LOCUS       NM_001107070            3977 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus endo-beta-N-acetylglucosaminidase (Engase), mRNA.
ACCESSION   NM_001107070 XM_001081774 XM_221141
VERSION     NM_001107070.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3977)
  AUTHORS   Huang C, Harada Y, Hosomi A, Masahara-Negishi Y, Seino J, Fujihira
            H, Funakoshi Y, Suzuki T, Dohmae N and Suzuki T.
  TITLE     Endo-beta-N-acetylglucosaminidase forms N-GlcNAc protein aggregates
            during ER-associated degradation in Ngly1-defective cells
  JOURNAL   Proc Natl Acad Sci U S A 112 (5), 1398-1403 (2015)
   PUBMED   25605922
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221141.4, XM_001081774.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3977
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..3977
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /note="endo-beta-N-acetylglucosaminidase"
                     /db_xref="GeneID:303702"
                     /db_xref="RGD:1310868"
     exon            1..270
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2356
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /EC_number="3.2.1.96"
                     /codon_start=1
                     /product="cytosolic endo-beta-N-acetylglucosaminidase"
                     /protein_id="NP_001100540.1"
                     /db_xref="GeneID:303702"
                     /db_xref="RGD:1310868"
                     /translation="METSSVLTRGASRQRGSTAPEKQAQDQPERRRRRQGRRINKDQE
                     EEAVFRDVVNFAPDPLPARYYDKDTTRPISFYLSTLEELLAWTPLMEDGFNVALEPLE
                     CRQPPLSSPRPRTLLCHDMMGGYLEDRFIQGSEVQNPYSFYHWQYIDIFVYFSHHTVT
                     IPPVCWTNAAHRHGVCVLGTFITEWQEGGKLCEAFLAGDERSFQAVADRLVQIAQFFR
                     FDGWLINIENSLSPAAVRNTPLFLQYLTRQLHQQVPGGLVLWYDSVVQSGQLKWQDEL
                     NEQNRVFFDSCDGFFTNYNWREDHLKRMVAQAGERLADVYVGIDVFARSNVVGGRFDT
                     DKSLELIRKHGFSAALFAPGWVYECLEKNDFFQNQDKFWRLLERFLPTHSICSLPFVT
                     SFCLGLGTRRVCYGKEQAVGPWYHPSAQETQPLFGEHKLAGGNRGWVKTHCCLVDAWH
                     GGSSLLLRGLIPPEVDSVAVRLFSMHVPVPPKVFLSMVYKFEGSTDVQVALELTTGDA
                     SSCHVGGVLVLNETGTRYSPRPLRVPPTRLARWASSCGQQLSGGWIQRCYEVNLRGCL
                     LQDLLVSFSRPPGSREEESFICRLGEIQVVDANSLLAPLPRVQNVTISQLRWLPLISG
                     SEGLPTRLLLSCTLHWSYLLPRARCFRIHCWERTGSSSATEESPGTEKPEFLGLAFAN
                     QYRVVDLAVEAARFGQDGRVEFLVEPVPREGFLVPQAEWGRAVLLYSAPQ"
     exon            271..341
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            342..543
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            544..692
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            693..850
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            851..999
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1165
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1269
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1378
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1569
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1718
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1824
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1939
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..3977
                     /gene="Engase"
                     /gene_synonym="RGD1310868"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaccaggt caacagccgg aactcggtgt gagccaaccg cggcgctgca cactctgcat
       61 tggctgagag ctgaggcagg ggcaggccca ggcttgcgat tggctgttgc agcagggtgt
      121 ctggagggct tagcggtcgg cgggccctac catagtcatg gagacctcgt cggtgctcac
      181 ccggggggct tcacggcagc ggggctccac ggccccggag aagcaggcgc aggaccagcc
      241 agagcggagg cggaggaggc aggggcggag gatcaacaag gatcaagagg aggaagctgt
      301 cttcagagat gtggtcaatt ttgctccgga tcctttacca gctagatatt atgacaagga
      361 tactaccaga cctatcagct tttacctatc aacgctggag gagctcctgg cctggacccc
      421 cctcatggaa gatggcttca atgtagccct ggaacccctg gagtgtcgcc agcccccact
      481 gagcagcccc aggccccgga ccctgctgtg ccatgacatg atgggcgggt acctggagga
      541 caggttcatc cagggctcag aggtgcagaa tccttactcc ttctaccact ggcagtacat
      601 cgacatcttt gtgtacttca gccatcacac ggtcaccatc ccaccagtgt gctggaccaa
      661 cgccgcccac aggcacgggg tgtgtgtgct ggggaccttt atcacagagt ggcaagaggg
      721 aggcaaactc tgtgaagcct tcctggccgg ggatgagcgc tccttccagg cagtggccga
      781 tcggctggtc cagattgctc agtttttccg ttttgacggc tggctcatca acattgagaa
      841 ctccctgagc ccagctgccg tgaggaacac acctctgttt ctccagtacc tgaccagaca
      901 gctccatcag caggtccccg gaggtctggt gctgtggtat gacagtgtgg tacagagcgg
      961 acagctcaag tggcaggatg aactgaacga acagaacagg gtcttcttcg actcctgtga
     1021 tggcttcttt accaactata actggcggga ggaccacctg aagaggatgg tggcgcaggc
     1081 cggggagcgc ctggctgacg tgtacgtggg catagatgtg tttgctcgga gcaatgtggt
     1141 cggaggccgt tttgatactg acaagtcact ggagctgatc cgtaagcatg gcttctcagc
     1201 ggccctgttt gctccggggt gggtgtatga gtgtctggag aagaacgact tctttcagaa
     1261 ccaggacaag ttctggagac tgctggagcg cttcctgccc acacacagta tctgttccct
     1321 cccctttgtc acttctttct gcctgggcct gggtactcga agagtctgct atggcaagga
     1381 gcaggcagtg gggccctggt accaccctag tgcccaggag acacagcccc tctttggtga
     1441 acataagctg gctggtggca atcggggctg ggtgaagaca cactgctgcc tggttgacgc
     1501 ctggcacggg ggcagctctc tgctgctccg gggcctgatc ccgcctgagg ttgacagtgt
     1561 agctgtgagg ctgttctcta tgcacgtccc agtgcctccc aaggttttcc tgtccatggt
     1621 gtacaagttt gaaggctcaa cggatgtcca ggtggctttg gagctcacga caggggatgc
     1681 cagcagctgc catgtgggcg gtgtgttggt gttaaatgaa actggcacac ggtacagccc
     1741 cagacccctc cgggtacccc caaccaggtt ggccagatgg gccagcagtt gtggccagca
     1801 gctcagtggg ggctggattc aacgctgcta tgaggtaaac cttcgtgggt gcctgctcca
     1861 ggacctcttg gtgagcttct cacggccacc aggcagccgg gaggaggaga gcttcatctg
     1921 tcgtcttgga gagatccagg tggttgatgc caacagcctt ctggcccctt tgccccgggt
     1981 gcagaatgtc accatttcac agctacgctg gcttcctctg atctctgggt ctgagggcct
     2041 ccctacccgg ctcctcctca gctgtaccct gcactggtcc tacctgctgc cccgagcccg
     2101 ctgcttccgg attcactgct gggaacggac aggaagcagc tctgcaacag aggaatcccc
     2161 agggacagag aagcccgagt tcctgggcct ggcttttgcc aaccagtacc gcgtggtgga
     2221 cttggcagtg gaggctgcta gatttgggca ggacggtcgt gtggagttcc tggtggagcc
     2281 tgtccccagg gagggtttcc tagtgcctca ggctgagtgg ggaagggcag tactgctcta
     2341 ctcggcccct cagtgagccc actccagagc acagaacctc cttgctcaag gcttgaggtc
     2401 tctccttggc cagcttccca agcttgagtg gatggctgag gatagctgga tccccaggag
     2461 acaaggtctc caggttctgg ctgtgatctc aggaagctct ggcccatggg tactaggtga
     2521 gtcacctagc acccacatcc tcctgtaatg ctctccgtgg gatgtggttc tcaaggaaga
     2581 aggagagagt ttgaggttcc ttccagaaaa ttctataaag actgtttctc ctaggctgaa
     2641 aagatgcttc tgttgagaac ggcggccatt aatccccata gctttgacaa tcagaggcaa
     2701 actgcactgg tggcagtaag gcttcttgaa gactgaagca acagtcaggg taggagtggg
     2761 agtcaggggt gctcacaggg tagctggagt ggtgctcccc aggaccagga gcaccatcag
     2821 gtggctactg gcaccacacc cccacctgta caagatgggc cagtcacatt tcggactgtc
     2881 tggatggtgg ctctggcagc tgactgtccc agggaacccc acgtccctca cctgtgcagt
     2941 ataggccgtt ggctatgtga aggcacagag ggtgccagca tctttttatg tcatccaaga
     3001 ggcagggctt gagccctgcc tccctgcaag cggtggcatc cttagcttta ccaaagccct
     3061 gtagatgaca ctaggctgca ccggaacttc ctgctgcgcg tctgtgtctc gggtgatgcc
     3121 accagcactt tcctgctgct tctcctagtg ttcaggacct ctcacatctt ttctgtgtta
     3181 agaatgtgac ccgctttttg tctgtggtct gacctgtggc cctcatgctg tagtatgggg
     3241 agaggccaca agatggcaga gtggcctttg ccatcttctg aggtataggg gttggatggg
     3301 tggggcttcc tcagattcct gagtgtgagg caagggagag cagctccagc ctgtatgggc
     3361 tgagcgctcc tccccccacc caccatcttc cctgcttccc tgggcaccct gttcttccgg
     3421 agtgaagtgt aagggtgaga ctgggaacat tctgccctgt ttctcatgtg gtcctaccag
     3481 ggcctctggt aaagcctagg ctactcctgt accccagctc tgggatgggg gagaggccct
     3541 ggggccgtgc tggccttcct ctggcttgtc gtccagaatc tgccccaccc caccccgggg
     3601 gccttggctc tcccactccc agccagggtt ctgtgtggct ggagtggagt cagtggggag
     3661 cagggcagcg ctcctgaatg ctctccttcc ccgtggcacc gagtctgctt ttaaaagtgc
     3721 tggttccttc aaatatttta tgcagagaag gagagaaaat ttatagtggc aattattccc
     3781 tcacagtctg gcaagcaagc aattagaagt aagggggctt agcagagcca cagcgtgagg
     3841 cagagcagcg caacctcact tcccaggagc atggtcccca gtcccagcaa cgctggctcc
     3901 tgcgcaggaa aattaatctg ccggcattta agcctcggcc cctctggtgg atataatcgc
     3961 tcggaaataa attatcc
//
