LOCUS       NP_001127977             602 aa            linear   ROD 24-JUN-2024
DEFINITION  enolase 4 [Rattus norvegicus].
ACCESSION   NP_001127977 XP_001073475 XP_214733
VERSION     NP_001127977.1
DBSOURCE    REFSEQ: accession NM_001134505.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 602)
  AUTHORS   Nakamura,N., Dai,Q., Williams,J., Goulding,E.H., Willis,W.D.,
            Brown,P.R. and Eddy,E.M.
  TITLE     Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4)
            gene causes sperm structural defects and male infertility
  JOURNAL   Biol Reprod 88 (4), 90 (2013)
   PUBMED   23446454
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473986.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XP_214733.4, XP_001073475.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..602
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     Protein         1..602
                     /product="enolase 4"
                     /EC_number="4.2.1.11"
                     /note="enolase-like protein ENO4; enolase family member 4"
                     /calculated_mol_wt=66135
     Region          15..78
                     /region_name="DD_ENO4"
                     /note="dimerization/docking (D/D) domain found in enolase
                     4 and similar proteins; cd22974"
                     /db_xref="CDD:438543"
     Site            order(28,32..33,36..37,40..41,44..45)
                     /site_type="other"
                     /note="putative AKAP interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:438543"
     Site            order(32,35..36,39..40,43..44,47..48,50..53,55..56,59,61)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:438543"
     Region          70..565
                     /region_name="enolase_like"
                     /note="Enolase-superfamily, characterized by the presence
                     of an enolate anion intermediate which is generated by
                     abstraction of the alpha-proton of the carboxylate
                     substrate by an active site residue and is stabilized by
                     coordination to the essential Mg2+ ion; cl40480"
                     /db_xref="CDD:477366"
     Site            order(394,439,477)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:238188"
     Site            order(492,543)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:238188"
     CDS             1..602
                     /gene="Eno4"
                     /gene_synonym="RGD1308333"
                     /coded_by="NM_001134505.1:33..1841"
                     /db_xref="GeneID:292138"
                     /db_xref="RGD:1308333"
ORIGIN      
        1 mgeegggrsg gisrdllklk qqamayyqen dvprkleell nstfylqpad vyghlanyfs
       61 klakppsick ivgktildgl glptlqveis ctiqnfpkyi csvaipthse vvenalpemv
      121 dadeaerqqa vskavrwinq fiteelwgli psnqaevdrr lriffehkvq adkdrkeler
      181 sqeepvpmtl pvilpppppp pskkkgqkag rrdtllekpi fppeppepvl hgsmaigavs
      241 lavaktsatl agtplyltla llkhdqeqps tfsmpllmgs vlscgksspg klhlmkevmc
      301 ipspglttkq giellleiqk qvnrametlp ppkpetkkgh nggkrsqppi tgrashlgcl
      361 tinydtieqp llliqgicsn lglelgvnfh laincaghel mdyskgkyev mvgtyksaae
      421 mvelyvdlin kypsiialid pfrkedseqw dslyaavasr cyliagaasr svsrlledrn
      481 isllkyhgli ikhtnqttms dlveithlin gkkhlavfgs tdsessddsl vdlavglgar
      541 fiklgglsrg ermtkynrll aieeeliqsg awedatttta eetlepldsi fptevieesa
      601 kt
//
