LOCUS       NM_053535               3963 bp    mRNA    linear   ROD 28-JUL-2024
DEFINITION  Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase
            1 (Enpp1), mRNA.
ACCESSION   NM_053535
VERSION     NM_053535.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3963)
  AUTHORS   Suito,H., Fujikawa,K. and Ohsako,M.
  TITLE     ENPP1 downregulation and FGF23 upregulation in growth-related
            calcification of the tibial tuberosity in rats
  JOURNAL   J Anat 244 (2), 333-342 (2024)
   PUBMED   37814911
  REMARK    GeneRIF: ENPP1 downregulation and FGF23 upregulation in
            growth-related calcification of the tibial tuberosity in rats.
REFERENCE   2  (bases 1 to 3963)
  AUTHORS   Kato,K., Nishimasu,H., Oikawa,D., Hirano,S., Hirano,H., Kasuya,G.,
            Ishitani,R., Tokunaga,F. and Nureki,O.
  TITLE     Structural insights into cGAMP degradation by Ecto-nucleotide
            pyrophosphatase phosphodiesterase 1
  JOURNAL   Nat Commun 9 (1), 4424 (2018)
   PUBMED   30356045
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3963)
  AUTHORS   Jin,Y., Cong,Q., Gvozdenovic-Jeremic,J., Hu,J., Zhang,Y.,
            Terkeltaub,R. and Yang,Y.
  TITLE     Enpp1 inhibits ectopic joint calcification and maintains articular
            chondrocytes by repressing hedgehog signaling
  JOURNAL   Development 145 (18) (2018)
   PUBMED   30111653
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3963)
  AUTHORS   Chourabi,M., Liew,M.S., Lim,S., H'mida-Ben Brahim,D.,
            Boussofara,L., Dai,L., Wong,P.M., Foo,J.N., Sriha,B.,
            Robinson,K.S., Denil,S., Common,J.E., Mamai,O., Ben Khalifa,Y.,
            Bollen,M., Liu,J., Denguezli,M., Bonnard,C., Saad,A. and
            Reversade,B.
  TITLE     ENPP1 Mutation Causes Recessive Cole Disease by Altering
            Melanogenesis
  JOURNAL   J Invest Dermatol 138 (2), 291-300 (2018)
   PUBMED   28964717
REFERENCE   5  (bases 1 to 3963)
  AUTHORS   Stella,J., Buers,I., van de Wetering,K., Hohne,W., Rutsch,F. and
            Nitschke,Y.
  TITLE     Effects of Different Variants in the ENPP1 Gene on the Functional
            Properties of Ectonucleotide Pyrophosphatase/Phosphodiesterase
            Family Member 1
  JOURNAL   Hum Mutat 37 (11), 1190-1201 (2016)
   PUBMED   27467858
REFERENCE   6  (bases 1 to 3963)
  AUTHORS   Okawa,A., Nakamura,I., Goto,S., Moriya,H., Nakamura,Y. and
            Ikegawa,S.
  TITLE     Mutation in Npps in a mouse model of ossification of the posterior
            longitudinal ligament of the spine
  JOURNAL   Nat Genet 19 (3), 271-273 (1998)
   PUBMED   9662402
REFERENCE   7  (bases 1 to 3963)
  AUTHORS   Maddux,B.A., Sbraccia,P., Kumakura,S., Sasson,S., Youngren,J.,
            Fisher,A., Spencer,S., Grupe,A., Henzel,W., Stewart,T.A. et al.
  TITLE     Membrane glycoprotein PC-1 and insulin resistance in
            non-insulin-dependent diabetes mellitus
  JOURNAL   Nature 373 (6513), 448-451 (1995)
   PUBMED   7830796
REFERENCE   8  (bases 1 to 3963)
  AUTHORS   Belli,S.I., van Driel,I.R. and Goding,J.W.
  TITLE     Identification and characterization of a soluble form of the plasma
            cell membrane glycoprotein PC-1 (5'-nucleotide phosphodiesterase)
  JOURNAL   Eur J Biochem 217 (1), 421-428 (1993)
   PUBMED   8223581
REFERENCE   9  (bases 1 to 3963)
  AUTHORS   Rebbe,N.F., Tong,B.D., Finley,E.M. and Hickman,S.
  TITLE     Identification of nucleotide pyrophosphatase/alkaline
            phosphodiesterase I activity associated with the mouse plasma cell
            differentiation antigen PC-1
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5192-5196 (1991)
   PUBMED   1647027
REFERENCE   10 (bases 1 to 3963)
  AUTHORS   van Driel,I.R. and Goding,J.W.
  TITLE     Plasma cell membrane glycoprotein PC-1. Primary structure deduced
            from cDNA clones
  JOURNAL   J Biol Chem 262 (10), 4882-4887 (1987)
   PUBMED   3104326
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 3, 2022 this sequence version replaced NM_053535.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3233055.1, AF340186.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000001.1  22518069-22518260
            193-265             JAXUCZ010000001.1  22548077-22548149
            266-382             JAXUCZ010000001.1  22549407-22549523
            383-508             JAXUCZ010000001.1  22550684-22550809
            509-569             JAXUCZ010000001.1  22552052-22552112
            570-667             JAXUCZ010000001.1  22554590-22554687
            668-747             JAXUCZ010000001.1  22556676-22556755
            748-867             JAXUCZ010000001.1  22556899-22557018
            868-977             JAXUCZ010000001.1  22557642-22557751
            978-1043            JAXUCZ010000001.1  22559445-22559510
            1044-1116           JAXUCZ010000001.1  22559836-22559908
            1117-1225           JAXUCZ010000001.1  22562496-22562604
            1226-1357           JAXUCZ010000001.1  22563965-22564096
            1358-1389           JAXUCZ010000001.1  22566078-22566109
            1390-1517           JAXUCZ010000001.1  22566785-22566912
            1518-1587           JAXUCZ010000001.1  22568002-22568071
            1588-1675           JAXUCZ010000001.1  22568966-22569053
            1676-1842           JAXUCZ010000001.1  22569865-22570031
            1843-1894           JAXUCZ010000001.1  22571055-22571106
            1895-2049           JAXUCZ010000001.1  22572563-22572717
            2050-2179           JAXUCZ010000001.1  22574181-22574310
            2180-2260           JAXUCZ010000001.1  22575492-22575572
            2261-2393           JAXUCZ010000001.1  22576358-22576490
            2394-2556           JAXUCZ010000001.1  22578241-22578403
            2557-3963           JAXUCZ010000001.1  22581638-22583044
FEATURES             Location/Qualifiers
     source          1..3963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..3963
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase 1"
                     /db_xref="GeneID:85496"
                     /db_xref="RGD:628825"
     exon            1..192
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..2727
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /EC_number="3.1.4.1"
                     /EC_number="3.6.1.9"
                     /note="E-NPP 1; plasma-cell membrane glycoprotein PC-1;
                     phosphodiesterase I/nucleotide pyrophosphatase 1; NPPase;
                     nucleotide diphosphatase; alkaline phosphodiesterase I"
                     /codon_start=1
                     /product="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 1"
                     /protein_id="NP_445987.2"
                     /db_xref="GeneID:85496"
                     /db_xref="RGD:628825"
                     /translation="MERDGEQAGQGPRHGPAGNGRELESPAAASLLAPMDLGEEPLEK
                     AERARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFSNC
                     RCDAACVSLGNCCLDFQETCVEPTHIWTCNKFRCGEKRLSRFVCSCADDCKAHNDCCI
                     NYSSVCQEKKSWVEEACETIDAPQCPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVIS
                     KLKNCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKE
                     KFNPLWYKGQPIWVTANHQEVRSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILA
                     VLEWLQLPSYERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDL
                     GLDKCLNLILISDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTEVPETYYS
                     FNYEALAKNLSCRETNQHFRPYLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSE
                     RKYCGSGFHGSDNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLGLIPAPN
                     NGSHGSLNHLLKKPIYTPSHPKEESFLSQCPIKSVSSDLGCTCDPSIVPIMDFEKQFN
                     LTTDAVEDVYSMTVPNGRPRNLQKQHRVCLLHQQQFLTGYSLDLLMPLWTSYTFLSND
                     QFSTDDFSNCLYQDLRIPLSPMHKCSYYKSTSKLSYGFLTPPRLNRVSRQIYSEALLT
                     SNIVPMYQSFQVIWQYLHDTVLRRYAQERNGVNVVSGPVFDFDYDGRYDSSEILKQNT
                     RVIRSQENLIPTHFFIVLTSCKQLSESPLKCTALESSAFLLPHRPDNIESCTHGKQES
                     AWVEELLALHRARVTDVELITGLSFYQDRQESVSELLRLKTHLPIFSQED"
     exon            193..265
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..382
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..508
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..569
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..667
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..747
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..867
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..977
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1043
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1116
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1225
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1357
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1389
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1517
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1587
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1675
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1842
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1894
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2049
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2179
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2260
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2393
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2556
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..3963
                     /gene="Enpp1"
                     /gene_synonym="Npps; Pc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcgatgg agcgcgacgg cgaacaggca gggcaagggc cccggcatgg gccagcggga
       61 aacggccgcg agctggagtc tccagccgcc gcttcgctgc tggcgcccat ggacctaggg
      121 gaggagccgc tggagaaggc ggagcgtgcg cgcaccgcca aagaccccaa cacctacaaa
      181 gtgctgtcgc tggttttgtc agtatgcgtg ctaacaacta ttcttggttg tatctttggg
      241 ttgaaaccaa gctgtgccaa agaagtgaaa agttgcaaag gccgctgctt tgaaaggacg
      301 ttcagcaatt gtcgctgcga tgctgcctgt gtcagccttg ggaactgctg tctggatttc
      361 caagagacct gtgtggaacc aacacatata tggacttgca acaagttcag gtgcggcgag
      421 aagaggctgt ccagatttgt gtgctcctgt gcggacgact gcaaagccca caatgactgt
      481 tgcatcaact acagttcagt gtgccaagaa aagaagagtt gggtagaaga agcctgcgaa
      541 accatcgatg caccacagtg tccagcagag tttgaatcac cccctactct cttgttttct
      601 ttggatggat tcagagctga atatttgcac acttggggtg gacttcttcc tgtcattagc
      661 aagctgaaaa actgtggaac gtacactaaa aacatgaggc ctgtgtaccc taccaagacg
      721 tttcccaatc attacagcat cgtcacagga ctttatccag aatcacatgg cataattgac
      781 aacaagatgt atgatcctaa aatgaacgct tctttctcac ttaaaagtaa agagaaattc
      841 aaccctctgt ggtacaaagg acagccgatc tgggtgaccg ctaatcatca ggaggtcagg
      901 tctggcacat acttctggcc aggatcagac gtggaaattg atgggattct gccagatatc
      961 tacaaagtgt ataatgggtc agtaccattt gaagaaagga ttttagctgt tctcgagtgg
     1021 ctacagcttc ctagctatga aagaccacac ttttacactc tgtatttaga agaaccagat
     1081 tcttcagggc attcacacgg accagtaagc agtgaggtca tcaaggccct gcagaaggtt
     1141 gaccacatag ttggcatgct gatggatggc ctgaaggacc tgggcttgga taaatgcctg
     1201 aacctcattc tcatttcaga tcacggcatg gaacaaggca gttgtaagaa gtacgtgtac
     1261 ctgaataagt acctggggga tgtgaacaat gtcaaggttg tgtatggacc tgctgctcga
     1321 ttgagaccca ccgaggttcc ggagacatac tattcgttta actatgaagc ccttgcaaaa
     1381 aatctttctt gccgggaaac aaaccagcac ttccggcctt atctgaaaca cttcttaccc
     1441 aagcgcttac actttgctaa aaatgacagg attgagccac tgaccttcta tctggaccct
     1501 caatggcaac ttgccttgaa tccgtcagaa aggaaatatt gtggaagtgg atttcatggc
     1561 tctgacaacc tgttttcaaa catgcaagct ctcttcattg gctatggacc tgccttcaag
     1621 cacggtgctg aggttgactc ctttgaaaat atcgaggtct ataacttaat gtgtgattta
     1681 ttgggtttga tcccagctcc taataatgga agtcacggca gtctcaacca tcttctaaag
     1741 aaacccattt ataccccaag tcatcccaaa gaagagagct tcctgtccca gtgtccaatc
     1801 aaatcagtgt ccagtgacct cggctgcaca tgtgacccct cgattgtgcc gatcatggac
     1861 ttcgagaagc agttcaatct gaccacggat gctgtagagg atgtttactc tatgactgtg
     1921 cccaacggga ggccccggaa tctgcagaag cagcaccgcg tctgtctgct ccatcagcaa
     1981 cagtttttga ctgggtacag cctggacctc ctcatgcccc tgtggacgtc ttacaccttt
     2041 ctcagtaatg accagttctc cacagatgac ttttccaact gtttgtacca ggaccttcgg
     2101 attcccctta gtcccatgca taaatgttcc tattataaaa gcacttctaa gctcagttat
     2161 gggttcctta caccgccaag actaaacaga gtctcacgtc aaatatattc tgaagccttg
     2221 cttacttcta acatagtgcc aatgtaccag agttttcaag ttatatggca ataccttcat
     2281 gacaccgtac tgcgaaggta tgcccaagaa aggaatggcg tcaatgttgt cagcggcccc
     2341 gtgttcgact ttgattatga tggacggtat gattcctcag agatcctgaa acaaaacacc
     2401 agagtcatcc gcagtcaaga aaatctgatt cccactcact tcttcattgt gcttaccagc
     2461 tgcaagcagc tgtctgagag ccccttaaag tgtacagcct tagagtcttc agccttcctc
     2521 ttgcctcaca ggcctgataa catcgagagc tgtacacatg gaaagcagga gtctgcatgg
     2581 gttgaagagt tgctggcatt gcacagagct cgggtcacag acgttgagct catcacgggt
     2641 ctcagcttct accaggaccg acaggagtca gtttcagaac tgctgaggtt gaaaacacac
     2701 ttaccaatct tcagccaaga agactgattg ttttttatta aaaaaaaaaa aacaaaacac
     2761 catagatctt tttgaaagag tcttatattt tatacagtcc tctacacttt tgcaatgttt
     2821 ggaagctgta aagtggagtt aaaactggga gtcccatgtg gtgctggtgt ctccaggctg
     2881 tgcgacaacc ccacacgtct gtagagtgtt cctgtcctgt gccgtgcaga tttcctgtct
     2941 aagaattaga tgtgttccta atgcgctagg agtaaagaca cttcacctca cacccagaag
     3001 tgctcttggg tctcccttat gggacaaggg gcagtgaaca tggtctgggg acctgatgtt
     3061 ggaatcgtgc tattgttaat aaaactaggt aaaggactgg ggtagctcat gacccattaa
     3121 gaaaaaggga aaactgtctt ggattaattt ttatctagag actgagtttt aattcagtga
     3181 ggtcctattt ctatcttttc tttctcctcc gccaataacc aaatagttgg ccttgtgctt
     3241 ttaaaacaaa ttgtgatcgg atctcttcag gtgtagtgac tttcaaaaat tggactttga
     3301 tggaaaattt gtgagttgag tgtatctagc ttttataaaa aatcagactc tacatttgta
     3361 tacacctgaa caagtgcaca tgtacatgct cttgcacatg cacacacaca cacacacaca
     3421 cacactcaca ctcacacacg tgtacatgtg cacgctctcc caatacgcgt cccagttctc
     3481 ttcactagaa ataaatgaag accaaaaaag agccctgagc atggctttct caggccatta
     3541 aaattaggct tcgtttgggt gaaaccccag agaactattg gcatttacaa agtgacattt
     3601 tttcatcgag aagagtgttt cctcgcacaa gagaccggcc agtggaagaa ggactttacc
     3661 tggcctagct cttcaatttg aagctgtgtc gataagaaga gaatgtgtca cccctcactt
     3721 aacatcttca ctatgcacac aacgaatgac acgctgatgt aatttcccct ctgcattgat
     3781 tctgcccttg ttccaaccgg tgatcctcca gaggctgtgt tacattttag gtttcctggg
     3841 tccattttga tataatatta ccctaccaaa gattttcata tgtccttcct aggataatca
     3901 ttccttttgt catctgtaaa gatgtttagg taataaaact tgcaatcaac attgccatga
     3961 taa
//
