LOCUS       NM_019370               2799 bp    mRNA    linear   ROD 28-JUL-2024
DEFINITION  Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase
            3 (Enpp3), mRNA.
ACCESSION   NM_019370 XM_346528
VERSION     NM_019370.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2799)
  AUTHORS   Dohler,C., Zebisch,M., Krinke,D., Robitzki,A. and Strater,N.
  TITLE     Crystallization of ectonucleotide
            phosphodiesterase/pyrophosphatase-3 and orientation of the SMB
            domains in the full-length ectodomain
  JOURNAL   Acta Crystallogr F Struct Biol Commun 74 (Pt 11), 696-703 (2018)
   PUBMED   30387774
  REMARK    GeneRIF: NPP3 crystall structure at 2.77 A resolution reveals that
            the active-site zinc ions are missing and a large part of the
            active site and the surrounding residues are flexible.
REFERENCE   2  (bases 1 to 2799)
  AUTHORS   Gorelik,A., Randriamihaja,A., Illes,K. and Nagar,B.
  TITLE     Structural basis for nucleotide recognition by the ectoenzyme
            CD203c
  JOURNAL   FEBS J 285 (13), 2481-2494 (2018)
   PUBMED   29717535
REFERENCE   3  (bases 1 to 2799)
  AUTHORS   Tsai,S.H., Kinoshita,M., Kusu,T., Kayama,H., Okumura,R., Ikeda,K.,
            Shimada,Y., Takeda,A., Yoshikawa,S., Obata-Ninomiya,K.,
            Kurashima,Y., Sato,S., Umemoto,E., Kiyono,H., Karasuyama,H. and
            Takeda,K.
  TITLE     The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic
            allergic responses by basophils and mast cells
  JOURNAL   Immunity 42 (2), 279-293 (2015)
   PUBMED   25692702
REFERENCE   4  (bases 1 to 2799)
  AUTHORS   Jankowski,M., Piwkowska,A., Rogacka,D., Audzeyenka,I.,
            Janaszak-Jasiecka,A. and Angielski,S.
  TITLE     Expression of membrane-bound NPP-type ecto-phosphodiesterases in
            rat podocytes cultured at normal and high glucose concentrations
  JOURNAL   Biochem Biophys Res Commun 416 (1-2), 64-69 (2011)
   PUBMED   22086174
  REMARK    GeneRIF: ecto-nucleotide pyrophosphatase/phosphodiesterase 1 and 3
            are expressed on podocytes, but changes in expression of these
            enzymes are most likely not involved in etiology of insulin
            resistance in podocytes.
REFERENCE   5  (bases 1 to 2799)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 2799)
  AUTHORS   Meerson,N.R., Bello,V., Delaunay,J.L., Slimane,T.A., Delautier,D.,
            Lenoir,C., Trugnan,G. and Maurice,M.
  TITLE     Intracellular traffic of the ecto-nucleotide
            pyrophosphatase/phosphodiesterase NPP3 to the apical plasma
            membrane of MDCK and Caco-2 cells: apical targeting occurs in the
            absence of N-glycosylation
  JOURNAL   J Cell Sci 113 Pt 23, 4193-4202 (2000)
   PUBMED   11069764
REFERENCE   7  (bases 1 to 2799)
  AUTHORS   Johnson,K., Vaingankar,S., Chen,Y., Moffa,A., Goldring,M.B.,
            Sano,K., Jin-Hua,P., Sali,A., Goding,J. and Terkeltaub,R.
  TITLE     Differential mechanisms of inorganic pyrophosphate production by
            plasma cell membrane glycoprotein-1 and B10 in chondrocytes
  JOURNAL   Arthritis Rheum 42 (9), 1986-1997 (1999)
   PUBMED   10513816
REFERENCE   8  (bases 1 to 2799)
  AUTHORS   Kettenhofen,R., Meyer zu Brickwedde,M.K., KO,Y., Vetter,H. and
            Sachinidis,A.
  TITLE     Identification of a phosphodiesterase I/nucleotide
            pyrophosphatase-related gene mRNA in rat vascular smooth muscle
            cells by the differential display approach
  JOURNAL   J Mol Biol 279 (2), 323-329 (1998)
   PUBMED   9642040
REFERENCE   9  (bases 1 to 2799)
  AUTHORS   Scott,L.J., Delautier,D., Meerson,N.R., Trugnan,G., Goding,J.W. and
            Maurice,M.
  TITLE     Biochemical and molecular identification of distinct forms of
            alkaline phosphodiesterase I expressed on the apical and
            basolateral plasma membrane surfaces of rat hepatocytes
  JOURNAL   Hepatology 25 (4), 995-1002 (1997)
   PUBMED   9096610
REFERENCE   10 (bases 1 to 2799)
  AUTHORS   Deissler,H., Lottspeich,F. and Rajewsky,M.F.
  TITLE     Affinity purification and cDNA cloning of rat neural
            differentiation and tumor cell surface antigen gp130RB13-6 reveals
            relationship to human and murine PC-1
  JOURNAL   J Biol Chem 270 (17), 9849-9855 (1995)
   PUBMED   7730366
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097326.1.
            
            On Dec 11, 2007 this sequence version replaced NM_019370.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097326.1, U78787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2799
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..2799
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 3"
                     /db_xref="GeneID:54410"
                     /db_xref="RGD:708511"
     exon            1..134
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2684
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /EC_number="3.1.4.1"
                     /EC_number="3.6.1.9"
                     /note="RB13-6 antigen; NPPase; phosphodiesterase I beta;
                     phosphodiesterase I/nucleotide pyrophosphatase 3; alkaline
                     phosphodiesterase; ectonucleotide
                     pyrophosphatase/phosphodiesterase family member 3-like;
                     nucleotide diphosphatase; alkaline phosphodiesterase I;
                     dinucleoside polyphosphatase"
                     /codon_start=1
                     /product="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 3"
                     /protein_id="NP_062243.2"
                     /db_xref="GeneID:54410"
                     /db_xref="RGD:708511"
                     /translation="MDSRLALATEEPIKKDSLKRYKILCAVLLALLVIVSLGLGLGLG
                     LRKPEEHIGSCRKKCFDSSHRGLEGCRCDSGCTDRGDCCWDFEDTCVKSTQIWTCNSF
                     RCGETRLEAALCSCADDCLQRKDCCTDYKAVCQGEVPWVTEACASSQEPQCPEGFDQP
                     PVILFSMDGFRAEYLQTWSTLLPNINKLKTCGLHSKYMRAMYPTKTFPNHYTIVTGLY
                     PESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWSGQPIWLTAMYQGLKAASYYWPGSD
                     VAVNGSFPNIYRNYSNSVPYESRIATLLQWLDLPKAERPSFYTIYVEEPDSAGHKSGP
                     VSAGVIKALQLVDDAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFP
                     EINFYMYQGPAPRIRTRNIPQDFFTFNSEEIVRDLSCRKSDQHFKPYLTPDLPKRLHY
                     AKNVRIDKVHLMVDRQWLAYRNKGSSNCEGGTHGYNNEFKSMEAIFLAHGPSFKEKTV
                     IEPFENIEVYNLLCDLLHIQPAPNNGSHGSLNHLLKAPFYQPSHAEELSKSAGCGFTT
                     PLPKDSLNCSCLALQTSGQEEQVNQRLNLSGGEVSATEKTNLPFGRPRVIQKNKDHCL
                     LYHREYVSGFGKAMKMPMWSSYTVPKPGDTSSLPPTVPDCLRADVRVDPSESQKCSFY
                     LADQNIDHGFLYPPAIKGNNESQYDALITSNLVPMYKEFKKMWDYFHKVLLIKYAIER
                     NGVNVVSGPIFDYNYDGHFDAPDEITNYVAGTDVPVPTHYFVVLTSCKNKTHTPDSCP
                     GWLDVLPFVVPHRPTNVESCPENKAEDLWVEERFKAHIARVRDVELLTGLDFYQEKTQ
                     PVSEILQLKTYLPTFETII"
     exon            135..213
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            214..336
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            337..462
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            463..523
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            524..621
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            622..701
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            702..821
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            822..931
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            932..997
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1070
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1179
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1308
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1340
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1468
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1535
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1623
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1802
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1854
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2009
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2145
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2223
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2356
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2513
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2773
                     /gene="Enpp3"
                     /gene_synonym="B10; E-NPP 3; Npp3; PD-Ibeta; RB13-6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggaaagaa agagccttat tttctggcta aacaggttta cacagctaca ggaacaatgg
       61 attccaggct agctttagcc acggaggagc ccattaagaa agacagcctg aagagatata
      121 agatcctttg tgcggttctt cttgctttgc tggtgatcgt gtcgcttgga ttgggcctgg
      181 gcctgggact caggaaacct gaagagcata taggcagctg caggaaaaaa tgctttgatt
      241 cgtcacacag aggactggag ggttgccgct gtgactccgg atgcacagac cggggagact
      301 gctgctggga ctttgaagat acctgtgtga aatcaactca aatctggacg tgtaattcgt
      361 tccgctgtgg ggagaccaga ctagaggcag ccctctgttc ctgtgcggat gactgtctgc
      421 agaggaagga ctgctgcact gactacaagg ctgtgtgcca aggagaagtc ccatgggtga
      481 cagaagcctg tgcctcatcc caggagcccc agtgtccaga agggtttgac cagccaccgg
      541 ttatcttgtt ctccatggac ggctttagag cggagtactt acaaacatgg agcaccctgc
      601 tgccaaacat taacaaactg aaaacatgtg gactccattc caaatatatg agagcaatgt
      661 atcccaccaa aacctttcca aatcattata ccattgtcac gggtttgtat ccagagtcgc
      721 acggcatcat tgacaataac atgtatgatg tgtacctcaa caagaatttt tcactttctt
      781 cagtggagaa aagtaaccct gcctggtgga gtgggcagcc gatttggtta acagcaatgt
      841 atcaaggctt aaaagctgct tcctactact ggccaggatc agatgtggct gtcaatggct
      901 ccttccctaa catctacagg aattacagca attccgtccc atatgaaagt aggattgcta
      961 cactgttgca atggctggac ctgcccaaag ctgaacgacc cagtttttac accatatatg
     1021 tggaagagcc cgattctgcg gggcacaaga gtggaccagt cagtgctgga gtcattaaag
     1081 ccttacagtt agttgatgat gcctttggga tgctgatgga gggtttgaaa cagaggaatt
     1141 tacacaactg tgtcaacata atcgttctgg ctgatcatgg aatggaccag acctcttgtg
     1201 acagagtgga atacatgaca gattattttc ctgaaataaa cttctacatg taccaaggac
     1261 ctgcccctcg aatcaggact cgtaatatac ctcaggactt ctttaccttt aattccgaag
     1321 agattgtcag agacctcagc tgtcgaaaat ccgatcaaca cttcaaaccc tacttgactc
     1381 cggatttgcc gaaacgactg cactatgcca agaacgtcag gattgacaaa gttcatctaa
     1441 tggtggatcg gcaatggctg gcttacagga acaaagggag ttccaactgc gaaggcggaa
     1501 cacacggtta caacaatgaa tttaaaagta tggaggcaat ctttttggca catggaccca
     1561 gctttaaaga gaagactgtt atcgaaccat ttgaaaacat cgaagtctat aatctactgt
     1621 gtgatcttct gcacatccaa ccggcaccaa acaacggttc tcacggtagc ctgaatcatc
     1681 ttctgaaggc accattttac cagccgtcgc atgcagagga attgtcaaag tctgctggct
     1741 gtggttttac tactccattg cctaaggact cactaaactg ctcctgcctc gcactgcaga
     1801 cttctggtca agaagagcaa gtcaaccaaa gactaaatct cagtggagga gaggtctcag
     1861 caacagagaa gacaaatttg ccatttggga ggcccagggt gatacagaag aacaaagacc
     1921 actgtctgct ttaccacagg gaatacgtca gtgggtttgg gaaagctatg aagatgccca
     1981 tgtggagttc atacaccgtt cccaagccgg gagacacatc atctcttcct cccacagttc
     2041 cagactgtct gcgggctgat gtcagggttg atccttcgga gagccaaaaa tgttccttct
     2101 atttagcaga ccagaatatc gaccatggct tcctctatcc tcccgcaatc aaaggaaata
     2161 atgagagtca atatgatgct ttaattacaa gtaatttggt cccaatgtat aaagaattca
     2221 aaaaaatgtg ggactacttc cataaagttc tccttataaa atacgctata gaaagaaatg
     2281 gagtgaatgt ggttagtgga cccatatttg attacaatta tgatggccat tttgatgccc
     2341 ccgatgaaat cacaaactat gtagctggca ccgatgttcc tgtcccgaca cactactttg
     2401 tggtactgac aagctgtaaa aacaaaaccc acacacccga cagctgccct gggtggctgg
     2461 atgtcctgcc ctttgtcgtc cctcaccggc ccaccaacgt ggaaagctgt cctgaaaaca
     2521 aagcagaaga cctttgggtt gaagagagat ttaaagcaca catcgcccgg gtccgtgatg
     2581 tggagctcct cactggcctt gacttttatc aggaaaaaac acagcccgtc tctgaaattt
     2641 tgcagctgaa gacatatttg cccacattcg aaaccattat ttgaatagat gtgtaaagcc
     2701 atttgacaaa atggaaacat tttctgtcaa gaaattataa aataaaattt tctatttttc
     2761 tttaatcctt aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
