LOCUS       NM_057104               3139 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase
            2 (Enpp2), mRNA.
ACCESSION   NM_057104 XM_346799
VERSION     NM_057104.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3139)
  AUTHORS   Ravalli,S., Roggio,F., Magri,B., Lauretta,G., Broggi,G.,
            Caltabiano,R., Vecchio,G.M., Magro,G., Loreto,C., Castorina,A. and
            Musumeci,G.
  TITLE     Immunohistochemical evaluation of autotaxin and lubricin in mild
            osteoarthritic rat model performing moderate physical activity
  JOURNAL   Acta Histochem 124 (6), 151936 (2022)
   PUBMED   35917632
  REMARK    GeneRIF: Immunohistochemical evaluation of autotaxin and lubricin
            in mild osteoarthritic rat model performing moderate physical
            activity.
REFERENCE   2  (bases 1 to 3139)
  AUTHORS   Bai,Y.T., Chang,R., Wang,H., Xiao,F.J., Ge,R.L. and Wang,L.S.
  TITLE     ENPP2 protects cardiomyocytes from erastin-induced ferroptosis
  JOURNAL   Biochem Biophys Res Commun 499 (1), 44-51 (2018)
   PUBMED   29551679
  REMARK    GeneRIF: ENPP2 protects cardiomyocytes from ferroptosis.
REFERENCE   3  (bases 1 to 3139)
  AUTHORS   Meng,G., Tang,X., Yang,Z., Benesch,M.G.K., Marshall,A., Murray,D.,
            Hemmings,D.G., Wuest,F., McMullen,T.P.W. and Brindley,D.N.
  TITLE     Implications for breast cancer treatment from increased autotaxin
            production in adipose tissue after radiotherapy
  JOURNAL   FASEB J 31 (9), 4064-4077 (2017)
   PUBMED   28539367
  REMARK    GeneRIF: The effects of gamma radiation on mRNA levels of autotaxin
            and 14 inflammatory mediators in adipose tissue and the
            consequences for radiation therapy and chemotherapy are discussed.
REFERENCE   4  (bases 1 to 3139)
  AUTHORS   Keune,W.J., Hausmann,J., Bolier,R., Tolenaars,D., Kremer,A.,
            Heidebrecht,T., Joosten,R.P., Sunkara,M., Morris,A.J.,
            Matas-Rico,E., Moolenaar,W.H., Oude Elferink,R.P. and Perrakis,A.
  TITLE     Steroid binding to Autotaxin links bile salts and lysophosphatidic
            acid signalling
  JOURNAL   Nat Commun 7, 11248 (2016)
   PUBMED   27075612
  REMARK    GeneRIF: Data show that bile salts bind autotaxin (ATX) and inhibit
            lysophosphatidic acid (LPA) production.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3139)
  AUTHORS   da Conceicao,R.R., Laureano-Melo,R., Oliveira,K.C., de Carvalho
            Melo,M.C., Kasamatsu,T.S., de Barros Maciel,R.M., de Souza,J.S. and
            Giannocco,G.
  TITLE     Antidepressant behavior in thyroidectomized Wistar rats is induced
            by hippocampal hypothyroidism
  JOURNAL   Physiol Behav 157, 158-164 (2016)
   PUBMED   26861177
  REMARK    GeneRIF: This study demonstrated that reduction of the Enpp2 mRNA
            expression in hippocampus of thyroidectomized Wistar rats.
REFERENCE   6  (bases 1 to 3139)
  AUTHORS   Gijsbers,R., Aoki,J., Arai,H. and Bollen,M.
  TITLE     The hydrolysis of lysophospholipids and nucleotides by autotaxin
            (NPP2) involves a single catalytic site
  JOURNAL   FEBS Lett 538 (1-3), 60-64 (2003)
   PUBMED   12633853
REFERENCE   7  (bases 1 to 3139)
  AUTHORS   Aoki,J., Taira,A., Takanezawa,Y., Kishi,Y., Hama,K., Kishimoto,T.,
            Mizuno,K., Saku,K., Taguchi,R. and Arai,H.
  TITLE     Serum lysophosphatidic acid is produced through diverse
            phospholipase pathways
  JOURNAL   J Biol Chem 277 (50), 48737-48744 (2002)
   PUBMED   12354767
REFERENCE   8  (bases 1 to 3139)
  AUTHORS   Umezu-Goto,M., Kishi,Y., Taira,A., Hama,K., Dohmae,N., Takio,K.,
            Yamori,T., Mills,G.B., Inoue,K., Aoki,J. and Arai,H.
  TITLE     Autotaxin has lysophospholipase D activity leading to tumor cell
            growth and motility by lysophosphatidic acid production
  JOURNAL   J Cell Biol 158 (2), 227-233 (2002)
   PUBMED   12119361
  REMARK    GeneRIF: Autotaxin has lysophospholipase D activity. It suggests
            that autocrine or paracrine production of LPA contributes to tumor
            cell motility, survival, and proliferation
REFERENCE   9  (bases 1 to 3139)
  AUTHORS   Narita,M., Goji,J., Nakamura,H. and Sano,K.
  TITLE     Molecular cloning, expression, and localization of a brain-specific
            phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from
            rat brain
  JOURNAL   J Biol Chem 269 (45), 28235-28242 (1994)
   PUBMED   7961762
REFERENCE   10 (bases 1 to 3139)
  AUTHORS   Stracke,M.L., Krutzsch,H.C., Unsworth,E.J., Arestad,A., Cioce,V.,
            Schiffmann,E. and Liotta,L.A.
  TITLE     Identification, purification, and partial sequence analysis of
            autotaxin, a novel motility-stimulating protein
  JOURNAL   J Biol Chem 267 (4), 2524-2529 (1992)
   PUBMED   1733949
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_057104.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ131564.1, BC081747.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               JAXUCZ010000007.1  88172130-88172247   c
            119-218             JAXUCZ010000007.1  88171807-88171906   c
            219-374             JAXUCZ010000007.1  88161030-88161185   c
            375-500             JAXUCZ010000007.1  88158237-88158362   c
            501-561             JAXUCZ010000007.1  88153241-88153301   c
            562-659             JAXUCZ010000007.1  88150816-88150913   c
            660-739             JAXUCZ010000007.1  88150397-88150476   c
            740-859             JAXUCZ010000007.1  88149188-88149307   c
            860-915             JAXUCZ010000007.1  88140083-88140138   c
            916-981             JAXUCZ010000007.1  88135848-88135913   c
            982-1054            JAXUCZ010000007.1  88135021-88135093   c
            1055-1163           JAXUCZ010000007.1  88128573-88128681   c
            1164-1289           JAXUCZ010000007.1  88123120-88123245   c
            1290-1321           JAXUCZ010000007.1  88119590-88119621   c
            1322-1449           JAXUCZ010000007.1  88118747-88118874   c
            1450-1537           JAXUCZ010000007.1  88116502-88116589   c
            1538-1625           JAXUCZ010000007.1  88116252-88116339   c
            1626-1810           JAXUCZ010000007.1  88114990-88115174   c
            1811-1862           JAXUCZ010000007.1  88112405-88112456   c
            1863-1999           JAXUCZ010000007.1  88101594-88101730   c
            2000-2135           JAXUCZ010000007.1  88100751-88100886   c
            2136-2213           JAXUCZ010000007.1  88099810-88099887   c
            2214-2346           JAXUCZ010000007.1  88099025-88099157   c
            2347-2503           JAXUCZ010000007.1  88097597-88097753   c
            2504-3139           JAXUCZ010000007.1  88092140-88092775   c
FEATURES             Location/Qualifiers
     source          1..3139
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q32"
     gene            1..3139
                     /gene="Enpp2"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 2"
                     /db_xref="GeneID:84050"
                     /db_xref="RGD:69298"
     exon            1..118
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2674
                     /gene="Enpp2"
                     /EC_number="3.1.4.4"
                     /EC_number="3.1.4.39"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 2; E-NPP 2; lysoPLD; extracellular
                     lysophospholipase D; phosphodiesterase I/nucleotide
                     pyrophosphatase 2 (autotaxin)"
                     /codon_start=1
                     /product="autotaxin"
                     /protein_id="NP_476445.2"
                     /db_xref="GeneID:84050"
                     /db_xref="RGD:69298"
                     /translation="MARQGCLGSFQVISLFTFAISVNICLGFTASRIKRAEWDEGPPT
                     VLSDSPWTNTSGSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWEC
                     TKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGF
                     VRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLAT
                     GLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWS
                     VSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKT
                     VGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRI
                     RAKSINNSKYDPKTIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRR
                     WHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIEL
                     YNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQSEFDLGC
                     TCDDKVEPKNKLEELNKRLHTKGSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEI
                     FLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFP
                     PYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDY
                     NYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHR
                     PDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLH
                     TYESEI"
     exon            119..218
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..374
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..500
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            501..561
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..659
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..739
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..859
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..915
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..981
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1054
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1163
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1289
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1321
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1449
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1537
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1625
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1810
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1862
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1999
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2135
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2213
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2346
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2503
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..3139
                     /gene="Enpp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacagcctga actcagagcc ccgagagcag agcattcagg gcaagcagag aacaccctgc
       61 agaggctttc caagaatccc tcggcatggc aagacaaggc tgtctcgggt cattccaggt
      121 aatatccttg ttcacttttg ccatcagtgt caatatctgc ttaggattca cagcaagtcg
      181 aattaagagg gcagaatggg atgaaggacc tcccacagtg ctgtctgact ctccatggac
      241 caacacctct ggatcctgca aaggtagatg ctttgagctt caagaggttg gccctccaga
      301 ctgtcggtgt gacaacctgt gtaagagcta cagcagctgc tgccacgatt tcgatgagct
      361 ctgtttgaaa acagctcgag gctgggagtg caccaaagac agatgtgggg aagtacgaaa
      421 cgaggaaaat gcctgtcact gctcagaaga ctgcttgtcc aggggagact gctgtaccaa
      481 ctaccaagtg gtctgcaaag gagaatcaca ctgggtagat gatgactgcg aagaaatcaa
      541 agttcccgaa tgccctgcag ggtttgtccg ccctccgtta atcatcttct ctgtggatgg
      601 tttccgtgca tcatacatga agaaaggcag caaggttatg cccaacattg agaaactgcg
      661 gtcctgtggc acccatgctc cctacatgag gcctgtgtac cccacaaaaa ccttccctaa
      721 tctatatacg ctggccactg gtttatatcc ggaatcccat ggaattgtcg gtaattcaat
      781 gtatgatcct gtctttgatg cttcgttcca tctacgaggg cgagagaagt ttaatcatag
      841 gtggtgggga ggccaaccgc tatggattac agccaccaag caaggggtga gagctggaac
      901 attcttttgg tctgtgagca tccctcatga acggaggatc ctaaccattc ttcagtggct
      961 ttctctgcca gacaacgaga ggccttcagt ttatgccttc tactcagagc agcctgattt
     1021 ttctggacac aagtacggcc cttttggccc tgagatgaca aatcctctga gggagattga
     1081 caagaccgtg gggcagttaa tggatggact gaaacaactc aggctgcatc gctgtgtgaa
     1141 cgttatcttt gttggagacc atggaatgga agatgtgaca tgtgacagaa ctgagttctt
     1201 gagcaactat ctgactaatg tggatgacat tactttagtg cctggaactc tgggaagaat
     1261 tcgagccaaa tctatcaata attctaaata tgaccctaaa accattattg ctaacctcac
     1321 gtgcaaaaaa ccggatcagc actttaagcc ttacatgaaa cagcaccttc ccaaacggtt
     1381 gcactatgcc aacaacagaa gaattgaaga catccattta ttggtcgatc gaagatggca
     1441 tgttgcaagg aaacctttgg acgtttataa gaaaccatca ggaaaatgtt ttttccaggg
     1501 tgaccacggc tttgataaca aggtcaatag catgcagact gttttcgtag gttatggccc
     1561 aacttttaag tacaggacta aagtgcctcc atttgaaaac attgaacttt acaatgttat
     1621 gtgcgatctc ctaggcttga agcccgctcc caataatgga actcatggaa gcttgaatca
     1681 cctactgcgt acaaatacct ttaggccaac catgccagac gaagtcagcc gacctaacta
     1741 cccagggatt atgtaccttc agtccgagtt tgacctgggc tgcacctgtg acgataaggt
     1801 agagccaaag aacaaattgg aagaactcaa taaacgtctt cataccaaag gatcaacaga
     1861 agagagacat ctcctgtatg gacggcctgc agtgctctat cggactagct atgatatctt
     1921 ataccatacg gactttgaaa gtggttatag tgaaatattc ttaatgcctc tctggacatc
     1981 gtataccatt tctaagcagg ctgaggtctc cagcatccca gaacacctga ccaactgtgt
     2041 tcgtcctgat gtccgtgtgt ctccaggatt cagtcagaac tgtttagctt ataaaaatga
     2101 taaacagatg tcatatggat tcctttttcc tccctacctg agctcctccc cagaagctaa
     2161 gtatgatgca ttcctcgtaa ccaacatggt tccaatgtac cccgccttca aacgtgtttg
     2221 ggcttatttc caaagggttt tggtgaagaa atatgcttca gaaaggaatg gagtcaacgt
     2281 aataagtgga ccgatttttg actacaatta cgatggccta cgtgacactg aagatgaaat
     2341 taaacagtat gtggaaggca gctctatacc tgtccccacc cactactaca gcatcatcac
     2401 cagctgcctg gacttcactc agcctgcaga caagtgtgac ggtcccctct ctgtgtcttc
     2461 cttcatcctt cctcaccgac ccgacaatga tgagagctgt aatagctccg aggatgagtc
     2521 gaagtgggta gaggaactca tgaagatgca cacagctcgg gtgcgggaca ttgagcacct
     2581 cactggtctg gatttctacc ggaagactag ccgtagctat tcggaaattc tgaccctcaa
     2641 gacatacctg catacatatg agagcgagat ttaactttct gggcctgggc agtgtagtct
     2701 tagcaactgg tgtatatttt tatattgtgt ttgtatttat taatttgaaa ccaggacaca
     2761 aacaaagaaa caaacaaata aaaaaaaaaa ccacttagta ttttaatcct gtaccaaatc
     2821 tgacatatta agctgaatga ctgtgctatt ttttttcctc taattcttga tttagacaga
     2881 gttgtgttct gagcagagtt tatagtgaac actgaggctc acaatccaag tagaagctac
     2941 gtggatctac aaggtgctgc aggttgaaaa tttgcattga ggaaatatta gttttccagg
     3001 gcacagtcac cacgtatagt tctgttctgt tttgaaagac tgattttgta aaggtgcatt
     3061 catctgctgt taactttgac agacatattt atgccttata gaccaatctt aaatataata
     3121 aatcacacat tcagatttt
//
