LOCUS       NM_001282336             952 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Rattus norvegicus energy homeostasis associated (Enho), mRNA.
ACCESSION   NM_001282336 XM_003749926 XM_003754007
VERSION     NM_001282336.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 952)
  AUTHORS   Aydin,S., Kilinc,F., Ugur,K., Aydin,M.A., Yalcin,M.H., Kuloglu,T.,
            Kaya Tektemur,N., Albayrak,S., Emre,E., Yardim,M., Akkoc,R.F.,
            Hancer,S., Sahin,I., Cinar,V., Akbulut,T., Demircan,S., Evren,B.,
            Gencer,B.T., Aksoy,A., Yilmaz Bozoglan,M., Aydemir,I. and Aydin,S.
  TITLE     Effects of irisin and exercise on adropin and betatrophin in a new
            metabolic syndrome model
  JOURNAL   Biotech Histochem 99 (1), 21-32 (2024)
   PUBMED   37933453
  REMARK    GeneRIF: Effects of irisin and exercise on adropin and betatrophin
            in a new metabolic syndrome model.
REFERENCE   2  (bases 1 to 952)
  AUTHORS   Ali,I.I., D'Souza,C., Tariq,S. and Adeghate,E.A.
  TITLE     Adropin Is Expressed in Pancreatic Islet Cells and Reduces Glucagon
            Release in Diabetes Mellitus
  JOURNAL   Int J Mol Sci 25 (18), 9824 (2024)
   PUBMED   39337311
  REMARK    GeneRIF: Adropin Is Expressed in Pancreatic Islet Cells and Reduces
            Glucagon Release in Diabetes Mellitus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 952)
  AUTHORS   Parlak,H., Ozkan,A., Sinen,O., Bulbul,M., Aslan,M.A. and Agar,A.
  TITLE     Adropin increases with swimming exercise and exerts a protective
            effect on the brain of aged rats
  JOURNAL   Exp Gerontol 169, 111972 (2022)
   PUBMED   36216130
  REMARK    GeneRIF: Adropin increases with swimming exercise and exerts a
            protective effect on the brain of aged rats.
REFERENCE   4  (bases 1 to 952)
  AUTHORS   Mogulkoc,R., Dasdelen,D., Baltaci,S.B., Baltaci,A.K. and
            Sivrikaya,A.
  TITLE     The effect of thyroid dysfunction and treatment on adropin,
            asprosin and preptin levels in rats
  JOURNAL   Horm Mol Biol Clin Investig 42 (1), 37-42 (2020)
   PUBMED   33781005
  REMARK    GeneRIF: The effect of thyroid dysfunction and treatment on
            adropin, asprosin and preptin levels in rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 952)
  AUTHORS   Jasaszwili,M., Wojciechowicz,T., Strowski,M.Z., Nowak,K.W. and
            Skrzypski,M.
  TITLE     Adropin stimulates proliferation but suppresses differentiation in
            rat primary brown preadipocytes
  JOURNAL   Arch Biochem Biophys 692, 108536 (2020)
   PUBMED   32798458
  REMARK    GeneRIF: Adropin stimulates proliferation but suppresses
            differentiation in rat primary brown preadipocytes.
REFERENCE   6  (bases 1 to 952)
  AUTHORS   Wong,C.M., Wang,Y., Lee,J.T., Huang,Z., Wu,D., Xu,A. and Lam,K.S.
  TITLE     Adropin is a brain membrane-bound protein regulating physical
            activity via the NB-3/Notch signaling pathway in mice
  JOURNAL   J Biol Chem 289 (37), 25976-25986 (2014)
   PUBMED   25074942
REFERENCE   7  (bases 1 to 952)
  AUTHORS   Aydin,S., Kuloglu,T., Aydin,S., Kalayci,M., Yilmaz,M., Cakmak,T.
            and Eren,M.N.
  TITLE     Elevated adropin: a candidate diagnostic marker for myocardial
            infarction in conjunction with troponin-I
  JOURNAL   Peptides 58, 91-97 (2014)
   PUBMED   24932661
  REMARK    GeneRIF: The findings elucidate the pathogenesis of MI, and the
            gradual increase in serum adropin could be a novel diagnostic
            marker and serve as an alternative to troponin-I measurement for
            diagnosing MI.
REFERENCE   8  (bases 1 to 952)
  AUTHORS   Aydin,S., Kuloglu,T., Aydin,S., Eren,M.N., Yilmaz,M., Kalayci,M.,
            Sahin,I., Kocaman,N., Citil,C. and Kendir,Y.
  TITLE     Expression of adropin in rat brain, cerebellum, kidneys, heart,
            liver, and pancreas in streptozotocin-induced diabetes
  JOURNAL   Mol Cell Biochem 380 (1-2), 73-81 (2013)
   PUBMED   23620340
  REMARK    GeneRIF: Data show that adropin (ADR) is expressed in various
            tissues in the rats and its levels increased in STZ-induced
            diabetes.
REFERENCE   9  (bases 1 to 952)
  AUTHORS   Ganesh Kumar,K., Zhang,J., Gao,S., Rossi,J., McGuinness,O.P.,
            Halem,H.H., Culler,M.D., Mynatt,R.L. and Butler,A.A.
  TITLE     Adropin deficiency is associated with increased adiposity and
            insulin resistance
  JOURNAL   Obesity (Silver Spring) 20 (7), 1394-1402 (2012)
   PUBMED   22318315
REFERENCE   10 (bases 1 to 952)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Aug 30, 2013 this sequence version replaced
            XM_003749926.1, XM_003754007.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV779288.1, SRR26360194.1120505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840109
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000005.1  61598509-61598657   c
            150-952             JAXUCZ010000005.1  61596860-61597662   c
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..952
                     /gene="Enho"
                     /gene_synonym="RGD1565232"
                     /note="energy homeostasis associated"
                     /db_xref="GeneID:100912292"
                     /db_xref="RGD:6487582"
     exon            1..149
                     /gene="Enho"
                     /gene_synonym="RGD1565232"
                     /inference="alignment:Splign:2.1.0"
     exon            150..952
                     /gene="Enho"
                     /gene_synonym="RGD1565232"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..539
                     /gene="Enho"
                     /gene_synonym="RGD1565232"
                     /note="adropin-like"
                     /codon_start=1
                     /product="adropin"
                     /protein_id="NP_001269265.1"
                     /db_xref="GeneID:100912292"
                     /db_xref="RGD:6487582"
                     /translation="MGAAISQGALIAIVCNGLVGFLLLLLWVILCWACHSRSADVDSL
                     SESSPNSSPGPCPEKAPPPQKPSHEGSYLLQP"
ORIGIN      
        1 ctgcgcggcc cagggggagg gcccggggag tggacgtcgc ccctgcccgc ctcccgccgc
       61 cccccgcccg caggctctcg agcctcagtc ggcgctgagc atcccgctgt cccggaccct
      121 cccgcgggcg cgcaccgggc tcaactcagg ctcaggactg caggtggcca tcttcactgc
      181 ccagaagtcg ttgtgtgtgg acaggacagc ctccttggaa agtcggccac accagagttg
      241 tgcctcggca tgggccttgc cactgaggca gctccgctgt ctgcgctggc ctgagggcgc
      301 tgcctgtcat gggggcagcc atctcccagg gggctctcat tgccatagtc tgcaatggcc
      361 tggtaggctt cctgctgctg ctgctctggg tcattctctg ctgggcctgc cactctcgct
      421 ctgctgacgt cgactctctc tcagaatcca gtcccaactc cagccctggc ccctgtcctg
      481 agaaggcgcc gccgccccag aagccaagcc atgaaggcag ctacctgctg cagccctgaa
      541 ggcccctggc ctggcctgga gtcctggacc tgagaatacc tgagtcagag cctggaatcg
      601 atccctgcat tcagtctgcc tggggtccag aatttagatc cagttggttt gaagctggac
      661 ccagcagcct agagtgtaac cagcctggct ccaagagagg cctgagtagc cctggagaga
      721 tgggcctgga gtggggggtt aggagttggt gctagggcca ggaccgtctg gactctgctt
      781 catcccaagg gccaagggct gagttcacac ctttcctagg ctcagcacct ctgggctcgc
      841 ttggctgggg aagcaaaccg aagctcatgg cagtaacagg agggcgtcca ggctgggccc
      901 cttctctggc cctcccactg tttgctggag aataaatgga acgatggctg ac
//
