LOCUS       NM_012554               1754 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus enolase 1 (Eno1), transcript variant 1, mRNA.
ACCESSION   NM_012554
VERSION     NM_012554.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   Li,L., Luo,Y., Zhang,Y., Wei,M., Zhang,M., Liu,H. and Su,Z.
  TITLE     CircZNF609 aggravates neuropathic pain via miR-22-3p/ENO1 axis in
            CCI rat models
  JOURNAL   Gene 763, 145069 (2020)
   PUBMED   32827683
  REMARK    GeneRIF: CircZNF609 aggravates neuropathic pain via miR-22-3p/ENO1
            axis in CCI rat models.
REFERENCE   2  (bases 1 to 1754)
  AUTHORS   El Waly,B., Mignon-Ravix,C., Cacciagli,P., Buhler,E., Ben Zeev,B.
            and Villard,L.
  TITLE     Molecular characterization of a 1p36 chromosomal duplication and in
            utero interference define ENO1 as a candidate gene for
            polymicrogyria
  JOURNAL   Eur J Hum Genet 28 (12), 1703-1713 (2020)
   PUBMED   32488097
  REMARK    GeneRIF: Molecular characterization of a 1p36 chromosomal
            duplication and in utero interference define ENO1 as a candidate
            gene for polymicrogyria.
REFERENCE   3  (bases 1 to 1754)
  AUTHORS   Zhang,Z.H., Zhang,H., Wang,Y.R., Liu,X.L., Huang,H. and Xu,X.H.
  TITLE     SIRT 1 binding with PKM and NSE and modulate their acetylation and
            activities
  JOURNAL   Biochim Biophys Acta Proteins Proteom 1867 (9), 794-801 (2019)
   PUBMED   31202897
  REMARK    GeneRIF: SIRT1 may regulate acetylation level of NSE and PKM
            through deacetylation and further regulate their catalytic
            activity.
REFERENCE   4  (bases 1 to 1754)
  AUTHORS   Dai,J., Zhou,Q., Chen,J., Rexius-Hall,M.L., Rehman,J. and Zhou,G.
  TITLE     Alpha-enolase regulates the malignant phenotype of pulmonary artery
            smooth muscle cells via the AMPK-Akt pathway
  JOURNAL   Nat Commun 9 (1), 3850 (2018)
   PUBMED   30242159
  REMARK    GeneRIF: regulates the metabolic reprogramming and malignant
            phenotype of pulmonary artery smooth muscle cells in pulmonary
            arterial hypertension
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1754)
  AUTHORS   Huang,H., Tang,S., Ji,M., Tang,Z., Shimada,M., Liu,X., Qi,S.,
            Locasale,J.W., Roeder,R.G., Zhao,Y. and Li,X.
  TITLE     p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis
  JOURNAL   Mol Cell 70 (4), 663-678 (2018)
   PUBMED   29775581
  REMARK    Erratum:[Mol Cell. 2018 Jun 7;70(5):984. Title and abstract
            corrected. PMID: 29883613]
REFERENCE   6  (bases 1 to 1754)
  AUTHORS   Ray,R. and Miller,D.M.
  TITLE     Cloning and characterization of a human c-myc promoter-binding
            protein
  JOURNAL   Mol Cell Biol 11 (4), 2154-2161 (1991)
   PUBMED   2005901
REFERENCE   7  (bases 1 to 1754)
  AUTHORS   Berry,M.N., Gregory,R.B., Grivell,A.R., Henly,D.C., Phillips,J.W.,
            Wallace,P.G. and Welch,G.R.
  TITLE     Evidence that stimulation of gluconeogenesis by fatty acid is
            mediated through thermodynamic mechanisms
  JOURNAL   FEBS Lett 231 (1), 19-24 (1988)
   PUBMED   2966075
REFERENCE   8  (bases 1 to 1754)
  AUTHORS   Giallongo,A., Feo,S., Moore,R., Croce,C.M. and Showe,L.C.
  TITLE     Molecular cloning and nucleotide sequence of a full-length cDNA for
            human alpha enolase
  JOURNAL   Proc Natl Acad Sci U S A 83 (18), 6741-6745 (1986)
   PUBMED   3529090
REFERENCE   9  (bases 1 to 1754)
  AUTHORS   Sakimura,K., Kushiya,E., Obinata,M. and Takahashi,Y.
  TITLE     Molecular cloning and the nucleotide sequence of cDNA to mRNA for
            non-neuronal enolase (alpha alpha enolase) of rat brain and liver
  JOURNAL   Nucleic Acids Res 13 (12), 4365-4378 (1985)
   PUBMED   2989793
REFERENCE   10 (bases 1 to 1754)
  AUTHORS   Jorgensen,O.S. and Centervall,G.
  TITLE     Alpha gamma-enolase in the rat: ontogeny and tissue distribution
  JOURNAL   J Neurochem 39 (2), 537-542 (1982)
   PUBMED   7086434
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB809779.1 and BC091572.1.
            
            [WARNING] On Apr 15, 2024 this sequence was replaced by
            NM_012554.4.
            
            On Jun 6, 2012 this sequence version replaced NM_012554.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ225935.1, BC063174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                CB809779.1         1-30
            31-1754             BC091572.1         1-1724
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1754
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /note="enolase 1"
                     /db_xref="GeneID:24333"
                     /db_xref="RGD:2553"
     exon            1..112
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     exon            113..206
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1426
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /EC_number="4.2.1.11"
                     /note="non-neural enolase; 2-phospho-D-glycerate
                     hydro-lyase; enolase 1, alpha non-neuron; enolase 1,
                     (alpha)"
                     /codon_start=1
                     /product="alpha-enolase"
                     /protein_id="NP_036686.2"
                     /db_xref="GeneID:24333"
                     /db_xref="RGD:2553"
                     /translation="MSILKIHAREIFDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIY
                     EALELRDNDKTRFMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDQLMIEMDGTEN
                     KSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNPEVILPVPAFNVINGGSHAG
                     NKLAMQEFMILPVGASSFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNIL
                     ENKEALELLKSAIAKAGYTDQVVIGMDVAASEFYRAGKYDLDFKSPDDASRYITPDQL
                     ADLYKSFIKDYPVVSIEDPFDQDDWDAWQKFTATAGIQVVGDDLTVTNPKRIAKAAGE
                     KSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQ
                     IKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK"
     exon            207..302
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     exon            303..361
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     exon            362..431
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     exon            432..565
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     exon            566..788
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     exon            789..986
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1188
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1297
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1356
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1731
                     /gene="Eno1"
                     /gene_synonym="Nne"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggcgct tagtgctgct ccggtaccga gtcgcgctca cgtttgtcct taagactccc
       61 ttcggtgtct ccaggaccct ctttccttcc tccgcagcga tcctactgcc agaacttcac
      121 catgtccatt ctcaagatcc atgccagaga gatctttgac tcccgcggga atcccaccgt
      181 tgaggtggat ctctacaccg caaaaggtct cttccgtgct gcggtgccca gcggtgcgtc
      241 cactggcatc tacgaggccc tagaactccg agacaatgat aagacccgct tcatggggaa
      301 gggtgtctca aaggctgttg agcacatcaa taaaactatt gcacctgctc tggttagcaa
      361 gaaactgaat gttgtggagc aggagaagat tgaccagctg atgatcgaga tggacggcac
      421 agagaataaa tctaagtttg gtgcaaatgc catcctggga gtgtccctgg ctgtctgcaa
      481 ggctggtgcc gtggagaagg gggtgcccct ttaccgtcac attgccgact tggccggcaa
      541 ccctgaagtc atcctgccgg tcccagcttt caatgtgatc aacggcggtt ctcatgctgg
      601 caacaagttg gccatgcaag agttcatgat cctgcctgtg ggggcatcct ctttccggga
      661 agccatgcgc attggagcag aggtttacca caacctgaag aacgtcatca aggagaagta
      721 cgggaaagac gccaccaatg tgggtgatga gggtggattc gcacctaaca tcctggagaa
      781 caaagaagca ctggagctgc tcaagtctgc cattgcaaag gccggctaca ctgaccaggt
      841 tgtcatcggc atggatgtgg ctgcctccga gttctacagg gctggcaagt atgacctgga
      901 cttcaagtct ccagatgatg ccagccggta catcacaccc gaccagctgg ccgacctgta
      961 caagtccttc atcaaggact acccagtggt gtccattgaa gatccctttg accaggacga
     1021 ctgggatgct tggcagaagt tcacagctac tgcaggcatc caggtggtgg gggatgacct
     1081 cacagtgacc aaccctaagc ggatcgccaa ggctgcaggc gaaaagtcct gcaactgcct
     1141 cctgctcaaa gtgaaccaga ttggctctgt gaccgagtct ctgcaggcgt gtaagctggc
     1201 ccagtccaat ggctggggtg tcatggtgtc ccatcgatct ggggagactg aggacacttt
     1261 cattgccgac ctggtggtgg ggctctgcac tgggcagatc aagactggtg ccccctgccg
     1321 atctgagcgc ctggccaagt acaatcagat ccttagaatc gaggaggagc tgggcagcaa
     1381 agccaagttt gccggcaggt ccttcaggaa ccccctggcc aagtaaggca tggaccggag
     1441 atccctggag ctaccagatc ctctgtctct gtcatccagg cggctcaagg ctggcccagt
     1501 gcttgcccct cccatgtcac tgcttcctta gatgtccacc ccgaccacct ggagccctgc
     1561 tggagccccc agctttgtaa tcatgtgatc agtctgaatc attgtttctg tcacctgact
     1621 ttccagctag tgtctggagc cctctgaact ccagcgtaat ctctagggtg cccacaccat
     1681 caagactccc cccagtggtt tacttgcaaa aataaaagct gcagaagccc aaaaaaaaaa
     1741 aaaaaaaaaa aaaa
//
