattatca ctgaactttc tgctaataat tctgtttata
     3841 tcttggaaaa aaattatcac tattgcctac agttttgctc tgagaaaagc tttttagtaa
     3901 gggtagcctt tgacgtgggg gtttgggtgt gtgtgttgca aagaattaac tgaacctgct
     3961 ctgctttctg gtcaggagaa aatcatttgg cttcaggaaa tatttagctc ttggtgatag
     4021 tacccaaagg tcagaggaaa gtatttagtc tccttagttt ttgttaattg cactagtcag
     4081 ctcagaactg tgtaccttga ctttctagta gagggccagt tgtgttcctg ttagccacct
     4141 atcatgcatg ttcttctgta aaagcaatgg ggtatagcaa aggcttgctc accgtgctgc
     4201 ccagaggact tcctttttga acccacaagc atagccttgg gatattaaag gatcaaatgc
     4261 ctttgcactg atcttgggca tatccctctc tgcccacctg gtaagcttta aggatggttg
     4321 gctttaattc cttttaggaa gagtggttta tttcatttta aatttataac attataaatg
     4381 aaggacaaag attaggtata aagtatgtat ttatgtcagt tctcaaacag catgtaaata
     4441 ctgtgagtat gctgtaagga aatttgcagt gccttaagtt aaaggaaata cattgtttca
     4501 acttgtagct aacgactttg cttatgattt caatttatgt aaataaagtc tacgcaaaca
     4561 aatacatcag ccttcttaat ttgtcacctt cttatataat gtgcctactg tgaaagctga
     4621 atgttcatga cttgagcaat tctgtaac
//
